6P3V
Crystal structure of Eis from Mycobacterium tuberculosis in complex with inhibitor SGT416
Summary for 6P3V
Entry DOI | 10.2210/pdb6p3v/pdb |
Descriptor | N-acetyltransferase Eis, N,N-diethyl-2-[(8-fluoro-5-methyl-5H-[1,2,4]triazino[5,6-b]indol-3-yl)sulfanyl]ethan-1-amine, SULFATE ION, ... (5 entities in total) |
Functional Keywords | acetyltransferase, aminoglycoside resistance, competitive inhibitor, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
Total number of polymer chains | 1 |
Total formula weight | 46506.74 |
Authors | Punetha, A.,Garneau-Tsodikova, S.,Tsodikov, O.V. (deposition date: 2019-05-24, release date: 2019-09-04, Last modification date: 2023-10-11) |
Primary citation | Green, K.D.,Punetha, A.,Hou, C.,Garneau-Tsodikova, S.,Tsodikov, O.V. Probing the Robustness of Inhibitors of Tuberculosis Aminoglycoside Resistance Enzyme Eis by Mutagenesis. Acs Infect Dis., 5:1772-1778, 2019 Cited by PubMed: 31433614DOI: 10.1021/acsinfecdis.9b00228 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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