7F46
 
 | | Cryo-EM structure of the SARS-CoV-2 S-6P in complex with 35B5 Fab (state1, local refinement of the RBD, NTD and 35B5 Fab) | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of 35B5 Fab, Light chain of 35B5 Fab, ... | | Authors: | Wang, X.F, Zhu, Y.Q. | | Deposit date: | 2021-06-17 | | Release date: | 2022-03-23 | | Last modified: | 2024-11-13 | | Method: | ELECTRON MICROSCOPY (4.79 Å) | | Cite: | A potent human monoclonal antibody with pan-neutralizing activities directly dislocates S trimer of SARS-CoV-2 through binding both up and down forms of RBD
Signal Transduct Target Ther, 7, 2022
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4PNZ
 | | Human dipeptidyl peptidase IV/CD26 in complex with the long-acting inhibitor Omarigliptin (MK-3102) | | Descriptor: | (2R,3S,5R)-5-[2-(methylsulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl]-2-(2,4,5-trifluorophenyl)tetrahydro-2H-pyran-3-amine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Scapin, G, Yan, Y. | | Deposit date: | 2014-02-22 | | Release date: | 2014-04-09 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Omarigliptin (MK-3102): A Novel Long-Acting DPP-4 Inhibitor for Once-Weekly Treatment of Type 2 Diabetes.
J.Med.Chem., 57, 2014
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8I8A
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8I8C
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8I8B
 | | Outer shell and inner layer structures of Autographa californica multiple nucleopolyhedrovirus (AcMNPV) | | Descriptor: | 38K, AcOrf-109 peptide, Early 49 Daa protein, ... | | Authors: | Jia, X, Gao, Y, Zhang, Q. | | Deposit date: | 2023-02-03 | | Release date: | 2023-12-13 | | Last modified: | 2024-10-16 | | Method: | ELECTRON MICROSCOPY (4.31 Å) | | Cite: | Architecture of the baculovirus nucleocapsid revealed by cryo-EM.
Nat Commun, 14, 2023
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8IAZ
 | | Cryo-EM structure of the ISFba1 TnpB-reRNA-dsDNA complex | | Descriptor: | DNA (5'-D(P*AP*CP*AP*TP*GP*GP*AP*CP*CP*AP*TP*CP*AP*GP*CP*TP*CP*CP*TP*AP*AP*TP*GP*G)-3'), DNA (5'-D(P*CP*CP*AP*TP*TP*AP*GP*GP*AP*GP*CP*TP*GP*AP*TP*G)-3'), RNA (207-MER), ... | | Authors: | Yin, M, Zhou, F, Zhu, Y, Huang, Z. | | Deposit date: | 2023-02-09 | | Release date: | 2024-04-17 | | Last modified: | 2024-05-15 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Discovery and structural mechanism of DNA endonucleases guided by RAGATH-18-derived RNAs.
Cell Res., 34, 2024
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5YC0
 | | Crystal structure of LP-46/N44 | | Descriptor: | Envelope glycoprotein, LP-46 | | Authors: | Zhang, X, Wang, X, He, Y. | | Deposit date: | 2017-09-05 | | Release date: | 2018-02-14 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Exceptional potency and structural basis of a T1249-derived lipopeptide fusion inhibitor against HIV-1, HIV-2, and simian immunodeficiency virus
J. Biol. Chem., 293, 2018
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6IIC
 | | CryoEM structure of Mud Crab Dicistrovirus | | Descriptor: | VP1 of Mud crab dicistrovirus, VP2 of Mud crab dicistrovirus, VP3 of Mud crab dicistrovirus, ... | | Authors: | Zhang, Q, Gao, Y. | | Deposit date: | 2018-10-04 | | Release date: | 2019-01-16 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Cryo-electron Microscopy Structures of Novel Viruses from Mud CrabScylla paramamosainwith Multiple Infections.
J. Virol., 93, 2019
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6IZL
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8ZNZ
 | | CD73 bound with HB0045 | | Descriptor: | 5'-nucleotidase, CALCIUM ION, HB0038 Fab heavy chain, ... | | Authors: | Xu, J, Wan, L, He, Y. | | Deposit date: | 2024-05-28 | | Release date: | 2025-02-05 | | Last modified: | 2025-02-19 | | Method: | ELECTRON MICROSCOPY (3.06 Å) | | Cite: | An antibody cocktail targeting two different CD73 epitopes enhances enzyme inhibition and tumor control.
