7D1M
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![BU of 7d1m by Molmil](/molmil-images/mine/7d1m) | CRYSTAL STRUCTURE OF THE SARS-CoV-2 MAIN PROTEASE COMPLEXED WITH GC376 | Descriptor: | (1S,2S)-2-({N-[(benzyloxy)carbonyl]-L-leucyl}amino)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid, 3C-like proteinase, DIMETHYL SULFOXIDE | Authors: | Fu, L.F, Gilski, M, Shabalin, I, Gao, G.F, Qi, J.X. | Deposit date: | 2020-09-14 | Release date: | 2020-10-28 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.35 Å) | Cite: | Both Boceprevir and GC376 efficaciously inhibit SARS-CoV-2 by targeting its main protease. Nat Commun, 11, 2020
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7EQT
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7EQS
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7EQW
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7ER1
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![BU of 7er1 by Molmil](/molmil-images/mine/7er1) | |
7ER0
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7EW9
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![BU of 7ew9 by Molmil](/molmil-images/mine/7ew9) | GDP-bound KRAS G12D in complex with TH-Z816 | Descriptor: | 7-(8-methylnaphthalen-1-yl)-4-[(2~{R})-2-methylpiperazin-1-yl]-2-[[(2~{S})-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5~{H}-pyrido[3,4-d]pyrimidine, GUANOSINE-5'-DIPHOSPHATE, Isoform 2B of GTPase KRas, ... | Authors: | Shen, P, Yang, Y, Yang, Y, Zhang, L, Chen, C.-C, Guo, R.-T. | Deposit date: | 2021-05-25 | Release date: | 2021-12-29 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.13 Å) | Cite: | KRAS(G12D) can be targeted by potent inhibitors via formation of salt bridge. Cell Discov, 8, 2022
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7EWB
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![BU of 7ewb by Molmil](/molmil-images/mine/7ewb) | GDP-bound KRAS G12D in complex with TH-Z835 | Descriptor: | 4-[(1~{S},5~{R})-3,8-diazabicyclo[3.2.1]octan-3-yl]-7-(8-methylnaphthalen-1-yl)-2-[[(2~{S})-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5~{H}-pyrido[3,4-d]pyrimidine, GUANOSINE-5'-DIPHOSPHATE, Isoform 2B of GTPase KRas, ... | Authors: | Shen, P, Yang, Y, Yang, Y, Zhang, L, Chen, C.-C, Guo, R.-T. | Deposit date: | 2021-05-25 | Release date: | 2021-12-29 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.99 Å) | Cite: | KRAS(G12D) can be targeted by potent inhibitors via formation of salt bridge. Cell Discov, 8, 2022
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7EWA
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![BU of 7ewa by Molmil](/molmil-images/mine/7ewa) | GDP-bound KRAS G12D in complex with TH-Z827 | Descriptor: | 4-[(1~{R},5~{S})-3,8-diazabicyclo[3.2.1]octan-8-yl]-7-(8-methylnaphthalen-1-yl)-2-[[(2~{S})-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5~{H}-pyrido[3,4-d]pyrimidine, GUANOSINE-5'-DIPHOSPHATE, Isoform 2B of GTPase KRas, ... | Authors: | Shen, P, Yang, Y, Yang, Y, Zhang, L, Chen, C.-C, Guo, R.-T. | Deposit date: | 2021-05-25 | Release date: | 2021-12-29 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | KRAS(G12D) can be targeted by potent inhibitors via formation of salt bridge. Cell Discov, 8, 2022
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7EYK
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7EYP
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![BU of 7eyp by Molmil](/molmil-images/mine/7eyp) | Crystal structure of Pseudomonas aeruginosa ppnP | Descriptor: | Pyrimidine/purine nucleoside phosphorylase | Authors: | Wen, Y, Wu, B.X. | Deposit date: | 2021-05-31 | Release date: | 2022-02-09 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Crystal structures of a new class of pyrimidine/purine nucleoside phosphorylase revealed a Cupin fold. Proteins, 90, 2022
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7EYJ
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![BU of 7eyj by Molmil](/molmil-images/mine/7eyj) | Crystal structure of Escherichia coli ppnP | Descriptor: | Pyrimidine/purine nucleoside phosphorylase, SULFATE ION | Authors: | Wen, Y, Wu, B.X. | Deposit date: | 2021-05-31 | Release date: | 2022-02-09 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (1.38 Å) | Cite: | Crystal structures of a new class of pyrimidine/purine nucleoside phosphorylase revealed a Cupin fold. Proteins, 90, 2022
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7EYL
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![BU of 7eyl by Molmil](/molmil-images/mine/7eyl) | Crystal structure of Salmonella enterica ppnP | Descriptor: | Pyrimidine/purine nucleoside phosphorylase | Authors: | Wen, Y, Wu, B.X. | Deposit date: | 2021-05-31 | Release date: | 2022-02-09 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.2 Å) | Cite: | Crystal structures of a new class of pyrimidine/purine nucleoside phosphorylase revealed a Cupin fold. Proteins, 90, 2022
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7EYM
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![BU of 7eym by Molmil](/molmil-images/mine/7eym) | Crystal structure of Vibrio cholerae ppnP | Descriptor: | Pyrimidine/purine nucleoside phosphorylase | Authors: | Wen, Y, Wu, B.X. | Deposit date: | 2021-05-31 | Release date: | 2022-02-09 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.38 Å) | Cite: | Crystal structures of a new class of pyrimidine/purine nucleoside phosphorylase revealed a Cupin fold. Proteins, 90, 2022
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7EJU
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![BU of 7eju by Molmil](/molmil-images/mine/7eju) | Junin virus(JUNV) RNA polymerase L complexed with Z protein | Descriptor: | MAGNESIUM ION, RING finger protein Z, RNA-directed RNA polymerase L, ... | Authors: | Chen, Y. | Deposit date: | 2021-04-02 | Release date: | 2021-07-07 | Last modified: | 2022-01-19 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Structural basis for recognition and regulation of arenavirus polymerase L by Z protein. Nat Commun, 12, 2021
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