5HPK
 
 | | System-wide modulation of HECT E3 ligases with selective ubiquitin variant probes: NEDD4L and UbV NL.1 | | Descriptor: | E3 ubiquitin-protein ligase NEDD4-like, Ubiquitin variant NL.1 | | Authors: | Wu, K.-P, Mukherjee, M, Mercredi, P.Y, Schulman, B.A. | | Deposit date: | 2016-01-20 | | Release date: | 2016-03-16 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.431 Å) | | Cite: | System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes.
Mol.Cell, 62, 2016
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5HPT
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5HPL
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8YJL
 | | Structure of the human endogenous PCNA-FEN1 complex - State B | | Descriptor: | 5 prime DNA, Flap endonuclease 1, Proliferating cell nuclear antigen, ... | | Authors: | Tian, Y, Gao, N. | | Deposit date: | 2024-03-02 | | Release date: | 2024-12-04 | | Last modified: | 2025-01-29 | | Method: | ELECTRON MICROSCOPY (3.51 Å) | | Cite: | Structural insight into Okazaki fragment maturation mediated by PCNA-bound FEN1 and RNaseH2.
Embo J., 44, 2025
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5HPS
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7CE2
 | | The Crystal structure of TeNT Hc complexed with neutralizing antibody | | Descriptor: | Tetanus toxin, neutralizing antibody heavy chain, neutralizing antibody light chain | | Authors: | Wang, X, Wang, Y, Wu, C, Yu, J, Liao, H. | | Deposit date: | 2020-06-21 | | Release date: | 2021-04-07 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2.01 Å) | | Cite: | Structural basis of tetanus toxin neutralization by native human monoclonal antibodies.
Cell Rep, 35, 2021
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7S5H
 | | PCSK9(deltaCRD) in complex with cyclic peptide 35 | | Descriptor: | (2E)-but-2-ene-1,4-diol, Pro-peptide from Proprotein convertase subtilisin/kexin type 9, Proprotein convertase subtilisin/kexin type 9, ... | | Authors: | Orth, P. | | Deposit date: | 2021-09-10 | | Release date: | 2021-11-03 | | Last modified: | 2024-04-24 | | Method: | X-RAY DIFFRACTION (1.272 Å) | | Cite: | A Series of Novel, Highly Potent, and Orally Bioavailable Next-Generation Tricyclic Peptide PCSK9 Inhibitors.
J.Med.Chem., 64, 2021
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5C7M
 | | CRYSTAL STRUCTURE OF E3 LIGASE ITCH WITH A UB VARIANT | | Descriptor: | E3 ubiquitin-protein ligase Itchy homolog, Polyubiquitin-C | | Authors: | Walker, J.R, Hu, J, Dong, A, Wernimont, A, Zhang, W, Sidhu, S, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Tong, Y, Structural Genomics Consortium (SGC) | | Deposit date: | 2015-06-24 | | Release date: | 2016-03-16 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (3.03 Å) | | Cite: | System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes.
Mol.Cell, 62, 2016
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8YJS
 | | Structure of the human endogenous PCNA-FEN1 complex - State E | | Descriptor: | 5 prime flap DNA, Flap endonuclease 1, Proliferating cell nuclear antigen, ... | | Authors: | Tian, Y, Gao, N. | | Deposit date: | 2024-03-02 | | Release date: | 2024-12-04 | | Last modified: | 2025-01-29 | | Method: | ELECTRON MICROSCOPY (3.55 Å) | | Cite: | Structural insight into Okazaki fragment maturation mediated by PCNA-bound FEN1 and RNaseH2.
Embo J., 44, 2025
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8YJZ
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8YJV
 | | Structure of the human endogenous PCNA-FEN1 complex - State G | | Descriptor: | 5 prime flap DNA, Flap endonuclease 1, Proliferating cell nuclear antigen, ... | | Authors: | Tian, Y, Gao, N. | | Deposit date: | 2024-03-03 | | Release date: | 2024-12-04 | | Last modified: | 2025-01-29 | | Method: | ELECTRON MICROSCOPY (3.51 Å) | | Cite: | Structural insight into Okazaki fragment maturation mediated by PCNA-bound FEN1 and RNaseH2.
