7KI9

Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in complex with NADP and inhibitor SDDC-0001912

Summary for 7KI9

• Entry DOI: 10.2210/pdb7ki9/pdb
• Descriptor: Dihydrofolate reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 1-[2-(3-{[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]methyl}azetidin-1-yl)phenyl]piperidine-4-carboxylic acid, ... (4 entities in total)
• Functional Keywords: ssgcid, sddc, inhibitor, structural genomics, seattle structural genomics center for infectious disease, oxidoreductase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• Biological source: Mycobacterium ulcerans (strain Agy99)
• Total number of polymer chains: 1
• Total formula weight: 20205.54

Authors

Seattle Structural Genomics Center for Infectious Disease (SSGCID) (deposition date: 2020-10-23, release date: 2021-07-07, Last modification date: 2023-10-18)

• Primary citation: Abendroth, J.A.,Dranow, D.M.,Zigweid, R.M.,Lorimer, D.D.,Horanyi, P.S.,Edwards, T.E.; Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in complex with NADP and inhibitor SDDC-0001912; to be published,

Experimental method

X-RAY DIFFRACTION (1.25 Å)