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Crystal structure of human ALDH2 modified with the beta-elimination product of Aldi-3; 1-(4-ethylbenzene)prop-2-en-1-one
Descriptor:	1,2-ETHANEDIOL, 1-(4-ethylphenyl)propan-1-one, Aldehyde dehydrogenase, ...
Authors:	Perez-Miller, S, Hurley, T.D.
Deposit date:	2011-07-18
Release date:	2011-11-02
Last modified:	2023-09-13
Method:	X-RAY DIFFRACTION (2.1 Å)
Cite:	Discovery of a novel class of covalent inhibitor for aldehyde dehydrogenases. J.Biol.Chem., 286, 2011

HUMAN PI3KDELTA IN COMPLEX WITH COMPOUND 2F
Descriptor:	(3S)-3-benzyl-5-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-3-methyl-1,3-dihydro-2H-indol-2-one, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
Authors:	Lesburg, C.A, Augustin, M.
Deposit date:	2020-07-23
Release date:	2021-06-30
Last modified:	2024-04-03
Method:	X-RAY DIFFRACTION (2.12 Å)
Cite:	Optimization of Versatile Oxindoles as Selective PI3K delta Inhibitors. Acs Med.Chem.Lett., 11, 2020

HUMAN PI3KDELTA IN COMPLEX WITH COMPOUND 2F
Descriptor:	(3S)-3-benzyl-5-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-3-methyl-1,3-dihydro-2H-indol-2-one, Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
Authors:	Lesburg, C.A, Augustin, M.
Deposit date:	2020-07-23
Release date:	2020-12-30
Last modified:	2024-04-03
Method:	X-RAY DIFFRACTION (2.42 Å)
Cite:	Optimization of Versatile Oxindoles as Selective PI3K delta Inhibitors. Acs Med.Chem.Lett., 11, 2020