4AQL
HUMAN GUANINE DEAMINASE IN COMPLEX WITH VALACYCLOVIR
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000255 | biological_process | allantoin metabolic process |
| A | 0005829 | cellular_component | cytosol |
| A | 0006139 | biological_process | nucleobase-containing compound metabolic process |
| A | 0006147 | biological_process | guanine catabolic process |
| A | 0006161 | biological_process | deoxyguanosine catabolic process |
| A | 0007399 | biological_process | nervous system development |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0008892 | molecular_function | guanine deaminase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0016810 | molecular_function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds |
| A | 0043605 | biological_process | amide catabolic process |
| A | 0046038 | biological_process | GMP catabolic process |
| A | 0046055 | biological_process | dGMP catabolic process |
| A | 0046098 | biological_process | guanine metabolic process |
| A | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN A 1451 |
| Chain | Residue |
| A | HIS82 |
| A | HIS84 |
| A | HIS240 |
| A | ASP330 |
| A | TXC1452 |
| site_id | AC2 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE TXC A 1452 |
| Chain | Residue |
| A | LEU103 |
| A | ARG213 |
| A | PHE214 |
| A | LEU216 |
| A | HIS240 |
| A | GLU243 |
| A | GLU247 |
| A | ALA250 |
| A | HIS279 |
| A | ASP330 |
| A | ZN1451 |
| A | HOH2033 |
| A | HIS84 |
| A | GLN87 |
| A | LEU99 |
| A | LEU100 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:22662200, ECO:0007744|PDB:2UZ9 |
| Chain | Residue | Details |
| A | HIS82 | |
| A | HIS84 | |
| A | HIS240 | |
| A | ASP330 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:22662200, ECO:0007744|PDB:2UZ9 |
| Chain | Residue | Details |
| A | ARG213 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q9WTT6 |
| Chain | Residue | Details |
| A | SER453 |
