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5EE5
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BU of 5ee5 by Molmil
Structure of human ARL1 in complex with the DCB domain of BIG1
Descriptor: ACETATE ION, ADP-ribosylation factor-like protein 1, Brefeldin A-inhibited guanine nucleotide-exchange protein 1, ...
Authors:Galindo, A, Soler, N, Munro, S.
Deposit date:2015-10-22
Release date:2016-07-06
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (2.279 Å)
Cite:Structural Insights into Arl1-Mediated Targeting of the Arf-GEF BIG1 to the trans-Golgi.
Cell Rep, 16, 2016
4EG7
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BU of 4eg7 by Molmil
Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor Chem 1331
Descriptor: DIMETHYL SULFOXIDE, GLYCEROL, METHIONINE, ...
Authors:Koh, C.Y, Kim, J.E, Shibata, S, Fan, E, Verlinde, C.L.M.J, Hol, W.G.J.
Deposit date:2012-03-30
Release date:2012-09-12
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.747 Å)
Cite:Distinct States of Methionyl-tRNA Synthetase Indicate Inhibitor Binding by Conformational Selection.
Structure, 20, 2012
4EG5
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BU of 4eg5 by Molmil
Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor Chem 1312
Descriptor: 2-({3-[(3,5-dichlorobenzyl)amino]propyl}amino)quinolin-4(1H)-one, DIMETHYL SULFOXIDE, GLYCEROL, ...
Authors:Koh, C.Y, Kim, J.E, Shibata, S, Fan, E, Verlinde, C.L.M.J, Hol, W.G.J.
Deposit date:2012-03-30
Release date:2012-09-12
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Distinct States of Methionyl-tRNA Synthetase Indicate Inhibitor Binding by Conformational Selection.
Structure, 20, 2012
4EG4
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BU of 4eg4 by Molmil
Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor Chem 1289
Descriptor: 2-({3-[(3,5-dibromo-2-ethoxybenzyl)amino]propyl}amino)quinolin-4(1H)-one, DIMETHYL SULFOXIDE, GLYCEROL, ...
Authors:Koh, C.Y, Kim, J.E, Shibata, S, Fan, E, Verlinde, C.L.M.J, Hol, W.G.J.
Deposit date:2012-03-30
Release date:2012-09-12
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (3.151 Å)
Cite:Distinct States of Methionyl-tRNA Synthetase Indicate Inhibitor Binding by Conformational Selection.
Structure, 20, 2012
4EGA
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BU of 4ega by Molmil
Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor Chem 1320
Descriptor: 2-({3-[(3,5-dibromo-2-methoxybenzyl)amino]propyl}amino)quinolin-4(1H)-one, DIMETHYL SULFOXIDE, GLYCEROL, ...
Authors:Koh, C.Y, Kim, J.E, Shibata, S, Fan, E, Verlinde, C.L.M.J, Hol, W.G.J.
Deposit date:2012-03-30
Release date:2012-09-12
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (2.698 Å)
Cite:Distinct States of Methionyl-tRNA Synthetase Indicate Inhibitor Binding by Conformational Selection.
Structure, 20, 2012
4EG3
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BU of 4eg3 by Molmil
Trypanosoma brucei methionyl-tRNA synthetase in complex with product methionyl-adenylate
Descriptor: GLYCEROL, Methionyl-tRNA synthetase, putative, ...
Authors:Koh, C.Y, Kim, J.E, Shibata, S, Fan, E, Verlinde, C.L.M.J, Hol, W.G.J.
Deposit date:2012-03-30
Release date:2012-09-12
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (2.94 Å)
Cite:Distinct States of Methionyl-tRNA Synthetase Indicate Inhibitor Binding by Conformational Selection.
Structure, 20, 2012
8XEP
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BU of 8xep by Molmil
Crystal structure of a Legionella pneumophila type IV effector in complex with ubiquitin
Descriptor: SULFATE ION, Type IV effector MavL, Ubiquitin
Authors:Tan, J.X, Wang, X.F, Zhou, Y, Zhu, Y.Q.
Deposit date:2023-12-12
Release date:2024-05-01
Last modified:2024-07-24
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Legionella effector LnaB is a phosphoryl AMPylase that impairs phosphosignalling.
