5B25
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![BU of 5b25 by Molmil](/molmil-images/mine/5b25) | Crystal structure of human PDE1B with inhibitor 3 | 分子名称: | (11R,15S)-4-{[4-(6-fluoropyridin-2-yl)phenyl]methyl}-8-methyl-5-(phenylamino)-1,3,4,8,10-pentaazatetracyclo[7.6.0.02,6.011,15]pentadeca-2,5,9-trien-7-one, Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B, GLYCEROL, ... | 著者 | Ida, K, Lane, W, Snell, G, Sogabe, S. | 登録日 | 2016-01-07 | 公開日 | 2016-02-03 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Discovery of Potent and Selective Inhibitors of Phosphodiesterase 1 for the Treatment of Cognitive Impairment Associated with Neurodegenerative and Neuropsychiatric Diseases J.Med.Chem., 59, 2016
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4RBX
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5IN9
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![BU of 5in9 by Molmil](/molmil-images/mine/5in9) | Crystal structure of Grp94 bound to methyl 3-chloro-2-(2-(1-((5-chlorofuran-2-yl)methyl)-1H-imidazol-2-yl)ethyl)-4,6-dihydroxybenzoate, an inhibitor based on the BnIm and Radamide scaffolds. | 分子名称: | Endoplasmin, GLYCEROL, TRIETHYLENE GLYCOL, ... | 著者 | Lieberman, R.L, Huard, D.J.E, Kizziah, J.L. | 登録日 | 2016-03-07 | 公開日 | 2016-05-04 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Development of Glucose Regulated Protein 94-Selective Inhibitors Based on the BnIm and Radamide Scaffold. J.Med.Chem., 59, 2016
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4RBW
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![BU of 4rbw by Molmil](/molmil-images/mine/4rbw) | Crystal structure of human alpha-defensin 5, HD5 (Thr7Arg Glu21Arg mutant) | 分子名称: | CHLORIDE ION, Defensin-5, SULFATE ION | 著者 | Pazgier, M, Gohain, N, Tolbert, W.D. | 登録日 | 2014-09-13 | 公開日 | 2015-07-29 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Design of a potent antibiotic peptide based on the active region of human defensin 5. J.Med.Chem., 58, 2015
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8C3W
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![BU of 8c3w by Molmil](/molmil-images/mine/8c3w) | Crystal structure of a computationally designed heme binding protein, dnHEM1 | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, ... | 著者 | Ortmayer, M, Levy, C. | 登録日 | 2022-12-29 | 公開日 | 2023-07-05 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Design of Heme Enzymes with a Tunable Substrate Binding Pocket Adjacent to an Open Metal Coordination Site. J.Am.Chem.Soc., 145, 2023
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6JTG
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7Y8C
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![BU of 7y8c by Molmil](/molmil-images/mine/7y8c) | Crystal structure of CotA laccase complexed with syringaldehyde | 分子名称: | 3,5-dimethoxy-4-oxidanyl-benzaldehyde, COPPER (II) ION, Spore coat protein A, ... | 著者 | Liu, Z.C, Xie, T, Wang, G.G. | 登録日 | 2022-06-23 | 公開日 | 2023-06-28 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Molecular insights into substrate promiscuity of CotA laccase catalyzing lignin-phenol derivatives. Int.J.Biol.Macromol., 256, 2023
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7Y8B
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![BU of 7y8b by Molmil](/molmil-images/mine/7y8b) | Crystal structure of CotA laccase complexed with syringic acid | 分子名称: | 3,5-dimethoxy-4-oxidanyl-benzoic acid, COPPER (II) ION, Spore coat protein A, ... | 著者 | Liu, Z.C, Xie, T, Wang, G.G. | 登録日 | 2022-06-23 | 公開日 | 2023-06-28 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Molecular insights into substrate promiscuity of CotA laccase catalyzing lignin-phenol derivatives. Int.J.Biol.Macromol., 256, 2023
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1BKO
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1BSF
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1BKP
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1BSP
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![BU of 1bsp by Molmil](/molmil-images/mine/1bsp) | THERMOSTABLE THYMIDYLATE SYNTHASE A FROM BACILLUS SUBTILIS | 分子名称: | PHOSPHATE ION, THYMIDYLATE SYNTHASE A | 著者 | Stout, T.J, Schellenberger, U, Santi, D.V, Stroud, R.M. | 登録日 | 1998-07-09 | 公開日 | 1999-02-16 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Crystal structures of a unique thermal-stable thymidylate synthase from Bacillus subtilis. Biochemistry, 37, 1998
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1I7E
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![BU of 1i7e by Molmil](/molmil-images/mine/1i7e) | C-Terminal Domain Of Mouse Brain Tubby Protein bound to Phosphatidylinositol 4,5-bis-phosphate | 分子名称: | L-ALPHA-GLYCEROPHOSPHO-D-MYO-INOSITOL-4,5-BIS-PHOSPHATE, TUBBY PROTEIN | 著者 | Santagata, S, Boggon, T.J, Baird, C.L, Shan, W.S, Shapiro, L. | 登録日 | 2001-03-08 | 公開日 | 2001-06-27 | 最終更新日 | 2023-08-09 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | G-protein signaling through tubby proteins. Science, 292, 2001
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4J3K
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4OUS
