2ZG6
 
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3AWI
 | | Bifunctional tRNA modification enzyme MnmC from Escherichia coli | | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, SULFATE ION, tRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein mnmC | | Authors: | Kitamura, A, Sengoku, T, Nishimoto, M, Yokoyama, S, Bessho, Y. | | Deposit date: | 2011-03-23 | | Release date: | 2011-06-01 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Crystal structure of the bifunctional tRNA modification enzyme MnmC from Escherichia coli
Protein Sci., 2011
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3AXS
 | | Complex structure of tRNA methyltransferase Trm1 from Aquifex aeolicus with sinefungin | | Descriptor: | Probable N(2),N(2)-dimethylguanosine tRNA methyltransferase Trm1, SINEFUNGIN, SULFATE ION, ... | | Authors: | Ihsanawati, Sengoku, T, Yokoyama, S, Bessho, Y, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2011-04-13 | | Release date: | 2011-08-03 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.162 Å) | | Cite: | Substrate tRNA recognition mechanism of a multisite-specific tRNA methyltransferase, Aquifex aeolicus Trm1, based on the X-ray crystal structure
J.Biol.Chem., 286, 2011
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3AXT
 | | Complex structure of tRNA methyltransferase Trm1 from Aquifex aeolicus with S-adenosyl-L-Methionine | | Descriptor: | Probable N(2),N(2)-dimethylguanosine tRNA methyltransferase Trm1, S-ADENOSYLMETHIONINE, SULFATE ION, ... | | Authors: | Ihsanawati, Sengoku, T, Yokoyama, S, Bessho, Y, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2011-04-14 | | Release date: | 2011-08-03 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.491 Å) | | Cite: | Substrate tRNA recognition mechanism of a multisite-specific tRNA methyltransferase, Aquifex aeolicus Trm1, based on the X-ray crystal structure
J.Biol.Chem., 286, 2011
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2YXD
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2YZ2
 | | Crystal structure of the ABC transporter in the cobalt transport system | | Descriptor: | Putative ABC transporter ATP-binding protein TM_0222 | | Authors: | Ethayathullah, A.S, Bessho, Y, Padmanabhan, B, Singh, T.P, Kaur, P, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2007-05-02 | | Release date: | 2007-11-06 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Crystal structure of the ABC transporter in the cobalt transport system
To be Published
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2YR1
 | | Crystal Structure of 3-dehydroquinate dehydratase from Geobacillus kaustophilus HTA426 | | Descriptor: | 3-dehydroquinate dehydratase | | Authors: | Kagawa, W, Kurumizaka, H, Bessho, Y, Chen, L, Fu, Z.Q, Chrzas, J, Wang, B.C, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2007-04-01 | | Release date: | 2007-10-02 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Crystal Structure of 3-dehydroquinate dehydratase from Geobacillus kaustophilus HTA426
To be published
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2YVU
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7VBU
 | | Crystal structure of human pyruvate dehydrogenase kinase 2 in complex with compound 5 | | Descriptor: | 8-cyclopropyl-2-methyl-9H-pyrido[2,3-b]indole, ACETATE ION, CHLORIDE ION, ... | | Authors: | Orita, T, Doi, S, Iwanaga, T, Fujishima, A, Adachi, T. | | Deposit date: | 2021-09-01 | | Release date: | 2022-02-16 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.89 Å) | | Cite: | Structure-based drug design of novel and highly potent pyruvate dehydrogenase kinase inhibitors.
Bioorg.Med.Chem., 52, 2021
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7VBV
 | | Crystal structure of human pyruvate dehydrogenase kinase 2 in complex with compound 7 | | Descriptor: | ACETATE ION, CHLORIDE ION, DIMETHYL SULFOXIDE, ... | | Authors: | Orita, T, Doi, S, Iwanaga, T, Fujishima, A, Adachi, T. | | Deposit date: | 2021-09-01 | | Release date: | 2022-02-16 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.21 Å) | | Cite: | Structure-based drug design of novel and highly potent pyruvate dehydrogenase kinase inhibitors.
