2JNW
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![BU of 2jnw by Molmil](/molmil-images/mine/2jnw) | Solution structure of a ERCC1-XPA heterodimer | Descriptor: | DNA excision repair protein ERCC-1, DNA-repair protein complementing XP-A cells | Authors: | Tsodikov, O.V, Ivanov, D, Orelli, B, Staresincic, L, Scharer, O.D, Wagner, G. | Deposit date: | 2007-02-07 | Release date: | 2007-10-30 | Last modified: | 2023-12-20 | Method: | SOLUTION NMR | Cite: | Structural basis for the recruitment of ERCC1-XPF to nucleotide excision repair complexes by XPA Embo J., 26, 2007
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3PVP
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![BU of 3pvp by Molmil](/molmil-images/mine/3pvp) | Structure of Mycobacterium tuberculosis DnaA-DBD in complex with box2 DNA | Descriptor: | Chromosomal replication initiator protein dnaA, DNA (5'-D(*CP*GP*TP*TP*AP*TP*CP*CP*AP*CP*AP*AP*C)-3'), DNA (5'-D(*GP*TP*TP*GP*TP*GP*GP*AP*TP*AP*AP*CP*G)-3') | Authors: | Tsodikov, O.V, Biswas, T. | Deposit date: | 2010-12-07 | Release date: | 2011-05-25 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural and Thermodynamic Signatures of DNA Recognition by Mycobacterium tuberculosis DnaA. J.Mol.Biol., 410, 2011
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3PVV
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![BU of 3pvv by Molmil](/molmil-images/mine/3pvv) | Structure of Mycobacterium tuberculosis DnaA-DBD in complex with box1 DNA | Descriptor: | Chromosomal replication initiator protein dnaA, DNA (5'-D(*CP*GP*TP*TP*GP*TP*CP*CP*AP*CP*AP*AP*C)-3'), DNA (5'-D(*GP*TP*TP*GP*TP*GP*GP*AP*CP*AP*AP*CP*G)-3') | Authors: | Tsodikov, O.V, Biswas, T. | Deposit date: | 2010-12-07 | Release date: | 2011-05-25 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural and Thermodynamic Signatures of DNA Recognition by Mycobacterium tuberculosis DnaA. J.Mol.Biol., 410, 2011
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2A1I
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![BU of 2a1i by Molmil](/molmil-images/mine/2a1i) | Crystal Structure of the Central Domain of Human ERCC1 | Descriptor: | DNA excision repair protein ERCC-1, MERCURY (II) ION | Authors: | Tsodikov, O.V, Enzlin, J.H, Scharer, O.D, Ellenberger, T. | Deposit date: | 2005-06-20 | Release date: | 2005-08-02 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Crystal structure and DNA binding functions of ERCC1, a subunit of the DNA structure-specific endonuclease XPF-ERCC1. Proc.Natl.Acad.Sci.Usa, 102, 2005
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2A1J
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![BU of 2a1j by Molmil](/molmil-images/mine/2a1j) | Crystal Structure of the Complex between the C-Terminal Domains of Human XPF and ERCC1 | Descriptor: | DNA excision repair protein ERCC-1, DNA repair endonuclease XPF, MERCURY (II) ION | Authors: | Tsodikov, O.V, Enzlin, J.H, Scharer, O.D, Ellenberger, T. | Deposit date: | 2005-06-20 | Release date: | 2005-08-02 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Crystal structure and DNA binding functions of ERCC1, a subunit of the DNA structure-specific endonuclease XPF-ERCC1. Proc.Natl.Acad.Sci.Usa, 102, 2005
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3HYC
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![BU of 3hyc by Molmil](/molmil-images/mine/3hyc) | |
4Z2Y
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![BU of 4z2y by Molmil](/molmil-images/mine/4z2y) | Crystal structure of methyltransferase CalO6 | Descriptor: | CalO6, MERCURY (II) ION | Authors: | Hou, C, Garneau-Tsodikova, S, Tsodikov, O.V. | Deposit date: | 2015-03-30 | Release date: | 2015-07-22 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | Crystal structure of O-methyltransferase CalO6 from the calicheamicin biosynthetic pathway: a case of challenging structure determination at low resolution. Bmc Struct.Biol., 15, 2015
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4RVH
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![BU of 4rvh by Molmil](/molmil-images/mine/4rvh) | Crystal structure of MtmC in complex with SAH and TDP-4-keto-D-olivose | Descriptor: | D-mycarose 3-C-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE, ZINC ION, ... | Authors: | Tsodikov, O.V, Hou, C, Chen, J.-M, Rohr, J. | Deposit date: | 2014-11-26 | Release date: | 2015-01-28 | Last modified: | 2015-05-06 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural Insight into MtmC, a Bifunctional Ketoreductase-Methyltransferase Involved in the Assembly of the Mithramycin Trisaccharide Chain. Biochemistry, 54, 2015
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4RVG
