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6R1H
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BU of 6r1h by Molmil
Crystal structure of the LRR ectodomain of the receptor kinase SOBIR1 from Arabidopsis thaliana.
Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ...
Authors:Hohmann, U, Hothorn, M.
Deposit date:2019-03-14
Release date:2019-05-08
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Crystal structure of the leucine-rich repeat ectodomain of the plant immune receptor kinase SOBIR1.
Acta Crystallogr D Struct Biol, 75, 2019
6S6Q
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BU of 6s6q by Molmil
Crystal structure of the LRR ectodomain of the plant membrane receptor kinase GASSHO1/SCHENGEN3 from Arabidopsis thaliana in complex with CASPARIAN STRIP INTEGRITY FACTOR 2.
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, LRR receptor-like serine/threonine-protein kinase GSO1, ...
Authors:Okuda, S, Moretti, A, Hothorn, M.
Deposit date:2019-07-03
Release date:2020-01-29
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Molecular mechanism for the recognition of sequence-divergent CIF peptides by the plant receptor kinases GSO1/SGN3 and GSO2.
Proc.Natl.Acad.Sci.USA, 117, 2020
4LSA
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BU of 4lsa by Molmil
Crystal structure of BRI1 sud1 (Gly643Glu) bound to brassinolide
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Brassinolide, Protein BRASSINOSTEROID INSENSITIVE 1, ...
Authors:Santiago, J, Henzler, C, Hothorn, M.
Deposit date:2013-07-22
Release date:2013-09-04
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Molecular mechanism for plant steroid receptor activation by somatic embryogenesis co-receptor kinases.
Science, 341, 2013
2V9K
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BU of 2v9k by Molmil
Crystal structure of human PUS10, a novel pseudouridine synthase.
Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CHLORIDE ION, GLYCEROL, ...
Authors:McCleverty, C.J, Hornsby, M, Spraggon, G, Kreusch, A.
Deposit date:2007-08-23
Release date:2007-10-09
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structure of Human Pus10, a Novel Pseudouridine Synthase.
J.Mol.Biol., 373, 2007
4LSX
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BU of 4lsx by Molmil
Plant steroid receptor ectodomain bound to brassinolide and SERK1 co-receptor ectodomain
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Brassinolide, ...
Authors:Santiago, J, Henzler, C, Hothorn, M.
Deposit date:2013-07-23
Release date:2013-09-04
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3.302 Å)
Cite:Molecular mechanism for plant steroid receptor activation by somatic embryogenesis co-receptor kinases.
Science, 341, 2013
4LSC
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BU of 4lsc by Molmil
Isolated SERK1 co-receptor ectodomain at high resolution
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Somatic embryogenesis receptor kinase 1, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Santiago, J, Henzler, C, Hothorn, M.
Deposit date:2013-07-22
Release date:2013-09-04
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.529 Å)
Cite:Molecular mechanism for plant steroid receptor activation by somatic embryogenesis co-receptor kinases.
Science, 341, 2013
3E1X
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BU of 3e1x by Molmil
The Crystal Structure of Apo Prostasin at 1.7 Angstroms Resolution
Descriptor: GLYCEROL, Prostasin
Authors:Spraggon, G, Hornsby, M, Shipway, A, Harris, J.L, Lesley, S.A.
Deposit date:2008-08-04
Release date:2009-05-05
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Active site conformational changes of prostasin provide a new mechanism of protease regulation by divalent cations.
Protein Sci., 18, 2009
3E0N
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BU of 3e0n by Molmil
The X-ray structure of Human Prostasin in complex with DFFR-chloromethyl ketone inhibitor
Descriptor: DPN-PHE-ARM, GLYCEROL, Prostasin heavy chain, ...
Authors:Spraggon, G, Hornsby, M, Shipway, A, Harris, J.L, Lesley, S.A.
Deposit date:2008-07-31
Release date:2009-06-16
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Active site conformational changes of prostasin provide a new mechanism of protease regulation by divalent cations.
