6LKZ
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8OIZ
| Crystal structure of human CRBN-DDB1 in complex with Pomalidomide | Descriptor: | 1,2-ETHANEDIOL, DNA damage-binding protein 1, Protein cereblon, ... | Authors: | Le Bihan, Y.-V, Cabry, M.P, van Montfort, R.L.M. | Deposit date: | 2023-03-23 | Release date: | 2023-07-19 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | A Degron Blocking Strategy Towards Improved CRL4 CRBN Recruiting PROTAC Selectivity. Chembiochem, 24, 2023
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8OJH
| Crystal structure of human CRBN-DDB1 in complex with compound 4 | Descriptor: | 1,2-ETHANEDIOL, 4-azanyl-2-[(3~{S})-2,6-bis(oxidanylidene)piperidin-3-yl]-7-methoxy-isoindole-1,3-dione, DNA damage-binding protein 1, ... | Authors: | Cabry, M.P, Le Bihan, Y.-V, van Montfort, R.L.M. | Deposit date: | 2023-03-24 | Release date: | 2023-07-19 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.72 Å) | Cite: | A Degron Blocking Strategy Towards Improved CRL4 CRBN Recruiting PROTAC Selectivity. Chembiochem, 24, 2023
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5T8Q
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7VLI
| Crystal structure of Zika NS2B-NS3 protease with compound MI2220 | Descriptor: | 1-[(3~{S},6~{S},19~{R})-3,6-bis(4-azanylbutyl)-2,5,8,12,15,18-hexakis(oxidanylidene)-1,4,7,11,14,17-hexazacyclotricos-19-yl]guanidine, NS3 protease, SULFATE ION, ... | Authors: | Quek, J.P. | Deposit date: | 2021-10-02 | Release date: | 2022-08-10 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.385 Å) | Cite: | Structure-Based Optimization and Characterization of Macrocyclic Zika Virus NS2B-NS3 Protease Inhibitors. J.Med.Chem., 65, 2022
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7VLH
| Crystal structure of Zika NS2B-NS3 protease with compound MI2219 | Descriptor: | 1-[(3~{S},6~{R},18~{R})-3,6-bis(4-azanylbutyl)-2,5,8,11,14,17-hexakis(oxidanylidene)-1,4,7,10,13,16-hexazacyclodocos-18-yl]guanidine, NS3 protease, SULFATE ION, ... | Authors: | Quek, J.P. | Deposit date: | 2021-10-02 | Release date: | 2022-08-10 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.621 Å) | Cite: | Structure-Based Optimization and Characterization of Macrocyclic Zika Virus NS2B-NS3 Protease Inhibitors. J.Med.Chem., 65, 2022
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7VO8
| Structure of AtHPPD complexed with LSY-1 | Descriptor: | 4-hydroxyphenylpyruvate dioxygenase, COBALT (II) ION, N-[6-[[9-(dimethylamino)-12H-benzo[a]phenoxazin-5-yl]amino]hexyl]-4-(2-oxidanyl-6-oxidanylidene-cyclohexen-1-yl)carbonyl-3-[oxidanyl(oxidanylidene)-$l^4-azanyl]benzamide | Authors: | Yang, G.-F, Dong, J. | Deposit date: | 2021-10-12 | Release date: | 2022-09-21 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | In vivo diagnostics of abiotic plant stress responses via in situ real-time fluorescence imaging Plant Physiol., 190, 2022
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7X12
| Crystal structure of ME1 in complex with NADPH | Descriptor: | MANGANESE (II) ION, NADP-dependent malic enzyme, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | Authors: | Amano, Y. | Deposit date: | 2022-02-22 | Release date: | 2022-07-20 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.07 Å) | Cite: | Discovery and Characterization of a Novel Allosteric Small-Molecule Inhibitor of NADP + -Dependent Malic Enzyme 1. Biochemistry, 61, 2022
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7X11
| Crystal structure of ME1 in complex with NADPH | Descriptor: | 6-[(7-methyl-2-propyl-imidazo[4,5-b]pyridin-4-yl)methyl]-2-[2-(1H-1,2,3,4-tetrazol-5-yl)phenyl]-1,3-benzothiazole, MANGANESE (II) ION, NADP-dependent malic enzyme, ... | Authors: | Amano, Y. | Deposit date: | 2022-02-22 | Release date: | 2022-07-20 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.07 Å) | Cite: | Discovery and Characterization of a Novel Allosteric Small-Molecule Inhibitor of NADP + -Dependent Malic Enzyme 1. Biochemistry, 61, 2022
