8G9B
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![BU of 8g9b by Molmil](/molmil-images/mine/8g9b) | Human IMPDH2 mutant - L245P, treated with GTP, ATP, IMP, and NAD+; compressed filament segment reconstruction | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, INOSINIC ACID, ... | Authors: | O'Neill, A.G, Kollman, J.M. | Deposit date: | 2023-02-21 | Release date: | 2023-04-19 | Last modified: | 2023-08-09 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Neurodevelopmental disorder mutations in the purine biosynthetic enzyme IMPDH2 disrupt its allosteric regulation. J.Biol.Chem., 299, 2023
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8G8F
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![BU of 8g8f by Molmil](/molmil-images/mine/8g8f) | Human IMPDH2 mutant - L245P, treated with ATP, IMP, and NAD+; extended filament segment reconstruction | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, INOSINIC ACID, Inosine-5'-monophosphate dehydrogenase 2, ... | Authors: | O'Neill, A.G, Kollman, J.M. | Deposit date: | 2023-02-17 | Release date: | 2023-04-19 | Last modified: | 2023-08-09 | Method: | ELECTRON MICROSCOPY (2.6 Å) | Cite: | Neurodevelopmental disorder mutations in the purine biosynthetic enzyme IMPDH2 disrupt its allosteric regulation. J.Biol.Chem., 299, 2023
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6CPU
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![BU of 6cpu by Molmil](/molmil-images/mine/6cpu) | Crystal structure of yeast caPDE2 | Descriptor: | MAGNESIUM ION, Phosphodiesterase, ZINC ION | Authors: | Ke, H, Wang, y. | Deposit date: | 2018-03-14 | Release date: | 2019-02-20 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal Structures of Candida albicans Phosphodiesterase 2 and Implications for Its Biological Functions. Biochemistry, 57, 2018
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5UZT
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![BU of 5uzt by Molmil](/molmil-images/mine/5uzt) | |
5UZZ
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![BU of 5uzz by Molmil](/molmil-images/mine/5uzz) | |
5WXY
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![BU of 5wxy by Molmil](/molmil-images/mine/5wxy) | Crystal structure of Microcystis aeruginosa PCC 7806 aspartate racemase in complex with L-aspartate | Descriptor: | ASPARTIC ACID, McyF | Authors: | Cao, D.D, Zhou, K, Jiang, Y.L, Zhou, C.Z. | Deposit date: | 2017-01-09 | Release date: | 2018-01-17 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.63 Å) | Cite: | Structural insights into the catalysis and substrate specificity of cyanobacterial aspartate racemase McyF. Biochem.Biophys.Res.Commun., 514, 2019
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5WXX
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![BU of 5wxx by Molmil](/molmil-images/mine/5wxx) | Crystal structure of Microcystis aeruginosa PCC 7806 aspartate racemase in complex with citrate | Descriptor: | CITRIC ACID, McyF | Authors: | Cao, D.D, Zhou, K, Jiang, Y.L, Zhou, C.Z. | Deposit date: | 2017-01-09 | Release date: | 2018-01-17 | Last modified: | 2019-07-31 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Structural insights into the catalysis and substrate specificity of cyanobacterial aspartate racemase McyF. Biochem.Biophys.Res.Commun., 514, 2019
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3KRJ
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![BU of 3krj by Molmil](/molmil-images/mine/3krj) | cFMS tyrosine kinase in complex with 4-Cyano-1H-imidazole-2-carboxylic acid (2-cyclohex-1-enyl-4-piperidin-4-yl-phenyl)-amide | Descriptor: | 4-cyano-N-(2-cyclohex-1-en-1-yl-4-piperidin-4-ylphenyl)-1H-imidazole-2-carboxamide, ACETATE ION, Macrophage colony-stimulating factor 1 receptor, ... | Authors: | Schubert, C. | Deposit date: | 2009-11-18 | Release date: | 2010-12-01 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Optimization of a Potent Class of Arylamide Colony-Stimulating Factor-1 Receptor Inhibitors Leading to Anti-inflammatory Clinical Candidate 4-Cyano-N-[2-(1-cyclohexen-1-yl)-4-[1-[(dimethylamino)acetyl]-4-piperidinyl]phenyl]-1H-imidazole-2-carboxamide (JNJ-28312141). J.Med.Chem., 54, 2011
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5WXZ
