7KI9
Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in complex with NADP and inhibitor SDDC-0001912
Summary for 7KI9
Entry DOI | 10.2210/pdb7ki9/pdb |
Descriptor | Dihydrofolate reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 1-[2-(3-{[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]methyl}azetidin-1-yl)phenyl]piperidine-4-carboxylic acid, ... (4 entities in total) |
Functional Keywords | ssgcid, sddc, inhibitor, structural genomics, seattle structural genomics center for infectious disease, oxidoreductase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
Biological source | Mycobacterium ulcerans (strain Agy99) |
Total number of polymer chains | 1 |
Total formula weight | 20205.54 |
Authors | Seattle Structural Genomics Center for Infectious Disease (SSGCID) (deposition date: 2020-10-23, release date: 2021-07-07, Last modification date: 2023-10-18) |
Primary citation | Abendroth, J.A.,Dranow, D.M.,Zigweid, R.M.,Lorimer, D.D.,Horanyi, P.S.,Edwards, T.E. Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in complex with NADP and inhibitor SDDC-0001912 to be published, |
Experimental method | X-RAY DIFFRACTION (1.25 Å) |
Structure validation
Download full validation report