1YVU
 
 | | Crystal structure of A. aeolicus Argonaute | | Descriptor: | CALCIUM ION, hypothetical protein aq_1447 | | Authors: | Yuan, Y.R, Pei, Y, Ma, J.B, Kuryavyi, V, Zhadina, M, Meister, G, Chen, H.Y, Dauter, Z, Tuschl, T, Patel, D.J. | | Deposit date: | 2005-02-16 | | Release date: | 2005-08-09 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Crystal structure of A. aeolicus Argonaute provides unique perspectives into the mechanism of guide strand-mediated mRNA cleavage
Mol.Cell, 19, 2005
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1YTU
 | | Structural basis for 5'-end-specific recognition of the guide RNA strand by the A. fulgidus PIWI protein | | Descriptor: | 5'-R(P*AP*GP*AP*CP*AP*G)-3', 5'-R(P*UP*GP*UP*C)-3', MAGNESIUM ION, ... | | Authors: | Ma, J.B, Yuan, Y.R, Meister, G, Pei, Y, Tuschl, T, Patel, D.J. | | Deposit date: | 2005-02-11 | | Release date: | 2005-04-05 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structural basis for 5'-end-specific recognition of guide RNA by the A. fulgidus Piwi protein.
Nature, 434, 2005
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8XQT
 | | Structure of human class T GPCR TAS2R14-Gi complex. | | Descriptor: | CHOLESTEROL, Exo-alpha-sialidase,Taste receptor type 2 member 14,LgBiT, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Hu, X.L, Pei, Y, Wu, L.J, Hua, T, Liu, Z.J. | | Deposit date: | 2024-01-05 | | Release date: | 2024-07-10 | | Last modified: | 2024-10-23 | | Method: | ELECTRON MICROSCOPY (2.94 Å) | | Cite: | Bitter taste TAS2R14 activation by intracellular tastants and cholesterol.
Nature, 631, 2024
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7EFX
 | | Crystal Structure of human PIN1 complexed with covalent inhibitor | | Descriptor: | 4-((5-bromofuran-2-yl)methyl)-8-(2-chloroacetyl)-1-thia-4,8-diazaspiro[4.5]decan-3-one, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | | Authors: | Liu, L, Li, J, Zhu, R, Pei, Y. | | Deposit date: | 2021-03-23 | | Release date: | 2022-02-16 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.41 Å) | | Cite: | Computational and Structure-Based Development of High Potent Cell-Active Covalent Inhibitor Targeting the Peptidyl-Prolyl Isomerase NIMA-Interacting-1 (Pin1).
J.Med.Chem., 65, 2022
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8JLZ
 | | ST1936-5HT6R complex | | Descriptor: | 2-(5-chloranyl-2-methyl-1~{H}-indol-3-yl)-N,N-dimethyl-ethanamine, 5-hydroxytryptamine receptor 6, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Wen, X, Sun, J. | | Deposit date: | 2023-06-04 | | Release date: | 2023-06-28 | | Last modified: | 2024-10-30 | | Method: | ELECTRON MICROSCOPY (3.09 Å) | | Cite: | Structural insight into the selective agonist ST1936 binding of serotonin receptor 5-HT6.
Biochem.Biophys.Res.Commun., 671, 2023
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5X5L
 | | Crystal structure of response regulator AdeR DNA binding domain in complex with an intercistronic region | | Descriptor: | AdeR, DNA (5'-D(P*TP*AP*AP*AP*GP*TP*GP*TP*GP*GP*AP*GP*TP*AP*AP*GP*TP*GP*TP*GP*GP*AP*GP*A)-3'), DNA (5'-D(P*TP*CP*TP*CP*CP*AP*CP*AP*CP*TP*TP*AP*CP*TP*CP*CP*AP*CP*AP*CP*TP*TP*TP*A)-3') | | Authors: | Wen, Y. | | Deposit date: | 2017-02-16 | | Release date: | 2017-08-30 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.75 Å) | | Cite: | Mechanistic insight into how multidrug resistant Acinetobacter baumannii response regulator AdeR recognizes an intercistronic region.
Nucleic Acids Res., 45, 2017
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5X5J
 | | Crystal structure of response regulator AdeR receiver domain | | Descriptor: | AdeR | | Authors: | Wen, Y. | | Deposit date: | 2017-02-16 | | Release date: | 2017-08-30 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (1.401 Å) | | Cite: | Mechanistic insight into how multidrug resistant Acinetobacter baumannii response regulator AdeR recognizes an intercistronic region.
