7XG1
| CryoEM structure of type IV-A Csf-crRNA binary complex | Descriptor: | Csf1, Csf2, Csf3, ... | Authors: | Zhang, J.T, Cui, N, Huang, H.D, Jia, N. | Deposit date: | 2022-04-02 | Release date: | 2023-08-02 | Last modified: | 2024-10-09 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Type IV-A CRISPR-Csf complex: Assembly, dsDNA targeting, and CasDinG recruitment Mol.Cell, 83, 2023
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7XG3
| CryoEM structure of type IV-A CasDinG bound NTS-nicked Csf-crRNA-dsDNA quaternary complex | Descriptor: | Csf1, Csf2, Csf3, ... | Authors: | Zhang, J.T, Cui, N, Huang, H.D, Jia, N. | Deposit date: | 2022-04-02 | Release date: | 2023-08-09 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Type IV-A CRISPR-Csf complex: Assembly, dsDNA targeting, and CasDinG recruitment. Mol.Cell, 83, 2023
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7XFZ
| CryoEM structure of type IV-A Csf-crRNAsp14-dsDNA ternary complex | Descriptor: | Csf1, Csf2, Csf3, ... | Authors: | Zhang, J.T, Cui, N, Huang, H.D, Jia, N. | Deposit date: | 2022-04-02 | Release date: | 2023-08-09 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Type IV-A CRISPR-Csf complex: Assembly, dsDNA targeting, and CasDinG recruitment. Mol.Cell, 83, 2023
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7XG0
| CryoEM structure of type IV-A Csf-crRNA-dsDNA ternary complex | Descriptor: | Csf1, Csf2, Csf3, ... | Authors: | Zhang, J.T, Cui, N, Huang, H.D, Jia, N. | Deposit date: | 2022-04-02 | Release date: | 2023-08-09 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (2.6 Å) | Cite: | Type IV-A CRISPR-Csf complex: Assembly, dsDNA targeting, and CasDinG recruitment. Mol.Cell, 83, 2023
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7XG4
| CryoEM structure of type IV-A CasDinG bound NTS-nicked Csf-crRNA-dsDNA quaternary complex in a second state | Descriptor: | Csf1, Csf2, Csf3, ... | Authors: | Zhang, J.T, Cui, N, Huang, H.D, Jia, N. | Deposit date: | 2022-04-02 | Release date: | 2023-08-09 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Type IV-A CRISPR-Csf complex: Assembly, dsDNA targeting, and CasDinG recruitment. Mol.Cell, 83, 2023
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7XG2
| CryoEM structure of type IV-A NTS-nicked dsDNA bound Csf-crRNA ternary complex | Descriptor: | Csf1, Csf2, Csf3, ... | Authors: | Zhang, J.T, Cui, N, Huang, H.D, Jia, N. | Deposit date: | 2022-04-02 | Release date: | 2023-08-09 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Type IV-A CRISPR-Csf complex: Assembly, dsDNA targeting, and CasDinG recruitment. Mol.Cell, 83, 2023
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7DM2
| crystal structure of the M. tuberculosis phosphate ABC transport receptor PstS-1 in complex with Fab p4-170 | Descriptor: | PHOSPHATE ION, Phosphate-binding protein PstS 1, heavy chain, ... | Authors: | Ma, B, Freund, N, Xiang, Y. | Deposit date: | 2020-12-01 | Release date: | 2020-12-23 | Last modified: | 2024-10-16 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Human antibodies targeting a Mycobacterium transporter protein mediate protection against tuberculosis. Nat Commun, 12, 2021
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7DM1
| crystal structure of the M.tuberculosis phosphate ABC transport receptor PstS-1 in complex with Fab p4-36 | Descriptor: | PHOSPHATE ION, Phosphate-binding protein PstS 1, heavy chain, ... | Authors: | Ma, B, Freund, N, Xiang, Y. | Deposit date: | 2020-12-01 | Release date: | 2020-12-23 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Human antibodies targeting a Mycobacterium transporter protein mediate protection against tuberculosis. Nat Commun, 12, 2021
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7Y81
| CryoEM structure of type III-E CRISPR Craspase gRAMP-crRNA complex bound to non-self RNA target | Descriptor: | MAGNESIUM ION, Non-self RNA target, RAMP superfamily protein, ... | Authors: | Zhang, J.T, Cui, N, Huang, H.D, Jia, N. | Deposit date: | 2022-06-22 | Release date: | 2022-12-14 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (2.54 Å) | Cite: | Structural basis for the non-self RNA-activated protease activity of the type III-E CRISPR nuclease-protease Craspase. Nat Commun, 13, 2022
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7Y85
| CryoEM structure of type III-E CRISPR Craspase gRAMP-crRNA in complex with TPR-CHAT protease bound to self RNA target | Descriptor: | CHAT domain protein, MAGNESIUM ION, RAMP superfamily protein, ... | Authors: | Zhang, J.T, Cui, N, Huang, H.D, Jia, N. | Deposit date: | 2022-06-22 | Release date: | 2022-12-14 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (2.73 Å) | Cite: | Structural basis for the non-self RNA-activated protease activity of the type III-E CRISPR nuclease-protease Craspase. Nat Commun, 13, 2022
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7Y82
| CryoEM structure of type III-E CRISPR Craspase gRAMP-crRNA complex bound to self RNA target | Descriptor: | MAGNESIUM ION, RAMP superfamily protein, Self RNA target, ... | Authors: | Zhang, J.T, Cui, N, Huang, H.D, Jia, N. | Deposit date: | 2022-06-22 | Release date: | 2022-12-14 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (2.83 Å) | Cite: | Structural basis for the non-self RNA-activated protease activity of the type III-E CRISPR nuclease-protease Craspase. Nat Commun, 13, 2022
