3UY8
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![BU of 3uy8 by Molmil](/molmil-images/mine/3uy8) | Designed protein KE59 R5_11/5F | Descriptor: | Kemp eliminase KE59 R5_11/5F, SULFATE ION | Authors: | Khersonsky, O, Kiss, G, Roethlisberger, D, Dym, O, Albeck, S, Houk, K.N, Baker, D, Tawfik, D.S, Israel Structural Proteomics Center (ISPC) | Deposit date: | 2011-12-06 | Release date: | 2012-06-06 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.41 Å) | Cite: | Bridging the gaps in design methodologies by evolutionary optimization of the stability and proficiency of designed Kemp eliminase KE59. Proc.Natl.Acad.Sci.USA, 109, 2012
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1VJQ
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![BU of 1vjq by Molmil](/molmil-images/mine/1vjq) | |
5JI4
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![BU of 5ji4 by Molmil](/molmil-images/mine/5ji4) | Solution structure of the de novo mini protein gEEHE_02 | Descriptor: | W37 | Authors: | Buchko, G.W, Bahl, C.D, Pulavarti, S.V, Baker, D, Szyperski, T. | Deposit date: | 2016-04-21 | Release date: | 2016-09-28 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | Accurate de novo design of hyperstable constrained peptides. Nature, 538, 2016
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5JHI
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![BU of 5jhi by Molmil](/molmil-images/mine/5jhi) | Solution structure of the de novo mini protein gEHE_06 | Descriptor: | W35 | Authors: | Buchko, G.W, Bahl, C.D, Gilmore, J.M, Pulavarti, S.V, Baker, D, Szyperski, T. | Deposit date: | 2016-04-21 | Release date: | 2016-09-28 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | Accurate de novo design of hyperstable constrained peptides. Nature, 538, 2016
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5JQZ
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![BU of 5jqz by Molmil](/molmil-images/mine/5jqz) | Designed two-ring homotetramer at 3.8A resolution | Descriptor: | De novo designed homotetramer | Authors: | Sankaran, B, Zwart, P.H, Pereira, J.H, Baker, D, Oberdorfer, G, Boyken, S.E, Chen, Z. | Deposit date: | 2016-05-05 | Release date: | 2016-06-29 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (3.83 Å) | Cite: | De novo design of protein homo-oligomers with modular hydrogen-bond network-mediated specificity. Science, 352, 2016
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5L33
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![BU of 5l33 by Molmil](/molmil-images/mine/5l33) | Crystal structure of a de novo designed protein with curved beta-sheet | Descriptor: | denovo NTF2 | Authors: | Oberdorfer, G, Marcos, E, Basanta, B, Chidyausiku, T.M, Sankaran, B, Baker, D. | Deposit date: | 2016-08-03 | Release date: | 2017-01-25 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Principles for designing proteins with cavities formed by curved beta sheets. Science, 355, 2017
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5KPE
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![BU of 5kpe by Molmil](/molmil-images/mine/5kpe) | Solution NMR Structure of Denovo Beta Sheet Design Protein, Northeast Structural Genomics Consortium (NESG) Target OR664 | Descriptor: | De novo Beta Sheet Design Protein OR664 | Authors: | Tang, Y, Liu, G, Baker, D, Montelione, G.T, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2016-07-03 | Release date: | 2016-09-21 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Principles for designing proteins with cavities formed by curved beta sheets. Science, 355, 2017
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3J03
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![BU of 3j03 by Molmil](/molmil-images/mine/3j03) | Lidless Mm-cpn in the closed state with ATP/AlFx | Descriptor: | Lidless Mm-cpn | Authors: | Zhang, J, Ma, B, DiMaio, F, Douglas, N.R, Joachimiak, L, Baker, D, Frydman, J, Levitt, M, Chiu, W. | Deposit date: | 2011-02-10 | Release date: | 2011-05-18 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (4.8 Å) | Cite: | Cryo-EM structure of a group II chaperonin in the prehydrolysis ATP-bound state leading to lid closure. Structure, 19, 2011
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6UF7
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![BU of 6uf7 by Molmil](/molmil-images/mine/6uf7) | S2 symmetric peptide design number 5, Uncle Fester | Descriptor: | S2-5, Uncle Fester | Authors: | Mulligan, V.K, Kang, C.S, Antselovich, I, Sawaya, M.R, Yeates, T.O, Baker, D. | Deposit date: | 2019-09-23 | Release date: | 2020-12-02 | Method: | X-RAY DIFFRACTION (0.8 Å) | Cite: | Computational design of mixed chirality peptide macrocycles with internal symmetry. Protein Sci., 29, 2020
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6UF8