Nucleic Acids Res., 45, 2017
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8YKY
 | | Structure of human class T GPCR TAS2R14-Ggustducin complex with agonist 28.1 | | Descriptor: | 4-methyl-N-[(2M)-2-(1H-tetrazol-5-yl)phenyl]-6-(trifluoromethyl)pyrimidin-2-amine, CHOLESTEROL, G alpha gustducin protein, ... | | Authors: | Hu, X.L, Wu, L.J, Hua, T, Liu, Z.J. | | Deposit date: | 2024-03-05 | | Release date: | 2024-07-10 | | Last modified: | 2024-10-23 | | Method: | ELECTRON MICROSCOPY (2.99 Å) | | Cite: | Bitter taste TAS2R14 activation by intracellular tastants and cholesterol.
Nature, 631, 2024
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8XQP
 | | Structure of human class T GPCR TAS2R14-Gustducin complex with Aristolochic acid A. | | Descriptor: | 8-methoxy-6-nitro-naphtho[1,2-e][1,3]benzodioxole-5-carboxylic acid, CHOLESTEROL, Exo-alpha-sialidase,Taste receptor type 2 member 14,LgBiT, ... | | Authors: | Hu, X.L, Wu, L.J, Hua, T, Liu, Z.J. | | Deposit date: | 2024-01-05 | | Release date: | 2024-07-10 | | Last modified: | 2024-11-06 | | Method: | ELECTRON MICROSCOPY (3.29 Å) | | Cite: | Bitter taste TAS2R14 activation by intracellular tastants and cholesterol.
Nature, 631, 2024
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8XQN
 | | Structure of human class T GPCR TAS2R14-DNGi complex with Aristolochic acid A. | | Descriptor: | 8-methoxy-6-nitro-naphtho[1,2-e][1,3]benzodioxole-5-carboxylic acid, CHOLESTEROL, Exo-alpha-sialidase,Taste receptor type 2 member 14,LgBiT, ... | | Authors: | Hu, X.L, Wu, L.J, Hua, T, Liu, Z.J. | | Deposit date: | 2024-01-05 | | Release date: | 2024-07-10 | | Last modified: | 2024-10-23 | | Method: | ELECTRON MICROSCOPY (3.05 Å) | | Cite: | Bitter taste TAS2R14 activation by intracellular tastants and cholesterol.
Nature, 631, 2024
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8XQL
 | | Structure of human class T GPCR TAS2R14-miniGs/gust complex with Aristolochic acid A. | | Descriptor: | 8-methoxy-6-nitro-naphtho[1,2-e][1,3]benzodioxole-5-carboxylic acid, CHOLESTEROL, Exo-alpha-sialidase,Taste receptor type 2 member 14,LgBiT, ... | | Authors: | Hu, X.L, Wu, L.J, Hua, T, Liu, Z.J. | | Deposit date: | 2024-01-05 | | Release date: | 2024-07-10 | | Last modified: | 2024-11-06 | | Method: | ELECTRON MICROSCOPY (2.99 Å) | | Cite: | Bitter taste TAS2R14 activation by intracellular tastants and cholesterol.
Nature, 631, 2024
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5XJP
 | | Crystal structure of response regulator AdeR receiver domain with Mg | | Descriptor: | AdeR, MAGNESIUM ION | | Authors: | Wen, Y. | | Deposit date: | 2017-05-03 | | Release date: | 2017-08-30 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.597 Å) | | Cite: | Mechanistic insight into how multidrug resistant Acinetobacter baumannii response regulator AdeR recognizes an intercistronic region.
Nucleic Acids Res., 45, 2017
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8XQR
 | | Structure 2 of human class T GPCR TAS2R14-miniGs/gust complex with Flufenamic acid. | | Descriptor: | 2-[[3-(TRIFLUOROMETHYL)PHENYL]AMINO] BENZOIC ACID, Exo-alpha-sialidase,Taste receptor type 2 member 14,LgBiT, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Hu, X.L, Wu, L.J, Hua, T, Liu, Z.J. | | Deposit date: | 2024-01-05 | | Release date: | 2024-07-10 | | Last modified: | 2024-07-24 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Bitter taste TAS2R14 activation by intracellular tastants and cholesterol.
