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2RSL
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BU of 2rsl by Molmil
REFINEMENT OF GAMMA DELTA RESOLVASE REVEALS A STRIKINGLY FLEXIBLE MOLECULE
Descriptor: GAMMA DELTA-RESOLVASE, SULFATE ION
Authors:Rice, P.A, Steitz, T.A.
Deposit date:1993-09-08
Release date:1994-04-30
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Refinement of gamma delta resolvase reveals a strikingly flexible molecule.
Structure, 2, 1994
6WAA
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BU of 6waa by Molmil
K. pneumoniae Topoisomerase IV (ParE-ParC) in complex with DNA and compound 34 (7-[(1S,5R)-1-amino-3-azabicyclo[3.1.0]hexan-3-yl]-4-(aminomethyl)-1-cyclopropyl-3,6-difluoro-8-methylquinolin-2(1H)-one)
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 7-[(1S,5R)-1-amino-3-azabicyclo[3.1.0]hexan-3-yl]-4-(aminomethyl)-1-cyclopropyl-3,6-difluoro-8-methylquinolin-2(1H)-one, CHLORIDE ION, ...
Authors:Noeske, J, Shu, W, Bellamacina, C.
Deposit date:2020-03-24
Release date:2020-07-15
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Topoisomerase Inhibitors Addressing Fluoroquinolone Resistance in Gram-Negative Bacteria.
J.Med.Chem., 63, 2020
1E52
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BU of 1e52 by Molmil
Solution structure of Escherichia coli UvrB C-terminal domain
Descriptor: EXCINUCLEASE ABC SUBUNIT
Authors:Alexandrovich, A.A, Kelly, G.G, Frenkiel, T.A, Moolenaar, G.F, Goosen, N.N, Sanderson, M.R, Lane, A.N.
Deposit date:2000-07-14
Release date:2001-07-12
Last modified:2024-06-19
Method:SOLUTION NMR
Cite:Solution Structure, Hydrodynamics and Thermodynamics of the Uvrb C-Terminal Domain.
J.Biomol.Struct.Dyn., 19, 2001
7LHZ
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BU of 7lhz by Molmil
K. pneumoniae Topoisomerase IV (ParE-ParC) in complex with DNA and (3S)-10-[(3R)-3-(1-aminocyclopropyl)pyrrolidin-1-yl]-9-fluoro-3-methyl-5-oxo-2,3-dihydro-5H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid (compound 25)
Descriptor: (3S)-10-[(3R)-3-(1-aminocyclopropyl)pyrrolidin-1-yl]-9-fluoro-3-methyl-5-oxo-2,3-dihydro-5H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid, (4S)-2-METHYL-2,4-PENTANEDIOL, DNA (5'-D(*GP*AP*TP*CP*AP*TP*AP*CP*AP*AP*CP*GP*TP*AP*A)-3'), ...
Authors:Noeske, J, Shu, W, Bellamacina, C.
Deposit date:2021-01-26
Release date:2021-05-12
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Discovery and Optimization of DNA Gyrase and Topoisomerase IV Inhibitors with Potent Activity against Fluoroquinolone-Resistant Gram-Positive Bacteria.
J.Med.Chem., 64, 2021
1D89
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BU of 1d89 by Molmil
A DNA DODECAMER CONTAINING AN ADENINE TRACT CRYSTALLIZES IN A UNIQUE LATTICE AND EXHIBITS A NEW BEND
Descriptor: DNA (5'-D(*CP*GP*CP*GP*AP*AP*AP*AP*AP*AP*CP*G)-3'), DNA (5'-D(*CP*GP*TP*TP*TP*TP*TP*TP*CP*GP*CP*G)-3')
Authors:DiGabriele, A.D, Steitz, T.A.
Deposit date:1992-07-17
Release date:1993-07-15
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:A DNA dodecamer containing an adenine tract crystallizes in a unique lattice and exhibits a new bend.
J.Mol.Biol., 231, 1993
1E2I
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BU of 1e2i by Molmil
The nucleoside binding site of Herpes simplex type 1 thymidine kinase analyzed by X-ray crystallography
Descriptor: 9-HYDROXYPROPYLADENINE, R-ISOMER, S-ISOMER, ...
Authors:Vogt, J, Scapozza, L, Schulz, G.E.
Deposit date:2000-05-23
Release date:2000-11-06
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Nucleoside Binding Site of Herpes Simplex Type 1 Thymidine Kinase Analyzed by X-Ray Crystallography
Proteins, 41, 2000
1E2K
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BU of 1e2k by Molmil
Kinetics and crystal structure of the wild-type and the engineered Y101F mutant of Herpes simplex virus type 1 thymidine kinase interacting with (North)-methanocarba-thymidine
Descriptor: 1-[4-HYDROXY-5-(HYDROXYMETHYL)BICYCLO[3.1.0]HEX-2-YL]-5-METHYLPYRIMIDINE-2,4(1H,3H)-DIONE, SULFATE ION, THYMIDINE KINASE
Authors:Vogt, J, Scapozza, L, Schulz, G.E.
