3EFW

Structure of AuroraA with pyridyl-pyrimidine urea inhibitor

Summary for 3EFW

• Entry DOI: 10.2210/pdb3efw/pdb
• Descriptor: Serine/threonine-protein kinase 6, 1-[3-methyl-4-({3-[2-(methylamino)pyrimidin-4-yl]pyridin-2-yl}oxy)phenyl]-3-[3-(trifluoromethyl)phenyl]urea, SULFATE ION, ... (4 entities in total)
• Functional Keywords: auroraa, stk6_human, atp-binding, cell cycle, kinase, nucleotide-binding, phosphoprotein, serine/threonine-protein kinase, transferase-inhibitor complex, transferase/inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Cytoplasm, cytoskeleton, centrosome: O14965
• Total number of polymer chains: 2
• Total formula weight: 63254.45

Authors

Bellon, S.F.,Cee, V.,Hughes, P.,Geuns-Meyer, S.,Whittington, D. (deposition date: 2008-09-10, release date: 2008-12-23, Last modification date: 2024-02-21)

• Primary citation: Cee, V.J.,Cheng, A.C.,Romero, K.,Bellon, S.,Mohr, C.,Whittington, D.A.,Bak, A.,Bready, J.,Caenepeel, S.,Coxon, A.,Deak, H.L.,Fretland, J.,Gu, Y.,Hodous, B.L.,Huang, X.,Kim, J.L.,Lin, J.,Long, A.M.,Nguyen, H.,Olivieri, P.R.,Patel, V.F.,Wang, L.,Zhou, Y.,Hughes, P.,Geuns-Meyer, S.; Pyridyl-pyrimidine benzimidazole derivatives as potent, selective, and orally bioavailable inhibitors of Tie-2 kinase.; Bioorg.Med.Chem.Lett., 19:424-427, 2009; PubMed: 19062275; DOI: 10.1016/j.bmcl.2008.11.056

Experimental method

X-RAY DIFFRACTION (2.29 Å)