8GCW
 
 | | Stx2A1(Y77A)-P6 peptide | | Descriptor: | P stalk protein, rRNA N-glycosylase | | Authors: | Rudolph, M.J, Li, X.P. | | Deposit date: | 2023-03-03 | | Release date: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | Structure of the Stx2A1(Y77A) in complex with P6 peptide.
To Be Published
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6OCD
 | | Ricin A chain bound to VHH antibody V6D4 | | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, IMIDAZOLE, ... | | Authors: | Rudolph, M.J. | | Deposit date: | 2019-03-22 | | Release date: | 2020-04-01 | | Last modified: | 2020-10-14 | | Method: | X-RAY DIFFRACTION (2.103 Å) | | Cite: | Intracellular Neutralization of Ricin Toxin by Single-domain Antibodies Targeting the Active Site.
J.Mol.Biol., 432, 2020
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8T9V
 | | RTA-RUNT-59 complex structure | | Descriptor: | (9aP)-7-fluoro-4,5-dihydronaphtho[1,2-b]thiophene-2-carboxylic acid, NONAETHYLENE GLYCOL, Ricin | | Authors: | Rudolph, M.J, Tumer, N. | | Deposit date: | 2023-06-26 | | Release date: | 2024-05-01 | | Method: | X-RAY DIFFRACTION (1.945 Å) | | Cite: | Structure-based design and optimization of a new class of small molecule inhibitors targeting the P-stalk binding pocket of ricin.
Bioorg.Med.Chem., 100, 2024
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8TAB
 | | RTA-PD00589 | | Descriptor: | 1,2-ETHANEDIOL, 4H,5H-naphtho[1,2-b]thiophene-2-carboxylic acid, CHLORIDE ION, ... | | Authors: | Rudolph, M.J, Tumer, N. | | Deposit date: | 2023-06-27 | | Release date: | 2024-05-01 | | Method: | X-RAY DIFFRACTION (2.26 Å) | | Cite: | Structure-based design and optimization of a new class of small molecule inhibitors targeting the P-stalk binding pocket of ricin.
Bioorg.Med.Chem., 100, 2024
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8TAD
 | | RTA in complex with inhibitor RUNT-206 | | Descriptor: | (9aM)-5,5-dimethyl-4,5-dihydronaphtho[1,2-b]thiophene-2-carboxylic acid, CHLORIDE ION, NONAETHYLENE GLYCOL, ... | | Authors: | Rudolph, M.J, Tumer, N. | | Deposit date: | 2023-06-27 | | Release date: | 2024-05-01 | | Method: | X-RAY DIFFRACTION (2.76 Å) | | Cite: | Structure-based design and optimization of a new class of small molecule inhibitors targeting the P-stalk binding pocket of ricin.
Bioorg.Med.Chem., 100, 2024
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4Z9K
 | | Ricin A chain bound to camelid nanobody (VHH2)(F5) | | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, Ricin, ... | | Authors: | Rudolph, M.J. | | Deposit date: | 2015-04-10 | | Release date: | 2016-07-20 | | Last modified: | 2019-12-11 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Structural analysis of nested neutralizing and non-neutralizing B cell epitopes on ricin toxin's enzymatic subunit.
Proteins, 84, 2016
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5BOZ
 | | Ricin A chain bound to camelid nanobody (VHH9)(E1) | | Descriptor: | CHLORIDE ION, Ricin, SULFATE ION, ... | | Authors: | Rudolph, M.J, Mantis, N. | | Deposit date: | 2015-05-27 | | Release date: | 2016-12-07 | | Last modified: | 2019-12-11 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | Structural Analysis of Single Domain Antibodies Bound to a Second Neutralizing Hot Spot on Ricin Toxin's Enzymatic Subunit.
