6P3V
Crystal structure of Eis from Mycobacterium tuberculosis in complex with inhibitor SGT416
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | N-acetyltransferase Eis | polymer | 422 | 45999.1 | 1 | UniProt (P9WFK7) Pfam (PF13527) Pfam (PF17668) Pfam (PF13530) | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) | Aminoglycoside N-acetyltransferase,Enhanced intracellular survival protein,Protein-lysine N-acetyltransferase |
| 2 | B (A) | N,N-diethyl-2-[(8-fluoro-5-methyl-5H-[1,2,4]triazino[5,6-b]indol-3-yl)sulfanyl]ethan-1-amine | non-polymer | 333.4 | 1 | Chemie (NRV) | |||
| 3 | C (A) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 4 | D (A) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 1 | Chemie (DMS) | |||
| 5 | E (A) | water | water | 18.0 | 80 | Chemie (HOH) |
Sequence modifications
A: 1 - 402 (UniProt: P9WFK7)
| PDB | External Database | Details |
|---|---|---|
| Met -19 | - | initiating methionine |
| Gly -18 | - | expression tag |
| Ser -17 | - | expression tag |
| Ser -16 | - | expression tag |
| His -15 | - | expression tag |
| His -14 | - | expression tag |
| His -13 | - | expression tag |
| His -12 | - | expression tag |
| His -11 | - | expression tag |
| His -10 | - | expression tag |
| Ser -9 | - | expression tag |
| Ser -8 | - | expression tag |
| Gly -7 | - | expression tag |
| Leu -6 | - | expression tag |
| Val -5 | - | expression tag |
| Pro -4 | - | expression tag |
| Arg -3 | - | expression tag |
| Gly -2 | - | expression tag |
| Ser -1 | - | expression tag |
| His 0 | - | expression tag |
| Ala 204 | Cys 204 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 45999.1 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 507.6 | |
| All* | Total formula weight | 46506.7 |
