5B25

Crystal structure of human PDE1B with inhibitor 3

Summary for 5B25

DescriptorCalcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B, ZINC ION, MAGNESIUM ION, ... (7 entities in total)
Functional Keywordshydrolase, inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHomo sapiens (Human)
Cellular locationCytoplasm Q01064
Total number of polymer chains4
Total molecular weight158383.14
Authors
Ida, K.,Lane, W.,Snell, G.,Sogabe, S. (deposition date: 2016-01-07, release date: 2016-02-03, Last modification date: 2016-02-24)
Primary citation
Li, P.,Zheng, H.,Zhao, J.,Zhang, L.,Yao, W.,Zhu, H.,Beard, J.D.,Ida, K.,Lane, W.,Snell, G.,Sogabe, S.,Heyser, C.J.,Snyder, G.L.,Hendrick, J.P.,Vanover, K.E.,Davis, R.E.,Wennogle, L.P.
Discovery of Potent and Selective Inhibitors of Phosphodiesterase 1 for the Treatment of Cognitive Impairment Associated with Neurodegenerative and Neuropsychiatric Diseases
J.Med.Chem., 59:1149-1164, 2016
PubMed: 26789933 (PDB entries with the same primary citation)
DOI: 10.1021/acs.jmedchem.5b01751
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.9 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.20320 0.8% 3.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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171916
PDB entries from 2020-12-02