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![BU of 4rvg by Molmil](/molmil-images/mine/4rvg) | Crystal structure of MtmC in complex with SAM and TDP | Descriptor: | ACETATE ION, D-mycarose 3-C-methyltransferase, S-ADENOSYLMETHIONINE, ... | Authors: | Tsodikov, O.V, Hou, C, Chen, J.-M, Rohr, J. | Deposit date: | 2014-11-26 | Release date: | 2015-01-28 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural Insight into MtmC, a Bifunctional Ketoreductase-Methyltransferase Involved in the Assembly of the Mithramycin Trisaccharide Chain. Biochemistry, 54, 2015
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4RVD
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![BU of 4rvd by Molmil](/molmil-images/mine/4rvd) | Crystal structure of MtmC in complex with SAM | Descriptor: | ACETATE ION, D-mycarose 3-C-methyltransferase, S-ADENOSYLMETHIONINE, ... | Authors: | Tsodikov, O.V, Hou, C, Chen, J.-M, Rohr, J. | Deposit date: | 2014-11-26 | Release date: | 2015-01-28 | Last modified: | 2015-05-06 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structural Insight into MtmC, a Bifunctional Ketoreductase-Methyltransferase Involved in the Assembly of the Mithramycin Trisaccharide Chain. Biochemistry, 54, 2015
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4RVF
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![BU of 4rvf by Molmil](/molmil-images/mine/4rvf) | Crystal structure of MtmC in complex with TDP | Descriptor: | D-mycarose 3-C-methyltransferase, THYMIDINE-5'-DIPHOSPHATE, ZINC ION | Authors: | Tsodikov, O.V, Hou, C, Chen, J.-M, Rohr, J. | Deposit date: | 2014-11-26 | Release date: | 2015-01-28 | Last modified: | 2015-05-06 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structural Insight into MtmC, a Bifunctional Ketoreductase-Methyltransferase Involved in the Assembly of the Mithramycin Trisaccharide Chain. Biochemistry, 54, 2015
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2R8Z
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![BU of 2r8z by Molmil](/molmil-images/mine/2r8z) | Crystal structure of YrbI phosphatase from Escherichia coli in complex with a phosphate and a calcium ion | Descriptor: | 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase, CALCIUM ION, PHOSPHATE ION | Authors: | Tsodikov, O.V, Aggarwal, P, Rubin, J.R, Stuckey, J.A, Woodard, R.W, Biswas, T. | Deposit date: | 2007-09-11 | Release date: | 2008-09-23 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | The Tail of KdsC: CONFORMATIONAL CHANGES CONTROL THE ACTIVITY OF A HALOACID DEHALOGENASE SUPERFAMILY PHOSPHATASE. J.Biol.Chem., 284, 2009
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2R8E
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![BU of 2r8e by Molmil](/molmil-images/mine/2r8e) | Crystal structure of YrbI from Escherichia coli in complex with Mg | Descriptor: | 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase, CHLORIDE ION, MAGNESIUM ION | Authors: | Tsodikov, O.V, Aggarwal, P, Rubin, J.R, Stuckey, J.A, Woodard, R, Biswas, T. | Deposit date: | 2007-09-10 | Release date: | 2008-09-23 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | The Tail of KdsC: CONFORMATIONAL CHANGES CONTROL THE ACTIVITY OF A HALOACID DEHALOGENASE SUPERFAMILY PHOSPHATASE. J.Biol.Chem., 284, 2009
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2R8X
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![BU of 2r8x by Molmil](/molmil-images/mine/2r8x) | Crystal structure of YrbI phosphatase from Escherichia coli | Descriptor: | 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase, CHLORIDE ION | Authors: | Tsodikov, O.V, Aggarwal, P, Rubin, J.R, Stuckey, J.A, Woodard, R.W, Biswas, T. | Deposit date: | 2007-09-11 | Release date: | 2008-09-23 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | The Tail of KdsC: CONFORMATIONAL CHANGES CONTROL THE ACTIVITY OF A HALOACID DEHALOGENASE SUPERFAMILY PHOSPHATASE. J.Biol.Chem., 284, 2009
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2R8Y
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![BU of 2r8y by Molmil](/molmil-images/mine/2r8y) | Crystal structure of YrbI phosphatase from Escherichia coli in a complex with Ca | Descriptor: | CALCIUM ION, CHLORIDE ION, YrbI from Escherichia coli | Authors: | Tsodikov, O.V, Aggarwal, P, Rubin, J.R, Stuckey, J.A, Woodard, R.W, Biswas, T. | Deposit date: | 2007-09-11 | Release date: | 2008-09-23 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | The Tail of KdsC: CONFORMATIONAL CHANGES CONTROL THE ACTIVITY OF A HALOACID DEHALOGENASE SUPERFAMILY PHOSPHATASE. J.Biol.Chem., 284, 2009
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5IV0
