7EWA

GDP-bound KRAS G12D in complex with TH-Z827

Summary for 7EWA

• Entry DOI: 10.2210/pdb7ewa/pdb
• Descriptor: Isoform 2B of GTPase KRas, MAGNESIUM ION, GUANOSINE-5'-DIPHOSPHATE, ... (6 entities in total)
• Functional Keywords: kras, g12d, salt-bridge, inhibitor, complex, th-z827, hydrolase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 3
• Total formula weight: 60718.38

Authors

Shen, P.,Yang, Y.,Yang, Y.,Zhang, L.,Chen, C.-C.,Guo, R.-T. (deposition date: 2021-05-25, release date: 2021-12-29, Last modification date: 2023-11-29)

• Primary citation: Mao, Z.,Xiao, H.,Shen, P.,Yang, Y.,Xue, J.,Yang, Y.,Shang, Y.,Zhang, L.,Li, X.,Zhang, Y.,Du, Y.,Chen, C.C.,Guo, R.T.,Zhang, Y.; KRAS(G12D) can be targeted by potent inhibitors via formation of salt bridge.; Cell Discov, 8:5-5, 2022; PubMed: 35075146; DOI: 10.1038/s41421-021-00368-w

Experimental method

X-RAY DIFFRACTION (2.25 Å)