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6NWS

RORgamma Ligand Binding Domain

Summary for 6NWS
Entry DOI10.2210/pdb6nws/pdb
DescriptorNuclear receptor ROR-gamma, 2-chloro-6-fluoro-N-(1-{[3-(trifluoromethyl)phenyl]sulfonyl}-2,3-dihydro-1H-indol-6-yl)benzamide (3 entities in total)
Functional Keywordsorphan nuclear receptor, synthetic modulator, chemical probe, nuclear protein
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total formula weight30581.74
Authors
Strutzenberg, T.S.,Park, H.J.,Griffin, P.R. (deposition date: 2019-02-07, release date: 2019-07-10, Last modification date: 2023-10-11)
Primary citationStrutzenberg, T.S.,Garcia-Ordonez, R.D.,Novick, S.J.,Park, H.,Chang, M.R.,Doebellin, C.,He, Y.,Patouret, R.,Kamenecka, T.M.,Griffin, P.R.
HDX-MS reveals structural determinants for ROR gamma hyperactivation by synthetic agonists.
Elife, 8:-, 2019
Cited by
PubMed: 31172947
DOI: 10.7554/eLife.47172
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.44 Å)
Structure validation

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