8FHS
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![BU of 8fhs by Molmil](/molmil-images/mine/8fhs) | Human L-type voltage-gated calcium channel Cav1.2 in the presence of amiodarone and sofosbuvir at 3.3 Angstrom resolution | Descriptor: | (2-butyl-1-benzofuran-3-yl){4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl}methanone, 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Gao, S, Yao, X, Yan, N. | Deposit date: | 2022-12-15 | Release date: | 2023-12-13 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Structural basis for human Ca v 1.2 inhibition by multiple drugs and the neurotoxin calciseptine. Cell, 186, 2023
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8I5B
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![BU of 8i5b by Molmil](/molmil-images/mine/8i5b) | Structure of human Nav1.7 in complex with bupivacaine | Descriptor: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Wu, Q.R, Yan, N. | Deposit date: | 2023-01-24 | Release date: | 2023-06-14 | Last modified: | 2023-11-08 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | Structural mapping of Na v 1.7 antagonists. Nat Commun, 14, 2023
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8I5X
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![BU of 8i5x by Molmil](/molmil-images/mine/8i5x) | Structure of human Nav1.7 in complex with Vinpocetine | Descriptor: | (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ... | Authors: | Wu, Q.R, Yan, N. | Deposit date: | 2023-01-26 | Release date: | 2023-06-14 | Last modified: | 2023-11-08 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Structural mapping of Na v 1.7 antagonists. Nat Commun, 14, 2023
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8I5Y
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![BU of 8i5y by Molmil](/molmil-images/mine/8i5y) | Structure of human Nav1.7 in complex with vixotrigine | Descriptor: | (2S,3R,4E)-2-(acetylamino)-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate, (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ... | Authors: | Wu, Q.R, Yan, N. | Deposit date: | 2023-01-26 | Release date: | 2023-06-14 | Last modified: | 2023-11-08 | Method: | ELECTRON MICROSCOPY (2.6 Å) | Cite: | Structural mapping of Na v 1.7 antagonists. Nat Commun, 14, 2023
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8I5G
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![BU of 8i5g by Molmil](/molmil-images/mine/8i5g) | Structure of human Nav1.7 in complex with PF-05089771 | Descriptor: | (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ... | Authors: | Wu, Q.R, Yan, N. | Deposit date: | 2023-01-25 | Release date: | 2023-06-14 | Last modified: | 2023-11-08 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | Structural mapping of Na v 1.7 antagonists. Nat Commun, 14, 2023
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6WZW
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![BU of 6wzw by Molmil](/molmil-images/mine/6wzw) | Ash1L SET domain in complex with AS-85 | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Histone-lysine N-methyltransferase ASH1L, N-{[3-(3-carbamothioylphenyl)-1-{1-[(trifluoromethyl)sulfonyl]piperidin-4-yl}-1H-indol-6-yl]methyl}azetidine-3-carboxamide, ... | Authors: | Li, H, Deng, J, Cierpicki, T, Grembecka, J. | Deposit date: | 2020-05-14 | Release date: | 2021-04-07 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.69 Å) | Cite: | Discovery of first-in-class inhibitors of ASH1L histone methyltransferase with anti-leukemic activity. Nat Commun, 12, 2021
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6X0P
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![BU of 6x0p by Molmil](/molmil-images/mine/6x0p) | Ash1L SET domain Q2265A mutant in complex with AS-5 | Descriptor: | 3-[6-(aminomethyl)-1-(2-hydroxyethyl)-1H-indol-3-yl]benzene-1-carbothioamide, Histone-lysine N-methyltransferase ASH1L, S-ADENOSYLMETHIONINE, ... | Authors: | Rogawski, D.S, Li, H, Borkin, D, Cierpicki, T, Grembecka, J. | Deposit date: | 2020-05-17 | Release date: | 2021-04-07 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.69 Å) | Cite: | Discovery of first-in-class inhibitors of ASH1L histone methyltransferase with anti-leukemic activity. Nat Commun, 12, 2021
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7E93
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![BU of 7e93 by Molmil](/molmil-images/mine/7e93) | Intact TRAPPII (state III). | Descriptor: | TRAPP-associated protein TCA17, Trafficking protein particle complex II-specific subunit 120, Trafficking protein particle complex II-specific subunit 130, ... | Authors: | Mi, C.C, Sui, S.F. | Deposit date: | 2021-03-03 | Release date: | 2022-02-09 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (6.54 Å) | Cite: | Structural basis for assembly of TRAPPII complex and specific activation of GTPase Ypt31/32. Sci Adv, 8, 2022
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7E8T