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7Y83
| CryoEM structure of type III-E CRISPR Craspase gRAMP-crRNA in complex with TPR-CHAT protease bound to non-self RNA target | Descriptor: | CHAT domain protein, MAGNESIUM ION, RAMP superfamily protein, ... | Authors: | Zhang, J.T, Cui, N, Huang, H.D, Jia, N. | Deposit date: | 2022-06-22 | Release date: | 2022-12-14 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (2.93 Å) | Cite: | Structural basis for the non-self RNA-activated protease activity of the type III-E CRISPR nuclease-protease Craspase. Nat Commun, 13, 2022
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7Y80
| CryoEM structure of type III-E CRISPR Craspase gRAMP-crRNA binary complex | Descriptor: | MAGNESIUM ION, RAMP superfamily protein, ZINC ION, ... | Authors: | Zhang, J.T, Cui, N, Huang, H.D, Jia, N. | Deposit date: | 2022-06-22 | Release date: | 2022-12-14 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (2.71 Å) | Cite: | Structural basis for the non-self RNA-activated protease activity of the type III-E CRISPR nuclease-protease Craspase. Nat Commun, 13, 2022
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7Y84
| CryoEM structure of type III-E CRISPR Craspase gRAMP-crRNA in complex with TPR-CHAT protease | Descriptor: | CHAT domain protein, MAGNESIUM ION, RAMP superfamily protein, ... | Authors: | Zhang, J.T, Cui, N, Huang, H.D, Jia, N. | Deposit date: | 2022-06-22 | Release date: | 2022-12-14 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (2.61 Å) | Cite: | Structural basis for the non-self RNA-activated protease activity of the type III-E CRISPR nuclease-protease Craspase. Nat Commun, 13, 2022
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7WH8
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7WHB
| SARS-CoV-2 spike in complex with the ZB8 neutralizing antibody Fab (3U) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ... | Authors: | Zeng, J.W, Ge, J.W, Wang, X.Q. | Deposit date: | 2021-12-30 | Release date: | 2023-01-18 | Last modified: | 2024-10-09 | Method: | ELECTRON MICROSCOPY (2.67 Å) | Cite: | SARS-CoV-2 hijacks neutralizing dimeric IgA for nasal infection and injury in Syrian hamsters 1 . Emerg Microbes Infect, 12, 2023
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7WHD
| SARS-CoV-2 spike in complex with the ZB8 neutralizing antibody Fab (2u1d) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ... | Authors: | Zeng, J.W, Wang, X.W, Ge, J.W, Wang, Z.Y. | Deposit date: | 2021-12-30 | Release date: | 2023-01-18 | Last modified: | 2023-09-06 | Method: | ELECTRON MICROSCOPY (2.65 Å) | Cite: | SARS-CoV-2 hijacks neutralizing dimeric IgA for nasal infection and injury in Syrian hamsters 1 . Emerg Microbes Infect, 12, 2023
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8JF4
| The crystal structure of human AURKA kinase domain in complex with AURKA-compound 9 | Descriptor: | 2-[4-[4-[bis(oxidanylidene)-$l^5-sulfanyl]oxyphenyl]carbonylpiperazin-1-yl]-6-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]-N-prop-2-ynyl-pyrimidine-4-carboxamide, Aurora kinase A | Authors: | Zhu, C.J. | Deposit date: | 2023-05-17 | Release date: | 2024-02-14 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.89288354 Å) | Cite: | Global Reactivity Profiling of the Catalytic Lysine in Human Kinome for Covalent Inhibitor Development. Angew.Chem.Int.Ed.Engl., 63, 2024
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5TVT
| Structure of Maternal Embryonic Leucine Zipper Kinase | Descriptor: | 9-(3,5-dichloro-4-hydroxyphenyl)-1-{trans-4-[(dimethylamino)methyl]cyclohexyl}-3-methyl-3,4-dihydropyrimido[5,4-c][1,5]naphthyridin-2(1H)-one, Maternal embryonic leucine zipper kinase | Authors: | Seo, H.-Y, Huang, H, Gray, N.S, Dhe-Paganon, S. | Deposit date: | 2016-11-10 | Release date: | 2017-11-15 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.28 Å) | Cite: | Structure of Maternal Embryonic Leucine Zipper Kinase To Be Published
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8JG8
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7W5M
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7XRP
| Cryo-EM structure of SARS-CoV-2 spike protein in complex with nanobody C5G2 (localized refinement) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, C5G2 nanobody, Spike protein S1 | Authors: | Liu, L, Sun, H, Jiang, Y, Liu, X, Zhao, D, Zheng, Q, Li, S, Xia, N. | Deposit date: | 2022-05-11 | Release date: | 2022-10-05 | Last modified: | 2024-10-16 | Method: | ELECTRON MICROSCOPY (3.88 Å) | Cite: | A potent synthetic nanobody with broad-spectrum activity neutralizes SARS-CoV-2 virus and the Omicron variant BA.1 through a unique binding mode. J Nanobiotechnology, 20, 2022
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7VCQ
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7VCL
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1EVB
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