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Precisely patterned nanofibers made from extendable protein multiplexes
Descriptor:	C4HR1_4r
Authors:	Bera, A.K, Bethel, N.P.
Deposit date:	2022-10-04
Release date:	2023-08-16
Last modified:	2023-12-20
Method:	X-RAY DIFFRACTION (3.3 Å)
Cite:	Precisely patterned nanofibres made from extendable protein multiplexes. Nat.Chem., 15, 2023

1ZO9

Crystal Structure Of The Wild Type Heme Domain Of P450BM-3 with N-palmitoylmethionine
Descriptor:	2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Bifunctional P-450:NADPH-P450 reductase, GLYCEROL, ...
Authors:	Hegda, A, Chen, B, Tomchick, D.R, Bondlela, M, Haines, D.C, Schaffer, N, Machius, M, Graham, S.E, Peterson, J.A.
Deposit date:	2005-05-12
Release date:	2006-08-01
Last modified:	2023-08-23
Method:	X-RAY DIFFRACTION (1.7 Å)
Cite:	Interactions of substrates at the surface of P450s can greatly enhance substrate potency. Biochemistry, 46, 2007

5WEV

Identification of an imidazopyridine scaffold to generate potent and selective TYK2 inhibitors that demonstrate activity in an in vivo psoriasis model
Descriptor:	N-[2-(2,6-dichlorophenyl)-1H-imidazo[4,5-c]pyridin-4-yl]cyclopropanecarboxamide, Tyrosine-protein kinase JAK2
Authors:	Ultsch, M.H, Magnuson, S.
Deposit date:	2017-07-10
Release date:	2017-09-06
Last modified:	2023-11-15
Method:	X-RAY DIFFRACTION (1.854 Å)
Cite:	Identification of an imidazopyridine scaffold to generate potent and selective TYK2 inhibitors that demonstrate activity in an in vivo psoriasis model. Bioorg. Med. Chem. Lett., 27, 2017

5WAL

Identification of an imidazopyridine scaffold to generate potent and selective TYK2 inhibitors that demonstrate activity in an in vivo psoriasis model
Descriptor:	N-[2-(2,6-dichlorophenyl)-1H-imidazo[4,5-c]pyridin-4-yl]cyclopropanecarboxamide, Non-receptor tyrosine-protein kinase TYK2
Authors:	Ultsch, M.H, Magnuson, S.
Deposit date:	2017-06-26
Release date:	2017-09-06
Last modified:	2023-10-04
Method:	X-RAY DIFFRACTION (2.45 Å)
Cite:	Identification of an imidazopyridine scaffold to generate potent and selective TYK2 inhibitors that demonstrate activity in an in vivo psoriasis model. Bioorg. Med. Chem. Lett., 27, 2017

3EFW

Structure of AuroraA with pyridyl-pyrimidine urea inhibitor
Descriptor:	1-[3-methyl-4-({3-[2-(methylamino)pyrimidin-4-yl]pyridin-2-yl}oxy)phenyl]-3-[3-(trifluoromethyl)phenyl]urea, SULFATE ION, Serine/threonine-protein kinase 6
Authors:	Bellon, S.F, Cee, V, Hughes, P, Geuns-Meyer, S, Whittington, D.
Deposit date:	2008-09-10
Release date:	2008-12-23
Last modified:	2024-02-21
Method:	X-RAY DIFFRACTION (2.29 Å)
Cite:	Pyridyl-pyrimidine benzimidazole derivatives as potent, selective, and orally bioavailable inhibitors of Tie-2 kinase. Bioorg.Med.Chem.Lett., 19, 2009

8FBO

Improving the secretion of designed protein assemblies through negative design of cryptic transmembrane domains
Descriptor:	KWOCA_102
Authors:	Wang, J.Y, Khmelinskaia, A, Bera, A.K, King, N.P.
Deposit date:	2022-11-29
Release date:	2023-03-22
Last modified:	2024-05-22
Method:	X-RAY DIFFRACTION (3.4 Å)
Cite:	Improving the secretion of designed protein assemblies through negative design of cryptic transmembrane domains. Proc.Natl.Acad.Sci.USA, 120, 2023

8FBN

Improving the secretion of designed protein assemblies through negative design of cryptic transmembrane domains
Descriptor:	KWOCA_73
Authors:	Wang, J.Y, Khmelinskaia, A, Bera, A.K, King, N.P.
Deposit date:	2022-11-29
Release date:	2023-03-22
Last modified:	2024-05-22
Method:	X-RAY DIFFRACTION (3.04 Å)
Cite:	Improving the secretion of designed protein assemblies through negative design of cryptic transmembrane domains. Proc.Natl.Acad.Sci.USA, 120, 2023