J. Biol. Chem., 292, 2017
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7UIJ
 | | Structural studies of B5-OspC complex | | Descriptor: | 1,2-ETHANEDIOL, Monoclonal B5 Fab Heavy Chain, Monoclonal B5 Fab Light Chain, ... | | Authors: | Rudolph, M.J, Mantis, N. | | Deposit date: | 2022-03-29 | | Release date: | 2023-04-05 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.701 Å) | | Cite: | Structural Elucidation of a Protective B Cell Epitope on Outer Surface Protein C (OspC) of the Lyme Disease Spirochete, Borreliella burgdorferi.
Mbio, 14, 2023
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7UJ2
 | | OspC Type B | | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, Outer surface protein C | | Authors: | Rudolph, M.J, Mantis, N. | | Deposit date: | 2022-03-30 | | Release date: | 2023-04-05 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (1.503 Å) | | Cite: | Structural Elucidation of a Protective B Cell Epitope on Outer Surface Protein C (OspC) of the Lyme Disease Spirochete, Borreliella burgdorferi.
Mbio, 14, 2023
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7UJ6
 | | Outer Surface Protein C Type K | | Descriptor: | Outer surface protein C | | Authors: | Rudolph, M.J, Mantis, N. | | Deposit date: | 2022-03-30 | | Release date: | 2023-04-05 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (1.951 Å) | | Cite: | Structural Elucidation of a Protective B Cell Epitope on Outer Surface Protein C (OspC) of the Lyme Disease Spirochete, Borreliella burgdorferi.
Mbio, 14, 2023
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6CWK
 | | Anti-RTA VHH antibody | | Descriptor: | 1,2-ETHANEDIOL, Anti-Ricin antibody, CHLORIDE ION, ... | | Authors: | Rudolph, M.J, Mantis, N. | | Deposit date: | 2018-03-30 | | Release date: | 2019-01-16 | | Last modified: | 2019-12-18 | | Method: | X-RAY DIFFRACTION (1.256 Å) | | Cite: | Contribution of an unusual CDR2 element of a single domain antibody in ricin toxin binding affinity and neutralizing activity.
Protein Eng. Des. Sel., 31, 2018
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6CWG
 | | Ricin catalytic subunit bound go A9 VHH antibody | | Descriptor: | CHLORIDE ION, Ricin, VHH antibody | | Authors: | Rudolph, M.J, Mantis, N. | | Deposit date: | 2018-03-30 | | Release date: | 2019-01-16 | | Last modified: | 2019-12-18 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Contribution of an unusual CDR2 element of a single domain antibody in ricin toxin binding affinity and neutralizing activity.
Protein Eng. Des. Sel., 31, 2018
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8SZ2
 | | Stx2A1 bound to P8 stalk peptide | | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, NONAETHYLENE GLYCOL, ... | | Authors: | rudolph, M.J, Li, X.P. | | Deposit date: | 2023-05-26 | | Release date: | 2024-05-29 | | Method: | X-RAY DIFFRACTION (2.01 Å) | | Cite: | Structure of Shiga toxin 2 A1 subunit with peptides that bind at the ribosome binding site and inhibit activity
To Be Published
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6OBM
 | | Ricin A chain bound to VHH antibody V6A7 | | Descriptor: | CHLORIDE ION, Ricin A chain, VHH antibody V6A7 | | Authors: | Rudolph, M.J. | | Deposit date: | 2019-03-21 | | Release date: | 2020-04-01 | | Last modified: | 2020-10-14 | | Method: | X-RAY DIFFRACTION (2.495 Å) | | Cite: | Intracellular Neutralization of Ricin Toxin by Single-domain Antibodies Targeting the Active Site.
J.Mol.Biol., 432, 2020
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6OCA
 | | Ricin A chain bound to VHH antibody V2G10 | | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, Ricin A chain, ... | | Authors: | Rudolph, M.J. | | Deposit date: | 2019-03-22 | | Release date: | 2020-04-01 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (2.113 Å) | | Cite: | Intracellular Neutralization of Ricin Toxin by Single-domain Antibodies Targeting the Active Site.
