2C8Y
thrombin inhibitors
Summary for 2C8Y
Entry DOI | 10.2210/pdb2c8y/pdb |
Related | 2C8W 2C8X 2C8Z 2C90 2C93 |
Descriptor | THROMBIN LIGHT CHAIN, THROMBIN HEAVY CHAIN, HIRUDIN VARIANT-2, ... (7 entities in total) |
Functional Keywords | protease, blood coagulation, thrombin, acute phase, disease mutation, gamma-carboxyglutamic acid, glycoprotein, kringle, plasma, serine protease, zymogen, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | HOMO SAPIENS (HUMAN) More |
Cellular location | Secreted, extracellular space: P00734 P00734 Secreted: P09945 |
Total number of polymer chains | 3 |
Total formula weight | 36053.19 |
Authors | Howard, N.,Abell, C.,Blakemore, W.,Carr, R.,Chessari, G.,Congreve, M.,Howard, S.,Jhoti, H.,Murray, C.W.,Seavers, L.C.A.,van Montfort, R.L.M. (deposition date: 2005-12-08, release date: 2006-07-04, Last modification date: 2023-12-13) |
Primary citation | Howard, N.,Abell, C.,Blakemore, W.,Chessari, G.,Congreve, M.,Howard, S.,Jhoti, H.,Murray, C.W.,Seavers, L.C.A.,Van Montfort, R.L.M. Application of Fragment Screening and Fragment Linking to the Discovery of Novel Thrombin Inhibitors J.Med.Chem., 49:1346-, 2006 Cited by PubMed: 16480269DOI: 10.1021/JM050850V PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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