Summary for 5B25
| Descriptor | Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B, ZINC ION, MAGNESIUM ION, ... (7 entities in total) |
|---|---|
| Functional Keywords | hydrolase, inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
| Biological source | Homo sapiens (Human) |
| Cellular location | Cytoplasm Q01064 |
| Total number of polymer chains | 4 |
| Total molecular weight | 158383.14 |
| Authors | Ida, K.,Lane, W.,Snell, G.,Sogabe, S. (deposition date: 2016-01-07, release date: 2016-02-03, Last modification date: 2016-02-24) |
| Primary citation | Li, P.,Zheng, H.,Zhao, J.,Zhang, L.,Yao, W.,Zhu, H.,Beard, J.D.,Ida, K.,Lane, W.,Snell, G.,Sogabe, S.,Heyser, C.J.,Snyder, G.L.,Hendrick, J.P.,Vanover, K.E.,Davis, R.E.,Wennogle, L.P. Discovery of Potent and Selective Inhibitors of Phosphodiesterase 1 for the Treatment of Cognitive Impairment Associated with Neurodegenerative and Neuropsychiatric Diseases J.Med.Chem., 59:1149-1164, 2016 PubMed: 26789933 (PDB entries with the same primary citation) DOI: 10.1021/acs.jmedchem.5b01751  Import into Mendeley |
| Experimental method | X-RAY DIFFRACTION (1.9 Å) |
