5CJ9
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![BU of 5cj9 by Molmil](/molmil-images/mine/5cj9) | Bacillus halodurans Arginine repressor, ArgR | Descriptor: | Arginine repressor, S-1,2-PROPANEDIOL | Authors: | Park, Y.W, Kang, J, Yeo, H.Y, Lee, J.Y. | Deposit date: | 2015-07-14 | Release date: | 2016-06-29 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.409 Å) | Cite: | Structural Analysis and Insights into the Oligomeric State of an Arginine-Dependent Transcriptional Regulator from Bacillus halodurans. Plos One, 11, 2016
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5ZZ6
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![BU of 5zz6 by Molmil](/molmil-images/mine/5zz6) | Redox-sensing transcriptional repressor Rex | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, Redox-sensing transcriptional repressor Rex 1 | Authors: | Park, Y.W, Jang, Y.Y, Joo, H.K, Lee, J.Y. | Deposit date: | 2018-05-30 | Release date: | 2018-11-07 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structural Analysis of Redox-sensing Transcriptional Repressor Rex from Thermotoga maritima Sci Rep, 8, 2018
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5ZZ7
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![BU of 5zz7 by Molmil](/molmil-images/mine/5zz7) | Redox-sensing transcriptional repressor Rex | Descriptor: | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, GLYCEROL, Redox-sensing transcriptional repressor Rex 1 | Authors: | Park, Y.W, Jang, Y.Y, Joo, H.K, Lee, J.Y. | Deposit date: | 2018-05-30 | Release date: | 2018-11-07 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | Structural Analysis of Redox-sensing Transcriptional Repressor Rex from Thermotoga maritima Sci Rep, 8, 2018
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5ZZ5
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![BU of 5zz5 by Molmil](/molmil-images/mine/5zz5) | Redox-sensing transcriptional repressor Rex | Descriptor: | GLYCEROL, Redox-sensing transcriptional repressor Rex | Authors: | Park, Y.W, Jang, Y.Y, Joo, H.K, Lee, J.Y. | Deposit date: | 2018-05-30 | Release date: | 2018-11-07 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural Analysis of Redox-sensing Transcriptional Repressor Rex from Thermotoga maritima Sci Rep, 8, 2018
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7WB3
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![BU of 7wb3 by Molmil](/molmil-images/mine/7wb3) | Crystal structure of T. maritima Rex in ternary complex | Descriptor: | DNA (5'-D(*AP*TP*TP*TP*GP*AP*GP*AP*AP*AP*TP*TP*TP*AP*TP*CP*AP*CP*AP*AP*AP*A)-3'), DNA (5'-D(*TP*TP*TP*TP*GP*TP*GP*AP*TP*AP*AP*AP*TP*TP*TP*CP*TP*CP*AP*AP*AP*T)-3'), NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... | Authors: | Lee, J.Y, Jeong, K.H, Lee, H.J, Park, Y.W. | Deposit date: | 2021-12-15 | Release date: | 2022-02-16 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.401 Å) | Cite: | Structural Basis of Redox-Sensing Transcriptional Repressor Rex with Cofactor NAD + and Operator DNA. Int J Mol Sci, 23, 2022
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7CV2
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![BU of 7cv2 by Molmil](/molmil-images/mine/7cv2) | Crystal structure of B. halodurans NiaR in niacin-bound form | Descriptor: | NICOTINIC ACID, Transcriptional regulator NiaR, ZINC ION | Authors: | Lee, J.Y, Lee, D.W, Park, Y.W, Lee, M.Y, Jeong, K.H. | Deposit date: | 2020-08-25 | Release date: | 2020-12-16 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.802 Å) | Cite: | Structural analysis and insight into effector binding of the niacin-responsive repressor NiaR from Bacillus halodurans. Sci Rep, 10, 2020
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7CV0
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![BU of 7cv0 by Molmil](/molmil-images/mine/7cv0) | Crystal structure of B. halodurans NiaR in apo form | Descriptor: | Transcriptional regulator NiaR, ZINC ION | Authors: | Lee, J.Y, Lee, D.W, Park, Y.W, Lee, M.Y, Jeong, K.H. | Deposit date: | 2020-08-25 | Release date: | 2020-12-16 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.998 Å) | Cite: | Structural analysis and insight into effector binding of the niacin-responsive repressor NiaR from Bacillus halodurans. Sci Rep, 10, 2020
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4Q16
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5GP9
