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Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in complex with NADP and inhibitor SDDC-0001912
Descriptor:	1-[2-(3-{[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]methyl}azetidin-1-yl)phenyl]piperidine-4-carboxylic acid, Dihydrofolate reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2020-10-23
Release date:	2021-07-07
Last modified:	2023-10-18
Method:	X-RAY DIFFRACTION (1.25 Å)
Cite:	Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in complex with NADP and inhibitor SDDC-0001912 to be published

7KM7

Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in complex with NADP and inhibitor SDDC-0001914, tetragonal crystal from
Descriptor:	(2S)-2-[(3-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propoxy}phenyl)methyl]-3,3-difluoropropanoic acid, BROMIDE ION, Dihydrofolate reductase, ...
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2020-11-02
Release date:	2021-07-07
Last modified:	2023-10-18
Method:	X-RAY DIFFRACTION (1.8 Å)
Cite:	Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in complex with NADP and inhibitor SDDC-0001914, tetragonal crystal form to be published

6C86

Crystal Structure of Lysyl-tRNA Synthetase from Cryptosporidium parvum complexed with L-Lysylsulfamoyl Adenosine
Descriptor:	1,2-ETHANEDIOL, 5'-O-[(L-LYSYLAMINO)SULFONYL]ADENOSINE, CHLORIDE ION, ...
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2018-01-24
Release date:	2018-02-28
Last modified:	2023-10-04
Method:	X-RAY DIFFRACTION (2.15 Å)
Cite:	Crystal Structure of Lysyl-tRNA Synthetase from Cryptosporidium parvum complexed with L-Lysylsulfamoyl Adenosine to be published

7KMW

Crystal structure of IspD from Mycobacterium paratuberculosis
Descriptor:	1,2-ETHANEDIOL, 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2020-11-03
Release date:	2020-11-11
Last modified:	2023-10-18
Method:	X-RAY DIFFRACTION (2.35 Å)
Cite:	Crystal structure of IspD from Mycobacterium paratuberculosis To Be Published

7KN1

Crystal structure of UDP-glucose-4-epimerase (galE) from Stenotrophomonas maltophila with bound NAD and formylated UDP-arabinopyranose
Descriptor:	1,2-ETHANEDIOL, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, UDP-4-deoxy-4-formamido-beta-L-arabinopyranose, ...
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2020-11-03
Release date:	2020-11-11
Last modified:	2023-10-18
Method:	X-RAY DIFFRACTION (1.45 Å)
Cite:	Crystal structure of UDP-glucose-4-epimerase (galE) from Stenotrophomonas maltophila with bound NAD and formylated UDP-arabinopyranose To Be Published

7K69

Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in complex with NADP and inhibitor SDDC-0001574
Descriptor:	1-{2-[2-(2,4-diamino-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidin-6-yl)-2-oxoethoxy]phenyl}piperidine-4-carboxylic acid, Dihydrofolate reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2020-09-19
Release date:	2021-03-17
Last modified:	2023-10-18
Method:	X-RAY DIFFRACTION (1.6 Å)
Cite:	Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in complex with NADP and inhibitor SDDC-0001574 To Be Published

7K6A

Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in complex with NADP and inhibitor SDDC-0001575
Descriptor:	1,2-ETHANEDIOL, 6-ethyl-5-[3-({3-[4-(trifluoromethyl)piperidin-1-yl]pyridin-2-yl}oxy)propoxy]pyrimidine-2,4-diamine, CHLORIDE ION, ...
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2020-09-19
Release date:	2021-03-17
Last modified:	2023-10-18
Method:	X-RAY DIFFRACTION (1.6 Å)
Cite:	Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in complex with NADP and inhibitor SDDC-0001575 to be published

7K6C

Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium abscessus ATCC 19977 / DSM 44196 with NADP and inhibitor P218
Descriptor:	1,2-ETHANEDIOL, 3-(2-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propoxy}phenyl)propanoic acid, CALCIUM ION, ...
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID), Abendroth, J, Santhakumar, V, Walpole, C, Lorimer, D.D, Horanyi, P.S, Edwards, T.E.
Deposit date:	2020-09-19
Release date:	2021-03-17
Last modified:	2024-11-13
Method:	X-RAY DIFFRACTION (2 Å)
Cite:	Rational Exploration of 2,4-Diaminopyrimidines as DHFR Inhibitors Active against Mycobacterium abscessus and Mycobacterium avium , Two Emerging Human Pathogens. J.Med.Chem., 2024