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![BU of 6uf8 by Molmil](/molmil-images/mine/6uf8) | S2 symmetric peptide design number 6, London Bridge | Descriptor: | S2-6, London Bridge | Authors: | Mulligan, V.K, Kang, C.S, Antselovich, I, Sawaya, M.R, Yeates, T.O, Baker, D. | Deposit date: | 2019-09-23 | Release date: | 2020-12-02 | Method: | X-RAY DIFFRACTION (0.8 Å) | Cite: | Computational design of mixed chirality peptide macrocycles with internal symmetry. Protein Sci., 29, 2020
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6UFU
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![BU of 6ufu by Molmil](/molmil-images/mine/6ufu) | C2 symmetric peptide design number 1, Zappy, crystal form 1 | Descriptor: | C2-1, Zappy, crystal form 1 | Authors: | Mulligan, V.K, Kang, C.S, Antselovich, I, Sawaya, M.R, Yeates, T.O, Baker, D. | Deposit date: | 2019-09-25 | Release date: | 2020-12-02 | Method: | X-RAY DIFFRACTION (1.101 Å) | Cite: | Computational design of mixed chirality peptide macrocycles with internal symmetry. Protein Sci., 29, 2020
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6UG3
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![BU of 6ug3 by Molmil](/molmil-images/mine/6ug3) | C3 symmetric peptide design number 1, Sporty, crystal form 1 | Descriptor: | C3-1, Sporty, crystal form 1, ... | Authors: | Mulligan, V.K, Kang, C.S, Antselovich, I, Sawaya, M.R, Yeates, T.O, Baker, D. | Deposit date: | 2019-09-25 | Release date: | 2020-12-02 | Method: | X-RAY DIFFRACTION (1.1 Å) | Cite: | Computational design of mixed chirality peptide macrocycles with internal symmetry. Protein Sci., 29, 2020
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6UGC
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![BU of 6ugc by Molmil](/molmil-images/mine/6ugc) | C3 symmetric peptide design number 3 | Descriptor: | C3-3 cyclic peptide design, CADMIUM ION, SODIUM ION | Authors: | Mulligan, V.K, Kang, C.S, Antselovich, I, Sawaya, M.R, Yeates, T.O, Baker, D. | Deposit date: | 2019-09-26 | Release date: | 2020-12-02 | Method: | X-RAY DIFFRACTION (0.9 Å) | Cite: | Computational design of mixed chirality peptide macrocycles with internal symmetry. Protein Sci., 29, 2020
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6UDR
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![BU of 6udr by Molmil](/molmil-images/mine/6udr) | S2 symmetric peptide design number 3 crystal form 1, Lurch | Descriptor: | S2-3, Lurch crystal form 1 | Authors: | Mulligan, V.K, Kang, C.S, Antselovich, I, Sawaya, M.R, Yeates, T.O, Baker, D. | Deposit date: | 2019-09-19 | Release date: | 2020-09-23 | Last modified: | 2020-12-02 | Method: | X-RAY DIFFRACTION (1 Å) | Cite: | Computational design of mixed chirality peptide macrocycles with internal symmetry. Protein Sci., 29, 2020
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6UD9
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![BU of 6ud9 by Molmil](/molmil-images/mine/6ud9) | S2 symmetric peptide design number 2, Morticia | Descriptor: | S2-2, Morticia | Authors: | Mulligan, V.K, Kang, C.S, Antselovich, I, Sawaya, M.R, Yeates, T.O, Baker, D. | Deposit date: | 2019-09-19 | Release date: | 2020-09-23 | Last modified: | 2020-12-02 | Method: | X-RAY DIFFRACTION (1.1 Å) | Cite: | Computational design of mixed chirality peptide macrocycles with internal symmetry. Protein Sci., 29, 2020
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6UCX
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![BU of 6ucx by Molmil](/molmil-images/mine/6ucx) | S2 symmetric peptide design number 1, Wednesday | Descriptor: | S2-1, Wednesday, trifluoroacetic acid | Authors: | Mulligan, V.K, Kang, C.S, Antselovich, I, Sawaya, M.R, Yeates, T.O, Baker, D. | Deposit date: | 2019-09-18 | Release date: | 2020-09-23 | Last modified: | 2021-07-28 | Method: | X-RAY DIFFRACTION (0.85 Å) | Cite: | Computational design of mixed chirality peptide macrocycles with internal symmetry. Protein Sci., 29, 2020
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6UDZ
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![BU of 6udz by Molmil](/molmil-images/mine/6udz) | S2 symmetric peptide design number 4 crystal form 1, Pugsley | Descriptor: | S2-4, Pusgley crystal form 1, trifluoroacetic acid | Authors: | Mulligan, V.K, Kang, C.S, Antselovich, I, Sawaya, M.R, Yeates, T.O, Baker, D. | Deposit date: | 2019-09-20 | Release date: | 2020-09-23 | Last modified: | 2020-12-02 | Method: | X-RAY DIFFRACTION (1.1 Å) | Cite: | Computational design of mixed chirality peptide macrocycles with internal symmetry. Protein Sci., 29, 2020
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6V67
