4J5D

Human Cyclophilin D Complexed with an Inhibitor

Summary for 4J5D

Entry DOI	10.2210/pdb4j5d/pdb
Related	4J58 4J59 4J5A 4J5B 4J5C 4J5E
Descriptor	Peptidyl-prolyl cis-trans isomerase F, mitochondrial, 1-(4-aminobenzyl)-3-{2-[(2R)-2-(2-bromophenyl)pyrrolidin-1-yl]-2-oxoethyl}urea (3 entities in total)
Functional Keywords	isomerase-isomerase inhibitor complex complex, isomerase/isomerase inhibitor complex
Biological source	Homo sapiens (human)
Cellular location	Mitochondrion matrix : P30405
Total number of polymer chains	1
Total formula weight	18083.45
Authors	Gelin, M.,Colliandre, L.,Bessin, Y.,Guichou, J.F. (deposition date: 2013-02-08, release date: 2014-02-19, Last modification date: 2024-02-28)
Primary citation	Ahmed-Belkacem, A.,Colliandre, L.,Ahnou, N.,Nevers, Q.,Gelin, M.,Bessin, Y.,Brillet, R.,Cala, O.,Douguet, D.,Bourguet, W.,Krimm, I.,Pawlotsky, J.M.,Guichou, J.F. Fragment-based discovery of a new family of non-peptidic small-molecule cyclophilin inhibitors with potent antiviral activities. Nat Commun, 7:12777-12777, 2016 Cited by PubMed: 27652979 DOI: 10.1038/ncomms12777 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.32 Å)

Structure validation