7EWA
GDP-bound KRAS G12D in complex with TH-Z827
Summary for 7EWA
Entry DOI | 10.2210/pdb7ewa/pdb |
Descriptor | Isoform 2B of GTPase KRas, MAGNESIUM ION, GUANOSINE-5'-DIPHOSPHATE, ... (6 entities in total) |
Functional Keywords | kras, g12d, salt-bridge, inhibitor, complex, th-z827, hydrolase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 3 |
Total formula weight | 60718.38 |
Authors | Shen, P.,Yang, Y.,Yang, Y.,Zhang, L.,Chen, C.-C.,Guo, R.-T. (deposition date: 2021-05-25, release date: 2021-12-29, Last modification date: 2023-11-29) |
Primary citation | Mao, Z.,Xiao, H.,Shen, P.,Yang, Y.,Xue, J.,Yang, Y.,Shang, Y.,Zhang, L.,Li, X.,Zhang, Y.,Du, Y.,Chen, C.C.,Guo, R.T.,Zhang, Y. KRAS(G12D) can be targeted by potent inhibitors via formation of salt bridge. Cell Discov, 8:5-5, 2022 Cited by PubMed: 35075146DOI: 10.1038/s41421-021-00368-w PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.25 Å) |
Structure validation
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