6P3V

Crystal structure of Eis from Mycobacterium tuberculosis in complex with inhibitor SGT416

Summary for 6P3V

• Entry DOI: 10.2210/pdb6p3v/pdb
• Descriptor: N-acetyltransferase Eis, N,N-diethyl-2-[(8-fluoro-5-methyl-5H-[1,2,4]triazino[5,6-b]indol-3-yl)sulfanyl]ethan-1-amine, SULFATE ION, ... (5 entities in total)
• Functional Keywords: acetyltransferase, aminoglycoside resistance, competitive inhibitor, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
• Total number of polymer chains: 1
• Total formula weight: 46506.74

Authors

Punetha, A.,Garneau-Tsodikova, S.,Tsodikov, O.V. (deposition date: 2019-05-24, release date: 2019-09-04, Last modification date: 2023-10-11)

• Primary citation: Green, K.D.,Punetha, A.,Hou, C.,Garneau-Tsodikova, S.,Tsodikov, O.V.; Probing the Robustness of Inhibitors of Tuberculosis Aminoglycoside Resistance Enzyme Eis by Mutagenesis.; Acs Infect Dis., 5:1772-1778, 2019; PubMed: 31433614; DOI: 10.1021/acsinfecdis.9b00228

Experimental method

X-RAY DIFFRACTION (2.5 Å)