2C8X

thrombin inhibitors

Summary for 2C8X

Related2C8W 2C8Y 2C8Z 2C90 2C93
DescriptorTHROMBIN LIGHT CHAIN, THROMBIN HEAVY CHAIN, HIRUDIN VARIANT-2, ... (7 entities in total)
Functional Keywordsprotease, blood coagulation, thrombin, gamma-carboxyglutamic acid, glycoprotein, kringle, serine protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHOMO SAPIENS (HUMAN)
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Cellular locationSecreted, extracellular space P00734 P00734
Secreted P09945
Total number of polymer chains3
Total molecular weight36121.67
Authors
Howard, N.,Abell, C.,Blakemore, W.,Carr, R.,Chessari, G.,Congreve, M.,Howard, S.,Jhoti, H.,Murray, C.W.,Seavers, L.C.A.,van Montfort, R.L.M. (deposition date: 2005-12-08, release date: 2006-07-04, Last modification date: 2017-06-28)
Primary citation
Howard, N.,Abell, C.,Blakemore, W.,Chessari, G.,Congreve, M.,Howard, S.,Jhoti, H.,Murray, C.W.,Seavers, L.C.A.,Van Montfort, R.L.M.
Application of Fragment Screening and Fragment Linking to the Discovery of Novel Thrombin Inhibitors
J.Med.Chem., 49:1346-, 2006
PubMed: 16480269 (PDB entries with the same primary citation)
DOI: 10.1021/JM050850V
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.17 Å)
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Structure validation

ClashscoreRamachandran outliersSidechain outliersRSRZ outliers302.8%1.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload