3UUO
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![BU of 3uuo by Molmil](/molmil-images/mine/3uuo) | The discovery of potent, selectivity, and orally bioavailable pyrozoloquinolines as PDE10 inhibitors for the treatment of Schizophrenia | Descriptor: | 6-methoxy-3,8-dimethyl-4-(piperazin-1-yl)-1H-pyrazolo[3,4-b]quinoline, MAGNESIUM ION, PHOSPHATE ION, ... | Authors: | Ho, G.D, Yang, S, Smotryski, J, Bercovici, A, Nechuta, T, Smith, E.M, McElroy, W, Tan, Z, Tulshian, D, Mckittrick, B, Greenlee, W.J, Hruza, A, Xiao, L, Rindgen, D, Guzzi, M, Zhang, X, Bleickardt, C, Mullins, D, Hodgson, R. | Deposit date: | 2011-11-28 | Release date: | 2012-01-25 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.11 Å) | Cite: | The discovery of potent, selective, and orally active pyrazoloquinolines as PDE10A inhibitors for the treatment of Schizophrenia. Bioorg.Med.Chem.Lett., 22, 2012
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7CBD
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![BU of 7cbd by Molmil](/molmil-images/mine/7cbd) | Catalytic domain of Cellulomonas fimi Cel6B | Descriptor: | Exoglucanase A | Authors: | Nakamura, A, Ishiwata, D, Visootsat, A, Uchiyama, T, Mizutani, K, Kaneko, S, Murata, T, Igarashi, K, Iino, R. | Deposit date: | 2020-06-12 | Release date: | 2020-08-26 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Domain architecture divergence leads to functional divergence in binding and catalytic domains of bacterial and fungal cellobiohydrolases. J.Biol.Chem., 295, 2020
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6K54
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![BU of 6k54 by Molmil](/molmil-images/mine/6k54) | Hyperthermophilic GH6 cellobiohydrolase II (HmCel6A) in complex with trisaccharide | Descriptor: | 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ... | Authors: | Baba, S, Takeda, M, Okuma, J, Hirose, Y, Nishimura, A, Takata, M, Oda, K, Shibata, D, Kondo, Y, Kumasaka, T. | Deposit date: | 2019-05-28 | Release date: | 2020-06-03 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.905 Å) | Cite: | Novel hyperthermophilic cellobiohydrolase II isolated from hot spring microbial community To Be Published
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6K53
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![BU of 6k53 by Molmil](/molmil-images/mine/6k53) | A variant of metagenome-derived GH6 cellobiohydrolase, HmCel6A (P88S/L230F/F414S) | Descriptor: | CITRATE ANION, GH6 cellobiohydrolase, HMCEL6A, ... | Authors: | Baba, S, Takeda, M, Okuma, J, Hirose, Y, Nishimura, A, Takata, M, Oda, K, Shibata, D, Kondo, Y, Kumasaka, T. | Deposit date: | 2019-05-28 | Release date: | 2020-06-03 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.89 Å) | Cite: | A hyperthermophilic GH6 cellobiohydrolase (HmCel6A) from a hot spring metagenomic data To Be Published
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6K52
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![BU of 6k52 by Molmil](/molmil-images/mine/6k52) | Hyperthermophilic GH6 cellobiohydrolase (HmCel6A) from the microbial flora of a Japanese hot spring | Descriptor: | ACETATE ION, CALCIUM ION, GH6 cellobiohydrolase, ... | Authors: | Baba, S, Takeda, M, Okuma, J, Hirose, Y, Nishimura, A, Takata, M, Oda, K, Shibata, D, Kondo, Y, Kumasaka, T. | Deposit date: | 2019-05-28 | Release date: | 2020-06-03 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.68000138 Å) | Cite: | A hyperthermophilic cellobiohydrolase mined from a hot spring metagenomic data To Be Published
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6K55
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![BU of 6k55 by Molmil](/molmil-images/mine/6k55) | Inactivated mutant (D140A) of Hyperthermophilic GH6 cellobiohydrolase II (HmCel6A) in complex with hexasaccharide | Descriptor: | Glucanase, MAGNESIUM ION, beta-D-glucopyranose-(1-4)-beta-D-glucopyranose-(1-4)-beta-D-glucopyranose-(1-4)-beta-D-glucopyranose-(1-4)-beta-D-glucopyranose-(1-4)-beta-D-glucopyranose-(1-4)-beta-D-glucopyranose | Authors: | Baba, S, Takeda, M, Okuma, J, Hirose, Y, Nishimura, A, Takata, M, Oda, K, Shibata, D, Kondo, Y, Kumasaka, T. | Deposit date: | 2019-05-28 | Release date: | 2020-06-03 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.883 Å) | Cite: | A hyperthermophilic cellobiohydrolase mined from a hot spring metagenomic data To Be Published
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3UI7
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![BU of 3ui7 by Molmil](/molmil-images/mine/3ui7) | Discovery of orally active pyrazoloquinoline as a potent PDE10 inhibitor for the management of schizophrenia | Descriptor: | 6-methoxy-3,8-dimethyl-4-(morpholin-4-ylmethyl)-1H-pyrazolo[3,4-b]quinoline, MAGNESIUM ION, ZINC ION, ... | Authors: | Yang, S, Smotryski, J, Mcelroy, W, Ho, G, Tulshian, D, Greenlee, W.J, Hodgson, R, Xiao, L, Hruza, A. | Deposit date: | 2011-11-04 | Release date: | 2011-12-21 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.28 Å) | Cite: | Discovery of orally active pyrazoloquinolines as potent PDE10 inhibitors for the management of schizophrenia. Bioorg.Med.Chem.Lett., 22, 2012
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3WFR
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![BU of 3wfr by Molmil](/molmil-images/mine/3wfr) | tRNA processing enzyme complex 2 | Descriptor: | CYTIDINE-5'-TRIPHOSPHATE, MAGNESIUM ION, PYROPHOSPHATE 2-, ... | Authors: | Yamashita, S, Takeshita, D, Tomita, K. | Deposit date: | 2013-07-23 | Release date: | 2014-01-01 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (3.501 Å) | Cite: | Translocation and rotation of tRNA during template-independent RNA polymerization by tRNA nucleotidyltransferase Structure, 22, 2014
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3WFS
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![BU of 3wfs by Molmil](/molmil-images/mine/3wfs) | tRNA processing enzyme complex 3 | Descriptor: | Poly A polymerase, RNA (74-MER), SULFATE ION | Authors: | Yamashita, S, Takeshita, D, Tomita, K. | Deposit date: | 2013-07-23 | Release date: | 2014-01-01 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (3.311 Å) | Cite: | Translocation and rotation of tRNA during template-independent RNA polymerization by tRNA nucleotidyltransferase Structure, 22, 2014
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3WFO
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![BU of 3wfo by Molmil](/molmil-images/mine/3wfo) | tRNA processing enzyme (apo form 1) | Descriptor: | Poly A polymerase, SULFATE ION | Authors: | Yamashita, S, Takeshita, D, Tomita, K. | Deposit date: | 2013-07-23 | Release date: | 2014-01-01 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | Translocation and rotation of tRNA during template-independent RNA polymerization by tRNA nucleotidyltransferase Structure, 22, 2014
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3WFP
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![BU of 3wfp by Molmil](/molmil-images/mine/3wfp) | tRNA processing enzyme (apo form 2) | Descriptor: | Poly A polymerase, SULFATE ION | Authors: | Yamashita, S, Takeshita, D, Tomita, K. | Deposit date: | 2013-07-23 | Release date: | 2014-01-01 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (4.005 Å) | Cite: | Translocation and rotation of tRNA during template-independent RNA polymerization by tRNA nucleotidyltransferase Structure, 22, 2014
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3WFQ
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![BU of 3wfq by Molmil](/molmil-images/mine/3wfq) | tRNA processing enzyme complex 1 | Descriptor: | Poly A polymerase, RNA (73-MER) | Authors: | Yamashita, S, Takeshita, D, Tomita, K. | Deposit date: | 2013-07-23 | Release date: | 2014-01-01 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (3.619 Å) | Cite: | Translocation and rotation of tRNA during template-independent RNA polymerization by tRNA nucleotidyltransferase Structure, 22, 2014
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1Q2J
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![BU of 1q2j by Molmil](/molmil-images/mine/1q2j) | Structural basis for tetrodotoxin-resistant sodium channel binding by mu-conotoxin SmIIIA | Descriptor: | Mu-conotoxin SmIIIA | Authors: | Keizer, D.W, West, P.J, Lee, E.F, Olivera, B.M, Bulaj, G, Yoshikami, D, Norton, R.S. | Deposit date: | 2003-07-24 | Release date: | 2004-02-24 | Last modified: | 2020-06-24 | Method: | SOLUTION NMR | Cite: | Structural basis for tetrodotoxin-resistant sodium channel binding by mu-conotoxin SmIIIA. J.Biol.Chem., 278, 2003
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5HZH
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![BU of 5hzh by Molmil](/molmil-images/mine/5hzh) | Crystal structure of photoinhibitable Rac1 containing C450A mutant LOV2 domain | Descriptor: | CALCIUM ION, FLAVIN MONONUCLEOTIDE, GUANOSINE-5'-TRIPHOSPHATE, ... | Authors: | Tarnawski, M, Dagliyan, O, Chu, P.H, Shirvanyants, D, Dokholyan, N.V, Hahn, K.M, Schlichting, I. | Deposit date: | 2016-02-02 | Release date: | 2016-12-21 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Engineering extrinsic disorder to control protein activity in living cells. Science, 354, 2016
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3JRW
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![BU of 3jrw by Molmil](/molmil-images/mine/3jrw) | Phosphorylated BC domain of ACC2 | Descriptor: | Acetyl-CoA carboxylase 2 | Authors: | Cho, Y.S, Lee, J.I, Shin, D, Kim, H.T, Lee, T.G, Heo, Y.S. | Deposit date: | 2009-09-09 | Release date: | 2010-01-12 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Molecular mechanism for the regulation of human ACC2 through phosphorylation by AMPK Biochem.Biophys.Res.Commun., 391, 2010
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3JRX
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![BU of 3jrx by Molmil](/molmil-images/mine/3jrx) | Crystal structure of the BC domain of ACC2 in complex with soraphen A | Descriptor: | Acetyl-CoA carboxylase 2, SORAPHEN A | Authors: | Cho, Y.S, Lee, J.I, Shin, D, Kim, H.T, Lee, T.G, Heo, Y.S. | Deposit date: | 2009-09-09 | Release date: | 2010-01-12 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Molecular mechanism for the regulation of human ACC2 through phosphorylation by AMPK. Biochem.Biophys.Res.Commun., 391, 2010
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6HYL
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![BU of 6hyl by Molmil](/molmil-images/mine/6hyl) | Structure of PCM1 LIR motif bound to GABARAP | Descriptor: | Pericentriolar material 1 protein,Gamma-aminobutyric acid receptor-associated protein | Authors: | Mouilleron, S, Wirth, M, Zhang, W, O'Reilly, N, Tooze, S, Johansen, T, Razi, M, Nyoni, L, Joshi, D. | Deposit date: | 2018-10-22 | Release date: | 2019-05-08 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.559 Å) | Cite: | Molecular determinants regulating selective binding of autophagy adapters and receptors to ATG8 proteins. Nat Commun, 10, 2019
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2KN1
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![BU of 2kn1 by Molmil](/molmil-images/mine/2kn1) | Solution NMR Structure of BCMA | Descriptor: | Tumor necrosis factor receptor superfamily member 17 | Authors: | Pellegrini, M, Willen, L, Perroud, M, Krushinskie, D, Strauch, K, Cuervo, H, Sun, Y, Day, E.S, Schneider, P, Zheng, T.S. | Deposit date: | 2009-08-11 | Release date: | 2011-02-23 | Last modified: | 2013-05-01 | Method: | SOLUTION NMR | Cite: | Structure of the extracellular domains of human and Xenopus Fn14: implications in the evolution of TWEAK and Fn14 interactions. Febs J., 280, 2013
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6HYM
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![BU of 6hym by Molmil](/molmil-images/mine/6hym) | Structure of PCM1 LIR motif bound to GABARAP | Descriptor: | 1,2-ETHANEDIOL, GLYCEROL, Pericentriolar material 1 protein,Gamma-aminobutyric acid receptor-associated protein | Authors: | Mouilleron, S, Wirth, M, Zhang, W, O'Reilly, N, Tooze, S, Johansen, T, Razi, M, Nyoni, L, Joshi, D. | Deposit date: | 2018-10-22 | Release date: | 2019-05-08 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.86 Å) | Cite: | Molecular determinants regulating selective binding of autophagy adapters and receptors to ATG8 proteins. Nat Commun, 10, 2019
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2KN0
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![BU of 2kn0 by Molmil](/molmil-images/mine/2kn0) | Solution NMR Structure of xenopus Fn14 | Descriptor: | Fn14 | Authors: | Pellegrini, M, Willen, L, Perroud, M, Krushinskie, D, Strauch, K, Cuervo, H, Sun, Y, Day, E.S, Schneider, P, Zheng, T.S. | Deposit date: | 2009-08-11 | Release date: | 2011-06-29 | Last modified: | 2013-05-01 | Method: | SOLUTION NMR | Cite: | Structure of the extracellular domains of human and Xenopus Fn14: implications in the evolution of TWEAK and Fn14 interactions. Febs J., 280, 2013
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2KMZ
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![BU of 2kmz by Molmil](/molmil-images/mine/2kmz) | NMR Structure of hFn14 | Descriptor: | Tumor necrosis factor receptor superfamily member 12A | Authors: | Pellegrini, M, Willen, L, Perroud, M, Krushinskie, D, Strauch, K, Cuervo, H, Sun, Y, Day, E.S, Schneider, P, Zheng, T.S. | Deposit date: | 2009-08-10 | Release date: | 2011-06-29 | Last modified: | 2013-05-01 | Method: | SOLUTION NMR | Cite: | Structure of the extracellular domains of human and Xenopus Fn14: implications in the evolution of TWEAK and Fn14 interactions. Febs J., 280, 2013
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6HYN
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![BU of 6hyn by Molmil](/molmil-images/mine/6hyn) | Structure of ATG13 LIR motif bound to GABARAP | Descriptor: | Autophagy-related protein 13,Gamma-aminobutyric acid receptor-associated protein | Authors: | Mouilleron, S, Wirth, M, Zhang, W, O'Reilly, N, Tooze, S, Johansen, T, Razi, M, Nyoni, L, Joshi, D. | Deposit date: | 2018-10-22 | Release date: | 2019-05-08 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.14 Å) | Cite: | Molecular determinants regulating selective binding of autophagy adapters and receptors to ATG8 proteins. Nat Commun, 10, 2019
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2HJW
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![BU of 2hjw by Molmil](/molmil-images/mine/2hjw) | Crystal Structure of the BC domain of ACC2 | Descriptor: | Acetyl-CoA carboxylase 2 | Authors: | Cho, Y.S, Lee, J.I, Shin, D, Kim, H.T, Lee, T.G, Heo, Y.S. | Deposit date: | 2006-07-02 | Release date: | 2007-07-03 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystal structure of the biotin carboxylase domain of human acetyl-CoA carboxylase 2. Proteins, 70, 2008
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6HYO
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![BU of 6hyo by Molmil](/molmil-images/mine/6hyo) | Structure of ULK1 LIR motif bound to GABARAP | Descriptor: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... | Authors: | Mouilleron, S, Wirth, M, Zhang, W, O'Reilly, N, Tooze, S, Johansen, T, Razi, M, Nyoni, L, Joshi, D. | Deposit date: | 2018-10-22 | Release date: | 2019-05-08 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.07 Å) | Cite: | Molecular determinants regulating selective binding of autophagy adapters and receptors to ATG8 proteins. Nat Commun, 10, 2019
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7E5P
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![BU of 7e5p by Molmil](/molmil-images/mine/7e5p) | Aptamer enhancing peroxidase activity of myoglobin | Descriptor: | DNA (5'-D(*GP*GP*GP*TP*GP*GP*GP*TP*TP*GP*GP*GP*AP*GP*GP*G)-3') | Authors: | Tsukakoshi, K, Matsugami, A, Khunathai, K, Kanazashi, M, Yamagishi, Y, Nakama, K, Oshikawa, D, Hayashi, F, Kuno, H, Ikebukuro, K. | Deposit date: | 2021-02-19 | Release date: | 2021-06-16 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | G-quadruplex-forming aptamer enhances the peroxidase activity of myoglobin against luminol. Nucleic Acids Res., 49, 2021
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