2O71

Crystal structure of RAIDD DD

Summary for 2O71

• Entry DOI: 10.2210/pdb2o71/pdb
• Descriptor: Death domain-containing protein CRADD (1 entity in total)
• Functional Keywords: raidd, death domain, apoptosis
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 13224.93

Authors

Wu, H.,Park, H. (deposition date: 2006-12-09, release date: 2007-01-30, Last modification date: 2023-12-27)

Primary citation

Park, H.H.,Wu, H.
Crystal Structure of RAIDD Death Domain Implicates Potential Mechanism of PIDDosome Assembly
J.Mol.Biol., 357:358-364, 2006

PubMed Abstract: Caspase-2 is implicated in stress-induced apoptosis that acts as an upstream initiator of mitochondrial permeabilization. Recent studies have shown that caspase-2 activation requires a molecular complex known as the PIDDosome comprising the p53-inducible protein PIDD, the adapter protein RAIDD and caspase-2. RAIDD has an N-terminal caspase recruitment domain (CARD) that interacts with the CARD of caspase-2 and a C-terminal death domain (DD) that interacts with the DD in PIDD. As a first step towards elucidating the molecular mechanisms of caspase-2 activation, we report the crystal structure of RAIDD DD at 2.0 A resolution. The high-resolution structure reveals important features of RAIDD DD that may be important for DD folding and dynamics and for assembly of the PIDDosome.

PubMed: 16434054
DOI: 10.1016/j.jmb.2005.12.082

Experimental method

X-RAY DIFFRACTION (2 Å)