6ITX

Structure of the C-terminal head domain of the avian adenovirus EDSV fiber

Summary for 6ITX

• Entry DOI: 10.2210/pdb6itx/pdb
• Descriptor: Fiber protein, GLUTAMINE, SULFATE ION, ... (4 entities in total)
• Functional Keywords: avian adenovirus, fiber protein, cell adhesion
• Biological source: Duck adenovirus 1
• Total number of polymer chains: 6
• Total formula weight: 193816.69

Authors

Wei, Q.,Song, Y. (deposition date: 2018-11-26, release date: 2019-10-09, Last modification date: 2024-03-27)

Primary citation

Song, Y.,Wei, Q.,Liu, Y.,Feng, H.,Chen, Y.,Wang, Y.,Bai, Y.,Xing, G.,Deng, R.,Zhang, G.
Unravelling the receptor binding property of egg drop syndrome virus (EDSV) from the crystal structure of EDSV fiber head.
Int.J.Biol.Macromol., 139:587-595, 2019

PubMed Abstract: Egg drop syndrome virus (EDSV) is an avian adenovirus that causes markedly decrease in egg production, and in the quality of the eggs when it infects chickens. Until now, EDSV virus-cell interactions are poorly understood, and the cellular receptor is still unknown. In the present study, we determined the atomic structure of the fiber head of EDSV (residues 377-644) at 2.74 Å resolution. Structure comparison with the (chick embryo lethal orphan) CELO long fiber head and human adenovirus fiber heads reveals that the avian adenovirus may interact with the same attachment factor in a unique fashion. Based on the previous studies of CELO virus, we assumed that the chicken coxsackievirus and adenovirus receptor (CAR) may be the attachment factor. We then demonstrate that the chicken CAR serves as a cellular attachment factor for EDSV based on three lines of evidences. Taken together, the results presented here are helpful for further exploring the pathogenesis related to the interaction between EDSV and host cells, and may be used for vaccine development and intervention strategies against EDSV infection.

PubMed: 31381914
DOI: 10.1016/j.ijbiomac.2019.08.005

Experimental method

X-RAY DIFFRACTION (2.75 Å)