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Crystal structure of Nucleoside 2-deoxyribosyltransferase from Trypanosoma brucei at 1.7 A resolution with 5-Aminoisoquinoline bound
Descriptor:	GLYCEROL, ISOQUINOLIN-5-AMINE, Nucleoside 2-deoxyribosyltransferase, ...
Authors:	Bosch, J, Robien, M.A, Hol, W.G.J, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:	2005-11-17
Release date:	2005-11-22
Last modified:	2023-11-15
Method:	X-RAY DIFFRACTION (1.7 Å)
Cite:	Using fragment cocktail crystallography to assist inhibitor design of Trypanosoma brucei nucleoside 2-deoxyribosyltransferase. J.Med.Chem., 49, 2006

3BJE

Crystal structure of Trypanosoma brucei nucleoside phosphorylase shows uridine phosphorylase activity
Descriptor:	1-O-phosphono-alpha-D-ribofuranose, CALCIUM ION, Nucleoside phosphorylase, ...
Authors:	Larson, E.T, Merritt, E.A, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:	2007-12-03
Release date:	2007-12-18
Last modified:	2024-02-21
Method:	X-RAY DIFFRACTION (1.44 Å)
Cite:	The Crystal Structure and Activity of a Putative Trypanosomal Nucleoside Phosphorylase Reveal It to be a Homodimeric Uridine Phosphorylase J.Mol.Biol., 396, 2010

4JBV

Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with inhibitor UW1268
Descriptor:	1-[(1-methylpiperidin-4-yl)methyl]-3-[6-(2-methylpropoxy)naphthalen-2-yl]pyrazolo[3,4-d]pyrimidin-4-amine, Calmodulin-domain protein kinase 1
Authors:	Merritt, E.A, Larson, E.T.
Deposit date:	2013-02-20
Release date:	2014-03-19
Last modified:	2024-02-28
Method:	X-RAY DIFFRACTION (1.95 Å)
Cite:	Development of potent and selective Plasmodium falciparum calcium-dependent protein kinase 4 (PfCDPK4) inhibitors that block the transmission of malaria to mosquitoes. Eur.J.Med.Chem., 74, 2014

4ONA

Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with inhibitor UW1517
Descriptor:	5-amino-1-tert-butyl-3-(7-ethoxyquinolin-3-yl)-1H-pyrazole-4-carboxamide, Calmodulin-domain protein kinase 1
Authors:	Merritt, E.A.
Deposit date:	2014-01-28
Release date:	2014-03-19
Last modified:	2023-09-20
Method:	X-RAY DIFFRACTION (2.4 Å)
Cite:	Potent and selective inhibitors of CDPK1 from T. gondii and C. parvum based on a 5-aminopyrazole-4-carboxamide scaffold. ACS Med Chem Lett, 5, 2014

5K0S

Crystal structure of methionyl-tRNA synthetase MetRS from Brucella melitensis in complex with inhibitor Chem 1312
Descriptor:	2-({3-[(3,5-dichlorobenzyl)amino]propyl}amino)quinolin-4(1H)-one, Methionine--tRNA ligase
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2016-05-17
Release date:	2016-05-25
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (2.45 Å)
Cite:	Brucella melitensis Methionyl-tRNA-Synthetase (MetRS), a Potential Drug Target for Brucellosis. Plos One, 11, 2016

5K0T

Crystal structure of methionyl-tRNA synthetase MetRS from Brucella melitensis in complex with inhibitor Chem 1415
Descriptor:	1,2-ETHANEDIOL, 1-{3-[(3-chloro-5-methoxybenzyl)amino]propyl}-3-phenylurea, Methionine--tRNA ligase
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2016-05-17
Release date:	2016-05-25
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (2.6 Å)
Cite:	Brucella melitensis Methionyl-tRNA-Synthetase (MetRS), a Potential Drug Target for Brucellosis. Plos One, 11, 2016