J.Mol.Biol., 432, 2020
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6OBC
 | | Ricin A chain bound to camelid | | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, Ricin A chain, ... | | Authors: | Rudolph, M.J. | | Deposit date: | 2019-03-20 | | Release date: | 2020-04-01 | | Last modified: | 2020-10-14 | | Method: | X-RAY DIFFRACTION (1.762 Å) | | Cite: | Intracellular Neutralization of Ricin Toxin by Single-domain Antibodies Targeting the Active Site.
J.Mol.Biol., 432, 2020
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6OBE
 | | Ricin A chain bound to VHH antibody V6H8 | | Descriptor: | 1,2-ETHANEDIOL, IMIDAZOLE, NICKEL (II) ION, ... | | Authors: | Rudolph, M.J. | | Deposit date: | 2019-03-20 | | Release date: | 2020-04-01 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (1.732 Å) | | Cite: | Intracellular Neutralization of Ricin Toxin by Single-domain Antibodies Targeting the Active Site.
J.Mol.Biol., 432, 2020
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6OBO
 | | Ricin A chain bound to VHH antibody V6A6 | | Descriptor: | 1,2-ETHANEDIOL, ACETIC ACID, CALCIUM ION, ... | | Authors: | Rudolph, M.J. | | Deposit date: | 2019-03-21 | | Release date: | 2020-04-01 | | Last modified: | 2020-10-14 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Intracellular Neutralization of Ricin Toxin by Single-domain Antibodies Targeting the Active Site.
J.Mol.Biol., 432, 2020
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6OBG
 | | Ricin A chain bound to VHH antibody V8E6 | | Descriptor: | CHLORIDE ION, Ricin A chain, VHH antibody V8E6, ... | | Authors: | Rudolph, M.J. | | Deposit date: | 2019-03-20 | | Release date: | 2020-04-01 | | Last modified: | 2020-10-14 | | Method: | X-RAY DIFFRACTION (1.996 Å) | | Cite: | Intracellular Neutralization of Ricin Toxin by Single-domain Antibodies Targeting the Active Site.
J.Mol.Biol., 432, 2020
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1NVI
 | | Orthorhombic Crystal Form of Molybdopterin Synthase | | Descriptor: | GLYCEROL, Molybdopterin converting factor subunit 1, Molybdopterin converting factor subunit 2, ... | | Authors: | Rudolph, M.J, Wuebbens, M.M, Turque, O, Rajagopalan, K.V, Schindelin, H. | | Deposit date: | 2003-02-03 | | Release date: | 2003-05-06 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structural Studies of Molybdopterin Synthase Provide Insights into its Catalytic Mechanism
J.Biol.Chem., 278, 2003
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8CX8
 | | Stx2A1-BTB13086 | | Descriptor: | 1,2-ETHANEDIOL, 5-(4-chlorophenyl)furan-2-carboxylic acid, CHLORIDE ION, ... | | Authors: | Rudolph, M.J, Li, X.P. | | Deposit date: | 2022-05-20 | | Release date: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (1.905 Å) | | Cite: | Stx2A1-BTB13086
To Be Published
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7T25
 | | OspA-Fab 319-44 complex structure | | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 319-44 Fab heavy chain, ... | | Authors: | Rudolph, M.J. | | Deposit date: | 2021-12-03 | | Release date: | 2022-12-14 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.25 Å) | | Cite: | Structural analysis of OspA-31944 complex
To Be Published
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3HYH
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3MN3
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4LGR
 | | Ricin A chain bound to camelid nanobody (VHH3) | | Descriptor: | 1,2-ETHANEDIOL, ACETIC ACID, CHLORIDE ION, ... | | Authors: | Rudolph, M.J, Cheung, J, Franklin, M, Burshteyn, F, Cassidy, M, Gary, E, Mantis, N. | | Deposit date: | 2013-06-28 | | Release date: | 2014-06-11 | | Last modified: | 2017-11-15 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | Crystal Structures of Ricin Toxin's Enzymatic Subunit (RTA) in Complex with Neutralizing and Non-Neutralizing Single-Chain Antibodies.
J.Mol.Biol., 426, 2014
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