1RBH
 
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1RBD
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1ALI
 | | ALKALINE PHOSPHATASE MUTANT (H412N) | | Descriptor: | ALKALINE PHOSPHATASE, MAGNESIUM ION, PHOSPHATE ION, ... | | Authors: | Ma, L, Tibbitts, T.T, Kantrowitz, E.R. | | Deposit date: | 1995-06-02 | | Release date: | 1995-11-14 | | Last modified: | 2021-11-03 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Escherichia coli alkaline phosphatase: X-ray structural studies of a mutant enzyme (His-412-->Asn) at one of the catalytically important zinc binding sites.
Protein Sci., 4, 1995
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1ANI
 | | ALKALINE PHOSPHATASE (D153H, K328H) | | Descriptor: | ALKALINE PHOSPHATASE, PHOSPHATE ION, ZINC ION | | Authors: | Murphy, J.E, Tibbitts, T.T, Kantrowitz, E.R. | | Deposit date: | 1995-09-06 | | Release date: | 1996-01-29 | | Last modified: | 2021-11-03 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Mutations at positions 153 and 328 in Escherichia coli alkaline phosphatase provide insight towards the structure and function of mammalian and yeast alkaline phosphatases.
J.Mol.Biol., 253, 1995
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1ANJ
 | | ALKALINE PHOSPHATASE (K328H) | | Descriptor: | ALKALINE PHOSPHATASE, PHOSPHATE ION, ZINC ION | | Authors: | Murphy, J.E, Tibbitts, T.T, Kantrowitz, E.R. | | Deposit date: | 1995-09-06 | | Release date: | 1996-01-29 | | Last modified: | 2021-11-03 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Mutations at positions 153 and 328 in Escherichia coli alkaline phosphatase provide insight towards the structure and function of mammalian and yeast alkaline phosphatases.
J.Mol.Biol., 253, 1995
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1ALJ
 | | ALKALINE PHOSPHATASE MUTANT (H412N) | | Descriptor: | ALKALINE PHOSPHATASE, MAGNESIUM ION, PHOSPHATE ION, ... | | Authors: | Ma, L, Tibbitts, T.T, Kantrowitz, E.R. | | Deposit date: | 1995-06-02 | | Release date: | 1995-11-14 | | Last modified: | 2021-11-03 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Escherichia coli alkaline phosphatase: X-ray structural studies of a mutant enzyme (His-412-->Asn) at one of the catalytically important zinc binding sites.
Protein Sci., 4, 1995
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1ALH
 | | KINETICS AND CRYSTAL STRUCTURE OF A MUTANT E. COLI ALKALINE PHOSPHATASE (ASP-369-->ASN): A MECHANISM INVOLVING ONE ZINC PER ACTIVE SITE | | Descriptor: | ALKALINE PHOSPHATASE, PHOSPHATE ION, SULFATE ION, ... | | Authors: | Tibbitts, T.T, Xu, X, Kantrowitz, E.R. | | Deposit date: | 1994-08-23 | | Release date: | 1995-02-27 | | Last modified: | 2024-06-05 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Kinetics and crystal structure of a mutant Escherichia coli alkaline phosphatase (Asp-369-->Asn): a mechanism involving one zinc per active site.
Protein Sci., 3, 1994
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1B8J
 | | ALKALINE PHOSPHATASE COMPLEXED WITH VANADATE | | Descriptor: | MAGNESIUM ION, PROTEIN (ALKALINE PHOSPHATASE), SULFATE ION, ... | | Authors: | Holtz, K.M, Stec, B, Kantrowitz, E.R. | | Deposit date: | 1999-02-01 | | Release date: | 1999-02-18 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | A model of the transition state in the alkaline phosphatase reaction.
J.Biol.Chem., 274, 1999
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1URA
 | | ALKALINE PHOSPHATASE (D51ZN) | | Descriptor: | ALKALINE PHOSPHATASE, PHOSPHATE ION, ZINC ION | | Authors: | Tibbitts, T.T, Murphy, J.E, Kantrowitz, E.R. | | Deposit date: | 1996-02-03 | | Release date: | 1996-07-11 | | Last modified: | 2021-11-03 | | Method: | X-RAY DIFFRACTION (2.04 Å) | | Cite: | Kinetic and structural consequences of replacing the aspartate bridge by asparagine in the catalytic metal triad of Escherichia coli alkaline phosphatase.
J.Mol.Biol., 257, 1996
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1URB
 | | ALKALINE PHOSPHATASE (N51MG) | | Descriptor: | ALKALINE PHOSPHATASE, MAGNESIUM ION, PHOSPHATE ION, ... | | Authors: | Tibbitts, T.T, Murphy, J.E, Kantrowitz, E.R. | | Deposit date: | 1996-02-03 | | Release date: | 1996-07-11 | | Last modified: | 2021-11-03 | | Method: | X-RAY DIFFRACTION (2.14 Å) | | Cite: | Kinetic and structural consequences of replacing the aspartate bridge by asparagine in the catalytic metal triad of Escherichia coli alkaline phosphatase.