6DJ8

Structure of DNA polymerase III subunit beta from Borrelia burgdorferi in complex with a natural product
Descriptor:	Beta sliding clamp, Natural product peptide
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2018-05-24
Release date:	2019-05-29
Last modified:	2025-04-02
Method:	X-RAY DIFFRACTION (2.05 Å)
Cite:	Structure of DNA polymerase III subunit beta from Borrelia burgdorferi in complex with a natural product to be published

4IZ9

Crystal structure of an acetate kinase from Mycobacterium avium bound to an unknown acid-ApCpp conjugate and manganese
Descriptor:	1,2-ETHANEDIOL, Acetate kinase, DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, ...
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2013-01-29
Release date:	2013-02-20
Last modified:	2023-09-20
Method:	X-RAY DIFFRACTION (1.98 Å)
Cite:	Increasing the structural coverage of tuberculosis drug targets. Tuberculosis (Edinb), 95, 2015

6EFX

Crystal structure of a YjeF family protein from Cryptococcus neoformans var. grubii serotype A in complex with AMPPNP
Descriptor:	1,2-ETHANEDIOL, ATP-dependent (S)-NAD(P)H-hydrate dehydratase, MAGNESIUM ION, ...
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2018-08-17
Release date:	2018-09-05
Last modified:	2024-04-03
Method:	X-RAY DIFFRACTION (2 Å)
Cite:	Crystal structure of a YjeF family protein from Cryptococcus neoformans var. grubii serotype A in complex with AMPPNP TO BE PUBLISHED

7LA1

Crystal structure of phosphoglycerate kinase from Mycobacterium avium
Descriptor:	1,2-ETHANEDIOL, Phosphoglycerate kinase
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2021-01-05
Release date:	2021-03-03
Last modified:	2023-10-18
Method:	X-RAY DIFFRACTION (1.6 Å)
Cite:	Crystal structure of phosphoglycerate kinase from Mycobacterium avium to be published

3GK0

Crystal structure of pyridoxal phosphate biosynthetic protein from Burkholderia pseudomallei
Descriptor:	1-DEOXY-D-XYLULOSE-5-PHOSPHATE, PHOSPHATE ION, Pyridoxine 5'-phosphate synthase
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2009-03-09
Release date:	2009-03-17
Last modified:	2023-09-06
Method:	X-RAY DIFFRACTION (2.28 Å)
Cite:	Combining functional and structural genomics to sample the essential Burkholderia structome. Plos One, 8, 2013

4F82

X-ray crystal structure of a putative thioredoxin reductase from Burkholderia cenocepacia
Descriptor:	Thioredoxin Reductase
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2012-05-16
Release date:	2012-06-27
Last modified:	2023-09-13
Method:	X-RAY DIFFRACTION (1.85 Å)
Cite:	X-ray crystal structure of a putative thioredoxin reductase from Burkholderia cenocepacia TO BE PUBLISHED

4IV5

X-ray crystal structure of a putative aspartate carbamoyltransferase from Trypanosoma cruzi
Descriptor:	1,2-ETHANEDIOL, Aspartate carbamoyltransferase, putative, ...
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2013-01-22
Release date:	2013-04-10
Last modified:	2023-09-20
Method:	X-RAY DIFFRACTION (2.1 Å)
Cite:	X-ray crystal structure of a putative aspartate carbamoyltransferase from Trypanosoma cruzi TO BE PUBLISHED

4IZO

Crystal structure of kinase Phosphoribosylaminoimidazole carboxylase, ATPase subunit from Burkholderia thailandensis
Descriptor:	Phosphoribosylaminoimidazole carboxylase, ATPase subunit
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2013-01-30
Release date:	2013-02-27
Last modified:	2023-09-20
Method:	X-RAY DIFFRACTION (1.85 Å)
Cite:	Crystal structure of kinase Phosphoribosylaminoimidazole carboxylase, ATPase subunit from Burkholderia thailandensis To be Published

3GVF

1.7 Angstrom crystal structure of inorganic pyrophosphatase from burkholderia pseudomallei bound with phosphate
Descriptor:	DI(HYDROXYETHYL)ETHER, Inorganic pyrophosphatase, PHOSPHATE ION, ...
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2009-03-30
Release date:	2009-04-28
Last modified:	2023-09-06
Method:	X-RAY DIFFRACTION (1.75 Å)
Cite:	Combining functional and structural genomics to sample the essential Burkholderia structome. Plos One, 8, 2013

