5M2M
 
 | | Complex between human TNF alpha and Llama VHH3 | | Descriptor: | Llama nanobody VHH3, Tumor necrosis factor | | Authors: | Cambillau, C, Spinelli, S, Desmyter, A, de Haard, H. | | Deposit date: | 2016-10-13 | | Release date: | 2017-08-30 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Bivalent Llama Single-Domain Antibody Fragments against Tumor Necrosis Factor Have Picomolar Potencies due to Intramolecular Interactions.
Front Immunol, 8, 2017
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5M2Y
 | | Structure of TssK C-terminal domain from E. coli T6SS | | Descriptor: | TssK C | | Authors: | Cambillau, C, Nguyen, V.S, Spinelli, S, Desmyter, A, Legrand, P. | | Deposit date: | 2016-10-13 | | Release date: | 2017-06-28 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (1.61 Å) | | Cite: | Type VI secretion TssK baseplate protein exhibits structural similarity with phage receptor-binding proteins and evolved to bind the membrane complex.
Nat Microbiol, 2, 2017
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5M2I
 | | Structure of human Tumor Necrosis Factor (TNF) in complex with the Llama VHH1 | | Descriptor: | Tumor necrosis factor, VHH1 | | Authors: | Cambillau, C, Spinelli, S, Desmyter, A, de Haard, H. | | Deposit date: | 2016-10-13 | | Release date: | 2017-08-30 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | Bivalent Llama Single-Domain Antibody Fragments against Tumor Necrosis Factor Have Picomolar Potencies due to Intramolecular Interactions.
Front Immunol, 8, 2017
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5M2W
 | | Structure of nanobody nb18 raised against TssK from E. coli T6SS | | Descriptor: | Llama nanobody nb8 against TssK from T6SS, SULFATE ION | | Authors: | Cambillau, C, Nguyen, V.S, Spinelli, S, Desmyter, A. | | Deposit date: | 2016-10-13 | | Release date: | 2017-06-28 | | Last modified: | 2017-08-30 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Type VI secretion TssK baseplate protein exhibits structural similarity with phage receptor-binding proteins and evolved to bind the membrane complex.
Nat Microbiol, 2, 2017
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5LY8
 | | Structure of the CBM2 module of Lactobacillus casei BL23 phage J-1 evolved Dit. | | Descriptor: | MAGNESIUM ION, Tail component | | Authors: | Cambillau, C, Spinelli, S, Dieterle, M.-E, Piuri, M. | | Deposit date: | 2016-09-26 | | Release date: | 2017-03-22 | | Last modified: | 2024-05-01 | | Method: | X-RAY DIFFRACTION (1.28 Å) | | Cite: | Evolved distal tail carbohydrate binding modules of Lactobacillus phage J-1: a novel type of anti-receptor widespread among lactic acid bacteria phages.
Mol. Microbiol., 104, 2017
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5MWN
 | | Structure of the EAEC T6SS component TssK N-terminal domain in complex with llama nanobodies nbK18 and nbK27 | | Descriptor: | PHOSPHATE ION, Type VI secretion protein, llama nanobody raised against TssK, ... | | Authors: | Cambillau, C, Nguyen, V.S, Spinelli, S, Legrand, P. | | Deposit date: | 2017-01-18 | | Release date: | 2017-06-28 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Type VI secretion TssK baseplate protein exhibits structural similarity with phage receptor-binding proteins and evolved to bind the membrane complex.
Nat Microbiol, 2, 2017
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3R1V
 | | Odorant Binding Protein 7 from Anopheles gambiae with Four Disulfide Bridges, in complex with an azo compound | | Descriptor: | 4-{(E)-[4-(propan-2-yl)phenyl]diazenyl}phenol, Odorant binding protein, antennal | | Authors: | Lagarde, A, Spinelli, S, Tegoni, M, Field, L, He, X, Zhou, J.J, Cambillau, C. | | Deposit date: | 2011-03-11 | | Release date: | 2011-10-19 | | Last modified: | 2011-12-21 | | Method: | X-RAY DIFFRACTION (2.19 Å) | | Cite: | The Crystal Structure of Odorant Binding Protein 7 from Anopheles gambiae Exhibits an Outstanding Adaptability of Its Binding Site.