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![BU of 5wxz by Molmil](/molmil-images/mine/5wxz) | Crystal structure of Microcystis aeruginosa PCC 7806 aspartate racemase in complex with D-aspartate | Descriptor: | D-ASPARTIC ACID, McyF | Authors: | Cao, D.D, Zhou, K, Jiang, Y.L, Zhou, C.Z. | Deposit date: | 2017-01-09 | Release date: | 2018-01-17 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structural insights into the catalysis and substrate specificity of cyanobacterial aspartate racemase McyF. Biochem.Biophys.Res.Commun., 514, 2019
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5XM8
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![BU of 5xm8 by Molmil](/molmil-images/mine/5xm8) | |
7EOD
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![BU of 7eod by Molmil](/molmil-images/mine/7eod) | MITF HLHLZ Delta AKE | Descriptor: | GLYCEROL, Isoform M1 of Microphthalmia-associated transcription factor | Authors: | Li, P, Liu, Z, Fang, P, Wang, J. | Deposit date: | 2021-04-22 | Release date: | 2022-04-27 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | A unique hyperdynamic dimer interface permits small molecule perturbation of the melanoma oncoprotein MITF for melanoma therapy. Cell Res., 33, 2023
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7F4N
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![BU of 7f4n by Molmil](/molmil-images/mine/7f4n) | Crystal structure of SAH-bound MTA1-p1-p2 complex | Descriptor: | MT-a70 family protein, S-ADENOSYL-L-HOMOCYSTEINE, Transmembrane protein, ... | Authors: | Chen, J, Liu, L. | Deposit date: | 2021-06-21 | Release date: | 2022-06-15 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3.12 Å) | Cite: | Structural basis for MTA1c-mediated DNA N6-adenine methylation Nat Commun, 13, 2022
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7F4R
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![BU of 7f4r by Molmil](/molmil-images/mine/7f4r) | Crystal structure of MTA1 | Descriptor: | MT-a70 family protein | Authors: | Chen, J, Liu, L. | Deposit date: | 2021-06-21 | Release date: | 2022-06-15 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.83 Å) | Cite: | Structural basis for MTA1c-mediated DNA N6-adenine methylation Nat Commun, 13, 2022
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7F4P
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![BU of 7f4p by Molmil](/molmil-images/mine/7f4p) | Crystal structure of SAM-bound MTA1-p2 complex | Descriptor: | MT-a70 family protein, S-ADENOSYLMETHIONINE, Transmembrane protein, ... | Authors: | Chen, J, Liu, L. | Deposit date: | 2021-06-21 | Release date: | 2022-06-15 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.98 Å) | Cite: | Structural basis for MTA1c-mediated DNA N6-adenine methylation Nat Commun, 13, 2022
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7F4S
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![BU of 7f4s by Molmil](/molmil-images/mine/7f4s) | Crystal structure of TthMTA1-PteMTA9 complex | Descriptor: | MT-a70 family protein, MTA9 | Authors: | Chen, J, Liu, L. | Deposit date: | 2021-06-21 | Release date: | 2022-06-15 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3.09 Å) | Cite: | Structural basis for MTA1c-mediated DNA N6-adenine methylation Nat Commun, 13, 2022
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7F4O
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![BU of 7f4o by Molmil](/molmil-images/mine/7f4o) | Crystal structure of MTA1-p2 complex | Descriptor: | MT-a70 family protein, Transmembrane protein, putative | Authors: | Chen, J, Liu, L. | Deposit date: | 2021-06-21 | Release date: | 2022-06-15 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Structural basis for MTA1c-mediated DNA N6-adenine methylation Nat Commun, 13, 2022
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7F4Q
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![BU of 7f4q by Molmil](/molmil-images/mine/7f4q) | Crystal structure of SAH-bound MTA1-p2 complex | Descriptor: | MT-a70 family protein, S-ADENOSYL-L-HOMOCYSTEINE, Transmembrane protein, ... | Authors: | Chen, J, Liu, L. | Deposit date: | 2021-06-21 | Release date: | 2022-06-15 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3.42 Å) | Cite: | Structural basis for MTA1c-mediated DNA N6-adenine methylation Nat Commun, 13, 2022
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7F4T
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![BU of 7f4t by Molmil](/molmil-images/mine/7f4t) | |
7F4L