4KZP

Crystal Structure of a Putative Short Chain Dehydrogenase from Mycobacterium smegmatis
Descriptor:	1,2-ETHANEDIOL, GLYCEROL, Oxidoreductase, ...
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2013-05-30
Release date:	2013-07-24
Last modified:	2023-09-20
Method:	X-RAY DIFFRACTION (1.68 Å)
Cite:	Crystal Structure of a Putative Short Chain Dehydrogenase from Mycobacterium smegmatis To be Published

3K31

Crystal structure of eonyl-(acyl-carrier-protein) reductase from anaplasma phagocytophilum in complex with nad at 1.9a resolution
Descriptor:	1,2-ETHANEDIOL, Enoyl-(Acyl-carrier-protein) reductase, GLYCEROL, ...
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2009-09-30
Release date:	2009-10-20
Last modified:	2023-09-06
Method:	X-RAY DIFFRACTION (1.8 Å)
Cite:	Crystal structure of eonyl-(acyl-carrier-protein) reductase from anaplasma phagocytophilum in complex with nad at 1.9a resolution to be published

4U3W

X-ray crystal structure of 2-aminomuconate 6-semialdehyde dehydrogenase from Burkholderia cenocepacia
Descriptor:	1,2-ETHANEDIOL, 2-aminomuconate 6-semialdehyde dehydrogenase, MAGNESIUM ION
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2014-07-23
Release date:	2014-07-30
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (1.9501 Å)
Cite:	X-ray crystal structure of 2-aminomuconate 6-semialdehyde dehydrogenase from Burkholderia cenocepacia To Be Published

7KQZ

Crystal Structure of Acetyl-CoA synthetase in complex with adenosine-5'-ethylphosphate from Coccidioides immitis RS
Descriptor:	1,2-ETHANEDIOL, 5'-O-[(S)-ethoxy(hydroxy)phosphoryl]adenosine, Acetyl-coenzyme A synthetase
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2020-11-18
Release date:	2020-12-16
Last modified:	2023-10-18
Method:	X-RAY DIFFRACTION (2.15 Å)
Cite:	Crystal Structure of Acetyl-CoA synthetase in complex with adenosine-5'-ethylphosphate from Coccidioides immitis RS to be published

6BZB

Crystal Structure of Glucose-6-phosphate Isomerase from Elizabethkingia anophelis
Descriptor:	Glucose-6-phosphate isomerase
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2017-12-22
Release date:	2018-01-10
Last modified:	2023-10-04
Method:	X-RAY DIFFRACTION (1.6 Å)
Cite:	Crystal Structure of Glucose-6-phosphate Isomerase from Elizabethkingia anophelis to be published

3TML

Crystal structure of 2-dehydro-3-deoxyphosphooctonate aldolase from Burkholderia cenocepacia
Descriptor:	2-dehydro-3-deoxyphosphooctonate aldolase, CHLORIDE ION, SULFATE ION
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2011-08-31
Release date:	2011-09-21
Last modified:	2023-09-13
Method:	X-RAY DIFFRACTION (1.9 Å)
Cite:	Combining functional and structural genomics to sample the essential Burkholderia structome. Plos One, 8, 2013

3NRR

Co-crystal structure of dihydrofolate reductase-thymidylate synthase from Babesia bovis with dUMP, Raltitrexed and NADP
Descriptor:	1,2-ETHANEDIOL, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, CHLORIDE ION, ...
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2010-06-30
Release date:	2010-07-14
Last modified:	2023-09-06
Method:	X-RAY DIFFRACTION (1.8 Å)
Cite:	Inhibitor-bound complexes of dihydrofolate reductase-thymidylate synthase from Babesia bovis. Acta Crystallogr.,Sect.F, 67, 2011

3GVG

Crystal structure of Triosephosphate isomerase from Mycobacterium tuberculosis
Descriptor:	GLYCEROL, Triosephosphate isomerase
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2009-03-31
Release date:	2009-04-14
Last modified:	2023-09-06
Method:	X-RAY DIFFRACTION (1.55 Å)
Cite:	Increasing the structural coverage of tuberculosis drug targets. Tuberculosis (Edinb), 95, 2015

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