4DSO
 
 | | Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity | | Descriptor: | 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, BENZAMIDINE, GLYCEROL, ... | | Authors: | Oh, A, Maurer, T, Garrenton, L.S, Pitts, K, Anderson, D.J, Skelton, N.J, Fauber, B.P, Pan, B, Malek, S, Stokoe, D, Ludlam, M, Bowman, K.K, Wu, J, Giannetti, A.M, Starovasnik, M.A, Mellman, I, Jackson, P.K, Ruldolph, J, Fang, G, Wang, W. | | Deposit date: | 2012-02-19 | | Release date: | 2012-04-04 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity.
Proc.Natl.Acad.Sci.USA, 109, 2012
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4DSU
 | | Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity | | Descriptor: | BENZIMIDAZOLE, GTPase KRas, isoform 2B, ... | | Authors: | Oh, A, Maurer, T, Garrenton, L.S, Pitts, K, Anderson, D.J, Skelton, N.J, Fauber, B.P, Pan, B, Malek, S, Stokoe, D, Ludlam, M, Bowman, K.K, Wu, J, Giannetti, A.M, Starovasnik, M.A, Mellman, I, Jackson, P.K, Ruldolph, J, Fang, G, Wang, W. | | Deposit date: | 2012-02-19 | | Release date: | 2012-04-04 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity.
Proc.Natl.Acad.Sci.USA, 109, 2012
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4DST
 | | Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity | | Descriptor: | 1,2-ETHANEDIOL, 2-(4,6-dichloro-2-methyl-1H-indol-3-yl)ethanamine, ACETATE ION, ... | | Authors: | Oh, A, Maurer, T, Garrenton, L.S, Pitts, K, Anderson, D.J, Skelton, N.J, Fauber, B.P, Pan, B, Malek, S, Stokoe, D, Ludlam, M, Bowman, K.K, Wu, J, Giannetti, A.M, Starovasnik, M.A, Mellman, I, Jackson, P.K, Ruldolph, J, Fang, G, Wang, W. | | Deposit date: | 2012-02-19 | | Release date: | 2012-04-04 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity.
Proc.Natl.Acad.Sci.USA, 109, 2012
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1KCN
 | | Structure of e109 Zeta Peptide, an Antagonist of the High-Affinity IgE Receptor | | Descriptor: | e109 zeta peptide | | Authors: | Nakamura, G.R, Reynolds, M.E, Chen, Y.M, Starovasnik, M.A, Lowman, H.B. | | Deposit date: | 2001-11-09 | | Release date: | 2002-03-06 | | Last modified: | 2022-02-23 | | Method: | SOLUTION NMR | | Cite: | Stable "zeta" peptides that act as potent antagonists of the high-affinity IgE receptor.
Proc.Natl.Acad.Sci.USA, 99, 2002
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1KCO
 | | Structure of e131 Zeta Peptide, a Potent Antagonist of the High-Affinity IgE Receptor | | Descriptor: | e131 Zeta Peptide | | Authors: | Nakamura, G.R, Reynolds, M.E, Chen, Y.M, Starovasnik, M.A, Lowman, H.B. | | Deposit date: | 2001-11-09 | | Release date: | 2002-03-06 | | Last modified: | 2022-02-23 | | Method: | SOLUTION NMR | | Cite: | Stable "zeta" peptides that act as potent antagonists of the high-affinity IgE receptor.
Proc.Natl.Acad.Sci.USA, 99, 2002
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1OSX
 | | Solution Structure of the Extracellular Domain of BLyS Receptor 3 (BR3) | | Descriptor: | Tumor necrosis factor receptor superfamily member 13C | | Authors: | Gordon, N.C, Pan, B, Hymowitz, S.G, Yin, J.P, Kelley, R.F, Cochran, A.G, Yan, M, Dixit, V.M, Fairbrother, W.J, Starovasnik, M.A. | | Deposit date: | 2003-03-20 | | Release date: | 2003-05-27 | | Last modified: | 2022-02-23 | | Method: | SOLUTION NMR | | Cite: | BAFF/BLyS receptor 3 comprises a minimal TNF receptor-like module that encodes a highly focused ligand-binding site
Biochemistry, 42, 2003
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1F7M
 | | THE FIRST EGF-LIKE DOMAIN FROM HUMAN BLOOD COAGULATION FVII, NMR, MINIMIZED AVERAGE STRUCTURE | | Descriptor: | PROTEIN (Blood Coagulation Factor VII) | | Authors: | Kao, Y.-H, Lee, G.F, Wang, Y, Starovasnik, M.A, Kelley, R.F, Spellman, M.W, Lerner, L. | | Deposit date: | 1999-02-19 | | Release date: | 1999-06-16 | | Last modified: | 2023-12-27 | | Method: | SOLUTION NMR | | Cite: | The effect of O-fucosylation on the first EGF-like domain from human blood coagulation factor VII.