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![BU of 6v67 by Molmil](/molmil-images/mine/6v67) | Apo Structure of the De Novo PD-1 Binding Miniprotein GR918.2 | Descriptor: | PD-1 Binding Miniprotein GR918.2 | Authors: | Bick, M.J, Bryan, C.M, Baker, D, Dimaio, F, Kang, A. | Deposit date: | 2019-12-04 | Release date: | 2020-12-09 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.07 Å) | Cite: | Computational design of a synthetic PD-1 agonist. Proc.Natl.Acad.Sci.USA, 118, 2021
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2VLP
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![BU of 2vlp by Molmil](/molmil-images/mine/2vlp) | R54A mutant of E9 DNase domain in complex with Im9 | Descriptor: | COLICIN E9, COLICIN-E9 IMMUNITY PROTEIN, MALONIC ACID | Authors: | Keeble, A.H, Joachimiak, L.A, Mate, M.J, Meenan, N, Kirkpatrick, N, Baker, D, Kleanthous, C. | Deposit date: | 2008-01-15 | Release date: | 2008-05-20 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Experimental and Computational Analyses of the Energetic Basis for Dual Recognition of Immunity Proteins by Colicin Endonucleases. J.Mol.Biol., 379, 2008
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5V2G
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![BU of 5v2g by Molmil](/molmil-images/mine/5v2g) | De Novo Design of Novel Covalent Constrained Meso-size Peptide Scaffolds with Unique Tertiary Structures | Descriptor: | 1,3,5-tris(bromomethyl)benzene, 20-mer Peptide | Authors: | Dang, B, Wu, H, Mulligan, V.K, Mravic, M, Wu, Y, Lemmin, T, Ford, A, Silva, D, Baker, D, DeGrado, W.F. | Deposit date: | 2017-03-03 | Release date: | 2017-09-27 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | De novo design of covalently constrained mesosize protein scaffolds with unique tertiary structures. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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6W2V
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![BU of 6w2v by Molmil](/molmil-images/mine/6w2v) | Junction 23, DHR14-DHR18 | Descriptor: | Junction 23 DHR14-DHR18 | Authors: | Bick, M.J, Brunette, T.J, Baker, D. | Deposit date: | 2020-03-08 | Release date: | 2020-04-15 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.399 Å) | Cite: | Modular repeat protein sculpting using rigid helical junctions. Proc.Natl.Acad.Sci.USA, 117, 2020
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6W3W
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![BU of 6w3w by Molmil](/molmil-images/mine/6w3w) | An enumerative algorithm for de novo design of proteins with diverse pocket structures | Descriptor: | DENOVO NTF2, NITRATE ION | Authors: | Bera, A.K, Basanta, B, Dimaio, F, Sankaran, B, Baker, D. | Deposit date: | 2020-03-09 | Release date: | 2020-04-08 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | An enumerative algorithm for de novo design of proteins with diverse pocket structures. Proc.Natl.Acad.Sci.USA, 117, 2020
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2VLN
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![BU of 2vln by Molmil](/molmil-images/mine/2vln) | N75A mutant of E9 DNase domain in complex with Im9 | Descriptor: | COLICIN E9, COLICIN-E9 IMMUNITY PROTEIN, MALONIC ACID | Authors: | Keeble, A.H, Joachimiak, L.A, Mate, M.J, Meenan, N, Kirkpatrick, N, Baker, D, Kleanthous, C. | Deposit date: | 2008-01-15 | Release date: | 2008-05-20 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Experimental and Computational Analyses of the Energetic Basis for Dual Recognition of Immunity Proteins by Colicin Endonucleases. J.Mol.Biol., 379, 2008
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6W2W
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![BU of 6w2w by Molmil](/molmil-images/mine/6w2w) | Junction 24, DHR14-DHR18 | Descriptor: | Junction 24 DHR14-DHR18 | Authors: | Bick, M.J, Brunette, T.J, Baker, D. | Deposit date: | 2020-03-08 | Release date: | 2020-04-15 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.21 Å) | Cite: | Modular repeat protein sculpting using rigid helical junctions. Proc.Natl.Acad.Sci.USA, 117, 2020
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5V2O
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![BU of 5v2o by Molmil](/molmil-images/mine/5v2o) | De Novo Design of Novel Covalent Constrained Meso-size Peptide Scaffolds with Unique Tertiary Structures | Descriptor: | 1,3,5-BENZENETRICARBOXYLIC ACID, GLYCEROL, NONAETHYLENE GLYCOL, ... | Authors: | Dang, B, Wu, H, Mulligan, V.K, Mravic, M, Wu, Y, Lemmin, T, Ford, A, Silva, D, Baker, D, DeGrado, W.F. | Deposit date: | 2017-03-06 | Release date: | 2017-10-04 | Last modified: | 2017-11-08 | Method: | X-RAY DIFFRACTION (1.2 Å) | Cite: | De novo design of covalently constrained mesosize protein scaffolds with unique tertiary structures. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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