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7VLG
| Crystal structure of Zika NS2B-NS3 protease with compound MI2201 | Descriptor: | 1-[(5~{R},8~{R},15~{S},18~{S})-15,18-bis(4-azanylbutyl)-4,7,14,17,20-pentakis(oxidanylidene)-5-propan-2-yl-3,6,13,16,19-pentazabicyclo[20.3.1]hexacosa-1(25),22(26),23-trien-8-yl]guanidine, NS3 protease, SULFATE ION, ... | Authors: | Quek, J.P. | Deposit date: | 2021-10-02 | Release date: | 2022-08-10 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.771 Å) | Cite: | Structure-Based Optimization and Characterization of Macrocyclic Zika Virus NS2B-NS3 Protease Inhibitors. J.Med.Chem., 65, 2022
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3FX2
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7EST
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8JN1
| Cryo-EM structure of dengue virus serotype 3 strain EHIE46200Y19 in complex with human antibody DENV-115 IgG at 4 deg C (subparticle LLR-LRR) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope protein (Fragment), Human antibody DENV-115 heavy chain, ... | Authors: | Fibriansah, G, Ng, T.S, Tan, A.W.K, Shi, J, Lok, S.M. | Deposit date: | 2023-06-06 | Release date: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Ultrapotent human antibodies lock E protein dimers of diverse DENV3 morphological variants To Be Published
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8JN2
| Cryo-EM structure of dengue virus serotype 3 strain 863DK in complex with human antibody DENV-115 Fab at 4 deg C (subparticle LLR-LRR) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope protein, Human antibody DENV-115 heavy chain, ... | Authors: | Fibriansah, G, Ng, T.S, Tan, A.W.K, Shi, J, Lok, S.M. | Deposit date: | 2023-06-06 | Release date: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Ultrapotent human antibodies lock E protein dimers of diverse DENV3 morphological variants To Be Published
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8JN3
| Cryo-EM structure of dengue virus serotype 3 strain 863DK in complex with human antibody DENV-115 Fab at 37 deg C (subparticle LLR-LRR) | Descriptor: | Envelope protein, Human antibody DENV-115 heavy chain, Human antibody DENV-115 light chain, ... | Authors: | Fibriansah, G, Ng, T.S, Tan, A.W.K, Shi, J, Lok, S.M. | Deposit date: | 2023-06-06 | Release date: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (5.4 Å) | Cite: | Ultrapotent human antibodies lock E protein dimers of diverse DENV3 morphological variants To Be Published
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8JN4
| Cryo-EM structure of dengue virus serotype 3 strain 863DK in complex with human antibody DENV-290 Fab at 4 deg C (subparticle LLR-LRR) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope protein, Human antibody DENV-290 heavy chain, ... | Authors: | Fibriansah, G, Ng, T.S, Tan, A.W.K, Shi, J, Lok, S.M. | Deposit date: | 2023-06-06 | Release date: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Ultrapotent human antibodies lock E protein dimers of diverse DENV3 morphological variants To Be Published
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8JN5
| Cryo-EM structure of dengue virus serotype 3 strain 863DK in complex with human antibody DENV-290 Fab at 37 deg C (subparticle LLR-LRR) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope protein, Human antibody DENV-290 heavy chain, ... | Authors: | Fibriansah, G, Ng, T.S, Tan, A.W.K, Shi, J, Lok, S.M. | Deposit date: | 2023-06-06 | Release date: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Ultrapotent human antibodies lock E protein dimers of diverse DENV3 morphological variants To Be Published