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![BU of 7e8t by Molmil](/molmil-images/mine/7e8t) | Monomer of Ypt32-TRAPPII | Descriptor: | GTP-binding protein YPT32/YPT11, TRAPP-associated protein TCA17, Trafficking protein particle complex II-specific subunit 120, ... | Authors: | Mi, C.C, Sui, S.F. | Deposit date: | 2021-03-02 | Release date: | 2022-02-09 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Structural basis for assembly of TRAPPII complex and specific activation of GTPase Ypt31/32. Sci Adv, 8, 2022
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7E94
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![BU of 7e94 by Molmil](/molmil-images/mine/7e94) | Intact TRAPPII (State II) | Descriptor: | TRAPP-associated protein TCA17, Trafficking protein particle complex II-specific subunit 120, Trafficking protein particle complex II-specific subunit 130, ... | Authors: | Mi, C.C, Sui, S.F. | Deposit date: | 2021-03-03 | Release date: | 2022-02-09 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (4.67 Å) | Cite: | Structural basis for assembly of TRAPPII complex and specific activation of GTPase Ypt31/32. Sci Adv, 8, 2022
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7E2C
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![BU of 7e2c by Molmil](/molmil-images/mine/7e2c) | Monomer of TRAPPII (open) | Descriptor: | TRAPP-associated protein TCA17, Trafficking protein particle complex II-specific subunit 120, Trafficking protein particle complex II-specific subunit 130, ... | Authors: | Sui, S.F, Sun, S, Mi, C.C. | Deposit date: | 2021-02-05 | Release date: | 2022-02-09 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (4.18 Å) | Cite: | Structural basis for assembly of TRAPPII complex and specific activation of GTPase Ypt31/32. Sci Adv, 8, 2022
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7E8S
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![BU of 7e8s by Molmil](/molmil-images/mine/7e8s) | Intact TRAPPII (state I). | Descriptor: | TRAPP-associated protein TCA17, Trafficking protein particle complex II-specific subunit 120, Trafficking protein particle complex II-specific subunit 130, ... | Authors: | Mi, C.C, Sui, S.F. | Deposit date: | 2021-03-02 | Release date: | 2022-02-09 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (4.36 Å) | Cite: | Structural basis for assembly of TRAPPII complex and specific activation of GTPase Ypt31/32. Sci Adv, 8, 2022
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7E2D
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![BU of 7e2d by Molmil](/molmil-images/mine/7e2d) | Monomer of TRAPPII (Closed) | Descriptor: | TRAPP-associated protein TCA17, Trafficking protein particle complex II-specific subunit 120, Trafficking protein particle complex II-specific subunit 130, ... | Authors: | Sui, S.F, Sun, S, Mi, C.C. | Deposit date: | 2021-02-05 | Release date: | 2022-02-09 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (3.71 Å) | Cite: | Structural basis for assembly of TRAPPII complex and specific activation of GTPase Ypt31/32. Sci Adv, 8, 2022
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7EA3
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![BU of 7ea3 by Molmil](/molmil-images/mine/7ea3) | Intact Ypt32-TRAPPII (dimer). | Descriptor: | GTP-binding protein YPT32/YPT11, TRAPP-associated protein TCA17, Trafficking protein particle complex II-specific subunit 120, ... | Authors: | Mi, C.C, Sui, S.F. | Deposit date: | 2021-03-06 | Release date: | 2022-02-09 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (4.31 Å) | Cite: | Structural basis for assembly of TRAPPII complex and specific activation of GTPase Ypt31/32. Sci Adv, 8, 2022
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8J4F
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![BU of 8j4f by Molmil](/molmil-images/mine/8j4f) | Structure of human Nav1.7 in complex with Hardwickii acid | Descriptor: | (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, (4~{a}~{R},5~{S},6~{R},8~{a}~{R})-5-[2-(furan-3-yl)ethyl]-5,6,8~{a}-trimethyl-3,4,4~{a},6,7,8-hexahydronaphthalene-1-carboxylic acid, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ... | Authors: | Wu, Q.R, Yan, N. | Deposit date: | 2023-04-19 | Release date: | 2023-06-14 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structural mapping of Na v 1.7 antagonists. Nat Commun, 14, 2023
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7WFW
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![BU of 7wfw by Molmil](/molmil-images/mine/7wfw) | Apo human Nav1.8 | Descriptor: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Yan, N, Pan, X.J, Huang, X.S, Huang, G.X. | Deposit date: | 2021-12-27 | Release date: | 2022-08-03 | Last modified: | 2022-09-21 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural basis for high-voltage activation and subtype-specific inhibition of human Na v 1.8. Proc.Natl.Acad.Sci.USA, 119, 2022
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7WEL
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![BU of 7wel by Molmil](/molmil-images/mine/7wel) | Human Nav1.8 with A-803467, class II | Descriptor: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Yan, N, Pan, X.J, Huang, X.S, Huang, G.X. | Deposit date: | 2021-12-23 | Release date: | 2022-08-03 | Last modified: | 2022-09-21 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structural basis for high-voltage activation and subtype-specific inhibition of human Na v 1.8. Proc.Natl.Acad.Sci.USA, 119, 2022