4M84

Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with inhibitor UW1455
Descriptor:	5-amino-1-tert-butyl-3-(quinolin-2-yl)-1H-pyrazole-4-carboxamide, Calmodulin-domain protein kinase 1
Authors:	Merritt, E.A.
Deposit date:	2013-08-12
Release date:	2013-10-02
Last modified:	2023-09-20
Method:	X-RAY DIFFRACTION (1.998 Å)
Cite:	Potent and selective inhibitors of CDPK1 from T. gondii and C. parvum based on a 5-aminopyrazole-4-carboxamide scaffold. ACS Med Chem Lett, 5, 2014

3I7F

Aspartyl tRNA synthetase from Entamoeba histolytica
Descriptor:	Aspartyl-tRNA synthetase
Authors:	Arakaki, T, Merritt, E.A, Medical Structural Genomics of Pathogenic Protozoa (MSGPP)
Deposit date:	2009-07-08
Release date:	2009-07-21
Last modified:	2024-02-21
Method:	X-RAY DIFFRACTION (2.8 Å)
Cite:	Crystal structure of the aspartyl-tRNA synthetase from Entamoeba histolytica. Mol.Biochem.Parasitol., 169, 2010

3SX9

Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with Bumped Kinase Inhibitor, RM-1-132
Descriptor:	3-(6-ethoxynaphthalen-2-yl)-1-(piperidin-4-ylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, Calmodulin-domain protein kinase 1
Authors:	Larson, E.T, Merritt, E.A.
Deposit date:	2011-07-14
Release date:	2012-03-14
Last modified:	2023-09-13
Method:	X-RAY DIFFRACTION (2.65 Å)
Cite:	Multiple determinants for selective inhibition of apicomplexan calcium-dependent protein kinase CDPK1. J.Med.Chem., 55, 2012

5V49

Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor (Chem 1917)
Descriptor:	GLYCEROL, METHIONINE, Methionyl-tRNA synthetase, ...
Authors:	Barros-Alvarez, X, Hol, W.G.J.
Deposit date:	2017-03-08
Release date:	2017-07-26
Last modified:	2024-03-06
Method:	X-RAY DIFFRACTION (2.3 Å)
Cite:	Optimization of a binding fragment targeting the "enlarged methionine pocket" leads to potent Trypanosoma brucei methionyl-tRNA synthetase inhibitors. Bioorg. Med. Chem. Lett., 27, 2017

5VMT

Crystal structure of a glyceraldehyde-3-phosphate dehydrogenase from Neisseria gonorrhoeae bound to NAD
Descriptor:	CHLORIDE ION, Glyceraldehyde-3-phosphate dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2017-04-28
Release date:	2017-05-10
Last modified:	2023-10-04
Method:	X-RAY DIFFRACTION (2.5 Å)
Cite:	Structures of glyceraldehyde 3-phosphate dehydrogenase in Neisseria gonorrhoeae and Chlamydia trachomatis. Protein Sci., 29, 2020

2QVN

Crystal structure of adenosine deaminase from Plasmodium vivax in complex with guanosine
Descriptor:	2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, Adenosine deaminase, GUANOSINE
Authors:	Larson, E.T, Merritt, E.A, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:	2007-08-08
Release date:	2007-09-04
Last modified:	2023-11-15
Method:	X-RAY DIFFRACTION (2.19 Å)
Cite:	Structures of substrate- and inhibitor-bound adenosine deaminase from a human malaria parasite show a dramatic conformational change and shed light on drug selectivity. J.Mol.Biol., 381, 2008

3HZR

Tryptophanyl-tRNA synthetase homolog from Entamoeba histolytica
Descriptor:	Tryptophanyl-tRNA synthetase
Authors:	Arakaki, T, Merritt, E.A, Medical Structural Genomics of Pathogenic Protozoa (MSGPP)
Deposit date:	2009-06-24
Release date:	2009-07-28
Last modified:	2023-09-06
Method:	X-RAY DIFFRACTION (3 Å)
Cite:	Crystal structures of three protozoan homologs of tryptophanyl-tRNA synthetase. Mol.Biochem.Parasitol., 177, 2011

