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3Q8K
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BU of 3q8k by Molmil
Crystal Structure of Human Flap Endonuclease FEN1 (WT) in complex with product 5'-flap DNA, SM3+, and K+
Descriptor: DNA (5'-D(*AP*CP*CP*GP*TP*CP*C)-3'), DNA (5'-D(*AP*CP*TP*CP*TP*GP*CP*CP*TP*CP*AP*AP*GP*AP*CP*GP*GP*T)-3'), DNA (5'-D(P*TP*GP*AP*GP*GP*CP*AP*GP*AP*GP*T)-3'), ...
Authors:Tsutakawa, S.E, Classen, S, Chapados, B.R, Arvai, A, Finger, D.L, Guenther, G, Tomlinson, C.G, Thompson, P, Sarker, A.H, Shen, B, Cooper, P.K, Grasby, J.A, Tainer, J.A.
Deposit date:2011-01-06
Release date:2011-04-27
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.2001 Å)
Cite:Human Flap Endonuclease Structures, DNA Double-Base Flipping, and a Unified Understanding of the FEN1 Superfamily.
Cell(Cambridge,Mass.), 145, 2011
1QOM
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BU of 1qom by Molmil
MURINE INDUCIBLE NITRIC OXIDE SYNTHASE OXYGENASE DIMER (DELTA 65) WITH SWAPPED N-TERMINAL HOOK
Descriptor: 5,6,7,8-TETRAHYDROBIOPTERIN, NITRIC OXIDE SYNTHASE, PROTOPORPHYRIN IX CONTAINING FE
Authors:Crane, B.R, Rosenfeld, R.A, Arvai, A.S, Tainer, J.A, Stuehr, D.J, Getzoff, E.D.
Deposit date:1999-11-15
Release date:1999-12-15
Last modified:2019-10-09
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:N-Terminal Domain Swapping and Metal Ion Binding in Nitric Oxide Synthase Dimerization
Embo J., 18, 1999
1YHI
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BU of 1yhi by Molmil
Uncyclized precursor structure of S65A Y66S R96A GFP variant
Descriptor: Green Fluorescent Protein
Authors:Barondeau, D.P, Kassmann, C.J, Tainer, J.A, Getzoff, E.D.
Deposit date:2005-01-08
Release date:2005-02-15
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Understanding GFP Chromophore Biosynthesis: Controlling Backbone Cyclization and Modifying Post-translational Chemistry(,).
Biochemistry, 44, 2005
1YJ2
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BU of 1yj2 by Molmil
Cyclized, non-dehydrated post-translational product for S65A Y66S H148G GFP variant
Descriptor: 1,2-ETHANEDIOL, Green Fluorescent Protein, MAGNESIUM ION
Authors:Barondeau, D.P, Kassmann, C.J, Tainer, J.A, Getzoff, E.D.
Deposit date:2005-01-13
Release date:2005-02-15
Last modified:2021-10-20
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Understanding GFP Chromophore Biosynthesis: Controlling Backbone Cyclization and Modifying Post-translational Chemistry.
Biochemistry, 44, 2005
1YJF
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BU of 1yjf by Molmil
Cyclized post-translational product for S65A Y66S (GFPhal) green fluorescent protein variant
Descriptor: Green Fluorescent Protein, MAGNESIUM ION
Authors:Barondeau, D.P, Kassmann, C.J, Tainer, J.A, Getzoff, E.D.
Deposit date:2005-01-14
Release date:2005-02-15
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Understanding GFP Chromophore Biosynthesis: Controlling Backbone Cyclization and Modifying Post-translational Chemistry.
Biochemistry, 44, 2005
4IEM
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BU of 4iem by Molmil
Human apurinic/apyrimidinic endonuclease (APE1) with product DNA and Mg2+
Descriptor: DNA (5'-D(*CP*GP*AP*TP*CP*GP*GP*TP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*AP*C)-3'), DNA (5'-D(P*(3DR)P*GP*AP*TP*CP*G)-3'), ...
Authors:Tsutakawa, S.E, Mol, C.D, Arvai, A.S, Tainer, J.A.
Deposit date:2012-12-13
Release date:2013-01-23
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.3936 Å)
Cite:Conserved Structural Chemistry for Incision Activity in Structurally Non-homologous Apurinic/Apyrimidinic Endonuclease APE1 and Endonuclease IV DNA Repair Enzymes.
J.Biol.Chem., 288, 2013
4II7
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BU of 4ii7 by Molmil
Archaellum Assembly ATPase FlaI
Descriptor: FlaI ATPase
Authors:Reindl, S, Williams, G.J, Tainer, J.A.
Deposit date:2012-12-20
Release date:2013-03-06
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3.59 Å)
Cite:Insights into FlaI Functions in Archaeal Motor Assembly and Motility from Structures, Conformations, and Genetics.
Mol.Cell, 49, 2013
4IHQ
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BU of 4ihq by Molmil
Archaellum Assembly ATPase FlaI bound to ADP
Descriptor: 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, FlaI ATPase, ...