Nature, 631, 2024
4EG6
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BU of 4eg6 by Molmil
Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor Chem 1325
Descriptor: 4-{4-[(1H-benzimidazol-2-ylmethyl)amino]-6-(2-chloro-4-methoxyphenoxy)pyrimidin-2-yl}piperazin-2-one, DIMETHYL SULFOXIDE, GLYCEROL, ...
Authors:Koh, C.Y, Kim, J.E, Shibata, S, Fan, E, Verlinde, C.L.M.J, Hol, W.G.J.
Deposit date:2012-03-30
Release date:2012-09-12
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.901 Å)
Cite:Distinct States of Methionyl-tRNA Synthetase Indicate Inhibitor Binding by Conformational Selection.
Structure, 20, 2012
4EG1
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BU of 4eg1 by Molmil
Trypanosoma brucei methionyl-tRNA synthetase in complex with substrate Methionine
Descriptor: GLYCEROL, METHIONINE, Methionyl-tRNA synthetase, ...
Authors:Koh, C.Y, Kim, J.E, Shibata, S, Fan, E, Verlinde, C.L.M.J, Hol, W.G.J.
Deposit date:2012-03-30
Release date:2012-09-12
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Distinct States of Methionyl-tRNA Synthetase Indicate Inhibitor Binding by Conformational Selection.
Structure, 20, 2012
4EG8
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BU of 4eg8 by Molmil
Trypanosoma brucei methionyl-tRNA synthetase in complex with compound Chem 89
Descriptor: 2-aminoquinolin-8-ol, DIMETHYL SULFOXIDE, GLYCEROL, ...
Authors:Koh, C.Y, Kim, J.E, Shibata, S, Fan, E, Verlinde, C.L.M.J, Hol, W.G.J.
Deposit date:2012-03-30
Release date:2012-09-12
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.596 Å)
Cite:Distinct States of Methionyl-tRNA Synthetase Indicate Inhibitor Binding by Conformational Selection.
Structure, 20, 2012
4QOC
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BU of 4qoc by Molmil
crystal structure of compound 16 bound to MDM2(17-111), {(3R,5R,6S)-5-(3-CHLOROPHENYL)-6-(4-CHLOROPHENYL)-1-[(1S)-1-CYCLOPROPYL-2-(PYRROLIDIN-1-YLSULFONYL)ETHYL]-3-METHYL-2-OXOPIPERIDIN-3-YL}ACETIC ACID
Descriptor: E3 ubiquitin-protein ligase Mdm2, {(3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-[(1S)-1-cyclopropyl-2-(pyrrolidin-1-ylsulfonyl)ethyl]-3-methyl-2-oxopiperidin-3-yl}acetic acid
Authors:Huang, X.
Deposit date:2014-06-19
Release date:2015-05-06
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Optimization beyond AMG 232: discovery and SAR of sulfonamides on a piperidinone scaffold as potent inhibitors of the MDM2-p53 protein-protein interaction.
Bioorg.Med.Chem.Lett., 24, 2014
3SXK
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BU of 3sxk by Molmil
Zn2+-bound FCD domain of TM0439, a putative transcriptional regulator
Descriptor: BICARBONATE ION, SULFATE ION, Transcriptional regulator, ...
Authors:Czelakowski, G.P, Derewenda, Z.S, Integrated Center for Structure and Function Innovation (ISFI)
Deposit date:2011-07-15
Release date:2011-11-16
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:Zn2+-bound FCD domain of TM0439, a putative transcriptional regulator
To be Published
3SXM
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BU of 3sxm by Molmil
Metal-free FCD domain of TM0439 a putative transcriptional regulator
Descriptor: BICARBONATE ION, Transcriptional regulator, GntR family
Authors:Czelakowski, G.P, Derewenda, Z.S, Integrated Center for Structure and Function Innovation (ISFI)
Deposit date:2011-07-15
Release date:2011-11-16
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Metal-free FCD domain of TM0439 a putative transcriptional regulator
To be Published
3SXY
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BU of 3sxy by Molmil
Metal-free full-length structure of Tm0439, a metal-binding FCD family transcriptional regulator
Descriptor: Transcriptional regulator, GntR family
Authors:Czelakowski, G.P, Derewenda, Z.S, Integrated Center for Structure and Function Innovation (ISFI)
Deposit date:2011-07-15
Release date:2011-11-16
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.647 Å)
Cite:Metal-free full-length structure of Tm0439, a metal-binding FCD family transcriptional regulator
To be Published
3SXZ
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BU of 3sxz by Molmil
Metal-free FCD domain of TM0439 a putative transcriptional regulator
Descriptor: Transcriptional regulator, GntR family
Authors:Czelakowski, G.P, Derewenda, Z.S, Integrated Center for Structure and Function Innovation (ISFI)
Deposit date:2011-07-15
Release date:2011-11-16
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.322 Å)
Cite:Metal-free FCD domain of TM0439 a putative transcriptional regulator
To be Published
7FCV
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BU of 7fcv by Molmil
Cryo-EM structure of the Potassium channel AKT1 mutant from Arabidopsis thaliana
Descriptor: PHOSPHATIDYLETHANOLAMINE, POTASSIUM ION, Potassium channel AKT1
Authors:Yang, G.H, Lu, Y.M, Jia, Y.T, Zhang, Y.M, Tang, R.F, Xu, X, Li, X.M, Lei, J.L.
