5KA7
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![BU of 5ka7 by Molmil](/molmil-images/mine/5ka7) | Protein Tyrosine Phosphatase 1B T178A mutant in complex with TCS401, closed state | Descriptor: | 2-(OXALYL-AMINO)-4,5,6,7-TETRAHYDRO-THIENO[2,3-C]PYRIDINE-3-CARBOXYLIC ACID, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, ... | Authors: | Choy, M.S, Peti, W, Page, R. | Deposit date: | 2016-06-01 | Release date: | 2017-03-08 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.061 Å) | Cite: | Conformational Rigidity and Protein Dynamics at Distinct Timescales Regulate PTP1B Activity and Allostery. Mol. Cell, 65, 2017
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5K9V
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![BU of 5k9v by Molmil](/molmil-images/mine/5k9v) | Protein Tyrosine Phosphatase 1B (1-301), open state | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, GLYCEROL, ... | Authors: | Choy, M.S, Peti, W, Page, R. | Deposit date: | 2016-06-01 | Release date: | 2017-03-01 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.898 Å) | Cite: | Conformational Rigidity and Protein Dynamics at Distinct Timescales Regulate PTP1B Activity and Allostery. Mol. Cell, 65, 2017
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5KAA
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![BU of 5kaa by Molmil](/molmil-images/mine/5kaa) | Protein Tyrosine Phosphatase 1B Delta helix 7, P185G mutant, open state | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, GLYCEROL, ... | Authors: | Choy, M.S, Machado, L.E.S.F, Peti, W, Page, R. | Deposit date: | 2016-06-01 | Release date: | 2017-03-08 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.968 Å) | Cite: | Conformational Rigidity and Protein Dynamics at Distinct Timescales Regulate PTP1B Activity and Allostery. Mol. Cell, 65, 2017
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5KA4
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5KAB
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![BU of 5kab by Molmil](/molmil-images/mine/5kab) | Protein Tyrosine Phosphatase 1B Delta helix 7, P185G mutant in complex with TCS401, open state | Descriptor: | 2-(OXALYL-AMINO)-4,5,6,7-TETRAHYDRO-THIENO[2,3-C]PYRIDINE-3-CARBOXYLIC ACID, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, ... | Authors: | Choy, M.S, Machado, L.E.S.F, Peti, W, Page, R. | Deposit date: | 2016-06-01 | Release date: | 2017-03-08 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.968 Å) | Cite: | Conformational Rigidity and Protein Dynamics at Distinct Timescales Regulate PTP1B Activity and Allostery. Mol. Cell, 65, 2017
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6KBU
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![BU of 6kbu by Molmil](/molmil-images/mine/6kbu) | Crystal structure of yedK | Descriptor: | GLYCEROL, SOS response-associated protein | Authors: | Wang, N, Bao, H, Huang, H. | Deposit date: | 2019-06-26 | Release date: | 2019-07-10 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Molecular basis of abasic site sensing in single-stranded DNA by the SRAP domain of E. coli yedK. Nucleic Acids Res., 47, 2019
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5AXW
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![BU of 5axw by Molmil](/molmil-images/mine/5axw) | Crystal structure of Staphylococcus aureus Cas9 in complex with sgRNA and target DNA (TTGGGT PAM) | Descriptor: | 1,2-ETHANEDIOL, CRISPR-associated endonuclease Cas9, DNA (28-MER), ... | Authors: | Nishimasu, H, Ishitani, R, Nureki, O. | Deposit date: | 2015-08-01 | Release date: | 2015-09-02 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Crystal Structure of Staphylococcus aureus Cas9. Cell, 162, 2015
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6KIX
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![BU of 6kix by Molmil](/molmil-images/mine/6kix) | Cryo-EM structure of human MLL1-NCP complex, binding mode1 | Descriptor: | DNA (145-MER), GLUTAMINE, Histone H2A, ... | Authors: | Huang, J, Xue, H, Yao, T. | Deposit date: | 2019-07-20 | Release date: | 2019-09-11 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Structural basis of nucleosome recognition and modification by MLL methyltransferases. Nature, 573, 2019
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5ZGD
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![BU of 5zgd by Molmil](/molmil-images/mine/5zgd) | hnRNPA1 reversible amyloid core GFGGNDNFG (residues 209-217) determined by X-ray | Descriptor: | GLY-PHE-GLY-GLY-ASN-ASP-ASN-PHE-GLY | Authors: | Gui, X, Xie, M, Zhao, M, Luo, F, He, J, Li, D, Liu, C. | Deposit date: | 2018-03-08 | Release date: | 2019-04-03 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (1.401 Å) | Cite: | Structural basis for reversible amyloids of hnRNPA1 elucidates their role in stress granule assembly. Nat Commun, 10, 2019
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6KIV
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![BU of 6kiv by Molmil](/molmil-images/mine/6kiv) | Cryo-EM structure of human MLL1-ubNCP complex (4.0 angstrom) | Descriptor: | DNA (145-MER), Histone H2A, Histone H2B 1.1, ... | Authors: | Huang, J, Xue, H, Yao, T. | Deposit date: | 2019-07-20 | Release date: | 2019-09-11 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Structural basis of nucleosome recognition and modification by MLL methyltransferases. Nature, 573, 2019
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6KIJ