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![BU of 5gp9 by Molmil](/molmil-images/mine/5gp9) | Structural analysis of fatty acid degradation regulator FadR from Bacillus halodurans | Descriptor: | GLYCEROL, MAGNESIUM ION, PALMITIC ACID, ... | Authors: | Lee, J.Y, Yeo, H.K, Park, Y.W. | Deposit date: | 2016-08-01 | Release date: | 2017-03-01 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.755 Å) | Cite: | Structural basis of operator sites recognition and effector binding in the TetR family transcription regulator FadR. Nucleic Acids Res., 45, 2017
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5H38
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![BU of 5h38 by Molmil](/molmil-images/mine/5h38) | Structural analysis of KSHV thymidylate synthase | Descriptor: | ORF70, PHOSPHATE ION | Authors: | Choi, Y.M, Yeo, H.K, Park, Y.W, Lee, J.Y. | Deposit date: | 2016-10-21 | Release date: | 2017-01-18 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structural Analysis of Thymidylate Synthase from Kaposi's Sarcoma-Associated Herpesvirus with the Anticancer Drug Raltitrexed. PLoS ONE, 11, 2016
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5GPA
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5H3A
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![BU of 5h3a by Molmil](/molmil-images/mine/5h3a) | Structural analysis of KSHV thymidylate synthase | Descriptor: | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, ORF70, TOMUDEX | Authors: | Choi, Y.M, Yeo, H.K, Park, Y.W, Lee, J.Y. | Deposit date: | 2016-10-21 | Release date: | 2017-01-18 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural Analysis of Thymidylate Synthase from Kaposi's Sarcoma-Associated Herpesvirus with the Anticancer Drug Raltitrexed. PLoS ONE, 11, 2016
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5H39
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![BU of 5h39 by Molmil](/molmil-images/mine/5h39) | Structural analysis of KSHV thymidylate synthase | Descriptor: | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, ORF70 | Authors: | Choi, Y.M, Yeo, H.K, Park, Y.W, Lee, J.Y. | Deposit date: | 2016-10-21 | Release date: | 2017-01-18 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural Analysis of Thymidylate Synthase from Kaposi's Sarcoma-Associated Herpesvirus with the Anticancer Drug Raltitrexed. PLoS ONE, 11, 2016
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3S22
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![BU of 3s22 by Molmil](/molmil-images/mine/3s22) | AMP-C BETA-LACTAMASE (PSEUDOMONAS AERUGINOSA) in complex with an inhibitor | Descriptor: | Beta-lactamase, CHLORIDE ION, [(2S,3R)-2-formyl-1-{[4-(methylamino)butyl]carbamoyl}pyrrolidin-3-yl]sulfamic acid | Authors: | Scapin, G, Lu, J, Fitzgerald, P.M.D, Sharma, N. | Deposit date: | 2011-05-16 | Release date: | 2011-06-29 | Last modified: | 2013-06-26 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Side chain SAR of bicyclic Beta-lactamase inhibitors (BLIs). 2. N-Alkylated and open chain analogs of MK-8712 Bioorg.Med.Chem.Lett., 21, 2011
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5GPC
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![BU of 5gpc by Molmil](/molmil-images/mine/5gpc) | Structural analysis of fatty acid degradation regulator FadR from Bacillus halodurans | Descriptor: | DNA (5'-D(P*CP*AP*TP*GP*AP*AP*TP*GP*AP*GP*TP*AP*TP*TP*CP*AP*TP*TP*CP*AP*T)-3'), DNA (5'-D(P*GP*AP*TP*GP*AP*AP*TP*GP*AP*AP*TP*AP*CP*TP*CP*AP*TP*TP*CP*AP*T)-3'), Transcriptional regulator (TetR/AcrR family) | Authors: | Lee, J.Y, Yeo, H.K, Park, T.W. | Deposit date: | 2016-08-01 | Release date: | 2017-03-01 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structural basis of operator sites recognition and effector binding in the TetR family transcription regulator FadR. Nucleic Acids Res., 45, 2017
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3S1Y
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![BU of 3s1y by Molmil](/molmil-images/mine/3s1y) | AMP-C BETA-LACTAMASE (PSEUDOMONAS AERUGINOSA) in complex with a beta-lactamase inhibitor | Descriptor: | Beta-lactamase, CHLORIDE ION, ISOPROPYL ALCOHOL, ... | Authors: | Scapin, G, Lu, J, Fitzgerald, P.M.D, Sharma, N. | Deposit date: | 2011-05-16 | Release date: | 2011-06-29 | Last modified: | 2013-06-26 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Side chain SAR of bicyclic Beta-lactamase inhibitors (BLIs). 2. N-Alkylated and open chain analogs of MK-8712 Bioorg.Med.Chem.Lett., 21, 2011
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4O6J
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![BU of 4o6j by Molmil](/molmil-images/mine/4o6j) | Crystal sturucture of T. acidophilum IdeR | Descriptor: | FE (II) ION, Iron-dependent transcription repressor related protein | Authors: | Lee, J.Y, Yeo, H.K. | Deposit date: | 2013-12-20 | Release date: | 2014-05-21 | Last modified: | 2019-12-18 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural analysis and insight into metal-ion activation of the iron-dependent regulator from Thermoplasma acidophilum. Acta Crystallogr.,Sect.D, 70, 2014
