1AOG
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5FWH
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![BU of 5fwh by Molmil](/molmil-images/mine/5fwh) | N-terminal FHA domain from EssC a component of the bacterial Type VII secretion apparatus | Descriptor: | ESSC | Authors: | Zoltner, M, Ng, W.M.A.V, Money, J.J, Fyfe, P.K, Kneuper, H, Palmer, T, Hunter, W.N. | Deposit date: | 2016-02-17 | Release date: | 2016-04-06 | Last modified: | 2016-10-12 | Method: | X-RAY DIFFRACTION (2.06 Å) | Cite: | Essc: Domain Structures Inform on the Elusive Translocation Channel in the Type Vii Secretion System. Biochem.J., 473, 2016
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3JQA
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3JQB
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![BU of 3jqb by Molmil](/molmil-images/mine/3jqb) | Crystal structure of pteridine reductase 1 (PTR1) from Trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor 2-amino-5-(2-phenylethyl)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one (DX6) | Descriptor: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, 2-amino-5-(2-phenylethyl)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | Authors: | Tulloch, L.B, Hunter, W.N. | Deposit date: | 2009-09-06 | Release date: | 2009-12-08 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structure-based design of pteridine reductase inhibitors targeting african sleeping sickness and the leishmaniases. J.Med.Chem., 53, 2010
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3JQD
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![BU of 3jqd by Molmil](/molmil-images/mine/3jqd) | Crystal structure of pteridine reductase 1 (PTR1) from Trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor 2-amino-4-oxo-6-phenyl-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile (DX7) | Descriptor: | 2-amino-4-oxo-6-phenyl-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile, ACETATE ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | Authors: | Tulloch, L.B, Hunter, W.N. | Deposit date: | 2009-09-06 | Release date: | 2009-12-08 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structure-based design of pteridine reductase inhibitors targeting african sleeping sickness and the leishmaniases. J.Med.Chem., 53, 2010
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3GN1
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![BU of 3gn1 by Molmil](/molmil-images/mine/3gn1) | Structure of Pteridine Reductase 1 (PTR1) from TRYPANOSOMA BRUCEI in ternary complex with cofactor (NADP+) and inhibitor (DDD00067116) | Descriptor: | 1H-benzimidazol-2-amine, ACETATE ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | Authors: | Tulloch, L.B, Brenk, R, Hunter, W.N. | Deposit date: | 2009-03-16 | Release date: | 2009-12-29 | Last modified: | 2011-09-07 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | One scaffold, three binding modes: novel and selective pteridine reductase 1 inhibitors derived from fragment hits discovered by virtual screening. J.Med.Chem., 52, 2009
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5FV0
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![BU of 5fv0 by Molmil](/molmil-images/mine/5fv0) | The cytoplasmic domain of EssC | Descriptor: | 3'-O-[2-(METHYLAMINO)BENZOYL]ADENOSINE 5'-(TETRAHYDROGEN TRIPHOSPHATE), ADENOSINE-5'-TRIPHOSPHATE, ESX secretion system protein EccC, ... | Authors: | Zoltner, M, Ng, W.M.A.V, Palmer, T, Hunter, W.N. | Deposit date: | 2016-02-01 | Release date: | 2016-03-02 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.91 Å) | Cite: | EssC: domain structures inform on the elusive translocation channel in the Type VII secretion system. Biochem. J., 473, 2016
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5G1Q
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3MCV
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![BU of 3mcv by Molmil](/molmil-images/mine/3mcv) | Structure of PTR1 from Trypanosoma brucei in ternary complex with 2,4-diamino-5-[2-(2,5-dimethoxyphenyl)ethyl]thieno[2,3-d]-pyrimidine and NADP+ | Descriptor: | 5-[2-(2,5-dimethoxyphenyl)ethyl]thieno[2,3-d]pyrimidine-2,4-diamine, ACETATE ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | Authors: | Tulloch, L.B, Hunter, W.N. | Deposit date: | 2010-03-29 | Release date: | 2010-06-02 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | High-resolution structures of Trypanosoma brucei pteridine reductase ligand complexes inform on the placement of new molecular entities in the active site of a potential drug target. Acta Crystallogr.,Sect.D, 66, 2010