Bioorg.Med.Chem., 52, 2021
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7VBX
 | | Crystal structure of human pyruvate dehydrogenase kinase 2 in complex with compound 20 | | Descriptor: | (3~{S})-3-[5-(8-cyclopropyl-2-methyl-9~{H}-pyrido[2,3-b]indol-3-yl)-1,3,4-oxadiazol-2-yl]-4-methyl-~{N}-[(1~{R})-1-phenylethyl]pentanamide, ACETATE ION, CHLORIDE ION, ... | | Authors: | Orita, T, Doi, S, Iwanaga, T, Fujishima, A, Adachi, T. | | Deposit date: | 2021-09-01 | | Release date: | 2022-02-16 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Structure-based drug design of novel and highly potent pyruvate dehydrogenase kinase inhibitors.
Bioorg.Med.Chem., 52, 2021
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2H09
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1WEH
 | | Crystal structure of the conserved hypothetical protein TT1887 from Thermus thermophilus HB8 | | Descriptor: | Conserved hypothetical protein TT1887 | | Authors: | Kukimoto-Niino, M, Murayama, K, Idaka, M, Terada, T, Shirouzu, M, Kuramitsu, S, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2004-05-25 | | Release date: | 2004-11-25 | | Last modified: | 2014-11-12 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Crystal structures of possible lysine decarboxylases from Thermus thermophilus HB8
PROTEIN SCI., 13, 2004
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1WD5
 | | Crystal structure of TT1426 from Thermus thermophilus HB8 | | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, hypothetical protein TT1426 | | Authors: | Shibata, R, Kukimoto-Niino, M, Murayama, K, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2004-05-11 | | Release date: | 2004-11-11 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Crystal structure of a predicted phosphoribosyltransferase (TT1426) from Thermus thermophilus HB8 at 2.01 A resolution
Protein Sci., 14, 2005
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1WEK
 | | Crystal structure of the conserved hypothetical protein TT1465 from Thermus thermophilus HB8 | | Descriptor: | PHOSPHATE ION, hypothetical protein TT1465 | | Authors: | Kukimoto-Niino, M, Murayama, K, Kato-Murayama, M, Terada, T, Shirouzu, M, Kuramitsu, S, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2004-05-25 | | Release date: | 2004-11-25 | | Last modified: | 2014-11-12 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Crystal structures of possible lysine decarboxylases from Thermus thermophilus HB8
Protein Sci., 13, 2004
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6AKH
 | | Pre-catalytic Ternary Complex of Human DNA Polymerase Mu with Templating Adenine and Incoming Mn-dUMPNPP | | Descriptor: | 1,2-ETHANEDIOL, 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-TRIPHOSPHATE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... | | Authors: | Chang, Y.K, Wu, W.J, Tsai, M.D. | | Deposit date: | 2018-08-31 | | Release date: | 2019-05-29 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Human DNA Polymerase mu Can Use a Noncanonical Mechanism for Multiple Mn2+-Mediated Functions.
J.Am.Chem.Soc., 141, 2019
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6AEH
 | | Binary complex of human DNA Polymerase Mu with MnUTP | | Descriptor: | DNA-directed DNA/RNA polymerase mu, MANGANESE (II) ION, SULFATE ION, ... | | Authors: | Chang, Y.K, Wu, W.J, Tsai, M.D. | | Deposit date: | 2018-08-04 | | Release date: | 2019-05-29 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (1.64 Å) | | Cite: | Human DNA Polymerase mu Can Use a Noncanonical Mechanism for Multiple Mn2+-Mediated Functions.
J.Am.Chem.Soc., 141, 2019
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6AK6
 | | Binary Complex of Human DNA Polymerase Mu with MnCTP | | Descriptor: | CYTIDINE-5'-TRIPHOSPHATE, DNA-directed DNA/RNA polymerase mu, MANGANESE (II) ION, ... | | Authors: | Chang, Y.K, Wu, W.J, Tsai, M.D. | | Deposit date: | 2018-08-30 | | Release date: | 2019-05-29 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Human DNA Polymerase mu Can Use a Noncanonical Mechanism for Multiple Mn2+-Mediated Functions.
