6X2X
| Crystal Structure of Mek1NES peptide bound to CRM1(E571K) | Descriptor: | Dual specificity mitogen-activated protein kinase kinase 1, Exportin-1, GLYCEROL, ... | Authors: | Baumhardt, J.M. | Deposit date: | 2020-05-21 | Release date: | 2020-07-01 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.458 Å) | Cite: | Recognition of nuclear export signals by CRM1 carrying the oncogenic E571K mutation. Mol.Biol.Cell, 31, 2020
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6X2O
| Crystal Structure of unliganded CRM1(E571K)-Ran-RanBP1 | Descriptor: | Exportin-1, GTP-binding nuclear protein Ran, MAGNESIUM ION, ... | Authors: | Baumhardt, J.M. | Deposit date: | 2020-05-20 | Release date: | 2020-07-01 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.551 Å) | Cite: | Recognition of nuclear export signals by CRM1 carrying the oncogenic E571K mutation. Mol.Biol.Cell, 31, 2020
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6X2Y
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6X2R
| Crystal Structure of the 4E-TNES peptide bound to CRM1 | Descriptor: | Eukaryotic translation initiation factor 4E transporter, Exportin-1, GLYCEROL, ... | Authors: | Baumhardt, J.M. | Deposit date: | 2020-05-20 | Release date: | 2020-07-01 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.299 Å) | Cite: | Recognition of nuclear export signals by CRM1 carrying the oncogenic E571K mutation. Mol.Biol.Cell, 31, 2020
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1OBR
| CARBOXYPEPTIDASE T | Descriptor: | CALCIUM ION, CARBOXYPEPTIDASE T, SULFATE ION, ... | Authors: | Teplyakov, A, Polyakov, K, Obmolova, G, Osterman, A. | Deposit date: | 1996-06-22 | Release date: | 1997-01-11 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystal structure of carboxypeptidase T from Thermoactinomyces vulgaris. Eur.J.Biochem., 208, 1992
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6DEJ
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6ABK
| Crystal structure of Methanosarcina mazei PylRS(Y306A/Y384F) complexed with TeocLys | Descriptor: | (2S)-2-azanyl-6-(trimethylsilylmethoxycarbonylamino)hexanoic acid, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Yanagisawa, T, Kuratani, M, Yokoyama, S. | Deposit date: | 2018-07-22 | Release date: | 2019-04-17 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.58 Å) | Cite: | Structural Basis for Genetic-Code Expansion with Bulky Lysine Derivatives by an Engineered Pyrrolysyl-tRNA Synthetase. Cell Chem Biol, 26, 2019
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6AAO
| Crystal structure of Methanosarcina mazei PylRS(Y306A/Y384F) complexed with TCO*Lys | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, DI(HYDROXYETHYL)ETHER, MAGNESIUM ION, ... | Authors: | Yanagisawa, T, Kuratani, M, Yokoyama, S. | Deposit date: | 2018-07-18 | Release date: | 2019-04-17 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.403 Å) | Cite: | Structural Basis for Genetic-Code Expansion with Bulky Lysine Derivatives by an Engineered Pyrrolysyl-tRNA Synthetase. Cell Chem Biol, 26, 2019
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6AB0
| Crystal structure of Methanosarcina mazei PylRS(Y306A/Y384F) complexed with pAmPyLys | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, N6-{[(6-aminopyridin-3-yl)methoxy]carbonyl}-L-lysine, ... | Authors: | Yanagisawa, T, Kuratani, M, Yokoyama, S. | Deposit date: | 2018-07-19 | Release date: | 2019-04-17 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.441 Å) | Cite: | Structural Basis for Genetic-Code Expansion with Bulky Lysine Derivatives by an Engineered Pyrrolysyl-tRNA Synthetase. Cell Chem Biol, 26, 2019
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6AAP