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![BU of 7f4l by Molmil](/molmil-images/mine/7f4l) | Crystal structure of MTA1-p1-p2 complex | Descriptor: | MT-a70 family protein, Transmembrane protein, putative, ... | Authors: | Chen, J, Liu, L. | Deposit date: | 2021-06-21 | Release date: | 2022-06-15 | Method: | X-RAY DIFFRACTION (2.72 Å) | Cite: | Structural basis for MTA1c-mediated DNA N6-adenine methylation Nat Commun, 13, 2022
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7F4M
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![BU of 7f4m by Molmil](/molmil-images/mine/7f4m) | Crystal structure of SAM-bound MTA1-p1-p2 complex | Descriptor: | MT-a70 family protein, S-ADENOSYLMETHIONINE, Transmembrane protein, ... | Authors: | Chen, J, Liu, L. | Deposit date: | 2021-06-21 | Release date: | 2022-06-15 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3.58 Å) | Cite: | Structural basis for MTA1c-mediated DNA N6-adenine methylation Nat Commun, 13, 2022
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3HKS
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![BU of 3hks by Molmil](/molmil-images/mine/3hks) | Crystal structure of eukaryotic translation initiation factor eIF-5A2 from Arabidopsis thaliana | Descriptor: | 1,2-ETHANEDIOL, Eukaryotic translation initiation factor 5A-2 | Authors: | Teng, Y.B, He, Y.X, Jiang, Y.L, Chen, Y.X, Zhou, C.Z. | Deposit date: | 2009-05-25 | Release date: | 2009-09-29 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystal structure of Arabidopsis translation initiation factor eIF-5A2 Proteins, 77, 2009
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6A3N
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![BU of 6a3n by Molmil](/molmil-images/mine/6a3n) | Crystal structure of the PDE9 catalytic domain in complex with inhibitor 2 | Descriptor: | 1-cyclopentyl-6-({(2R)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxopropan-2-yl}amino)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A, MAGNESIUM ION, ... | Authors: | Wu, Y.N, Zhou, Q, Chen, Y.P, Luo, H.B. | Deposit date: | 2018-06-15 | Release date: | 2019-04-10 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Discovery of Potent, Selective, and Orally Bioavailable Inhibitors against Phosphodiesterase-9, a Novel Target for the Treatment of Vascular Dementia. J. Med. Chem., 62, 2019
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6O9D
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![BU of 6o9d by Molmil](/molmil-images/mine/6o9d) | Structure of the IRAK4 kinase domain with compound 5 | Descriptor: | Interleukin-1 receptor-associated kinase 4, N-{7-[4-(aminomethyl)piperidin-1-yl]quinolin-6-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide | Authors: | Yu, C, Drobnick, J, Bryan, M.C, Kiefer, J, Lupardus, P.J. | Deposit date: | 2019-03-13 | Release date: | 2019-05-22 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.51 Å) | Cite: | Development of Potent and Selective Pyrazolopyrimidine IRAK4 Inhibitors. J.Med.Chem., 62, 2019
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6O8U
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![BU of 6o8u by Molmil](/molmil-images/mine/6o8u) | Crystal structure of IRAK4 in complex with compound 23 | Descriptor: | GLYCEROL, Interleukin-1 receptor-associated kinase 4, N-[2,2-dimethyl-6-(morpholin-4-yl)-2,3-dihydro-1-benzofuran-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, ... | Authors: | Kiefer, J.R, Yu, C, Drobnick, J, Bryan, M.C, Lupardus, P.J. | Deposit date: | 2019-03-12 | Release date: | 2019-05-22 | Last modified: | 2019-07-24 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Development of Potent and Selective Pyrazolopyrimidine IRAK4 Inhibitors. J.Med.Chem., 62, 2019
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6O95
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![BU of 6o95 by Molmil](/molmil-images/mine/6o95) | Structure of the IRAK4 kinase domain with compound 41 | Descriptor: | Interleukin-1 receptor-associated kinase 4, N-[(2R)-2-(hydroxymethyl)-2-methyl-6-(morpholin-4-yl)-2,3-dihydro-1-benzofuran-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, SULFATE ION | Authors: | Yu, C, Drobnick, J, Bryan, M.C, Kiefer, J, Lupardus, P.J. | Deposit date: | 2019-03-13 | Release date: | 2019-05-22 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.77 Å) | Cite: | Development of Potent and Selective Pyrazolopyrimidine IRAK4 Inhibitors. J.Med.Chem., 62, 2019
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