J.Mol.Biol., 414, 2011
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3R1O
 | | Odorant Binding Protein 7 from Anopheles gambiae with Four Disulfide Bridges | | Descriptor: | Odorant binding protein, antennal, PALMITIC ACID | | Authors: | Lagarde, A, Spinelli, S, Tegoni, M, Field, L, He, X, Zhou, J.J, Cambillau, C. | | Deposit date: | 2011-03-11 | | Release date: | 2011-10-19 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | The Crystal Structure of Odorant Binding Protein 7 from Anopheles gambiae Exhibits an Outstanding Adaptability of Its Binding Site.
J.Mol.Biol., 414, 2011
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3R1P
 | | Odorant Binding Protein 7 from Anopheles gambiae with Four Disulfide Bridges, form P1 | | Descriptor: | Odorant binding protein, antennal, PALMITIC ACID | | Authors: | Lagarde, A, Spinelli, S, Tegoni, M, Field, L, He, X, Zhou, J.J, Cambillau, C. | | Deposit date: | 2011-03-11 | | Release date: | 2011-10-19 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | The Crystal Structure of Odorant Binding Protein 7 from Anopheles gambiae Exhibits an Outstanding Adaptability of Its Binding Site.
J.Mol.Biol., 414, 2011
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1KXV
 | | Camelid VHH Domains in Complex with Porcine Pancreatic alpha-Amylase | | Descriptor: | ALPHA-AMYLASE, PANCREATIC, CAMELID VHH DOMAIN CAB10 | | Authors: | Desmyter, A, Spinelli, S, Payan, F, Lauwereys, M, Wyns, L, Muyldermans, S, Cambillau, C. | | Deposit date: | 2002-02-01 | | Release date: | 2002-06-19 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Three camelid VHH domains in complex with porcine pancreatic alpha-amylase. Inhibition and versatility of binding topology.
J.Biol.Chem., 277, 2002
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4O9H
 | | Structure of Interleukin-6 in complex with a Camelid Fab fragment | | Descriptor: | Heavy Chain of the Camelid Fab fragment 61H7, Interleukin-6, Light Chain of the Camelid Fab fragment 61H7 | | Authors: | Klarenbeek, A, Blanchetot, C, Schragel, G, Sadi, A.S, Ongenae, N, Hemrika, W, Wijdenes, J, Spinelli, S, Desmyter, A, Cambillau, C, Hultberg, A, Kretz-rommel, A, Dreier, T, De haard, H.J.W, Roovers, R.C. | | Deposit date: | 2014-01-02 | | Release date: | 2015-04-15 | | Last modified: | 2015-04-29 | | Method: | X-RAY DIFFRACTION (2.42 Å) | | Cite: | Combining residues of naturally-occurring Camelid somatic affinity variants yields ultra-potent human therapeutic IL-6 antibodies
To be Published
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1KXQ
 | | Camelid VHH Domain in Complex with Porcine Pancreatic alpha-Amylase | | Descriptor: | CALCIUM ION, CHLORIDE ION, alpha-amylase, ... | | Authors: | Desmyter, A, Spinelli, S, Payan, F, Lauwereys, M, Wyns, L, Muyldermans, S, Cambillau, C. | | Deposit date: | 2002-02-01 | | Release date: | 2002-06-19 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Three camelid VHH domains in complex with porcine pancreatic alpha-amylase. Inhibition and versatility of binding topology.