Deposit date:2000-05-23
Release date:2000-08-19
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Kinetics and Crystal Structure of the Wild-Type and the Engineered Y101F Mutant of Herpes Simplex Virus Type 1 Thymidine Kinase Interacting with (North)-Methanocarba-Thymidine
Biochemistry, 39, 2000
1E2J
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BU of 1e2j by Molmil
The nucleoside binding site of Herpes simplex type 1 thymidine kinase analyzed by X-ray crystallography
Descriptor: SULFATE ION, THYMIDINE, THYMIDINE KINASE
Authors:Vogt, J, Scapozza, L, Schulz, G.E.
Deposit date:2000-05-23
Release date:2000-11-06
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Nucleoside Binding Site of Herpes Simplex Type 1 Thymidine Kinase Analyzed by X-Ray Crystallography
Proteins: Struct.,Funct., Genet., 41, 2000
1E2H
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BU of 1e2h by Molmil
The nucleoside binding site of Herpes simplex type 1 thymidine kinase analyzed by X-ray crystallography
Descriptor: SULFATE ION, THYMIDINE KINASE
Authors:Vogt, J, Scapozza, L, Schulz, G.E.
Deposit date:2000-05-23
Release date:2000-11-06
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Nucleoside Binding Site of Herpes Simplex Type 1 Thymidine Kinase Analyzed by X-Ray Crystallography
Proteins: Struct.,Funct., Genet., 41, 2000
1E2N
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BU of 1e2n by Molmil
HPT + HMTT
Descriptor: 6-{[4-(HYDROXYMETHYL)-5-METHYL-2,6-DIOXOHEXAHYDROPYRIMIDIN-5-YL]METHYL}-5-METHYLPYRIMIDINE-2,4(1H,3H)-DIONE, SULFATE ION, THYMIDINE KINASE
Authors:Vogt, J, Scapozza, L, Schulz, G.E.
Deposit date:2000-05-23
Release date:2001-03-31
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The Effect of Substrate Binding on the Conformation and Structural Stability of Herpes Simplex Virus Type 1 Thymidine Kinase
Protein Sci., 10, 2001
1E2P
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BU of 1e2p by Molmil
Thymidine kinase, DHBT
Descriptor: 6-[3-HYDROXY-2-(HYDROXYMETHYL)PROPYL]-5-METHYL-2,4(1H,3H)-PYRIMIDINEDIONE, SULFATE ION, THYMIDINE KINASE
Authors:Schulz, G.E, Kessler, U.
Deposit date:2000-05-23
Release date:2001-04-26
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The Effect of Substrate Binding on the Conformation and Structural Stability of Herpes Simplex Virus Type 1 Thymidine Kinase
Protein Sci., 10, 2001
1GDR
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BU of 1gdr by Molmil
MODEL FOR A DNA MEDIATED SYNAPTIC COMPLEX SUGGESTED BY CRYSTAL PACKING OF GAMMA DELTA RESOLVASE SUBUNITS
Descriptor: GAMMA DELTA-RESOLVASE
Authors:Rice, P.A, Steitz, T.A.
Deposit date:1993-08-31
Release date:1994-04-30
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Model for a DNA-mediated synaptic complex suggested by crystal packing of gamma delta resolvase subunits.
EMBO J., 13, 1994
1E2L
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BU of 1e2l by Molmil
Kinetics and crystal structure of the wild-type and the engineered Y101F mutant of Herpes simplex virus type 1 thymidine kinase interacting with (North)-methanocarba-thymidine
Descriptor: 1-[4-HYDROXY-5-(HYDROXYMETHYL)BICYCLO[3.1.0]HEX-2-YL]-5-METHYLPYRIMIDINE-2,4(1H,3H)-DIONE, SULFATE ION, THYMIDINE KINASE
Authors:Vogt, J, Scapozza, L, Schulz, G.E.
Deposit date:2000-05-23
Release date:2000-08-18
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Kinetics and Crystal Structure of the Wild-Type and the Engineered Y101F Mutant of Herpes Simplex Virus Type 1 Thymidine Kinase Interacting with (North)-Methanocarba-Thymidine
Biochemistry, 39, 2000
1E2M
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BU of 1e2m by Molmil
HPT + HMTT
Descriptor: 6-HYDROXYPROPYLTHYMINE, SULFATE ION, THYMIDINE KINASE
Authors:Vogt, J, Scapozza, L, Schulz, G.E.
Deposit date:2000-05-23
Release date:2001-03-31
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The Effect of Substrate Binding on the Conformation and Structural Stability of Herpes Simplex Virus Type 1 Thymidine Kinase
Protein Sci., 10, 2001
3F0T
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BU of 3f0t by Molmil
Crystal structure of thymidine kinase from Herpes simplex virus type 1 in complex with N-methyl-DHBT
Descriptor: N-Methyl-6-(1,3-dihydroxy-isobutyl)thymine, SULFATE ION, Thymidine kinase
Authors:Pernot, L, Perozzo, R, Westermaier, Y, Martic, M, Ametamey, S, Scapozza, L.
Deposit date:2008-10-26
Release date:2009-11-03
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2 Å)
Cite:Synthesis, crystal structure, and in vitro biological evaluation of C-6 pyrimidine derivatives: new lead structures for monitoring gene expression in vivo.
Nucleosides Nucleotides Nucleic Acids, 30, 2011
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