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7WFR
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![BU of 7wfr by Molmil](/molmil-images/mine/7wfr) | Human Nav1.8 with A-803467, class III | Descriptor: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Yan, N, Pan, X.J, Huang, X.S, Huang, G.X. | Deposit date: | 2021-12-27 | Release date: | 2022-08-03 | Last modified: | 2022-09-21 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structural basis for high-voltage activation and subtype-specific inhibition of human Na v 1.8. Proc.Natl.Acad.Sci.USA, 119, 2022
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7WE4
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![BU of 7we4 by Molmil](/molmil-images/mine/7we4) | Human Nav1.8 with A-803467, class I | Descriptor: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Yan, N, Pan, X.J, Huang, X.S, Huang, G.X. | Deposit date: | 2021-12-22 | Release date: | 2022-08-03 | Last modified: | 2022-09-21 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | Structural basis for high-voltage activation and subtype-specific inhibition of human Na v 1.8. Proc.Natl.Acad.Sci.USA, 119, 2022
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5M05
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![BU of 5m05 by Molmil](/molmil-images/mine/5m05) | Chicken smooth muscle myosin motor domain co-crystallized with the specific CK-571 inhibitor, MgADP form | Descriptor: | 4-{[(2-chloro-3-fluorobenzyl)carbamoyl](methyl)amino}-3,4-dideoxy-5-O-(isoquinolin-3-ylcarbamoyl)-D-erythro-pentitol, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Sirigu, S, Hartman, J, Houdusse, A. | Deposit date: | 2016-10-03 | Release date: | 2016-11-16 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.675 Å) | Cite: | Highly selective inhibition of myosin motors provides the basis of potential therapeutic application. Proc. Natl. Acad. Sci. U.S.A., 113, 2016
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7VZR
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![BU of 7vzr by Molmil](/molmil-images/mine/7vzr) | Structure of the Acidobacteria homodimeric reaction center bound with cytochrome c (the smaller form) | Descriptor: | BACTERIOCHLOROPHYLL A, CALCIUM ION, CHLOROPHYLL A, ... | Authors: | Huang, G.Q, Dong, S.S, Qin, X.C, Sui, S.F. | Deposit date: | 2021-11-16 | Release date: | 2022-12-28 | Last modified: | 2024-06-26 | Method: | ELECTRON MICROSCOPY (2.22 Å) | Cite: | Structure of the Acidobacteria homodimeric reaction center bound with cytochrome c Nat Commun, 13, 2022
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7VZG
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![BU of 7vzg by Molmil](/molmil-images/mine/7vzg) | Structure of the Acidobacteria homodimeric reaction center bound with cytochrome c (the larger form) | Descriptor: | BACTERIOCHLOROPHYLL A, CALCIUM ION, CHLOROPHYLL A, ... | Authors: | Huang, G.Q, Dong, S.S, Qin, X.C, Sui, S.F. | Deposit date: | 2021-11-16 | Release date: | 2023-02-22 | Method: | ELECTRON MICROSCOPY (2.61 Å) | Cite: | Structure of the Acidobacteria homodimeric reaction center bound with cytochrome c. Nat Commun, 13, 2022
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8HFR
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![BU of 8hfr by Molmil](/molmil-images/mine/8hfr) | NPC-trapped pre-60S particle | Descriptor: | 25S ribosomal RNA, 5.8S ribosomal RNA, 5S ribosomal RNA, ... | Authors: | Li, Z.Q, Chen, S.J, Sui, S.F. | Deposit date: | 2022-11-12 | Release date: | 2023-04-12 | Last modified: | 2023-06-28 | Method: | ELECTRON MICROSCOPY (2.64 Å) | Cite: | Nuclear export of pre-60S particles through the nuclear pore complex. Nature, 618, 2023
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8HBN
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![BU of 8hbn by Molmil](/molmil-images/mine/8hbn) | Structure of the Mex67-Mtr2-1 heterodimer | Descriptor: | mRNA export factor MEX67, mRNA transport regulator MTR2 | Authors: | Li, Z.Q, Chen, S.J, Sui, S.F. | Deposit date: | 2022-10-29 | Release date: | 2023-04-12 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.81 Å) | Cite: | Nuclear export of pre-60S particles through the nuclear pore complex. Nature, 618, 2023
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5XSY
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![BU of 5xsy by Molmil](/molmil-images/mine/5xsy) | Structure of the Nav1.4-beta1 complex from electric eel | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Sodium channel protein, Voltage-gated sodium channel beta subunit 1, ... | Authors: | Yan, Z, Zhou, Q, Wu, J.P, Yan, N. | Deposit date: | 2017-06-15 | Release date: | 2017-08-09 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Structure of the Nav1.4-beta 1 Complex from Electric Eel. Cell, 170, 2017
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