J.Biol.Chem., 277, 2002
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4NNZ
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1B6D
 | | BENCE JONES PROTEIN DEL: AN ENTIRE IMMUNOGLOBULIN KAPPA LIGHT-CHAIN DIMER | | Descriptor: | IMMUNOGLOBULIN | | Authors: | Roussel, A, Spinelli, S, Deret, S, Aucouturier, P, Cambillau, C. | | Deposit date: | 1999-01-13 | | Release date: | 1999-01-27 | | Last modified: | 2023-08-02 | | Method: | X-RAY DIFFRACTION (2.74 Å) | | Cite: | The structure of an entire noncovalent immunoglobulin kappa light-chain dimer (Bence-Jones protein) reveals a weak and unusual constant domains association.
Eur.J.Biochem., 260, 1999
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1DZM
 | | Porcine Odorant Binding Protein Complexed with benzoic acid phenylmethylester | | Descriptor: | BENZOIC ACID PHENYLMETHYLESTER, ODORANT-BINDING PROTEIN | | Authors: | Vincent, F, Spinelli, S, Ramoni, R, Grolli, S, Pelosi, P, Cambillau, C, Tegoni, M. | | Deposit date: | 2000-03-03 | | Release date: | 2000-12-06 | | Last modified: | 2019-05-08 | | Method: | X-RAY DIFFRACTION (1.93 Å) | | Cite: | Complexes of Porcine Odorant Binding Protein with Odorant Molecules Belonging to Different Chemical Classes
J.Mol.Biol., 300, 2000
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1KXT
 | | Camelid VHH Domains in Complex with Porcine Pancreatic alpha-Amylase | | Descriptor: | ALPHA-AMYLASE, PANCREATIC, CALCIUM ION, ... | | Authors: | Desmyter, A, Spinelli, S, Payan, F, Lauwereys, M, Wyns, L, Muyldermans, S, Cambillau, C. | | Deposit date: | 2002-02-01 | | Release date: | 2002-06-19 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Three camelid VHH domains in complex with porcine pancreatic alpha-amylase. Inhibition and versatility of binding topology.
J.Biol.Chem., 277, 2002
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4QGY
 | | Camelid (llama) nanobody n25 (VHH) against type 6 secretion system TssM protein | | Descriptor: | nanobody n25, VH domain | | Authors: | Nguyen, V.S, Desmyter, A, Le, T.T.H, Durand, E, Kellenberger, C, Douzi, B, Spinelli, S, Cascales, E, Cambillau, C, Roussel, A. | | Deposit date: | 2014-05-26 | | Release date: | 2015-04-08 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (1.38 Å) | | Cite: | Inhibition of Type VI Secretion by an Anti-TssM Llama Nanobody.
Plos One, 10, 2015
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4QLR
 | | Llama nanobody n02 raised against EAEC T6SS TssM | | Descriptor: | Llama nanobody n02 VH domain | | Authors: | Nguyen, V.S, Desmyter, A, Le, T.T.H, Durand, E, Kellenberger, C, Douzi, B, Spinelli, S, Cascales, E, Cambillau, C, Roussel, A. | | Deposit date: | 2014-06-13 | | Release date: | 2015-04-08 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Inhibition of Type VI Secretion by an Anti-TssM Llama Nanobody.
Plos One, 10, 2015
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4R90
 | | Anti CD70 Llama glama Fab 27B3 | | Descriptor: | Anti CD70 Llama glama Fab 27B3 Heavy chain, Anti CD70 Llama glama Fab 27B3 Light chain, CALCIUM ION, ... | | Authors: | Klarenbeek, A, El Mazouari, K, Desmyter, A, Blanchetot, C, Hultberg, A, Roovers, R.C, Cambillau, C, Spinelli, S, Del-Favero, J, Verrips, T, de Haard, H, Achour, I. | | Deposit date: | 2014-09-03 | | Release date: | 2015-06-24 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (1.746 Å) | | Cite: | Camelid Ig V genes reveal significant human homology not seen in therapeutic target genes, providing for a powerful therapeutic antibody platform.