Embo J., 44, 2025
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8YJQ
 | | Structure of the human endogenous PCNA-FEN1 complex - State C | | Descriptor: | 5 prime flap DNA, Flap endonuclease 1, Proliferating cell nuclear antigen, ... | | Authors: | Tian, Y, Gao, N. | | Deposit date: | 2024-03-02 | | Release date: | 2024-12-04 | | Last modified: | 2025-01-29 | | Method: | ELECTRON MICROSCOPY (3.51 Å) | | Cite: | Structural insight into Okazaki fragment maturation mediated by PCNA-bound FEN1 and RNaseH2.
Embo J., 44, 2025
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8YJW
 | | Structure of the human endogenous PCNA-FEN1 complex - State H | | Descriptor: | 5 prime flap DNA, Flap endonuclease 1, Proliferating cell nuclear antigen, ... | | Authors: | Tian, Y, Gao, N. | | Deposit date: | 2024-03-03 | | Release date: | 2024-12-04 | | Last modified: | 2025-01-29 | | Method: | ELECTRON MICROSCOPY (3.55 Å) | | Cite: | Structural insight into Okazaki fragment maturation mediated by PCNA-bound FEN1 and RNaseH2.
Embo J., 44, 2025
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8YJU
 | | Structure of the human endogenous PCNA-FEN1 complex - State F | | Descriptor: | 5 prime flap DNA, Flap endonuclease 1, Proliferating cell nuclear antigen, ... | | Authors: | Tian, Y, Gao, N. | | Deposit date: | 2024-03-02 | | Release date: | 2024-12-04 | | Last modified: | 2025-01-29 | | Method: | ELECTRON MICROSCOPY (3.78 Å) | | Cite: | Structural insight into Okazaki fragment maturation mediated by PCNA-bound FEN1 and RNaseH2.
Embo J., 44, 2025
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8YJR
 | | Structure of the human endogenous PCNA-FEN1 complex - State D | | Descriptor: | 5 prime flap DNA, Flap endonuclease 1, Proliferating cell nuclear antigen, ... | | Authors: | Tian, Y, Gao, N. | | Deposit date: | 2024-03-02 | | Release date: | 2024-12-04 | | Last modified: | 2025-01-29 | | Method: | ELECTRON MICROSCOPY (3.51 Å) | | Cite: | Structural insight into Okazaki fragment maturation mediated by PCNA-bound FEN1 and RNaseH2.
Embo J., 44, 2025
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8YJH
 | | Structure of the human endogenous PCNA-FEN1 complex - State A | | Descriptor: | 5 prime DNA, Flap endonuclease 1, Proliferating cell nuclear antigen, ... | | Authors: | Tian, Y, Gao, N. | | Deposit date: | 2024-03-01 | | Release date: | 2024-12-04 | | Last modified: | 2025-01-29 | | Method: | ELECTRON MICROSCOPY (3.68 Å) | | Cite: | Structural insight into Okazaki fragment maturation mediated by PCNA-bound FEN1 and RNaseH2.
Embo J., 44, 2025
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5C7J
 | | CRYSTAL STRUCTURE OF NEDD4 WITH A UB VARIANT | | Descriptor: | E3 ubiquitin-protein ligase NEDD4, Polyubiquitin-C | | Authors: | Walker, J.R, Hu, J, Dong, A, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Tong, Y, Structural Genomics Consortium (SGC) | | Deposit date: | 2015-06-24 | | Release date: | 2016-03-16 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes.
Mol.Cell, 62, 2016
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5ID6
 | | Structure of Cpf1/RNA Complex | | Descriptor: | Cpf1, MAGNESIUM ION, RNA (5'-R(P*AP*AP*UP*UP*UP*CP*UP*AP*CP*UP*AP*AP*GP*UP*GP*UP*AP*GP*AP*UP*C)-3') | | Authors: | Dong, D, Ren, K, Qiu, X, Wang, J, Huang, Z. | | Deposit date: | 2016-02-24 | | Release date: | 2016-04-27 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (2.382 Å) | | Cite: | The crystal structure of Cpf1 in complex with CRISPR RNA
Nature, 532, 2016
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9J7N
 | | Cryo-EM structure of TauT | | Descriptor: | BETA-ALANINE, CHLORIDE ION, CHOLESTEROL, ... | | Authors: | Zhao, Y, Xu, H. | | Deposit date: | 2024-08-19 | | Release date: | 2025-04-02 | | Last modified: | 2025-05-14 | | Method: | ELECTRON MICROSCOPY (3.14 Å) | | Cite: | Structural characterization reveals substrate recognition by the taurine transporter TauT.