Nat Commun, 15, 2024
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9LFU
 | | Crystal structure of human RIP3 kinase domain complexed with LK01003 | | Descriptor: | 2-cyclopentyl-~{N}-(6-propan-2-ylsulfonylquinolin-4-yl)-1,3-benzothiazol-5-amine, Receptor-interacting serine/threonine-protein kinase 3 | | Authors: | Xie, H, Su, H.X, Li, M.J, Xu, Y.C. | | Deposit date: | 2025-01-09 | | Release date: | 2025-05-07 | | Last modified: | 2025-05-21 | | Method: | X-RAY DIFFRACTION (2.93 Å) | | Cite: | Structure-based design of potent and selective inhibitors targeting RIPK3 for eliminating on-target toxicity in vitro.
Nat Commun, 16, 2025
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9LFW
 | | Crystal structure of mouse RIP3 kinase domain(R69H) complexed with LK01003 | | Descriptor: | 2-cyclopentyl-~{N}-(6-propan-2-ylsulfonylquinolin-4-yl)-1,3-benzothiazol-5-amine, Receptor-interacting serine/threonine-protein kinase 3 | | Authors: | Xie, H, Su, H.X, Li, M.J, Xu, Y.C. | | Deposit date: | 2025-01-09 | | Release date: | 2025-05-07 | | Last modified: | 2025-05-21 | | Method: | X-RAY DIFFRACTION (1.59 Å) | | Cite: | Structure-based design of potent and selective inhibitors targeting RIPK3 for eliminating on-target toxicity in vitro.
Nat Commun, 16, 2025
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9LFV
 | | Crystal structure of mouse RIP3 kinase domain complexed with LK01004 | | Descriptor: | 3-[2-[(2~{R})-butan-2-yl]-1,3-benzothiazol-5-yl]-1-~{tert}-butyl-pyrazolo[3,4-d]pyrimidin-4-amine, 3-[2-[(2~{S})-butan-2-yl]-1,3-benzothiazol-5-yl]-1-~{tert}-butyl-pyrazolo[3,4-d]pyrimidin-4-amine, Receptor-interacting serine/threonine-protein kinase 3 | | Authors: | Xie, H, Su, H.X, Li, M.J, Xu, Y.C. | | Deposit date: | 2025-01-09 | | Release date: | 2025-05-07 | | Last modified: | 2025-05-21 | | Method: | X-RAY DIFFRACTION (2.78 Å) | | Cite: | Structure-based design of potent and selective inhibitors targeting RIPK3 for eliminating on-target toxicity in vitro.
Nat Commun, 16, 2025
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6J1O
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6J60
 | | hnRNP A1 reversible amyloid core GFGGNDNFG (residues 209-217) | | Descriptor: | 9-mer peptide (GFGGNDNFG) from Heterogeneous nuclear ribonucleoprotein A1 | | Authors: | Luo, F, Zhou, H, Gui, X, Li, D, Li, X, Liu, C. | | Deposit date: | 2019-01-12 | | Release date: | 2019-04-03 | | Last modified: | 2024-03-27 | | Method: | ELECTRON CRYSTALLOGRAPHY (0.96 Å) | | Cite: | Structural basis for reversible amyloids of hnRNPA1 elucidates their role in stress granule assembly.
Nat Commun, 10, 2019
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6J46
 | | LepI-SAH complex structure | | Descriptor: | O-methyltransferase lepI, S-ADENOSYL-L-HOMOCYSTEINE | | Authors: | Qiu, S, Wei, C. | | Deposit date: | 2019-01-08 | | Release date: | 2019-05-01 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (2.621 Å) | | Cite: | Deciphering the regulatory and catalytic mechanisms of an unusual SAM-dependent enzyme.
Signal Transduct Target Ther, 4, 2019
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9J61
 | | Crystal structure of a cyclodipeptide synthase from Streptomyces sapporonensis | | Descriptor: | 1,2-ETHANEDIOL, Cyclodipeptide synthase, DI(HYDROXYETHYL)ETHER, ... | | Authors: | Li, P, Ren, Y, He, J, Wu, S, Wang, J, Tang, G, Fang, P. | | Deposit date: | 2024-08-14 | | Release date: | 2024-12-04 | | Last modified: | 2025-04-09 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Crystal Structure and Mutagenesis of an XYP Subfamily Cyclodipeptide Synthase Reveal Key Determinants of Enzyme Activity and Substrate Specificity.