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5G1R
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![BU of 5g1r by Molmil](/molmil-images/mine/5g1r) | Open conformation of Francisella tularensis ClpP at 1.9 A | Descriptor: | (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, ACETATE ION, ... | Authors: | Diaz-Saez, L, Hunter, W.N. | Deposit date: | 2016-03-29 | Release date: | 2016-10-19 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Open and compressed conformations of Francisella tularensis ClpP. Proteins, 85, 2017
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5G1S
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![BU of 5g1s by Molmil](/molmil-images/mine/5g1s) | Open conformation of Francisella tularensis ClpP at 1.7 A | Descriptor: | (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, ACETATE ION, ... | Authors: | Diaz-Saez, L, Pankov, G, Hunter, W.N. | Deposit date: | 2016-03-30 | Release date: | 2016-10-19 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Open and compressed conformations of Francisella tularensis ClpP. Proteins, 85, 2017
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3JQC
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![BU of 3jqc by Molmil](/molmil-images/mine/3jqc) | Crystal structure of pteridine reductase 1 (PTR1) from Trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor 2-amino-6-bromo-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile (JU2) | Descriptor: | 2-amino-6-bromo-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Pteridine reductase 1 | Authors: | Tulloch, L.B, Hunter, W.N. | Deposit date: | 2009-09-06 | Release date: | 2009-12-08 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structure-based design of pteridine reductase inhibitors targeting african sleeping sickness and the leishmaniases. J.Med.Chem., 53, 2010
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1H47
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![BU of 1h47 by Molmil](/molmil-images/mine/1h47) | Structures of MECP synthase in complex with (i) CMP and (ii) CMP and product | Descriptor: | 2C-METHYL-D-ERYTHRITOL-2,4-CYCLODIPHOSPHATE SYNTHASE, CYTIDINE-5'-MONOPHOSPHATE, GERANYL DIPHOSPHATE, ... | Authors: | Kemp, L.E, Alphey, M.S, Bond, C.S, Hunter, W.N. | Deposit date: | 2003-02-24 | Release date: | 2004-10-22 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.99 Å) | Cite: | The Identification of Isoprenoids that Bind in the Intersubunit Cavity of Escherichia Coli 2C-Methyl-D-Erythritol-2,4-Cyclodiphosphate Synthase by Complementary Biophysical Methods Acta Crystallogr.,Sect.D, 61, 2005
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2BNM
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2BNO
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![BU of 2bno by Molmil](/molmil-images/mine/2bno) | The structure of Hydroxypropylphosphonic acid epoxidase from S. wedmorenis. | Descriptor: | EPOXIDASE, MERCURY (II) ION, SULFATE ION, ... | Authors: | McLuskey, K, Cameron, S, Hunter, W.N. | Deposit date: | 2005-03-29 | Release date: | 2005-10-05 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structure and Reactivity of Hydroxypropylphosphonic Acid Epoxidase in Fosfomycin Biosynthesis by a Cation- and Flavin-Dependent Mechanism. Proc.Natl.Acad.Sci.USA, 102, 2005
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2BNN
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6T9R
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![BU of 6t9r by Molmil](/molmil-images/mine/6t9r) | Aplysia californica AChBP in complex with a cytisine derivative | Descriptor: | (1~{R},9~{S})-5-(3-oxidanylpropyl)-7,11-diazatricyclo[7.3.1.0^{2,7}]trideca-2,4-dien-6-one, 2-acetamido-2-deoxy-beta-D-glucopyranose, Acetylcholine binding protein, ... | Authors: | Davis, S, Hunter, W.N. | Deposit date: | 2019-10-28 | Release date: | 2020-02-12 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.72 Å) | Cite: | The thermodynamic profile and molecular interactions of a C(9)-cytisine derivative-binding acetylcholine-binding protein from Aplysia californica. Acta Crystallogr.,Sect.F, 76, 2020
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1O8W
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![BU of 1o8w by Molmil](/molmil-images/mine/1o8w) | Radiation-reduced Tryparedoxin-I | Descriptor: | TRYPAREDOXIN | Authors: | Alphey, M.S, Bond, C.S, Hunter, W.N. | Deposit date: | 2002-12-09 | Release date: | 2003-08-01 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Tryparedoxins from Crithidia Fasciculata and Trypanosoma Brucei: Photoreduction of the Redox Disulfide Using Synchrotron Radiation and Evidence for a Conformational Switch Implicated in Function J.Biol.Chem., 278, 2003