Nature, 631, 2024
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8XQO
 | | Structure of human class T GPCR TAS2R14-Gi complex with Aristolochic acid A. | | Descriptor: | 8-methoxy-6-nitro-naphtho[1,2-e][1,3]benzodioxole-5-carboxylic acid, CHOLESTEROL, Exo-alpha-sialidase,Taste receptor type 2 member 14,LgBiT, ... | | Authors: | Hu, X.L, Wu, L.J, Hua, T, Liu, Z.J. | | Deposit date: | 2024-01-05 | | Release date: | 2024-07-10 | | Last modified: | 2024-10-09 | | Method: | ELECTRON MICROSCOPY (2.77 Å) | | Cite: | Bitter taste TAS2R14 activation by intracellular tastants and cholesterol.
Nature, 631, 2024
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8XQS
 | | Structure of human class T GPCR TAS2R14-DNGi complex with Flufenamic acid. | | Descriptor: | 2-[[3-(TRIFLUOROMETHYL)PHENYL]AMINO] BENZOIC ACID, CHOLESTEROL, Exo-alpha-sialidase,Taste receptor type 2 member 14,LgBiT, ... | | Authors: | Hu, X.L, Wu, L.J, Hua, T, Liu, Z.J. | | Deposit date: | 2024-01-05 | | Release date: | 2024-07-10 | | Last modified: | 2024-10-16 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Bitter taste TAS2R14 activation by intracellular tastants and cholesterol.
Nature, 631, 2024
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6IS2
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6IS3
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6IS4
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6IS1
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6JJJ
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2F8S
 | | Crystal structure of Aa-Ago with externally-bound siRNA | | Descriptor: | 5'-R(P*AP*GP*AP*CP*AP*GP*CP*AP*UP*AP*UP*AP*UP*GP*CP*UP*GP*UP*CP*UP*UP*U)-3', Argonaute protein | | Authors: | Yuan, Y.R, Chen, H.Y, Patel, D.J. | | Deposit date: | 2005-12-03 | | Release date: | 2006-10-31 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | A Potential Protein-RNA Recognition Event along the RISC-Loading Pathway from the Structure of A. aeolicus Argonaute with Externally Bound siRNA.
Structure, 14, 2006
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2F8T
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7EKV
 | | Crystal Structure of human Pin1 complexed with a covalent inhibitor | | Descriptor: | 3,6,9,12,15,18,21-HEPTAOXATRICOSANE-1,23-DIOL, 8-(2-chloroacetyl)-4-((5-phenylfuran-2-yl)methyl)-1-thia-4,8-diazaspiro[4.5]decan-3-one, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | | Authors: | Liu, L, Li, J. | | Deposit date: | 2021-04-06 | | Release date: | 2022-02-16 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Computational and Structure-Based Development of High Potent Cell-Active Covalent Inhibitor Targeting the Peptidyl-Prolyl Isomerase NIMA-Interacting-1 (Pin1).
J.Med.Chem., 65, 2022
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7EFJ
 | | Crystal Structure Analysis of human PIN1 | | Descriptor: | 3,6,9,12,15,18,21-HEPTAOXATRICOSANE-1,23-DIOL, 8-(2-chloroacetyl)-4-(furan-2-ylmethyl)-1-thia-4,8-diazaspiro[4.5]decan-3-one, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | | Authors: | Liu, L, Li, J. | | Deposit date: | 2021-03-21 | | Release date: | 2022-02-16 | | Last modified: | 2024-10-09 | | Method: | X-RAY DIFFRACTION (1.992 Å) | | Cite: | Computational and Structure-Based Development of High Potent Cell-Active Covalent Inhibitor Targeting the Peptidyl-Prolyl Isomerase NIMA-Interacting-1 (Pin1).
J.Med.Chem., 65, 2022
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7XP6
 | | Cryo-EM structure of a class T GPCR in active state | | Descriptor: | Endoglucanase H,Taste receptor type 2 member 46,Endoglucanase H,Taste receptor type 2 member 46,Bitter taste receptor T2R46, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Liu, Z.J, Hua, T, Xu, W.X, Wu, L.J. | | Deposit date: | 2022-05-03 | | Release date: | 2022-10-12 | | Method: | ELECTRON MICROSCOPY (3.01 Å) | | Cite: | Structural basis for strychnine activation of human bitter taste receptor TAS2R46.
Science, 377, 2022
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