3I05

Tryptophanyl-tRNA synthetase from Trypanosoma brucei
Descriptor:	Tryptophanyl-tRNA synthetase
Authors:	Arakaki, T, Merritt, E.A, Medical Structural Genomics of Pathogenic Protozoa (MSGPP)
Deposit date:	2009-06-24
Release date:	2009-07-28
Last modified:	2023-09-06
Method:	X-RAY DIFFRACTION (2.8 Å)
Cite:	Crystal structures of three protozoan homologs of tryptophanyl-tRNA synthetase. Mol.Biochem.Parasitol., 177, 2011

3HV0

Tryptophanyl-tRNA synthetase from Cryptosporidium parvum
Descriptor:	TRYPTOPHAN, Tryptophanyl-tRNA synthetase
Authors:	Arakaki, T, Merritt, E.A, Medical Structural Genomics of Pathogenic Protozoa (MSGPP)
Deposit date:	2009-06-15
Release date:	2009-06-30
Last modified:	2023-09-06
Method:	X-RAY DIFFRACTION (2.42 Å)
Cite:	Crystal structures of three protozoan homologs of tryptophanyl-tRNA synthetase. Mol.Biochem.Parasitol., 177, 2011

6AX8

Mycobacterium tuberculosis methionyl-tRNA synthetase in complex with methionyl-adenylate
Descriptor:	Methionine-tRNA ligase, [[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl] (2S)-2-azanyl-4-methylsulfanyl-butanoate
Authors:	Barros-Alvarez, X, Hol, W.G.J.
Deposit date:	2017-09-06
Release date:	2018-04-11
Last modified:	2024-03-13
Method:	X-RAY DIFFRACTION (2.6 Å)
Cite:	The crystal structure of the drug target Mycobacterium tuberculosis methionyl-tRNA synthetase in complex with a catalytic intermediate. Acta Crystallogr F Struct Biol Commun, 74, 2018

5J5A

Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor (Chem 70786556)
Descriptor:	METHIONINE, Methionyl-tRNA synthetase, putative, ...
Authors:	Barros-Alvarez, X, Koh, C.Y, Hol, W.G.J.
Deposit date:	2016-04-01
Release date:	2017-01-25
Last modified:	2024-03-06
Method:	X-RAY DIFFRACTION (2.7 Å)
Cite:	Structure-guided design of novel Trypanosoma brucei Methionyl-tRNA synthetase inhibitors. Eur J Med Chem, 124, 2016

3KFL

Leishmania major methionyl-tRNA synthetase in complex with methionyladenylate and pyrophosphate
Descriptor:	1,2-ETHANEDIOL, FORMIC ACID, MAGNESIUM ION, ...
Authors:	Larson, E.T, Merritt, E.A, Medical Structural Genomics of Pathogenic Protozoa (MSGPP)
Deposit date:	2009-10-27
Release date:	2010-10-27
Last modified:	2023-09-06
Method:	X-RAY DIFFRACTION (2 Å)
Cite:	Structure of Leishmania major methionyl-tRNA synthetase in complex with intermediate products methionyladenylate and pyrophosphate. Biochimie, 93, 2011

3KSV

Hypothetical protein from Leishmania major
Descriptor:	Uncharacterized protein, ZINC ION
Authors:	Han, G.W, Merritt, E.A, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:	2009-11-23
Release date:	2010-01-12
Last modified:	2024-02-21
Method:	X-RAY DIFFRACTION (1.9 Å)
Cite:	Hypothetical protein (HIT family) from Leishmania major To be Published