Authors:Reindl, S, Williams, G.J, Tainer, J.A.
Deposit date:2012-12-19
Release date:2013-03-06
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2 Å)
Cite:Insights into FlaI Functions in Archaeal Motor Assembly and Motility from Structures, Conformations, and Genetics.
Mol.Cell, 49, 2013
6O9Y
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BU of 6o9y by Molmil
Structure of human PARG complexed with JA2-8
Descriptor: 7-[(2S)-2-hydroxy-3-(morpholin-4-yl)propyl]-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione, Poly(ADP-ribose) glycohydrolase
Authors:Stegeman, R.A, Jones, D.E, Ellenberger, T, Kim, I.K, Tainer, J.A.
Deposit date:2019-03-15
Release date:2019-12-25
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death.
Nat Commun, 10, 2019
6OAL
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BU of 6oal by Molmil
Structure of human PARG complexed with JA2120
Descriptor: 1,3-dimethyl-8-{[2-(morpholin-4-yl)ethyl]sulfanyl}-3,7-dihydro-1H-purine-2,6-dione, Poly(ADP-ribose) glycohydrolase
Authors:Brosey, C.A, Ahmed, Z, Warden, S, Tainer, J.A.
Deposit date:2019-03-16
Release date:2020-03-18
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death.
Nat Commun, 10, 2019
6OA3
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BU of 6oa3 by Molmil
Structure of human PARG complexed with JA2131
Descriptor: (8S)-1,3-dimethyl-8-{[2-(morpholin-4-yl)ethyl]sulfanyl}-6-sulfanylidene-1,3,6,7,8,9-hexahydro-2H-purin-2-one, Poly(ADP-ribose) glycohydrolase
Authors:Stegeman, R.A, Jones, D.E, Ellenberger, T, Kim, I.K, Tainer, J.A.
Deposit date:2019-03-15
Release date:2019-12-25
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death.
Nat Commun, 10, 2019
6OAK
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BU of 6oak by Molmil
Structure of human PARG complexed with JA2131
Descriptor: (8S)-1,3-dimethyl-8-{[2-(morpholin-4-yl)ethyl]sulfanyl}-6-sulfanylidene-1,3,6,7,8,9-hexahydro-2H-purin-2-one, Poly(ADP-ribose) glycohydrolase
Authors:Brosey, C.A, Ahmed, Z, Warden, S, Tainer, J.A.
Deposit date:2019-03-16
Release date:2020-03-18
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death.
Nat Commun, 10, 2019
6O9X
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BU of 6o9x by Molmil
Structure of human PARG complexed with JA2-4
Descriptor: 1,3-dimethyl-8-{[2-(pyrrolidin-1-yl)ethyl]sulfanyl}-6-sulfanylidene-1,3,6,9-tetrahydro-2H-purin-2-one, Poly(ADP-ribose) glycohydrolase
Authors:Stegeman, R.A, Jones, D.E, Ellenberger, T, Kim, I.K, Tainer, J.A.
Deposit date:2019-03-15
Release date:2019-12-25
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death.
Nat Commun, 10, 2019
6OA1
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BU of 6oa1 by Molmil
Structure of human PARG complexed with JA2120
Descriptor: 1,3-dimethyl-8-{[2-(morpholin-4-yl)ethyl]sulfanyl}-3,7-dihydro-1H-purine-2,6-dione, Poly(ADP-ribose) glycohydrolase
Authors:Stegeman, R.A, Jones, D.E, Ellenberger, T, Kim, I.K, Tainer, J.A.
Deposit date:2019-03-15
Release date:2019-12-25
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death.
Nat Commun, 10, 2019
6O9L
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BU of 6o9l by Molmil
Human holo-PIC in the closed state
Descriptor: CDK-activating kinase assembly factor MAT1, Cyclin-H, Cyclin-dependent kinase 7, ...
Authors:Yan, C.L, Dodd, T, He, Y, Tainer, J.A, Tsutakawa, S.E, Ivanov, I.
Deposit date:2019-03-14
Release date:2019-05-29
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (7.2 Å)
Cite:Transcription preinitiation complex structure and dynamics provide insight into genetic diseases.
Nat.Struct.Mol.Biol., 26, 2019
4L05
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BU of 4l05 by Molmil
Cu/Zn superoxide dismutase from Brucella abortus
Descriptor: COPPER (I) ION, COPPER (II) ION, GLYCEROL, ...
Authors:Shin, D.S, Didonato, M, Pratt, A.J, Bruns, C.K, Cabelli, D.E, Kroll, J.S, Belzer, C.A, Tabatabai, L.B, Tainer, J.A, Getzoff, E.D.
Deposit date:2013-05-30
Release date:2013-10-23
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.098 Å)
Cite:Structural, Functional, and Immunogenic Insights on Cu,Zn Superoxide Dismutase Pathogenic Virulence Factors from Neisseria meningitidis and Brucella abortus.