Deposit date:2021-07-15
Release date:2022-11-09
Last modified:2024-06-12
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Structural basis for the activity regulation of a potassium channel AKT1 from Arabidopsis.
Nat Commun, 13, 2022
1QDV
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BU of 1qdv by Molmil
N-TERMINAL DOMAIN, VOLTAGE-GATED POTASSIUM CHANNEL KV1.2 RESIDUES 33-131
Descriptor: KV1.2 VOLTAGE-GATED POTASSIUM CHANNEL
Authors:Minor Jr, D.L, Lin, Y.-F, Mobley, B.C, Yu, M, Jan, Y.N, Jan, L.Y, Berger, J.M.
Deposit date:1999-07-10
Release date:2000-09-20
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:The polar T1 interface is linked to conformational changes that open the voltage-gated potassium channel.
Cell(Cambridge,Mass.), 102, 2000
2A6P
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BU of 2a6p by Molmil
Structure Solution to 2.2 Angstrom and Functional Characterisation of the Open Reading Frame Rv3214 from Mycobacterium tuberculosis
Descriptor: GLYCEROL, POSSIBLE PHOSPHOGLYCERATE MUTASE GPM2, SULFATE ION
Authors:Watkins, H.A, Yu, M, Baker, E.N, TB Structural Genomics Consortium (TBSGC)
Deposit date:2005-07-03
Release date:2006-05-16
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural and Functional Analysis of Rv3214 from Mycobacterium tuberculosis, a Protein with Conflicting Functional Annotations, Leads to Its Characterization as a Phosphatase.
J.Bacteriol., 188, 2006
5ID2
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BU of 5id2 by Molmil
Asymmetry in the active site of Mycobacterium tuberculosis AhpE upon exposure to Mycothiol
Descriptor: ACETATE ION, GLYCEROL, Putative peroxiredoxin Rv2238c
Authors:Kumar, A, Balakrishna, A.M, Gruber, G.
Deposit date:2016-02-23
Release date:2016-08-03
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (2.43 Å)
Cite:Redox chemistry of Mycobacterium tuberculosis alkylhydroperoxide reductase E (AhpE): Structural and mechanistic insight into a mycoredoxin-1 independent reductive pathway of AhpE via mycothiol
Free Radic. Biol. Med., 97, 2016
3UNO
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BU of 3uno by Molmil
Mycobacterium tuberculosis ferritin homolog, BfrB
Descriptor: Probable bacterioferritin BfrB
Authors:McMath, L.M, Contreras, H, Goulding, C.W, TB Structural Genomics Consortium (TBSGC)
Deposit date:2011-11-16
Release date:2012-11-21
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.503 Å)
Cite:Mycobacterium tuberculosis ferritin homolog, BfrB
To be Published
4P0M
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BU of 4p0m by Molmil
Crystal structure of an evolved putative penicillin-binding protein homolog, Rv2911, from Mycobacterium tuberculosis
Descriptor: D-alanyl-D-alanine carboxypeptidase
Authors:Krieger, I, Yu, M, Bursey, E, Hung, L.-W, Terwilliger, T.C, TB Structural Genomics Consortium (TBSGC)
Deposit date:2014-02-21
Release date:2014-03-12
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2 Å)
Cite:Subfamily-Specific Adaptations in the Structures of Two Penicillin-Binding Proteins from Mycobacterium tuberculosis.
Plos One, 9, 2014

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