J.Mol.Biol., 257, 1996
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1ED9
 | | STRUCTURE OF E. COLI ALKALINE PHOSPHATASE WITHOUT THE INORGANIC PHOSPHATE AT 1.75A RESOLUTION | | Descriptor: | ALKALINE PHOSPHATASE, MAGNESIUM ION, SULFATE ION, ... | | Authors: | Stec, B, Holtz, K.M, Kantrowitz, E.R. | | Deposit date: | 2000-01-27 | | Release date: | 2000-09-20 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | A revised mechanism for the alkaline phosphatase reaction involving three metal ions.
J.Mol.Biol., 299, 2000
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1EW9
 | | ALKALINE PHOSPHATASE (E.C. 3.1.3.1) COMPLEX WITH MERCAPTOMETHYL PHOSPHONATE | | Descriptor: | ALKALINE PHOSPHATASE, MAGNESIUM ION, MERCAPTOMETHYL PHOSPHONATE, ... | | Authors: | Holtz, K.M, Stec, B, Meyers, J.K, Antonelli, S.M, Widlanski, T.S, Kantrowitz, E.R. | | Deposit date: | 2000-04-24 | | Release date: | 2002-05-01 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Alternate modes of binding in two crystal structures of alkaline phosphatase-inhibitor complexes.
Protein Sci., 9, 2000
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1EW8
 | | ALKALINE PHOSPHATASE (E.C. 3.1.3.1) COMPLEX WITH PHOSPHONOACETIC ACID | | Descriptor: | ALKALINE PHOSPHATASE, MAGNESIUM ION, PHOSPHATE ION, ... | | Authors: | Holtz, K.M, Stec, B, Myers, J.K, Antonelli, S.M, Widlanski, T.S, Kantrowitz, E.R. | | Deposit date: | 2000-04-24 | | Release date: | 2002-05-01 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Alternate modes of binding in two crystal structures of alkaline phosphatase-inhibitor complexes.
Protein Sci., 9, 2000
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1ELY
 | | E. COLI ALKALINE PHOSPHATASE MUTANT (S102C) | | Descriptor: | ALKALINE PHOSPHATASE, MAGNESIUM ION, PHOSPHATE ION, ... | | Authors: | Stec, B, Hehir, M, Brennan, C, Nolte, M, Kantrowitz, E.R. | | Deposit date: | 1998-02-10 | | Release date: | 1998-05-27 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Kinetic and X-ray structural studies of three mutant E. coli alkaline phosphatases: insights into the catalytic mechanism without the nucleophile Ser102.
J.Mol.Biol., 277, 1998
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1HQA
 | | ALKALINE PHOSPHATASE (H412Q) | | Descriptor: | ALKALINE PHOSPHATASE, ZINC ION | | Authors: | Ma, L, Kantrowitz, E.R. | | Deposit date: | 1995-11-30 | | Release date: | 1996-03-08 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2.25 Å) | | Cite: | Kinetic and X-ray structural studies of a mutant Escherichia coli alkaline phosphatase (His-412-->Gln) at one of the zinc binding sites.
Biochemistry, 35, 1996
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1ED8
 | | STRUCTURE OF E. COLI ALKALINE PHOSPHATASE INHIBITED BY THE INORGANIC PHOSPHATE AT 1.75A RESOLUTION | | Descriptor: | ALKALINE PHOSPHATASE, MAGNESIUM ION, PHOSPHATE ION, ... | | Authors: | Stec, B, Holtz, K.M, Kantrowitz, E.R. | | Deposit date: | 2000-01-27 | | Release date: | 2000-09-20 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | A revised mechanism for the alkaline phosphatase reaction involving three metal ions.
J.Mol.Biol., 299, 2000
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1ELX
 | | E. COLI ALKALINE PHOSPHATASE MUTANT (S102A) | | Descriptor: | ALKALINE PHOSPHATASE, MAGNESIUM ION, PHOSPHATE ION, ... | | Authors: | Stec, B, Hehir, M, Brennan, C, Nolte, M, Kantrowitz, E.R. | | Deposit date: | 1998-02-10 | | Release date: | 1998-05-27 | | Last modified: | 2023-08-09 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Kinetic and X-ray structural studies of three mutant E. coli alkaline phosphatases: insights into the catalytic mechanism without the nucleophile Ser102.