Protein Sci., 18, 2009
3FVF
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BU of 3fvf by Molmil
The Crystal Structure of Prostasin Complexed with Camostat at 1.6 Angstroms Resolution
Descriptor: 1-[4-(hydroxymethyl)phenyl]guanidine, DIMETHYL SULFOXIDE, GLYCEROL, ...
Authors:Spraggon, G, Hornsby, M, Shipway, A, Harris, J.L, Lesley, S.A.
Deposit date:2009-01-15
Release date:2009-05-05
Last modified:2021-10-20
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Active site conformational changes of prostasin provide a new mechanism of protease regulation by divalent cations.
Protein Sci., 18, 2009
1ZR3
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BU of 1zr3 by Molmil
Crystal structure of the macro-domain of human core histone variant macroH2A1.1 (form B)
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, histone macroH2A1.1
Authors:Kustatscher, G, Hothorn, M, Pugieux, C, Scheffzek, K, Ladurner, A.G.
Deposit date:2005-05-19
Release date:2006-02-14
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.66 Å)
Cite:Splicing regulates NAD metabolite binding to histone macroH2A.
Nat.Struct.Mol.Biol., 12, 2005
1ZR5
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BU of 1zr5 by Molmil
Crystal structure of the macro-domain of human core histone variant macroH2A1.2
Descriptor: H2AFY protein
Authors:Kustatscher, G, Hothorn, M, Pugieux, C, Scheffzek, K, Ladurner, A.G.
Deposit date:2005-05-19
Release date:2005-06-21
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.92 Å)
Cite:Splicing regulates NAD metabolite binding to histone macroH2A.
Nat.Struct.Mol.Biol., 12, 2005
2OP3
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BU of 2op3 by Molmil
The structure of cathepsin S with a novel 2-arylphenoxyacetaldehyde inhibitor derived by the Substrate Activity Screening (SAS) method
Descriptor: 2,5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50,53,56,59,62,65,68,71,74,77,80-HEPTACOSAOXADOOCTACONTAN-82-OL, 2-[(2',3',4'-TRIFLUOROBIPHENYL-2-YL)OXY]ETHANOL, Cathepsin S, ...
Authors:Spraggon, G, Inagaki, H, Tsuruoka, H, Hornsby, M, Lesley, S.A, Ellman, J.A.
Deposit date:2007-01-26
Release date:2007-05-22
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Characterization and optimization of selective, nonpeptidic inhibitors of cathepsin S with an unprecedented binding mode.
J.Med.Chem., 50, 2007
3GYM
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BU of 3gym by Molmil
Structure of Prostasin in Complex with Aprotinin
Descriptor: Pancreatic trypsin inhibitor, Prostasin
Authors:Spraggon, G, Hornsby, M, Shipway, A, Harris, J.L, Lesley, S.A.
Deposit date:2009-04-03
Release date:2009-05-05
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Active site conformational changes of prostasin provide a new mechanism of protease regulation by divalent cations.
Protein Sci., 18, 2009
3GYL
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BU of 3gyl by Molmil
Structure of Prostasin at 1.3 Angstroms resolution in complex with a Calcium Ion.
Descriptor: CALCIUM ION, GLYCEROL, Prostasin
Authors:Spraggon, G, Hornsby, M, Shipway, A, Harris, J.L, Lesley, S.A.
Deposit date:2009-04-03
Release date:2009-04-21
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Active site conformational changes of prostasin provide a new mechanism of protease regulation by divalent cations.
Protein Sci., 18, 2009
2HH5
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BU of 2hh5 by Molmil
Crystal Structure of Cathepsin S in complex with a Zinc mediated non-covalent arylaminoethyl amide
Descriptor: CHLORIDE ION, Cathepsin S, N-[(1R)-1-[(BENZYLSULFONYL)METHYL]-2-{[(1S)-1-METHYL-2-{[4-(TRIFLUOROMETHOXY)PHENYL]AMINO}ETHYL]AMINO}-2-OXOETHYL]MORPHOLINE-4-CARBOXAMIDE, ...
Authors:Spraggon, G, Hornsby, M, Lesley, S.A, Tully, D.C, Harris, J.L, Karenewsky, D.S.
Deposit date:2006-06-27
Release date:2006-08-15
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Synthesis and SAR of arylaminoethyl amides as noncovalent inhibitors of cathepsin S: P3 cyclic ethers.
Bioorg.Med.Chem.Lett., 16, 2006
2HHN
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BU of 2hhn by Molmil
Cathepsin S in complex with non covalent arylaminoethyl amide.
Descriptor: Cathepsin S, N-[(1R)-1-[(BENZYLSULFONYL)METHYL]-2-{[(1S)-1-METHYL-2-{[4-(TRIFLUOROMETHOXY)PHENYL]AMINO}ETHYL]AMINO}-2-OXOETHYL]MORPHOLINE-4-CARBOXAMIDE, SULFATE ION
Authors:Spraggon, G, Hornsby, M, Lesley, S.A, Tully, D.C, Harris, J.L, Karenewsky, D.S, Kulathila, R, Clark, K.
Deposit date:2006-06-28
Release date:2007-05-08
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Synthesis and SAR of arylaminoethyl amides as noncovalent inhibitors of cathepsin S: P3 cyclic ethers
Bioorg.Med.Chem.Lett., 16, 2006
2H7J
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BU of 2h7j by Molmil
Crystal Structure of Cathepsin S in complex with a Nonpeptidic Inhibitor.
Descriptor: 2,5,8,11,14,17-HEXAOXANONADECAN-19-OL, Cathepsin S, N-[(1S)-1-{1-[(1R,3E)-1-ACETYLPENT-3-EN-1-YL]-1H-1,2,3-TRIAZOL-4-YL}-1,2-DIMETHYLPROPYL]BENZAMIDE
Authors:Patterson, A.W, Wood, W.J, Hornsby, M, Lesley, S, Spraggon, G, Ellman, J.A.
Deposit date:2006-06-02
Release date:2006-10-24
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Identification of selective, nonpeptidic nitrile inhibitors of cathepsin s using the substrate activity screening method.
J.Med.Chem., 49, 2006
2HXZ
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BU of 2hxz by Molmil
Crystal Structure of Cathepsin S in complex with a Nonpeptidic Inhibitor (Hexagonal spacegroup)
Descriptor: Cathepsin S, N-[(1S)-1-{1-[(1R,3E)-1-ACETYLPENT-3-EN-1-YL]-1H-1,2,3-TRIAZOL-4-YL}-1,2-DIMETHYLPROPYL]BENZAMIDE, SULFATE ION
Authors:Patterson, A.W, Wood, W.J, Hornsby, M, Lesley, S, Spraggon, G, Ellman, J.A.
Deposit date:2006-08-04
Release date:2006-10-24
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Identification of selective, nonpeptidic nitrile inhibitors of cathepsin s using the substrate activity screening method.
J.Med.Chem., 49, 2006
6QBH
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BU of 6qbh by Molmil
Crystal structure of human cathepsin D in complex with macrocyclic inhibitor 33
Descriptor: (4~{S},5~{S},9~{S})-5-oxidanyl-4-(phenylmethyl)-9-propan-2-yl-1-oxa-3,8,11-triazacyclodocosane-2,7,10-trione, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Brynda, J, Houstecka, R, Majer, P, Mares, M.
Deposit date:2018-12-21
Release date:2020-01-29
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Biomimetic Macrocyclic Inhibitors of Human Cathepsin D: Structure-Activity Relationship and Binding Mode Analysis.
