4AQL

HUMAN GUANINE DEAMINASE IN COMPLEX WITH VALACYCLOVIR

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000255	biological_process	allantoin metabolic process
A	0005829	cellular_component	cytosol
A	0006139	biological_process	nucleobase-containing compound metabolic process
A	0006147	biological_process	guanine catabolic process
A	0006161	biological_process	deoxyguanosine catabolic process
A	0007399	biological_process	nervous system development
A	0008270	molecular_function	zinc ion binding
A	0008892	molecular_function	guanine deaminase activity
A	0016787	molecular_function	hydrolase activity
A	0016810	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
A	0043605	biological_process	amide catabolic process
A	0046038	biological_process	GMP catabolic process
A	0046055	biological_process	dGMP catabolic process
A	0046098	biological_process	guanine metabolic process
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN A 1451

Chain	Residue
A	HIS82
A	HIS84
A	HIS240
A	ASP330
A	TXC1452

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site_id	AC2
Number of Residues	16
Details	BINDING SITE FOR RESIDUE TXC A 1452

Chain	Residue
A	LEU103
A	ARG213
A	PHE214
A	LEU216
A	HIS240
A	GLU243
A	GLU247
A	ALA250
A	HIS279
A	ASP330
A	ZN1451
A	HOH2033
A	HIS84
A	GLN87
A	LEU99
A	LEU100

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22662200","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2UZ9","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	7
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22662200","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"2UZ9","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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