| Crystal structure of Methanosarcina mazei PylRS(Y306A/Y384F) complexed with ZaeSeCys | Descriptor: | 3-[(2-{[(benzyloxy)carbonyl]amino}ethyl)selanyl]-L-alanine, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Yanagisawa, T, Kuratani, M, Yokoyama, S. | Deposit date: | 2018-07-18 | Release date: | 2019-04-17 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Structural Basis for Genetic-Code Expansion with Bulky Lysine Derivatives by an Engineered Pyrrolysyl-tRNA Synthetase. Cell Chem Biol, 26, 2019
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6AAD
| Crystal structure of Methanosarcina mazei PylRS(Y306A/Y384F) complexed with mTmdZLys | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, N6-[({3-[3-(trifluoromethyl)-3H-diaziren-3-yl]phenyl}methoxy)carbonyl]-L-lysine, ... | Authors: | Yanagisawa, T, Kuratani, M, Yokoyama, S. | Deposit date: | 2018-07-18 | Release date: | 2019-04-17 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.444 Å) | Cite: | Structural Basis for Genetic-Code Expansion with Bulky Lysine Derivatives by an Engineered Pyrrolysyl-tRNA Synthetase. Cell Chem Biol, 26, 2019
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6AAQ
| Crystal structure of Methanosarcina mazei PylRS(Y306A/Y384F) complexed with BCNLys | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, N6-({[(1R,8S,9s)-bicyclo[6.1.0]non-4-yn-9-yl]methoxy}carbonyl)-L-lysine, ... | Authors: | Yanagisawa, T, Kuratani, M, Yokoyama, S. | Deposit date: | 2018-07-18 | Release date: | 2019-04-17 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.551 Å) | Cite: | Structural Basis for Genetic-Code Expansion with Bulky Lysine Derivatives by an Engineered Pyrrolysyl-tRNA Synthetase. Cell Chem Biol, 26, 2019
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6AAN
| Crystal structure of Methanosarcina mazei PylRS(Y306A/Y384F) complexed with mEtZLys | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, DI(HYDROXYETHYL)ETHER, MAGNESIUM ION, ... | Authors: | Yanagisawa, T, Kuratani, M, Yokoyama, S. | Deposit date: | 2018-07-18 | Release date: | 2019-04-17 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.51 Å) | Cite: | Structural Basis for Genetic-Code Expansion with Bulky Lysine Derivatives by an Engineered Pyrrolysyl-tRNA Synthetase. Cell Chem Biol, 26, 2019
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6AAC
| Crystal structure of Methanosarcina mazei PylRS(Y306A/Y384F) complexed with mAzZLys | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, DI(HYDROXYETHYL)ETHER, MAGNESIUM ION, ... | Authors: | Yanagisawa, T, Kuratani, M, Yokoyama, S. | Deposit date: | 2018-07-18 | Release date: | 2019-04-17 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.479 Å) | Cite: | Structural Basis for Genetic-Code Expansion with Bulky Lysine Derivatives by an Engineered Pyrrolysyl-tRNA Synthetase. Cell Chem Biol, 26, 2019
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6AB1
| Crystal structure of Methanosarcina mazei PylRS(Y306A/Y384F) complexed with oAzZLys | Descriptor: | (2S)-2-azanyl-6-[(2-azidophenyl)methoxycarbonylamino]hexanoic acid, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Yanagisawa, T, Kuratani, M, Yokoyama, S. | Deposit date: | 2018-07-19 | Release date: | 2019-04-17 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.381 Å) | Cite: | Structural Basis for Genetic-Code Expansion with Bulky Lysine Derivatives by an Engineered Pyrrolysyl-tRNA Synthetase. Cell Chem Biol, 26, 2019
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6ABL
| Crystal structure of Methanosarcina mazei PylRS(Y306A/Y384F) complexed with oBrZLys | Descriptor: | (2S)-2-azanyl-6-[(2-bromophenyl)methoxycarbonylamino]hexanoic acid, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Yanagisawa, T, Kuratani, M, Yokoyama, S. | Deposit date: | 2018-07-22 | Release date: | 2019-04-17 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.47 Å) | Cite: | Structural Basis for Genetic-Code Expansion with Bulky Lysine Derivatives by an Engineered Pyrrolysyl-tRNA Synthetase. Cell Chem Biol, 26, 2019
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6ABM