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8JN6
| Cryo-EM structure of the small tail club shape particle of dengue virus serotype 3 strain CH53489 in complex with human antibody DENV-290 Fab at 37 deg C | Descriptor: | Human antibody DENV-290 heavy chain, Human antibody DENV-290 light chain, Polyprotein (Fragment) | Authors: | Fibriansah, G, Ng, T.S, Tan, A.W.K, Shi, J, Lok, S.M. | Deposit date: | 2023-06-06 | Release date: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (9.8 Å) | Cite: | Ultrapotent human antibodies lock E protein dimers of diverse DENV3 morphological variants To Be Published
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8JN7
| Cryo-EM structure of the big tail club shape particle of dengue virus serotype 3 strain CH53489 in complex with human antibody DENV-290 Fab at 37 deg C | Descriptor: | Human antibody DENV-290 heavy chain, Human antibody DENV-290 light chain, Polyprotein (Fragment) | Authors: | Fibriansah, G, Ng, T.S, Tan, A.W.K, Shi, J, Lok, S.M. | Deposit date: | 2023-06-06 | Release date: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (11 Å) | Cite: | Ultrapotent human antibodies lock E protein dimers of diverse DENV3 morphological variants To Be Published
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2HMZ
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2HMQ
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4MSL
| Crystal structure of the Vps10p domain of human sortilin/NTS3 in complex with AF40431 | Descriptor: | N-[(7-hydroxy-4-methyl-2-oxo-2H-chromen-8-yl)methyl]-L-leucine, Sortilin, TETRAETHYLENE GLYCOL, ... | Authors: | Andersen, J.L, Strandbygaard, D, Thirup, S. | Deposit date: | 2013-09-18 | Release date: | 2014-02-12 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Identification of the first small-molecule ligand of the neuronal receptor sortilin and structure determination of the receptor-ligand complex. Acta Crystallogr.,Sect.D, 70, 2014
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4N58
| Crystal Structure of Pectocin M2 at 1.86 Angstroms | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, CHLORIDE ION, FE2/S2 (INORGANIC) CLUSTER, ... | Authors: | Grinter, R, Roszak, A.W, Zeth, K, Cogdell, C.J, Walker, D. | Deposit date: | 2013-10-09 | Release date: | 2014-06-04 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.86 Å) | Cite: | Structure of the atypical bacteriocin pectocin M2 implies a novel mechanism of protein uptake. Mol.Microbiol., 93, 2014
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4N7E
| Crystal structure of the Vps10p domain of human sortilin/NTS3 in complex with AF38469 | Descriptor: | 2-[(6-methylpyridin-2-yl)carbamoyl]-5-(trifluoromethyl)benzoic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Sortilin, ... | Authors: | Andersen, J.L, Strandbygaard, D, Thirup, S. | Deposit date: | 2013-10-15 | Release date: | 2014-01-22 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | The identification of AF38469: An orally bioavailable inhibitor of the VPS10P family sorting receptor Sortilin. Bioorg.Med.Chem.Lett., 24, 2014
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4N59
| The Crystal Structure of Pectocin M2 at 2.3 Angstroms | Descriptor: | CHLORIDE ION, FE2/S2 (INORGANIC) CLUSTER, Pectocin M2, ... | Authors: | Zeth, K, Grinter, R, Roszak, A.W, Cogdell, R.J, Walker, D. | Deposit date: | 2013-10-09 | Release date: | 2014-06-04 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structure of the atypical bacteriocin pectocin M2 implies a novel mechanism of protein uptake. Mol.Microbiol., 93, 2014
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