J.Bacteriol., 197, 2015
6O9M
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BU of 6o9m by Molmil
Structure of the human apo TFIIH
Descriptor: CDK-activating kinase assembly factor MAT1, General transcription factor IIH subunit 1, General transcription factor IIH subunit 2, ...
Authors:Yan, C.L, Dodd, T, He, Y, Tainer, J.A, Tsutakawa, S.E, Ivanov, I.
Deposit date:2019-03-14
Release date:2019-05-29
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (4.4 Å)
Cite:Transcription preinitiation complex structure and dynamics provide insight into genetic diseases.
Nat.Struct.Mol.Biol., 26, 2019
6OA0
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BU of 6oa0 by Molmil
Structure of human PARG complexed with JA2-9
Descriptor: 4-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)butanoic acid, Poly(ADP-ribose) glycohydrolase
Authors:Stegeman, R.A, Jones, D.E, Ellenberger, T, Kim, I.K, Tainer, J.A.
Deposit date:2019-03-15
Release date:2019-12-25
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death.
Nat Commun, 10, 2019
6PBK
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BU of 6pbk by Molmil
Archaellum periplasmic stator protein complex FlaF and FlaG from Sulfolobus acidocaldarius
Descriptor: 1,2-ETHANEDIOL, Conserved flagellar protein F, DI(HYDROXYETHYL)ETHER, ...
Authors:Tsai, C.-L, Tainer, J.A.
Deposit date:2019-06-14
Release date:2019-11-20
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.805 Å)
Cite:The structure of the periplasmic FlaG-FlaF complex and its essential role for archaellar swimming motility.
Nat Microbiol, 5, 2020
3RCZ
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BU of 3rcz by Molmil
Rad60 SLD2 Ubc9 Complex
Descriptor: DNA repair protein rad60, SUMO-conjugating enzyme ubc9
Authors:Perry, J.J.P, Arvai, A.S, Tainer, J.A.
Deposit date:2011-03-31
Release date:2011-04-27
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:DNA repair and global sumoylation are regulated by distinct Ubc9 noncovalent complexes.
Mol.Cell.Biol., 31, 2011
3RD2
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BU of 3rd2 by Molmil
NIP45 SUMO-like Domain 2
Descriptor: NFATC2-interacting protein
Authors:Perry, J.J.P, Arvai, A.S, Tainer, J.A.
Deposit date:2011-03-31
Release date:2011-04-27
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:DNA repair and global sumoylation are regulated by distinct Ubc9 noncovalent complexes.
Mol.Cell.Biol., 31, 2011
1YSO
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BU of 1yso by Molmil
YEAST CU, ZN SUPEROXIDE DISMUTASE WITH THE REDUCED BRIDGE BROKEN
Descriptor: COPPER (I) ION, YEAST CU, ZN SUPEROXIDE DISMUTASE, ...
Authors:Parge, H.E, Crane, B.R, Tsang, J, Tainer, J.A.
Deposit date:1995-12-21
Release date:1996-06-10
Last modified:2018-03-21
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:Unusual trigonal-planar copper configuration revealed in the atomic structure of yeast copper-zinc superoxide dismutase.
Biochemistry, 35, 1996
3SOJ
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BU of 3soj by Molmil
Francisella tularensis pilin PilE
Descriptor: PilE, SULFATE ION
Authors:Wood, T, Arvai, A.S, Shin, D.S, Hartung, S, Kolappan, S, Craig, L, Tainer, J.A.
Deposit date:2011-06-30
Release date:2011-11-02
Last modified:2014-05-14
Method:X-RAY DIFFRACTION (1 Å)
Cite:Ultrahigh Resolution and Full-length Pilin Structures with Insights for Filament Assembly, Pathogenic Functions, and Vaccine Potential.
J.Biol.Chem., 286, 2011
3SOD
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BU of 3sod by Molmil
CHANGES IN CRYSTALLOGRAPHIC STRUCTURE AND THERMOSTABILITY OF A CU,ZN SUPEROXIDE DISMUTASE MUTANT RESULTING FROM THE REMOVAL OF BURIED CYSTEINE
Descriptor: COPPER (II) ION, COPPER,ZINC SUPEROXIDE DISMUTASE, ZINC ION
Authors:Mcree, D.E, Redford, S.M, Getzoff, E.D, Lepock, J.R, Hallewell, R.A, Tainer, J.A.
Deposit date:1990-06-26
Release date:1993-04-15
Last modified:2024-06-05
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Changes in crystallographic structure and thermostability of a Cu,Zn superoxide dismutase mutant resulting from the removal of a buried cysteine.
J.Biol.Chem., 265, 1990
3SOK
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BU of 3sok by Molmil
Dichelobacter nodosus pilin FimA
Descriptor: Fimbrial protein
Authors:Arvai, A.S, Craig, L, Hartung, S, Wood, T, Kolappan, S, Shin, D.S, Tainer, J.A.
Deposit date:2011-06-30
Release date:2011-11-02
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Ultrahigh Resolution and Full-length Pilin Structures with Insights for Filament Assembly, Pathogenic Functions, and Vaccine Potential.
J.Biol.Chem., 286, 2011

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