5Z2D
| |
4ZMR
| |
6LVP
| |
6LVO
| |
3U2Z
| Activator-Bound Structure of Human Pyruvate Kinase M2 | 分子名称: | 1,6-di-O-phosphono-beta-D-fructofuranose, 6-(3-aminobenzyl)-4-methyl-2-methylsulfinyl-4,6-dihydro-5H-thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5-one, Pyruvate kinase isozymes M1/M2, ... | 著者 | Hong, B, Dimov, S, Tempel, W, Auld, D, Thomas, C, Boxer, M, Jianq, J.-K, Skoumbourdis, A, Min, S, Southall, N, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Inglese, J, Park, H, Structural Genomics Consortium (SGC) | 登録日 | 2011-10-04 | 公開日 | 2012-09-12 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis. Nat.Chem.Biol., 8, 2012
|
|
5WDH
| Motor domain of human kinesin family member C1 | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Kinesin-like protein KIFC1, MAGNESIUM ION, ... | 著者 | Zhu, H, Tempel, W, He, H, Shen, Y, Wang, J, Brothers, G, Landry, R, Arrowsmith, C.H, Edwards, A.M, Park, H, Structural Genomics Consortium (SGC) | 登録日 | 2017-07-05 | 公開日 | 2017-08-09 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.248 Å) | 主引用文献 | Structural basis of small molecule ATPase inhibition of a human mitotic kinesin motor protein. Sci Rep, 7, 2017
|
|
2CKX
| |
4IKC
| Crystal Structure of catalytic domain of PTPRQ | 分子名称: | CHLORIDE ION, Phosphotidylinositol phosphatase PTPRQ, SULFATE ION | 著者 | Yu, K.R, Ryu, S.E, Kim, S.J. | 登録日 | 2012-12-26 | 公開日 | 2013-07-31 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.56 Å) | 主引用文献 | Structural basis for the dephosphorylating activity of PTPRQ towards phosphatidylinositide substrates Acta Crystallogr.,Sect.D, 69, 2013
|
|
6VA3
| Solution Structure of the Tau pre-mRNA Exon 10 Splicing Regulatory Element Bound to MQC | 分子名称: | 4-[(3-methoxyphenyl)amino]-2-methylquinoline-6-carboximidamide, RNA (5'-R(*CP*AP*CP*AP*CP*GP*UP*CP*GP*G)-3'), RNA (5'-R(*CP*CP*GP*GP*CP*AP*GP*UP*GP*UP*G)-3') | 著者 | Chen, J.L, Fountain, M.A, Disney, M.D. | 登録日 | 2019-12-16 | 公開日 | 2020-05-20 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Design, Optimization, and Study of Small Molecules That Target Tau Pre-mRNA and Affect Splicing. J.Am.Chem.Soc., 142, 2020
|
|
6VA2
| Solution Structure of the Tau pre-mRNA Exon 10 Splicing Regulatory Element Bound to MH5 | 分子名称: | (2E,2'E)-2,2'-{dibenzo[b,d]thiene-2,8-diyldi[(1E)eth-1-yl-1-ylidene]}bis(N-methylhydrazine-1-carboximidamide), RNA (5'-R(*CP*AP*CP*AP*CP*GP*UP*CP*GP*G)-3'), RNA (5'-R(*CP*CP*GP*GP*CP*AP*GP*UP*GP*UP*G)-3') | 著者 | Chen, J.L, Fountain, M.A, Disney, M.D. | 登録日 | 2019-12-16 | 公開日 | 2020-05-20 | 最終更新日 | 2024-05-01 | 実験手法 | SOLUTION NMR | 主引用文献 | Design, Optimization, and Study of Small Molecules That Target Tau Pre-mRNA and Affect Splicing. J.Am.Chem.Soc., 142, 2020
|
|
6VA1
| Solution Structure of the Tau pre-mRNA Exon 10 Splicing Regulatory Element | 分子名称: | RNA (5'-R(*CP*AP*CP*AP*CP*GP*UP*CP*GP*G)-3'), RNA (5'-R(*CP*CP*GP*GP*CP*AP*GP*UP*GP*UP*G)-3') | 著者 | Chen, J.L, Fountain, M.A, Disney, M.D. | 登録日 | 2019-12-16 | 公開日 | 2020-05-20 | 最終更新日 | 2024-05-01 | 実験手法 | SOLUTION NMR | 主引用文献 | Design, Optimization, and Study of Small Molecules That Target Tau Pre-mRNA and Affect Splicing. J.Am.Chem.Soc., 142, 2020