| Crystal structure of Methanosarcina mazei PylRS(Y306A/Y384F) complexed with pTmdZLys | Descriptor: | (2S)-2-azanyl-6-[[4-[3-(trifluoromethyl)-1,2-diazirin-3-yl]phenyl]methoxycarbonylamino]hexanoic acid, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Yanagisawa, T, Kuratani, M, Yokoyama, S. | Deposit date: | 2018-07-22 | Release date: | 2019-04-17 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.368 Å) | Cite: | Structural Basis for Genetic-Code Expansion with Bulky Lysine Derivatives by an Engineered Pyrrolysyl-tRNA Synthetase. Cell Chem Biol, 26, 2019
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6AAZ
| Crystal structure of Methanosarcina mazei PylRS(Y306A/Y384F) complexed with pNO2ZLys | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, CITRIC ACID, MAGNESIUM ION, ... | Authors: | Yanagisawa, T, Kuratani, M, Yokoyama, S. | Deposit date: | 2018-07-19 | Release date: | 2019-04-17 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.842 Å) | Cite: | Structural Basis for Genetic-Code Expansion with Bulky Lysine Derivatives by an Engineered Pyrrolysyl-tRNA Synthetase. Cell Chem Biol, 26, 2019
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6AB8
| Crystal structure of Methanosarcina mazei PylRS(Y306A/Y384F) complexed with ZLys | Descriptor: | (2S)-2-azanyl-6-(phenylmethoxycarbonylamino)hexanoic acid, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Yanagisawa, T, Kuratani, M, Yokoyama, S. | Deposit date: | 2018-07-20 | Release date: | 2019-04-17 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.753 Å) | Cite: | Structural Basis for Genetic-Code Expansion with Bulky Lysine Derivatives by an Engineered Pyrrolysyl-tRNA Synthetase. Cell Chem Biol, 26, 2019
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6AB2
| Crystal structure of Methanosarcina mazei PylRS(Y306A/Y384F) complexed with oClZLys | Descriptor: | (2S)-2-azanyl-6-[(2-chlorophenyl)methoxycarbonylamino]hexanoic acid, 1,2-ETHANEDIOL, ADENOSINE-5'-TRIPHOSPHATE, ... | Authors: | Yanagisawa, T, Kuratani, M, Yokoyama, S. | Deposit date: | 2018-07-19 | Release date: | 2019-04-17 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Structural Basis for Genetic-Code Expansion with Bulky Lysine Derivatives by an Engineered Pyrrolysyl-tRNA Synthetase. Cell Chem Biol, 26, 2019
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2G0H
| Structure-based drug design of a novel family of PPAR partial agonists: virtual screening, x-ray crystallography and in vitro/in vivo biological activities | Descriptor: | N-[1-(4-FLUOROPHENYL)-3-(2-THIENYL)-1H-PYRAZOL-5-YL]-3,5-BIS(TRIFLUOROMETHYL)BENZENESULFONAMIDE, Peroxisome proliferator-activated receptor gamma | Authors: | Lu, I.L, Peng, Y.H, Huang, C.F, Lin, Y.T, Hsu, J.T.A, Wu, S.Y. | Deposit date: | 2006-02-13 | Release date: | 2006-05-16 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structure-Based Drug Design of a Novel Family of PPARgamma Partial Agonists: Virtual Screening, X-ray Crystallography, and in Vitro/in Vivo Biological Activities J.Med.Chem., 49, 2006
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2G0G
| Structure-based drug design of a novel family of PPAR partial agonists: virtual screening, x-ray crystallography and in vitro/in vivo biological activities | Descriptor: | 3-FLUORO-N-[1-(4-FLUOROPHENYL)-3-(2-THIENYL)-1H-PYRAZOL-5-YL]BENZENESULFONAMIDE, Peroxisome proliferator-activated receptor gamma | Authors: | Lu, I.L, Peng, Y.H, Huang, C.F, Lin, Y.T, Hsu, J.T.A, Wu, S.Y. | Deposit date: | 2006-02-13 | Release date: | 2006-05-16 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.54 Å) | Cite: | Structure-Based Drug Design of a Novel Family of PPARgamma Partial Agonists: Virtual Screening, X-ray Crystallography, and in Vitro/in Vivo Biological Activities J.Med.Chem., 49, 2006
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2GZ9
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2GZ8
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2GZ7
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