8FBJ

Improving the secretion of designed protein assemblies through negative design of cryptic transmembrane domains
Descriptor:	KWOCA_60
Authors:	Wang, J.Y, Khmelinskaia, A, Bera, A.K, King, N.P.
Deposit date:	2022-11-29
Release date:	2023-03-22
Last modified:	2024-05-22
Method:	X-RAY DIFFRACTION (3.25 Å)
Cite:	Improving the secretion of designed protein assemblies through negative design of cryptic transmembrane domains. Proc.Natl.Acad.Sci.USA, 120, 2023

8FBI

Improving the secretion of designed protein assemblies through negative design of cryptic transmembrane domains
Descriptor:	KWOCA_39
Authors:	Wang, J.Y, Khmelinskaia, A, Bera, A.K, King, N.P.
Deposit date:	2022-11-29
Release date:	2023-03-22
Last modified:	2024-05-22
Method:	X-RAY DIFFRACTION (3.61 Å)
Cite:	Improving the secretion of designed protein assemblies through negative design of cryptic transmembrane domains. Proc.Natl.Acad.Sci.USA, 120, 2023

8FBK

Improving the secretion of designed protein assemblies through negative design of cryptic transmembrane domains
Descriptor:	KWOCA_65
Authors:	Wang, J.Y, Khmelinskaia, A, Bera, A.K, King, N.P.
Deposit date:	2022-11-29
Release date:	2023-03-22
Last modified:	2024-05-22
Method:	X-RAY DIFFRACTION (3.15 Å)
Cite:	Improving the secretion of designed protein assemblies through negative design of cryptic transmembrane domains. Proc.Natl.Acad.Sci.USA, 120, 2023

8FIQ

Multi-state design of two-state switchable hinge proteins
Descriptor:	cs207AB
Authors:	Bera, A.K, Leung, P.J.Y, Baker, D.
Deposit date:	2022-12-16
Release date:	2023-08-16
Last modified:	2024-03-06
Method:	X-RAY DIFFRACTION (2.66 Å)
Cite:	Design of stimulus-responsive two-state hinge proteins. Science, 381, 2023

8FVT

Multi-state design of two-state switchable hinge proteins
Descriptor:	3hb12
Authors:	Bera, A.K, Broerman, A, Baker, D.
Deposit date:	2023-01-19
Release date:	2023-08-16
Last modified:	2024-03-06
Method:	X-RAY DIFFRACTION (3.07 Å)
Cite:	Design of stimulus-responsive two-state hinge proteins. Science, 381, 2023

8FIN

Multi-state design of two-state switchable hinge proteins
Descriptor:	cs207A
Authors:	Bera, A.K, Leung, P.J.Y, Baker, D.
Deposit date:	2022-12-16
Release date:	2023-08-16
Last modified:	2024-03-06
Method:	X-RAY DIFFRACTION (2.3 Å)
Cite:	Design of stimulus-responsive two-state hinge proteins. Science, 381, 2023

8FIH

Multi-state design of two-state switchable hinge proteins
Descriptor:	3hb05, PHOSPHATE ION
Authors:	Bera, A.K, Broerman, A, Baker, D.
Deposit date:	2022-12-16
Release date:	2023-08-16
Last modified:	2024-03-06
Method:	X-RAY DIFFRACTION (2.2 Å)
Cite:	Design of stimulus-responsive two-state hinge proteins. Science, 381, 2023

8FIT

Multi-state design of two-state switchable hinge proteins
Descriptor:	cs074A
Authors:	Bera, A.K, Praetorius, F, Baker, D.
Deposit date:	2022-12-16
Release date:	2023-08-16
Last modified:	2024-03-06
Method:	X-RAY DIFFRACTION (2.75 Å)
Cite:	Design of stimulus-responsive two-state hinge proteins. Science, 381, 2023

3ET2

Structure of PPARdelta with 3-[5-Methoxy-1-(4-methoxy-benzenesulfonyl)-1H-indol-3-yl]-propionic acid
Descriptor:	1-BUTANOL, 3-{5-methoxy-1-[(4-methoxyphenyl)sulfonyl]-1H-indol-3-yl}propanoic acid, Peroxisome proliferator-activated receptor delta
Authors:	Zhang, K.Y.J, Wang, W.
Deposit date:	2008-10-06
Release date:	2009-02-17
Last modified:	2023-09-06
Method:	X-RAY DIFFRACTION (2.24 Å)
Cite:	Scaffold-based discovery of indeglitazar, a PPAR pan-active anti-diabetic agent Proc.Natl.Acad.Sci.USA, 106, 2009