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![BU of 6kij by Molmil](/molmil-images/mine/6kij) | Crystal structure of yedK with ssDNA containing an abasic site | Descriptor: | DNA (5'-D(*GP*AP*TP*TP*CP*GP*TP*CP*G)-3'), GLYCEROL, PENTANE-3,4-DIOL-5-PHOSPHATE, ... | Authors: | Wang, N, Bao, H, Huang, H. | Deposit date: | 2019-07-18 | Release date: | 2019-08-07 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.58 Å) | Cite: | Molecular basis of abasic site sensing in single-stranded DNA by the SRAP domain of E. coli yedK. Nucleic Acids Res., 47, 2019
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6KIZ
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![BU of 6kiz by Molmil](/molmil-images/mine/6kiz) | Cryo-EM structure of human MLL1-NCP complex, binding mode2 | Descriptor: | DNA (145-MER), Histone H2A, Histone H2B 1.1, ... | Authors: | Huang, J, Xue, H, Yao, T. | Deposit date: | 2019-07-20 | Release date: | 2019-09-11 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (4.5 Å) | Cite: | Structural basis of nucleosome recognition and modification by MLL methyltransferases. Nature, 573, 2019
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5ZGL
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![BU of 5zgl by Molmil](/molmil-images/mine/5zgl) | hnRNP A1 segment GGGYGGS (residues 234-240) | Descriptor: | 7-mer peptide from Heterogeneous nuclear ribonucleoprotein A1 | Authors: | Xie, M, Luo, F, Gui, X, Zhao, M, He, J, Li, D, Liu, C. | Deposit date: | 2018-03-09 | Release date: | 2019-04-03 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (0.95 Å) | Cite: | Structural basis for reversible amyloids of hnRNPA1 elucidates their role in stress granule assembly. Nat Commun, 10, 2019
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5DH3
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![BU of 5dh3 by Molmil](/molmil-images/mine/5dh3) | Crystal structure of MST2 in complex with XMU-MP-1 | Descriptor: | 4-[(5,10-dimethyl-6-oxo-6,10-dihydro-5H-pyrimido[5,4-b]thieno[3,2-e][1,4]diazepin-2-yl)amino]benzenesulfonamide, CHLORIDE ION, SULFATE ION, ... | Authors: | Kong, L.L, Yun, C.H. | Deposit date: | 2015-08-29 | Release date: | 2016-08-31 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.468 Å) | Cite: | Pharmacological targeting of kinases MST1 and MST2 augments tissue repair and regeneration Sci Transl Med, 8, 2016
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5X5O
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![BU of 5x5o by Molmil](/molmil-images/mine/5x5o) | Crystal structure of ZAK in complex with compound D2829 | Descriptor: | Mitogen-activated protein kinase kinase kinase MLT, N-[2,4-bis(fluoranyl)-3-[2-(3-methoxy-1H-pyrazolo[3,4-b]pyridin-5-yl)ethynyl]phenyl]-3-bromanyl-benzenesulfonamide | Authors: | Dai, Y.B, Zhao, P, Yun, C.H. | Deposit date: | 2017-02-17 | Release date: | 2017-12-27 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (1.868 Å) | Cite: | Structure Based Design of N-(3-((1H-Pyrazolo[3,4-b]pyridin-5-yl)ethynyl)benzenesulfonamides as Selective Leucine-Zipper and Sterile-alpha Motif Kinase (ZAK) Inhibitors. J. Med. Chem., 60, 2017
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5X5M
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3LIP
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7CKK
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![BU of 7ckk by Molmil](/molmil-images/mine/7ckk) | Structural complex of FTO bound with Dac51 | Descriptor: | 2-{[2,6-dichloro-4-(3,5-dimethyl-1H-pyrazol-4-yl)phenyl]amino}-N-hydroxybenzamide, Alpha-ketoglutarate-dependent dioxygenase FTO, N-OXALYLGLYCINE | Authors: | Yang, C, Gan, J. | Deposit date: | 2020-07-17 | Release date: | 2021-07-21 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Tumors exploit FTO-mediated regulation of glycolytic metabolism to evade immune surveillance. Cell Metab., 33, 2021
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3O0Z
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3N7X
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7E17
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![BU of 7e17 by Molmil](/molmil-images/mine/7e17) | Structure of dimeric uPAR | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Urokinase plasminogen activator surface receptor | Authors: | Cai, Y, Huang, M. | Deposit date: | 2021-02-01 | Release date: | 2021-12-22 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.96 Å) | Cite: | Crystal structure and cellular functions of uPAR dimer Nat Commun, 13, 2022
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3P0S
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3P3C
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![BU of 3p3c by Molmil](/molmil-images/mine/3p3c) | Crystal Structure of the Aquifex aeolicus LpxC/LPC-009 complex | Descriptor: | N-[(1S,2R)-2-hydroxy-1-(hydroxycarbamoyl)propyl]-4-(4-phenylbuta-1,3-diyn-1-yl)benzamide, PHOSPHATE ION, UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase, ... | Authors: | Lee, C.-J, Zhou, P. | Deposit date: | 2010-10-04 | Release date: | 2011-01-05 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.25 Å) | Cite: | Species-specific and inhibitor-dependent conformations of LpxC: implications for antibiotic design. Chem.Biol., 18, 2011
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7C43
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7C4C
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![BU of 7c4c by Molmil](/molmil-images/mine/7c4c) | |