J.Med.Chem., 63, 2020
6QCB
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BU of 6qcb by Molmil
Crystal structure of human cathepsin D in complex with macrocyclic inhibitor 9
Descriptor: (3~{S},7~{S},8~{S})-7-oxidanyl-8-(phenylmethyl)-3-propan-2-yl-1,4,9-triazacyclohenicosane-2,5,10-trione, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Cathepsin D, ...
Authors:Brynda, J, Houstecka, R, Majer, P, Mares, M.
Deposit date:2018-12-27
Release date:2020-01-29
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Biomimetic Macrocyclic Inhibitors of Human Cathepsin D: Structure-Activity Relationship and Binding Mode Analysis.
J.Med.Chem., 63, 2020
6QBG
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BU of 6qbg by Molmil
Crystal structure of human cathepsin D in complex with macrocyclic inhibitor 14
Descriptor: (3~{S},7~{S},8~{S})-8-(naphthalen-2-ylmethyl)-7-oxidanyl-3-propan-2-yl-1,4,9-triazacyclohenicosane-2,5,10-trione, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Brynda, J, Houstecka, R, Majer, P, Mares, M.
Deposit date:2018-12-21
Release date:2020-01-29
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Biomimetic Macrocyclic Inhibitors of Human Cathepsin D: Structure-Activity Relationship and Binding Mode Analysis.
J.Med.Chem., 63, 2020
7NUU
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BU of 7nuu by Molmil
Crystal structure of human AMDHD2 in complex with Zn
Descriptor: GLYCEROL, N-acetylglucosamine-6-phosphate deacetylase, ZINC ION
Authors:Ruegenberg, S, Kroef, V, Baumann, U, Denzel, M.S.
Deposit date:2021-03-14
Release date:2021-04-28
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.836 Å)
Cite:GFPT2/GFAT2 and AMDHD2 act in tandem to control the hexosamine pathway.
Elife, 11, 2022
7NUT
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BU of 7nut by Molmil
Crystal structure of human AMDHD2 in complex with Zn and GlcN6P
Descriptor: 2-amino-2-deoxy-6-O-phosphono-alpha-D-glucopyranose, N-acetylglucosamine-6-phosphate deacetylase, ZINC ION
Authors:Ruegenberg, S, Kroef, V, Baumann, U, Denzel, M.S.
Deposit date:2021-03-14
Release date:2021-04-28
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.898 Å)
Cite:GFPT2/GFAT2 and AMDHD2 act in tandem to control the hexosamine pathway.
Elife, 11, 2022
6YI7
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BU of 6yi7 by Molmil
Structure of cathepsin B1 from Schistosoma mansoni (SmCB1) in complex with an azanitrile inhibitor
Descriptor: 1-[(2~{S})-1-[[iminomethyl(methyl)amino]-methyl-amino]-4-methyl-1-oxidanylidene-pentan-2-yl]-3-(phenylmethyl)urea, ACETATE ION, Cathepsin B-like peptidase (C01 family)
Authors:Jilkova, A, Rezacova, P, Pachl, P, Fanfrlik, J, Rubesova, P, Guetschow, M, Mares, M.
Deposit date:2020-04-01
Release date:2020-12-16
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.29 Å)
Cite:Azanitrile Inhibitors of the SmCB1 Protease Target Are Lethal to Schistosoma mansoni : Structural and Mechanistic Insights into Chemotype Reactivity.
Acs Infect Dis., 7, 2021
3L0R
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BU of 3l0r by Molmil
Crystal Structure of Salivary Cystatin from the Soft Tick Ornithodoros moubata
Descriptor: CHLORIDE ION, Cystatin-2, GLYCEROL
Authors:Rezacova, P, Brynda, J, Andersen, J.F, Salat, J, Kovarova, Z, Mares, M.
Deposit date:2009-12-10
Release date:2010-06-30
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Crystal structure and functional characterization of an immunomodulatory salivary cystatin from the soft tick Ornithodoros moubata
Biochem.J., 429, 2010

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