8U2D
 
 | | Bruton's tyrosine kinase in complex with N-[(2R)-1-[(3R)-3-(methylcarbamoyl)-1H,2H,3H,4H,9H-pyrido[3,4-b]indol-2-yl]-3-(3-methylphenyl)-1-oxopropan-2-yl]-1H-indazole-5-carboxamide | | Descriptor: | (3R)-2-[N-(1H-indazole-5-carbonyl)-3-methyl-D-phenylalanyl]-N-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxamide, 1,2-ETHANEDIOL, CHLORIDE ION, ... | | Authors: | Gajewski, S, Clifton, M.C. | | Deposit date: | 2023-09-05 | | Release date: | 2024-01-31 | | Last modified: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Discovery and Preclinical Pharmacology of NX-2127, an Orally Bioavailable Degrader of Bruton's Tyrosine Kinase with Immunomodulatory Activity for the Treatment of Patients with B Cell Malignancies.
J.Med.Chem., 67, 2024
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4U0L
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4U0N
 | | Structure of the Vibrio cholerae di-nucleotide cyclase (DncV) deletion mutant D-loop | | Descriptor: | Cyclic AMP-GMP synthase, MAGNESIUM ION, N-[4-({[(6S)-2-amino-5-methyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)benzoyl]-L-gamma-glutamyl-L-glutamic acid | | Authors: | Xiang, Y, Zhu, D.Y. | | Deposit date: | 2014-07-12 | | Release date: | 2014-09-17 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.102 Å) | | Cite: | Structural Biochemistry of a Vibrio cholerae Dinucleotide Cyclase Reveals Cyclase Activity Regulation by Folates.
Mol.Cell, 55, 2014
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6ITX
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6JDS
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6PE2
 | | Drosophila P element transposase strand transfer complex | | Descriptor: | DNA (27-MER), DNA (5'-D(P*CP*GP*AP*AP*CP*TP*AP*TP*A)-3'), DNA (56-MER), ... | | Authors: | Kellogg, E.H, Nogales, E, Ghanim, G, Rio, D.C. | | Deposit date: | 2019-06-19 | | Release date: | 2019-10-30 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (4 Å) | | Cite: | Structure of a P element transposase-DNA complex reveals unusual DNA structures and GTP-DNA contacts.
Nat.Struct.Mol.Biol., 26, 2019
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8JPQ
 | | SARS-CoV-2 Mpro in complex with D-5-96 | | Descriptor: | 3C-like proteinase nsp5, ACE-ALA-ILE-V3E | | Authors: | Liu, M, Huang, H. | | Deposit date: | 2023-06-12 | | Release date: | 2023-08-23 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | The S1'-S3' Pocket of the SARS-CoV-2 Main Protease Is Critical for Substrate Selectivity and Can Be Targeted with Covalent Inhibitors.
Angew.Chem.Int.Ed.Engl., 62, 2023
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6JDR
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6GY9
 | | Fucose-functionalized precision glycomacromolecules targeting human norovirus capsid protein | | Descriptor: | 1,2-ETHANEDIOL, 2-(1H-1,2,3-triazol-1-yl)ethyl 6-deoxy-alpha-L-galactopyranoside, Capsid protein | | Authors: | Ruoff, K, Kilic, T, Hansman, G.S. | | Deposit date: | 2018-06-28 | | Release date: | 2018-08-22 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (1.83 Å) | | Cite: | Fucose-Functionalized Precision Glycomacromolecules Targeting Human Norovirus Capsid Protein.
Biomacromolecules, 19, 2018
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8WBB
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8WBC
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8WBE
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8WBD
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6H6Y
 | | GI.1 human norovirus protruding domain in complex with Nano-7 | | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, Capsid protein VP1, ... | | Authors: | Kilic, T, Ruoff, K, Hansman, G.S. | | Deposit date: | 2018-07-30 | | Release date: | 2018-12-19 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (1.58 Å) | | Cite: | Structural Basis of Nanobodies Targeting the Prototype Norovirus.
J. Virol., 93, 2019
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6H72
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3ER3
 | | The active site of aspartic proteinases | | Descriptor: | 6-ammonio-N-[(2R,4R,5R)-5-{[N-(tert-butoxycarbonyl)-L-phenylalanyl-3-(1H-imidazol-3-ium-4-yl)-L-alanyl]amino}-6-cyclohexyl-4-hydroxy-2-(2-methylpropyl)hexanoyl]-L-norleucylphenylalanine, ENDOTHIAPEPSIN | | Authors: | Al-Karadaghi, S, Cooper, J.B, Veerapandian, B, Hoover, D, Blundell, T.L. | | Deposit date: | 1991-01-02 | | Release date: | 1991-04-15 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | The Active Site of Aspartic Proteinases
FEBS Lett., 174, 1984
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6H6Z
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6H70
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6H71
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8TBQ
 | | The crystal structure of human VISTA extra cellular domain in complex with Fab fragment of pH-selective anti-VISTA antibody | | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, SNS-101 Fab heavy chain, ... | | Authors: | van der Horst, E.H, Mukherjee, A, Thisted, T. | | Deposit date: | 2023-06-29 | | Release date: | 2024-03-20 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2.593 Å) | | Cite: | VISTA checkpoint inhibition by pH-selective antibody SNS-101 with optimized safety and pharmacokinetic profiles enhances PD-1 response.
Nat Commun, 15, 2024
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8CYL
 | | Ast89 P domain | | Descriptor: | Capsid protein VP60 | | Authors: | Leuthold, M, Kilic, T, Hansman, G. | | Deposit date: | 2022-05-23 | | Release date: | 2022-10-19 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (1.888 Å) | | Cite: | Structural Basis for Rabbit Hemorrhagic Disease Virus Antibody Specificity.
J.Virol., 96, 2022
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8CZ5
 | | N11 P domain 2D9 Fab P complex | | Descriptor: | ACETATE ION, CADMIUM ION, Fab 2D9 Heavy Chain, ... | | Authors: | Leuthold, M, Kilic, T, Hansman, G. | | Deposit date: | 2022-05-24 | | Release date: | 2022-10-19 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (2.645 Å) | | Cite: | Structural Basis for Rabbit Hemorrhagic Disease Virus Antibody Specificity.
J.Virol., 96, 2022
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8WBG
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8WBF
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8WBH
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