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4O5V
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![BU of 4o5v by Molmil](/molmil-images/mine/4o5v) | Crystal structure of T. acidophilum IdeR | Descriptor: | FE (II) ION, Iron-dependent transcription repressor related protein | Authors: | Lee, J.Y, Yeo, H.K. | Deposit date: | 2013-12-20 | Release date: | 2014-11-05 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural analysis and insight into metal-ion activation of the iron-dependent regulator from Thermoplasma acidophilum. Acta Crystallogr.,Sect.D, 70, 2014
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4NK3
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![BU of 4nk3 by Molmil](/molmil-images/mine/4nk3) | Amp-c beta-lactamase (pseudomonas aeruginosa) in complex with mk-7655 | Descriptor: | (2S,5R)-1-formyl-N-(piperidin-4-yl)-5-[(sulfooxy)amino]piperidine-2-carboxamide, Beta-lactamase | Authors: | Scapin, G, Lu, J, Fitzgerald, P.M.D, Sharma, N. | Deposit date: | 2013-11-12 | Release date: | 2014-02-19 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Discovery of MK-7655, a beta-lactamase inhibitor for combination with Primaxin(). Bioorg.Med.Chem.Lett., 24, 2014
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1MOL
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5ZLP
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![BU of 5zlp by Molmil](/molmil-images/mine/5zlp) | Crystal structure of glutamine synthetase from helicobacter pylori | Descriptor: | (2S)-2-AMINO-4-[METHYL(PHOSPHONOOXY)PHOSPHORYL]BUTANOIC ACID, ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ... | Authors: | Joo, H.K, Lee, J.Y. | Deposit date: | 2018-03-29 | Release date: | 2018-08-29 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.93 Å) | Cite: | Structural Analysis of Glutamine Synthetase from Helicobacter pylori. Sci Rep, 8, 2018
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5ZLI
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7CHT
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![BU of 7cht by Molmil](/molmil-images/mine/7cht) | Crystal structure of TTK kinase domain in complex with compound 30 | Descriptor: | 2-[[2-methoxy-4-(2-oxidanylidenepyrrolidin-1-yl)phenyl]amino]-4-(oxan-4-ylamino)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile, Dual specificity protein kinase TTK, MAGNESIUM ION | Authors: | Kim, H.L, Cho, H.Y, Park, Y.W, Lee, Y.H, Ko, E.H, Choi, H.G, Son, J.B, Kim, N.D. | Deposit date: | 2020-07-06 | Release date: | 2021-05-12 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | X-ray Crystal Structure-Guided Design and Optimization of 7 H -Pyrrolo[2,3- d ]pyrimidine-5-carbonitrile Scaffold as a Potent and Orally Active Monopolar Spindle 1 Inhibitor. J.Med.Chem., 64, 2021
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7CHM
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![BU of 7chm by Molmil](/molmil-images/mine/7chm) | Crystal structure of TTK kinase domain in complex with compound 8 | Descriptor: | 4-(cyclohexylamino)-2-[(2-methoxy-4-morpholin-4-ylcarbonyl-phenyl)amino]-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile, Dual specificity protein kinase TTK | Authors: | Kim, H.L, Cho, H.Y, Park, Y.W, Lee, Y.H, Son, J.B, Ko, E.H, Choi, H.G, Kim, N.D. | Deposit date: | 2020-07-06 | Release date: | 2021-05-12 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | X-ray Crystal Structure-Guided Design and Optimization of 7 H -Pyrrolo[2,3- d ]pyrimidine-5-carbonitrile Scaffold as a Potent and Orally Active Monopolar Spindle 1 Inhibitor. J.Med.Chem., 64, 2021
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7CHN
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![BU of 7chn by Molmil](/molmil-images/mine/7chn) | Crystal structure of TTK kinase domain in complex with compound 9 | Descriptor: | 4-(cyclohexylamino)-2-[[2-methoxy-4-(2-oxidanylidenepyrrolidin-1-yl)phenyl]amino]-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile, Dual specificity protein kinase TTK | Authors: | Kim, H.L, Cho, H.Y, Park, Y.W, Lee, Y.H, Son, J.B, Ko, E.H, Choi, H.G, Kim, N.D. | Deposit date: | 2020-07-06 | Release date: | 2021-05-12 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | X-ray Crystal Structure-Guided Design and Optimization of 7 H -Pyrrolo[2,3- d ]pyrimidine-5-carbonitrile Scaffold as a Potent and Orally Active Monopolar Spindle 1 Inhibitor. J.Med.Chem., 64, 2021
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