MAbs, 7, 2015
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4R96
 | | Structure of a Llama Glama Fab 48A2 against human cMet | | Descriptor: | Llama glama Fab 48A2 against human cMet H chain, Llama glama Fab 48A2 against human cMet L chain | | Authors: | Klarenbeek, A, El Mazouari, K, Desmyter, A, Blanchetot, C, Hultberg, A, Roovers, R.C, Cambillau, C, Spinelli, S, Del-Favero, J, Verrips, T, de Haard, H, Achour, I. | | Deposit date: | 2014-09-03 | | Release date: | 2015-06-24 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (3.31 Å) | | Cite: | Camelid Ig V genes reveal significant human homology not seen in therapeutic target genes, providing for a powerful therapeutic antibody platform.
MAbs, 7, 2015
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1E06
 | | Porcine Odorant Binding Protein Complexed with 5-methyl-2-(1-methylethyl)phenol | | Descriptor: | 5-METHYL-2-(1-METHYLETHYL)PHENOL, ODORANT-BINDING PROTEIN | | Authors: | Vincent, F, Spinelli, S, Cambillau, C, Tegoni, M. | | Deposit date: | 2000-03-10 | | Release date: | 2000-12-06 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.12 Å) | | Cite: | Complexes of Porcine Odorant Binding Protein with Odorant Molecules Belonging to Different Chemical Classes
J.Mol.Biol., 300, 2000
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1DZJ
 | | Porcine Odorant Binding Protein Complexed with 2-amino-4-butyl-5-propylselenazole | | Descriptor: | 4-butyl-5-propyl-1,3-selenazol-2-amine, ODORANT-BINDING PROTEIN | | Authors: | Vincent, F, Spinelli, S, Cambillau, C, Tegoni, M. | | Deposit date: | 2000-03-01 | | Release date: | 2000-12-06 | | Last modified: | 2019-05-08 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Complexes of Porcine Odorant Binding Protein with Odorant Molecules Belonging to Different Chemical Classes
J.Mol.Biol., 300, 2000
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1DZK
 | | Porcine Odorant Binding Protein Complexed with pyrazine (2-isobutyl-3-metoxypyrazine) | | Descriptor: | 2-ISOBUTYL-3-METHOXYPYRAZINE, ODORANT-BINDING PROTEIN | | Authors: | Vincent, F, Spinelli, S, Cambillau, C, Tegoni, M. | | Deposit date: | 2000-03-01 | | Release date: | 2000-12-06 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.48 Å) | | Cite: | Complexes of Porcine Odorant Binding Protein with Odorant Molecules Belonging to Different Chemical Classes
J.Mol.Biol., 300, 2000
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1E02
 | | Porcine Odorant Binding Protein Complexed with undecanal | | Descriptor: | ODORANT-BINDING PROTEIN, UNDECANAL | | Authors: | Vincent, F, Spinelli, S, Cambillau, C, Tegoni, M. | | Deposit date: | 2000-03-09 | | Release date: | 2000-12-06 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | Complexes of Porcine Odorant Binding Protein with Odorant Molecules Belonging to Different Chemical Classes
J.Mol.Biol., 300, 2000
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1DZP
 | | Porcine Odorant Binding Protein Complexed with diphenylmethanone | | Descriptor: | DIPHENYLMETHANONE, ODORANT-BINDING PROTEIN | | Authors: | Vincent, F, Spinelli, S, Cambillau, C, Tegoni, M. | | Deposit date: | 2000-03-06 | | Release date: | 2000-12-06 | | Last modified: | 2013-11-13 | | Method: | X-RAY DIFFRACTION (1.83 Å) | | Cite: | Complexes of Porcine Odorant Binding Protein with Odorant Molecules Belonging to Different Chemical Classes
J.Mol.Biol., 300, 2000
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