Cell Discov, 11, 2025
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9J7M
 | | Cryo-EM structure of TauT | | Descriptor: | 2-AMINOETHANESULFONIC ACID, CHLORIDE ION, CHOLESTEROL, ... | | Authors: | Zhao, Y, Xu, H. | | Deposit date: | 2024-08-19 | | Release date: | 2025-04-02 | | Last modified: | 2025-05-14 | | Method: | ELECTRON MICROSCOPY (2.82 Å) | | Cite: | Structural characterization reveals substrate recognition by the taurine transporter TauT.
Cell Discov, 11, 2025
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9J7O
 | | Cryo-EM structure of TauT | | Descriptor: | CHLORIDE ION, CHOLESTEROL, HEXADECANE, ... | | Authors: | Zhao, Y, Xu, H. | | Deposit date: | 2024-08-19 | | Release date: | 2025-04-02 | | Last modified: | 2025-05-14 | | Method: | ELECTRON MICROSCOPY (2.77 Å) | | Cite: | Structural characterization reveals substrate recognition by the taurine transporter TauT.
Cell Discov, 11, 2025
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8IVQ
 | | Cryo-EM structure of mouse BIRC6, Global map | | Descriptor: | Isoform 2 of Baculoviral IAP repeat-containing protein 6 | | Authors: | Liu, S, Jiang, T, Bu, F, Zhao, J, Wang, G, Li, N, Gao, N, Qiu, X. | | Deposit date: | 2023-03-28 | | Release date: | 2024-01-24 | | Last modified: | 2024-10-16 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Molecular mechanisms underlying the BIRC6-mediated regulation of apoptosis and autophagy.
Nat Commun, 15, 2024
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5DP4
 | | Crystal Structure of EV71 3C Proteinase in complex with compound 3 | | Descriptor: | 3C proteinase, ethyl (2Z,4S)-4-{[(2S)-2-methyl-3-phenylpropanoyl]amino}-5-[(3S)-2-oxopyrrolidin-3-yl]pent-2-enoate | | Authors: | Wu, C, Zhang, L, Li, P, Cai, Q, Peng, X, Li, N, Cai, Y, Li, J, Lin, T. | | Deposit date: | 2015-09-12 | | Release date: | 2016-03-30 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (2.21 Å) | | Cite: | Fragment-wise design of inhibitors to 3C proteinase from enterovirus 71
Biochim.Biophys.Acta, 1860, 2016
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7E3L
 | | Ultrapotent SARS-CoV-2 neutralizing antibodies with protective efficacy against newly emerged mutational variants | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 58G6 heavy chain, 58G6 light chain, ... | | Authors: | Guo, H, Li, T, Liu, F, Gao, Y, Ji, X, Yang, H. | | Deposit date: | 2021-02-09 | | Release date: | 2021-09-15 | | Last modified: | 2024-10-16 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Potent SARS-CoV-2 neutralizing antibodies with protective efficacy against newly emerged mutational variants.
Nat Commun, 12, 2021
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7E3K
 | | Ultrapotent SARS-CoV-2 neutralizing antibodies with protective efficacy against newly emerged mutational variants | | Descriptor: | 13G9 heavy chain, 13G9 light chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Guo, H, Li, T, Liu, F, Gao, Y, Ji, X, Yang, H. | | Deposit date: | 2021-02-09 | | Release date: | 2021-09-15 | | Last modified: | 2024-11-06 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Potent SARS-CoV-2 neutralizing antibodies with protective efficacy against newly emerged mutational variants.
Nat Commun, 12, 2021
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