2C90

thrombin inhibitors

Summary for 2C90
Related2C8W 2C8X 2C8Y 2C8Z 2C93
DescriptorTHROMBIN LIGHT CHAIN, THROMBIN HEAVY CHAIN, HIRUDIN VARIANT-2, ... (7 entities in total)
Functional Keywordsprotease, blood coagulation, acute phase, gamma-carboxyglutamic acid, glycoprotein, kringle, serine protease, zymogen, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHOMO SAPIENS (HUMAN)
More
Cellular locationSecreted, extracellular space: P00734 P00734
Secreted: P09945
Total number of polymer chains3
Total formula weight35707.05
Authors
Howard, N.,Abell, C.,Blakemore, W.,Carr, R.,Chessari, G.,Congreve, M.,Howard, S.,Jhoti, H.,Murray, C.W.,Seavers, L.C.A.,van Montfort, R.L.M. (deposition date: 2005-12-08, release date: 2006-07-04, Last modification date: 2017-06-28)
Primary citationAbell, C.,Blakemore, W.,Chessari, G.,Congreve, M.,Howard, N.,Howard, S.,Jhoti, H.,Murray, C.W.,Seavers, L.C.A.,Van Montfort, R.L.M.
Application of Fragment Screening and Fragment Linking to the Discovery of Novel Thrombin Inhibitors
J.Med.Chem., 49:1346-, 2006
PubMed: 16480269
DOI: 110.1021/JM050850V
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.25 Å)
Structure validation
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PDB entries from 2021-06-23