Biochemistry, 63, 2024
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6J24
 | | Crystal structure of a SAM-dependent methyltransferase LepI in complex with its substrate | | Descriptor: | (3~{S},4'~{R},4'~{a}~{S},6'~{R},8'~{a}~{S})-4',6'-dimethyl-5-phenyl-spiro[1~{H}-pyridine-3,5'-2,3,4,4~{a},6,8~{a}-hexahydro-1~{H}-naphthalene]-2,4-dione, O-methyltransferase, S-ADENOSYLMETHIONINE | | Authors: | Qiu, S, Wei, C. | | Deposit date: | 2018-12-30 | | Release date: | 2019-05-01 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.244 Å) | | Cite: | Deciphering the regulatory and catalytic mechanisms of an unusual SAM-dependent enzyme.
Signal Transduct Target Ther, 4, 2019
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5YB3
 | | Crystal structure of HP23L/N36 | | Descriptor: | Envelope glycoprotein, HP23L | | Authors: | Zhang, X, Wang, X, He, Y. | | Deposit date: | 2017-09-03 | | Release date: | 2018-02-28 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (2.043 Å) | | Cite: | Structural Insights into the Mechanisms of Action of Short-Peptide HIV-1 Fusion Inhibitors Targeting the Gp41 Pocket
Front Cell Infect Microbiol, 8, 2018
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5YB2
 | | Crystal structure of LP-11/N44 | | Descriptor: | Envelope glycoprotein, LP-11 | | Authors: | Zhang, X, Wang, X, He, Y. | | Deposit date: | 2017-09-03 | | Release date: | 2018-02-28 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (3.8 Å) | | Cite: | Structural Insights into the Mechanisms of Action of Short-Peptide HIV-1 Fusion Inhibitors Targeting the Gp41 Pocket
Front Cell Infect Microbiol, 8, 2018
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8DEG
 | | Crystal structure of DLK in complex with inhibitor DN0011197 | | Descriptor: | Mitogen-activated protein kinase kinase kinase 12, methyl (1S,4S)-5-{(4P)-4-[5-amino-6-(difluoromethoxy)pyrazin-2-yl]-6-[(1R,4R)-2-azabicyclo[2.1.1]hexan-2-yl]pyridin-2-yl}-2,5-diazabicyclo[2.2.1]heptane-2-carboxylate | | Authors: | Srivastava, A, Lexa, K, de Vicente, J. | | Deposit date: | 2022-06-20 | | Release date: | 2022-12-14 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.79 Å) | | Cite: | Discovery of Potent and Selective Dual Leucine Zipper Kinase/Leucine Zipper-Bearing Kinase Inhibitors with Neuroprotective Properties in In Vitro and In Vivo Models of Amyotrophic Lateral Sclerosis.
J.Med.Chem., 65, 2022
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5YB4
 | | Crystal structure of HP23LN36KR | | Descriptor: | HP23L, N36KR | | Authors: | Zhang, X, Wang, X, He, Y. | | Deposit date: | 2017-09-03 | | Release date: | 2018-02-28 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structural Insights into the Mechanisms of Action of Short-Peptide HIV-1 Fusion Inhibitors Targeting the Gp41 Pocket
Front Cell Infect Microbiol, 8, 2018
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6M31
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8Y0Q
 | | Complex of FMDV O/18074 and inter-serotype broadly neutralizing antibodies pOA-2 | | Descriptor: | VP1 of capsid protein, VP2 of capsid protein, VP3 of capsid protein, ... | | Authors: | Wu, S, Lei, D. | | Deposit date: | 2024-01-23 | | Release date: | 2024-10-09 | | Last modified: | 2024-11-13 | | Method: | ELECTRON MICROSCOPY (2.44 Å) | | Cite: | Discovery, recognized antigenic structures, and evolution of cross-serotype broadly neutralizing antibodies from porcine B-cell repertoires against foot-and-mouth disease virus.
Plos Pathog., 20, 2024
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4WUM
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