J.Am.Chem.Soc., 141, 2019
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4E1B
 | | Re-refinement of PDB entry 2EQA - SUA5 protein from Sulfolobus tokodaii with bound threonylcarbamoyladenylate | | Descriptor: | MAGNESIUM ION, YrdC/Sua5 family protein, threonylcarbamoyladenylate | | Authors: | Parthier, C, Goerlich, S, Jaenecke, F, Breithaupt, C, Braeuer, U, Fandrich, U, Clausnitzer, D, Wehmeier, U.F, Boettcher, C, Scheel, D, Stubbs, M.T. | | Deposit date: | 2012-03-06 | | Release date: | 2012-03-14 | | Last modified: | 2012-05-02 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | The O-Carbamoyltransferase TobZ Catalyzes an Ancient Enzymatic Reaction.
Angew.Chem.Int.Ed.Engl., 51, 2012
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1WV8
 | | Crystal structure of hypothetical protein TTHA1013 from an extremely thermophilic bacterium thermus thermophilus HB8 | | Descriptor: | hypothetical protein TTHA1013 | | Authors: | Mizohata, E, Hattori, M, Kuramitsu, S, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2004-12-12 | | Release date: | 2005-06-12 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Crystal structure of the hypothetical protein TTHA1013 from Thermus thermophilus HB8
Proteins, 61, 2005
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1X42
 | | Crystal structure of a haloacid dehalogenase family protein (PH0459) from Pyrococcus horikoshii OT3 | | Descriptor: | hypothetical protein PH0459 | | Authors: | Arai, R, Kukimoto-Niino, M, Sugahara, M, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2005-05-12 | | Release date: | 2005-11-12 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Crystal structure of the probable haloacid dehalogenase PH0459 from Pyrococcus horikoshii OT3
Protein Sci., 15, 2006
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5XZW
 | | Crystal structure of Rad53 1-466 | | Descriptor: | Serine/threonine-protein kinase RAD53 | | Authors: | Weng, J.H, Tsai, M.D. | | Deposit date: | 2017-07-14 | | Release date: | 2017-10-11 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Phospho-Priming Confers Functionally Relevant Specificities for Rad53 Kinase Autophosphorylation
Biochemistry, 56, 2017
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5XZV
 | | Crystal structure of Rad53 1-466 in complex with AMP-PNP | | Descriptor: | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Serine/threonine-protein kinase RAD53 | | Authors: | Weng, J.H, Tsai, M.D. | | Deposit date: | 2017-07-14 | | Release date: | 2017-10-11 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | Phospho-Priming Confers Functionally Relevant Specificities for Rad53 Kinase Autophosphorylation
Biochemistry, 56, 2017
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5ZLC
 | | Binary complex of human DNA Polymerase Mu with MndGTP | | Descriptor: | 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, DNA-directed DNA/RNA polymerase mu, MANGANESE (II) ION, ... | | Authors: | Chang, Y.K, Wu, W.J, Tsai, M.D. | | Deposit date: | 2018-03-27 | | Release date: | 2019-05-29 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Human DNA Polymerase mu Can Use a Noncanonical Mechanism for Multiple Mn2+-Mediated Functions.
J.Am.Chem.Soc., 141, 2019
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6AK9
 | | Pre-catalytic Ternary Complex of Human DNA Polymerase Mu with Templating Cytosine and Incoming Ca-8oxodGTP | | Descriptor: | 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 8-OXO-2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, ... | | Authors: | Chang, Y.K, Wu, W.J, Tsai, M.D. | | Deposit date: | 2018-08-30 | | Release date: | 2019-05-29 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (1.91 Å) | | Cite: | Human DNA Polymerase mu Can Use a Noncanonical Mechanism for Multiple Mn2+-Mediated Functions.
J.Am.Chem.Soc., 141, 2019
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