|
|
3FEH
| Crystal structure of full length centaurin alpha-1 | 分子名称: | Centaurin-alpha-1, UNKNOWN ATOM OR ION, ZINC ION | 著者 | Shen, L, Tong, Y, Tempel, W, MacKenzie, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC) | 登録日 | 2008-11-29 | 公開日 | 2008-12-23 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Phosphorylation-independent dual-site binding of the FHA domain of KIF13 mediates phosphoinositide transport via centaurin {alpha}1. Proc.Natl.Acad.Sci.USA, 107, 2010
|
|
6VA4
| Solution Structure of the Tau pre-mRNA Exon 10 Splicing Regulatory Element Bound to MIP | 分子名称: | N-[3-(8-methoxy-4-oxo-4,5-dihydro-3H-pyrimido[5,4-b]indol-3-yl)propyl]-N-methylcyclohexanaminium, RNA (5'-R(*CP*AP*CP*AP*CP*GP*UP*CP*GP*G)-3'), RNA (5'-R(*CP*CP*GP*GP*CP*AP*GP*UP*GP*UP*G)-3') | 著者 | Chen, J.L, Fountain, M.A, Disney, M.D. | 登録日 | 2019-12-16 | 公開日 | 2020-05-20 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Design, Optimization, and Study of Small Molecules That Target Tau Pre-mRNA and Affect Splicing. J.Am.Chem.Soc., 142, 2020
|
|
5YX4
| Isoliquiritigenin-complexed Chalcone isomerase (S189A) from the Antarctic vascular plant Deschampsia Antarctica (DaCHI1) | 分子名称: | 2',4,4'-TRIHYDROXYCHALCONE, Chalcone-flavonone isomerase family protein | 著者 | Lee, C.W, Park, S, Lee, J.H. | 登録日 | 2017-12-01 | 公開日 | 2018-02-14 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Crystal structure and enzymatic properties of chalcone isomerase from the Antarctic vascular plant Deschampsia antarctica Desv. PLoS ONE, 13, 2018
|
|
5YX3
| |
3FM8
| Crystal structure of full length centaurin alpha-1 bound with the FHA domain of KIF13B (CAPRI target) | 分子名称: | Centaurin-alpha-1, Kinesin-like protein KIF13B, SULFATE ION, ... | 著者 | Shen, L, Tong, Y, Tempel, W, MacKenzie, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC) | 登録日 | 2008-12-19 | 公開日 | 2009-08-25 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Phosphorylation-independent dual-site binding of the FHA domain of KIF13 mediates phosphoinositide transport via centaurin alpha1. Proc.Natl.Acad.Sci.USA, 107, 2010
|
|
6NWS
| RORgamma Ligand Binding Domain | 分子名称: | 2-chloro-6-fluoro-N-(1-{[3-(trifluoromethyl)phenyl]sulfonyl}-2,3-dihydro-1H-indol-6-yl)benzamide, Nuclear receptor ROR-gamma | 著者 | Strutzenberg, T.S, Park, H.J, Griffin, P.R. | 登録日 | 2019-02-07 | 公開日 | 2019-07-10 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.44 Å) | 主引用文献 | HDX-MS reveals structural determinants for ROR gamma hyperactivation by synthetic agonists. Elife, 8, 2019
|
|
2O71
| Crystal structure of RAIDD DD | 分子名称: | Death domain-containing protein CRADD | 著者 | Wu, H, Park, H. | 登録日 | 2006-12-09 | 公開日 | 2007-01-30 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystal Structure of RAIDD Death Domain Implicates Potential Mechanism of PIDDosome Assembly J.Mol.Biol., 357, 2006