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1O7U
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![BU of 1o7u by Molmil](/molmil-images/mine/1o7u) | Radiation induced tryparedoxin-I | Descriptor: | TRYPAREDOXIN | Authors: | Alphey, M.S, Bond, C.S, McSweeney, S.M, Hunter, W.N. | Deposit date: | 2002-11-14 | Release date: | 2003-04-24 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Tryparedoxins from Crithidia Fasciculata and Trypanosoma Brucei: Photoreduction of the Redox Disulfide Using Synchrotron Radiation and Evidence for a Conformational Switch Implicated in Function J.Biol.Chem., 278, 2003
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1O85
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![BU of 1o85 by Molmil](/molmil-images/mine/1o85) | Radiation-reduced Tryparedoxin-I | Descriptor: | TRYPAREDOXIN | Authors: | Alphey, M.S, Bond, C.S, Hunter, W.N. | Deposit date: | 2002-11-25 | Release date: | 2003-04-24 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Tryparedoxins from Crithidia Fasciculata and Trypanosoma Brucei: Photoreduction of the Redox Disulfide Using Synchrotron Radiation and Evidence for a Conformational Switch Implicated in Function J.Biol.Chem., 278, 2003
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1O8X
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![BU of 1o8x by Molmil](/molmil-images/mine/1o8x) | Mutant tryparedoxin-I Cys43Ala | Descriptor: | TRYPAREDOXIN | Authors: | Alphey, M.S, Bond, C.S, Hunter, W.N. | Deposit date: | 2002-12-09 | Release date: | 2003-04-24 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Tryparedoxins from Crithidia Fasciculata and Trypanosoma Brucei: Photoreduction of the Redox Disulfide Using Synchrotron Radiation and Evidence for a Conformational Switch Implicated in Function J.Biol.Chem., 278, 2003
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2HKE
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![BU of 2hke by Molmil](/molmil-images/mine/2hke) | Mevalonate diphosphate decarboxylase from Trypanosoma brucei | Descriptor: | Diphosphomevalonate decarboxylase, putative, SULFATE ION | Authors: | Byres, E, Alphey, M.S, Hunter, W.N. | Deposit date: | 2006-07-04 | Release date: | 2007-06-12 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal Structures of Trypanosoma brucei and Staphylococcus aureus Mevalonate Diphosphate Decarboxylase Inform on the Determinants of Specificity and Reactivity J.Mol.Biol., 371, 2007
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1W8D
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![BU of 1w8d by Molmil](/molmil-images/mine/1w8d) | Binary structure of human DECR. | Descriptor: | 2,4-DIENOYL-COA REDUCTASE, MITOCHONDRIAL PRECURSOR, GLYCEROL, ... | Authors: | Alphey, M.S, Byres, E, Hunter, W.N. | Deposit date: | 2004-09-20 | Release date: | 2004-10-28 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structure and Reactivity of Human Mitochondrial 2,4-Dienoyl-Coa Reductase: Enzyme-Ligand Interactions in a Distinctive Short-Chain Reductase Active Site J.Biol.Chem., 280, 2005
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1W55
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![BU of 1w55 by Molmil](/molmil-images/mine/1w55) | Structure of the Bifunctional IspDF from Campylobacter jejuni | Descriptor: | 1,2-ETHANEDIOL, CYTIDINE-5'-MONOPHOSPHATE, GERANYL DIPHOSPHATE, ... | Authors: | Gabrielsen, M, Bond, C.S, Hunter, W.N. | Deposit date: | 2004-08-05 | Release date: | 2004-10-04 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Hexameric Assembly of the Bifunctional Methylerythritol 2,4-Cyclodiphosphate Synthase and Protein-Protein Associations in the Deoxy-Xylulose-Dependent Pathway of Isoprenoid Precursor Biosynthesis J.Biol.Chem., 279, 2004
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1W73
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![BU of 1w73 by Molmil](/molmil-images/mine/1w73) | Binary structure of human DECR solved by SeMet SAD. | Descriptor: | 2,4-DIENOYL-COA REDUCTASE, GLYCEROL, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | Authors: | Alphey, M.S, Byres, E, Hunter, W.N. | Deposit date: | 2004-08-27 | Release date: | 2004-10-28 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structure and Reactivity of Human Mitochondrial 2,4-Dienoyl-Coa Reductase: Enzyme-Ligand Interactions in a Distinctive Short-Chain Reductase Active Site J.Biol.Chem., 280, 2005
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