6QBH
Crystal structure of human cathepsin D in complex with macrocyclic inhibitor 33
Summary for 6QBH
Entry DOI | 10.2210/pdb6qbh/pdb |
Related | 6QBG |
Descriptor | Cathepsin D, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, (4~{S},5~{S},9~{S})-5-oxidanyl-4-(phenylmethyl)-9-propan-2-yl-1-oxa-3,8,11-triazacyclodocosane-2,7,10-trione, ... (8 entities in total) |
Functional Keywords | aspartic protease, peptidomimetic inhibitor, hydrolase |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 38382.77 |
Authors | Brynda, J.,Houstecka, R.,Majer, P.,Mares, M. (deposition date: 2018-12-21, release date: 2020-01-29, Last modification date: 2024-01-24) |
Primary citation | Houstecka, R.,Hadzima, M.,Fanfrlik, J.,Brynda, J.,Pallova, L.,Hanova, I.,Mertlikova-Kaiserova, H.,Lepsik, M.,Horn, M.,Smrcina, M.,Majer, P.,Mares, M. Biomimetic Macrocyclic Inhibitors of Human Cathepsin D: Structure-Activity Relationship and Binding Mode Analysis. J.Med.Chem., 63:1576-1596, 2020 Cited by PubMed: 32003991DOI: 10.1021/acs.jmedchem.9b01351 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
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