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6LPF
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![BU of 6lpf by Molmil](/molmil-images/mine/6lpf) | The crystal structure of human cytoplasmic LRS | 分子名称: | 2'-(L-NORVALYL)AMINO-2'-DEOXYADENOSINE, 5'-O-(L-leucylsulfamoyl)adenosine, GLYCEROL, ... | 著者 | Liu, R.J, Long, T, Li, H, Li, J, Zhao, J.H, Lin, J.Z, Palencia, A, Wang, M.Z, Cusack, S, Wang, E.D. | 登録日 | 2020-01-10 | 公開日 | 2020-03-25 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.49 Å) | 主引用文献 | Molecular basis of the multifaceted functions of human leucyl-tRNA synthetase in protein synthesis and beyond. Nucleic Acids Res., 48, 2020
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6LR6
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![BU of 6lr6 by Molmil](/molmil-images/mine/6lr6) | The crystal structure of human cytoplasmic LRS | 分子名称: | 4-Chloro-3-aminomethyl-7-[ethoxy]-3H-benzo[C][1,2]oxaborol-1-ol modified adenosine, 5'-O-(L-leucylsulfamoyl)adenosine, Leucine--tRNA ligase, ... | 著者 | Liu, R.J, Long, T, Li, H, Li, J, Zhao, J.H, Lin, J.Z, Palencia, A, Wang, M.Z, Cusack, S, Wang, E.D. | 登録日 | 2020-01-15 | 公開日 | 2020-03-25 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (3.009 Å) | 主引用文献 | Molecular basis of the multifaceted functions of human leucyl-tRNA synthetase in protein synthesis and beyond. Nucleic Acids Res., 48, 2020
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4ONL
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![BU of 4onl by Molmil](/molmil-images/mine/4onl) | Crystal structure of human Mms2/Ubc13_D81N, R85S, A122V, N123P | 分子名称: | Ubiquitin-conjugating enzyme E2 N, Ubiquitin-conjugating enzyme E2 variant 2 | 著者 | Hodge, C.D, Edwards, R.A, Glover, J.N.M. | 登録日 | 2014-01-28 | 公開日 | 2015-05-06 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | 主引用文献 | Covalent Inhibition of Ubc13 Affects Ubiquitin Signaling and Reveals Active Site Elements Important for Targeting. Acs Chem.Biol., 10, 2015
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4OUL
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6EBA
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![BU of 6eba by Molmil](/molmil-images/mine/6eba) | Crystal Structure of A Bacterial Homolog to Human Lysosomal Transporter, Spinster, in Inward-facing And Unoccupied Conformation | 分子名称: | Major facilitator family transporter | 著者 | Zhou, F, Yao, D, Rao, B, Zhang, L, Cao, Y. | 登録日 | 2018-08-06 | 公開日 | 2019-08-21 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (3.812 Å) | 主引用文献 | Crystal structure of a bacterial homolog to human lysosomal transporter, spinster Sci Bull (Beijing), 64, 2019
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6E8J
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![BU of 6e8j by Molmil](/molmil-images/mine/6e8j) | Crystal Structure of A Bacterial Homolog to Human Lysosomal Transporter, Spinster, in Inward-facing And Occupied Conformation | 分子名称: | Major facilitator family transporter | 著者 | Zhou, F, Yao, D, Rao, B, Zhang, L, Cao, Y. | 登録日 | 2018-07-30 | 公開日 | 2019-08-14 | 最終更新日 | 2020-01-08 | 実験手法 | X-RAY DIFFRACTION (3.091 Å) | 主引用文献 | Crystal structure of a bacterial homolog to human lysosomal transporter, spinster Sci Bull (Beijing), 64, 2019
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6E9C
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![BU of 6e9c by Molmil](/molmil-images/mine/6e9c) | Selenomethionine Derivative Structure of A Bacterial Homolog to Human Lysosomal Transporter, Spinster | 分子名称: | Major facilitator family transporter | 著者 | Zhou, F, Yao, D, Rao, B, Zhang, L, Cao, Y. | 登録日 | 2018-07-31 | 公開日 | 2019-08-14 | 最終更新日 | 2020-01-08 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Crystal structure of a bacterial homolog to human lysosomal transporter, spinster Sci Bull (Beijing), 64, 2019
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8H7Z
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8H7L
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![BU of 8h7l by Molmil](/molmil-images/mine/8h7l) | Cryo-EM Structure of SARS-CoV-2 BA.2 Spike protein in complex with BA7535 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BA7535 fab heavt chain, ... | 著者 | Liu, Z, Yan, A, Gao, Y. | 登録日 | 2022-10-20 | 公開日 | 2023-08-30 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (2.44 Å) | 主引用文献 | Identification of a highly conserved neutralizing epitope within the RBD region of diverse SARS-CoV-2 variants. Nat Commun, 15, 2024
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5WSH
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![BU of 5wsh by Molmil](/molmil-images/mine/5wsh) | Structure of HLA-A2 P130 | 分子名称: | Beta-2-microglobulin, DI(HYDROXYETHYL)ETHER, GLY-VAL-TRP-ILE-ARG-THR-PRO-THR-ALA, ... | 著者 | Zhang, Y, Wu, Y, Qi, J, Liu, J, Gao, G.F, Meng, S. | 登録日 | 2016-12-07 | 公開日 | 2017-12-20 | 最終更新日 | 2019-01-23 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | CD8+T-Cell Response-Associated Evolution of Hepatitis B Virus Core Protein and Disease Progress. J. Virol., 92, 2018
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