J.Mol.Biol., 277, 1998
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1ELZ
 | | E. COLI ALKALINE PHOSPHATASE MUTANT (S102G) | | Descriptor: | ALKALINE PHOSPHATASE, MAGNESIUM ION, PHOSPHATE ION, ... | | Authors: | Stec, B, Hehir, M, Brennan, C, Nolte, M, Kantrowitz, E.R. | | Deposit date: | 1998-02-10 | | Release date: | 1998-05-27 | | Last modified: | 2023-08-09 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Kinetic and X-ray structural studies of three mutant E. coli alkaline phosphatases: insights into the catalytic mechanism without the nucleophile Ser102.
J.Mol.Biol., 277, 1998
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2ANH
 | | ALKALINE PHOSPHATASE (D153H) | | Descriptor: | ALKALINE PHOSPHATASE, PHOSPHATE ION, ZINC ION | | Authors: | Murphy, J.E, Tibbitts, T.T, Kantrowitz, E.R. | | Deposit date: | 1995-09-06 | | Release date: | 1996-01-29 | | Last modified: | 2021-11-03 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Mutations at positions 153 and 328 in Escherichia coli alkaline phosphatase provide insight towards the structure and function of mammalian and yeast alkaline phosphatases.
J.Mol.Biol., 253, 1995
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1HJK
 | | ALKALINE PHOSPHATASE MUTANT H331Q | | Descriptor: | ALKALINE PHOSPHATASE, MAGNESIUM ION, SULFATE ION, ... | | Authors: | Murphy, J.E, Stec, B, Ma, L, Kantrowitz, E.R. | | Deposit date: | 1997-05-30 | | Release date: | 1997-10-15 | | Last modified: | 2021-11-03 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Trapping and visualization of a covalent enzyme-phosphate intermediate.
Nat.Struct.Biol., 4, 1997
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1KHN
 | | E. COLI ALKALINE PHOSPHATASE MUTANT (D153HD330N) ZINC FORM | | Descriptor: | Alkaline phosphatase, ZINC ION | | Authors: | Le Du, M.H, Lamoure, C, Muller, B.H, Bulgakov, O.V, Lajeunesse, E, Menez, A, Boulain, J.C. | | Deposit date: | 2001-11-30 | | Release date: | 2002-03-13 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Artificial evolution of an enzyme active site: structural studies of three highly active mutants of Escherichia coli alkaline phosphatase.
J.Mol.Biol., 316, 2002
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1KH4
 | | E. COLI ALKALINE PHOSPHATASE MUTANT (D330N) IN COMPLEX WITH PHOSPHATE | | Descriptor: | ALKALINE PHOSPHATASE, MAGNESIUM ION, PHOSPHATE ION, ... | | Authors: | Le Du, M.H, Lamoure, C, Muller, B.H, Bulgakov, O.V, Lajeunesse, E. | | Deposit date: | 2001-11-29 | | Release date: | 2002-03-27 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Artificial evolution of an enzyme active site: structural studies of three highly active mutants of Escherichia coli alkaline phosphatase.
J.Mol.Biol., 316, 2002
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1KH7
 | | E. COLI ALKALINE PHOSPHATASE MUTANT (D153GD330N) | | Descriptor: | MAGNESIUM ION, SULFATE ION, ZINC ION, ... | | Authors: | Le Du, M.H, Lamoure, C, Muller, B.H, Bulgakov, O.V, Lajeunesse, E. | | Deposit date: | 2001-11-29 | | Release date: | 2002-03-27 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Artificial evolution of an enzyme active site: structural studies of three highly active mutants of Escherichia coli alkaline phosphatase.
J.Mol.Biol., 316, 2002
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1KHL
 | | E. COLI ALKALINE PHOSPHATASE MUTANT (D153HD330N) COMPLEX WITH PHOSPHATE | | Descriptor: | Alkaline Phosphatase, PHOSPHATE ION, ZINC ION | | Authors: | Le Du, M.H, Lamoure, C, Muller, B.H, Bulgakov, O.V, Lajeunesse, E, Menez, A, Boulain, J.C. | | Deposit date: | 2001-11-30 | | Release date: | 2002-03-13 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Artificial evolution of an enzyme active site: structural studies of three highly active mutants of Escherichia coli alkaline phosphatase.
J.Mol.Biol., 316, 2002
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1KH5
 | | E. COLI ALKALINE PHOSPHATASE MUTANT (D330N) MIMIC OF THE TRANSITION STATES WITH ALUMINIUM FLUORIDE | | Descriptor: | ALKALINE PHOSPHATASE, ALUMINUM FLUORIDE, MAGNESIUM ION, ... | | Authors: | Le Du, M.H, Lamoure, C, Muller, B.H, Bulgakov, O.V, Lajeunesse, E. | | Deposit date: | 2001-11-29 | | Release date: | 2002-03-13 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Artificial evolution of an enzyme active site: structural studies of three highly active mutants of Escherichia coli alkaline phosphatase.
J.Mol.Biol., 316, 2002
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