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![BU of 5iv0 by Molmil](/molmil-images/mine/5iv0) | Crystal structure of Eis from Mycobacterium tuberculosis in complex with sulfonamide inhibitor 39 and coenzyme A | Descriptor: | CHLORIDE ION, COENZYME A, Enhanced intracellular survival protein, ... | Authors: | Gajadeera, C.S, Hou, C, Garneau-Tsodikova, S, Tsodikov, O.V. | Deposit date: | 2016-03-18 | Release date: | 2017-01-11 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Sulfonamide-Based Inhibitors of Aminoglycoside Acetyltransferase Eis Abolish Resistance to Kanamycin in Mycobacterium tuberculosis. J. Med. Chem., 59, 2016
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6BZN
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![BU of 6bzn by Molmil](/molmil-images/mine/6bzn) | |
6BZI
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![BU of 6bzi by Molmil](/molmil-images/mine/6bzi) | Crystal structure of halogenase PltM in complex with ethyl mercury and mercury | Descriptor: | CALCIUM ION, ETHYL MERCURY ION, GLYCEROL, ... | Authors: | Pang, A.H, Garneau-Tsodikova, S, Tsodikov, O.V. | Deposit date: | 2017-12-24 | Release date: | 2019-03-20 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Unusual substrate and halide versatility of phenolic halogenase PltM. Nat Commun, 10, 2019
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3U9F
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3U9B
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![BU of 3u9b by Molmil](/molmil-images/mine/3u9b) | Structure of apo-CATI | Descriptor: | Chloramphenicol acetyltransferase | Authors: | Biswas, T, Garneau-Tsodikova, S, Tsodikov, O.V. | Deposit date: | 2011-10-18 | Release date: | 2012-02-15 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | The structural basis for substrate versatility of chloramphenicol acetyltransferase CAT(I). Protein Sci., 21, 2012
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4I9G
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![BU of 4i9g by Molmil](/molmil-images/mine/4i9g) | Crystal structure of glycerol phosphate phosphatase Rv1692 from Mycobacterium tuberculosis in complex with magnesium | Descriptor: | Glycerol 3-phosphate phosphatase, MAGNESIUM ION | Authors: | Biswas, T, Larrouy-Maumus, G, de Carvalho, L.P, Tsodikov, O.V. | Deposit date: | 2012-12-05 | Release date: | 2013-07-10 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (3.25 Å) | Cite: | Discovery of a glycerol 3-phosphate phosphatase reveals glycerophospholipid polar head recycling in Mycobacterium tuberculosis. Proc.Natl.Acad.Sci.USA, 110, 2013
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6P3V
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![BU of 6p3v by Molmil](/molmil-images/mine/6p3v) | Crystal structure of Eis from Mycobacterium tuberculosis in complex with inhibitor SGT416 | Descriptor: | DIMETHYL SULFOXIDE, N,N-diethyl-2-[(8-fluoro-5-methyl-5H-[1,2,4]triazino[5,6-b]indol-3-yl)sulfanyl]ethan-1-amine, N-acetyltransferase Eis, ... | Authors: | Punetha, A, Garneau-Tsodikova, S, Tsodikov, O.V. | Deposit date: | 2019-05-24 | Release date: | 2019-09-04 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Probing the Robustness of Inhibitors of Tuberculosis Aminoglycoside Resistance Enzyme Eis by Mutagenesis. Acs Infect Dis., 5, 2019
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6P3U
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![BU of 6p3u by Molmil](/molmil-images/mine/6p3u) | Crystal structure of Eis from Mycobacterium tuberculosis in complex with inhibitor SGT335 | Descriptor: | 1-(4-fluorophenyl)-2-[2-(4-fluorophenyl)-2-oxoethyl]pyrrolo[1,2-a]pyrazin-2-ium, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... | Authors: | Punetha, A, Garneau-Tsodikova, S, Tsodikov, O.V. | Deposit date: | 2019-05-24 | Release date: | 2019-09-04 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | Probing the Robustness of Inhibitors of Tuberculosis Aminoglycoside Resistance Enzyme Eis by Mutagenesis. Acs Infect Dis., 5, 2019
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6P3T
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![BU of 6p3t by Molmil](/molmil-images/mine/6p3t) | Crystal structure of Eis from Mycobacterium tuberculosis in complex with inhibitor SGT449 | Descriptor: | AMMONIUM ION, DI(HYDROXYETHYL)ETHER, DIMETHYL SULFOXIDE, ... | Authors: | Punetha, A, Garneau-Tsodikova, S, Tsodikov, O.V. | Deposit date: | 2019-05-24 | Release date: | 2019-09-04 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Probing the Robustness of Inhibitors of Tuberculosis Aminoglycoside Resistance Enzyme Eis by Mutagenesis. Acs Infect Dis., 5, 2019
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3ITW
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![BU of 3itw by Molmil](/molmil-images/mine/3itw) | |