8FJF

The three-repeat design H10
Descriptor:	H10
Authors:	Bera, A.K, An, L, Baker, D.
Deposit date:	2022-12-19
Release date:	2023-09-27
Last modified:	2023-11-22
Method:	X-RAY DIFFRACTION (1.6 Å)
Cite:	Hallucination of closed repeat proteins containing central pockets. Nat.Struct.Mol.Biol., 30, 2023

8FJE

The five-repeat design E8
Descriptor:	E8
Authors:	Bera, A.K, An, L, Baker, D.
Deposit date:	2022-12-19
Release date:	2023-09-27
Last modified:	2023-11-22
Method:	X-RAY DIFFRACTION (3 Å)
Cite:	Hallucination of closed repeat proteins containing central pockets. Nat.Struct.Mol.Biol., 30, 2023

8FJG

The two-repeat design H12
Descriptor:	H12
Authors:	Bera, A.K, An, L, Baker, D.
Deposit date:	2022-12-19
Release date:	2023-09-27
Last modified:	2023-11-22
Method:	X-RAY DIFFRACTION (2.13 Å)
Cite:	Hallucination of closed repeat proteins containing central pockets. Nat.Struct.Mol.Biol., 30, 2023

7BHD

FimH in complex with alpha1,6 core-fucosylated oligomannose-3, crystallized in the trigonal space group
Descriptor:	NICKEL (II) ION, SULFATE ION, Type 1 fimbrin D-mannose specific adhesin, ...
Authors:	Bridot, C, Bouckaert, J, Krammer, E.-M.
Deposit date:	2021-01-11
Release date:	2022-07-20
Last modified:	2024-02-07
Method:	X-RAY DIFFRACTION (1.4 Å)
Cite:	Structural insights into a cooperative switch between one and two FimH bacterial adhesins binding pauci- and high-mannose type N-glycan receptors. J.Biol.Chem., 299, 2023

8FG6

Design of amyloidogenic peptide traps
Descriptor:	C104.1, amyloidogenic peptide
Authors:	Sahtoe, D.D, Bera, A.K, Baker, D.
Deposit date:	2022-12-12
Release date:	2024-03-20
Last modified:	2024-04-03
Method:	X-RAY DIFFRACTION (2.3 Å)
Cite:	Design of amyloidogenic peptide traps. Nat.Chem.Biol., 2024

8GA9

C4HR1_4r: Extendable repeat protein tetramer
Descriptor:	C4HR1_4r
Authors:	Bethel, N.P, Borst, A.J.
Deposit date:	2023-02-22
Release date:	2023-08-30
Last modified:	2023-12-20
Method:	ELECTRON MICROSCOPY (3.71 Å)
Cite:	Precisely patterned nanofibres made from extendable protein multiplexes. Nat.Chem., 15, 2023

8G8I

C3HR3_9r_shift4: Extendable repeat protein fiber
Descriptor:	C3HR3_9r_shift4
Authors:	Bethel, N.P, Borst, A.J.
Deposit date:	2023-02-17
Release date:	2023-08-30
Last modified:	2023-12-13
Method:	ELECTRON MICROSCOPY (3.92 Å)
Cite:	Precisely patterned nanofibres made from extendable protein multiplexes. Nat.Chem., 15, 2023

8GAQ

C5HR2_4r: Extendable repeat protein pentamer
Descriptor:	C5HR2_4r
Authors:	Bethel, N.P, Borst, A.J.
Deposit date:	2023-02-23
Release date:	2023-08-30
Last modified:	2023-12-20
Method:	ELECTRON MICROSCOPY (3.73 Å)
Cite:	Precisely patterned nanofibres made from extendable protein multiplexes. Nat.Chem., 15, 2023

8GAA

C6HR1_4r: Extendable repeat protein hexamer
Descriptor:	C6HR1_4r
Authors:	Bethel, N.P, Borst, A.J, Baker, D.
Deposit date:	2023-02-22
Release date:	2023-08-30
Last modified:	2023-12-20
Method:	ELECTRON MICROSCOPY (4.24 Å)
Cite:	Precisely patterned nanofibres made from extendable protein multiplexes. Nat.Chem., 15, 2023

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