3P0I

Leishmania major Tyrosyl-tRNA synthetase in complex with tyrosinol, cubic crystal form
Descriptor:	4-[(2S)-2-amino-3-hydroxypropyl]phenol, Tyrosyl-tRNA synthetase
Authors:	Merritt, E.A, Larson, E.T, Medical Structural Genomics of Pathogenic Protozoa (MSGPP)
Deposit date:	2010-09-28
Release date:	2011-03-23
Last modified:	2023-12-06
Method:	X-RAY DIFFRACTION (3.13 Å)
Cite:	The Double-Length Tyrosyl-tRNA Synthetase from the Eukaryote Leishmania major Forms an Intrinsically Asymmetric Pseudo-Dimer. J.Mol.Biol., 409, 2011

3P0H

Leishmania major Tyrosyl-tRNA synthetase in complex with fisetin, cubic crystal form
Descriptor:	3,7,3',4'-TETRAHYDROXYFLAVONE, Tyrosyl-tRNA synthetase
Authors:	Larson, E.T, Merritt, E.A, Medical Structural Genomics of Pathogenic Protozoa (MSGPP)
Deposit date:	2010-09-28
Release date:	2011-03-23
Last modified:	2023-12-06
Method:	X-RAY DIFFRACTION (3 Å)
Cite:	The Double-Length Tyrosyl-tRNA Synthetase from the Eukaryote Leishmania major Forms an Intrinsically Asymmetric Pseudo-Dimer. J.Mol.Biol., 409, 2011

3LC0

Histidyl-tRNA synthetase from Trypanosoma cruzi (Histidine complex)
Descriptor:	HISTIDINE, Histidyl-tRNA synthetase
Authors:	Merritt, E.A, Larson, E.T, Medical Structural Genomics of Pathogenic Protozoa (MSGPP)
Deposit date:	2010-01-08
Release date:	2010-01-19
Last modified:	2024-02-21
Method:	X-RAY DIFFRACTION (1.8 Å)
Cite:	Crystal Structures of Trypanosomal Histidyl-tRNA Synthetase Illuminate Differences between Eukaryotic and Prokaryotic Homologs. J.Mol.Biol., 397, 2010

3LSQ

Trypanosoma brucei seryl-tRNA synthetase
Descriptor:	MALONATE ION, SODIUM ION, Seryl-tRNA synthetase
Authors:	Larson, E.T, Merritt, E.A, Medical Structural Genomics of Pathogenic Protozoa (MSGPP)
Deposit date:	2010-02-12
Release date:	2010-03-02
Last modified:	2023-09-06
Method:	X-RAY DIFFRACTION (2.1 Å)
Cite:	X-ray crystal structure of Seryl-tRNA synthetase from the eukaryotic parasite Trypanosoma brucei. to be published

3LJN

Ankyrin repeat protein from Leishmania major
Descriptor:	hypothetical protein
Authors:	Holmes, M.A, Merritt, E.A, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:	2010-01-26
Release date:	2010-02-09
Last modified:	2017-11-01
Method:	X-RAY DIFFRACTION (2.9 Å)
Cite:	Ankyrin repeat protein from Leishmania major To be Published

3P0J

Leishmania major Tyrosyl-tRNA synthetase in complex with tyrosinol, triclinic crystal form 1
Descriptor:	4-[(2S)-2-amino-3-hydroxypropyl]phenol, SODIUM ION, Tyrosyl-tRNA synthetase
Authors:	Larson, E.T, Merritt, E.A, Medical Structural Genomics of Pathogenic Protozoa (MSGPP)
Deposit date:	2010-09-28
Release date:	2011-03-23
Last modified:	2023-12-06
Method:	X-RAY DIFFRACTION (2.89 Å)
Cite:	The Double-Length Tyrosyl-tRNA Synthetase from the Eukaryote Leishmania major Forms an Intrinsically Asymmetric Pseudo-Dimer. J.Mol.Biol., 409, 2011

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