|
|
3KCX
| Factor inhibiting HIF-1 alpha in complex with Clioquinol | 分子名称: | 5-chloro-7-iodoquinolin-8-ol, FE (II) ION, GLYCEROL, ... | 著者 | Moon, H, Han, S, Choe, J. | 登録日 | 2009-10-22 | 公開日 | 2010-04-28 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Crystal structures of human FIH-1 in complex with quinol family inhibitors Mol.Cells, 29, 2010
|
|
3KCY
| Factor inhibiting HIF-1 alpha in complex with 8-hydroxyquinoline | 分子名称: | FE (II) ION, Hypoxia-inducible factor 1-alpha inhibitor, SULFATE ION, ... | 著者 | Moon, H, Han, S, Choe, J. | 登録日 | 2009-10-22 | 公開日 | 2010-04-28 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.59 Å) | 主引用文献 | Crystal structures of human FIH-1 in complex with quinol family inhibitors Mol.Cells, 29, 2010
|
|
5XTG
| Crystal structure of the cis-dihydrodiol naphthalene dehydrogenase NahB from Pseudomonas sp. MC1 in the presence of NAD+ and 2,3-dihydroxybiphenyl | 分子名称: | 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase, BIPHENYL-2,3-DIOL, CITRIC ACID, ... | 著者 | Park, A.K, Kim, H.-W. | 登録日 | 2017-06-19 | 公開日 | 2017-08-09 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.318 Å) | 主引用文献 | Crystal structure of cis-dihydrodiol naphthalene dehydrogenase (NahB) from Pseudomonas sp. MC1: Insights into the early binding process of the substrate Biochem. Biophys. Res. Commun., 491, 2017
|
|
5XTF
| |
4KI9
| Crystal structure of the catalytic domain of human DUSP12 at 2.0 A resolution | 分子名称: | Dual specificity protein phosphatase 12, PHOSPHATE ION | 著者 | Jeon, T.J, Chien, P.N, Ku, B, Kim, S.J, Ryu, S.E. | 登録日 | 2013-05-02 | 公開日 | 2014-02-26 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | The family-wide structure and function of human dual-specificity protein phosphatases Acta Crystallogr.,Sect.D, 70, 2014
|
|
6NSL
| CRYSTAL STRUCTURE OF TYROSINE KINASE 2 JH2 (PSEUDO KINASE DOMAIN) COMPLEXED WITH Compound-6c AKA 6-((1-(4-CYANOPHENY L)-2-OXO-1,2-DIHYDRO-3-PYRIDINYL)AMINO)-N-CYCLOPROPYL-8-(M ETHYLAMINO)IMIDAZO[1,2-B]PYRIDAZINE-3-CARBOXAMIDE | 分子名称: | 6-{[1-(4-cyanophenyl)-2-oxo-1,2-dihydropyridin-3-yl]amino}-N-cyclopropyl-8-(methylamino)imidazo[1,2-b]pyridazine-3-carboxamide, Non-receptor tyrosine-protein kinase TYK2, SULFATE ION | 著者 | Muckelbauer, J.M, Khan, J.A. | 登録日 | 2019-01-25 | 公開日 | 2020-01-29 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Identification of Imidazo[1,2-b]pyridazine Derivatives as Potent, Selective, and Orally Active Tyk2 JH2 Inhibitors. Acs Med.Chem.Lett., 10, 2019
|
|
4JNB
| Crystal structure of the Catalytic Domain of Human DUSP12 | 分子名称: | Dual specificity protein phosphatase 12, SULFATE ION | 著者 | Jeon, T.J, Chien, P.N, Ku, B, Kim, S.J, Ryu, S.E. | 登録日 | 2013-03-15 | 公開日 | 2014-03-26 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | The family-wide structure and function of human dual-specificity protein phosphatases. Acta Crystallogr.,Sect.D, 70, 2014
|
|