Biochemistry, 38, 1999
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1F7E
 | | THE FIRST EGF-LIKE DOMAIN FROM HUMAN BLOOD COAGULATION FVII, NMR, 20 STRUCTURES | | Descriptor: | PROTEIN (Blood Coagulation Factor VII) | | Authors: | Kao, Y.-H, Lee, G.F, Wang, Y, Starovasnik, M.A, Kelley, R.F, Spellman, M.W, Lerner, L. | | Deposit date: | 1999-02-19 | | Release date: | 1999-06-16 | | Last modified: | 2023-12-27 | | Method: | SOLUTION NMR | | Cite: | The effect of O-fucosylation on the first EGF-like domain from human blood coagulation factor VII.
Biochemistry, 38, 1999
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1OSG
 | | Complex between BAFF and a BR3 derived peptide presented in a beta-hairpin scaffold | | Descriptor: | BR3 derived PEPTIDE, MAGNESIUM ION, Tumor necrosis factor ligand superfamily member 13B | | Authors: | Gordon, N.C, Pan, B, Hymowitz, S.G, Yin, J.P, Kelley, R.F, Cochran, A.G, Yan, M, Dixit, V.M, Fairbrother, W.J, Starovasnik, M.A. | | Deposit date: | 2003-03-19 | | Release date: | 2003-05-27 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | BAFF/BLyS receptor 3 comprises a minimal TNF receptor-like module that encodes a highly focused ligand-binding site
Biochemistry, 42, 2003
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1MPV
 | | Structure of bhpBR3, the BAFF-binding loop of BR3 embedded in a beta-hairpin peptide | | Descriptor: | BLyS Receptor 3 | | Authors: | Kayagaki, N, Yan, M, Seshasayee, D, Wang, H, Lee, W, French, D.M, Grewal, I.S, Cochran, A.G, Gordon, N.C, Yin, J, Starovasnik, M.A, Dixit, V.M. | | Deposit date: | 2002-09-12 | | Release date: | 2002-10-30 | | Last modified: | 2022-02-23 | | Method: | SOLUTION NMR | | Cite: | BAFF/BLyS receptor 3 binds the B cell survival factor BAFF ligand through a discrete surface loop and promotes processing of NF-kappaB2.
Immunity, 17, 2002
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1FFM
 | | THE FIRST EGF-LIKE DOMAIN FROM HUMAN BLOOD COAGULATION FVII (FUCOSYLATED AT SER-60), NMR, MINIMIZED AVERAGE STRUCTURE | | Descriptor: | PROTEIN (Blood Coagulation Factor VII), alpha-L-fucopyranose | | Authors: | Kao, Y.-H, Lee, G.F, Wang, Y, Starovasnik, M.A, Kelley, R.F, Spellman, M.W, Lerner, L. | | Deposit date: | 1999-02-19 | | Release date: | 1999-06-16 | | Last modified: | 2023-12-27 | | Method: | SOLUTION NMR | | Cite: | The effect of O-fucosylation on the first EGF-like domain from human blood coagulation factor VII.
Biochemistry, 38, 1999
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1FF7
 | | THE FIRST EGF-LIKE DOMAIN FROM HUMAN BLOOD COAGULATION FVII (FUCOSYLATED AT SER-60), NMR, 20 STRUCTURES | | Descriptor: | PROTEIN (Blood Coagulation Factor VII), alpha-L-fucopyranose | | Authors: | Kao, Y.-H, Lee, G.F, Wang, Y, Starovasnik, M.A, Kelley, R.F, Spellman, M.W, Lerner, L. | | Deposit date: | 1999-02-19 | | Release date: | 1999-06-16 | | Last modified: | 2023-12-27 | | Method: | SOLUTION NMR | | Cite: | The effect of O-fucosylation on the first EGF-like domain from human blood coagulation factor VII.
Biochemistry, 38, 1999
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1JPY
 | | Crystal structure of IL-17F | | Descriptor: | 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Hymowitz, S.G, Filvaroff, E.H, Yin, J, Lee, J, Cai, L, Risser, P, Maruoka, M, Mao, W, Foster, J, Kelley, R, Pan, G, Gurney, A.L, de Vos, A.M, Starovasnik, M.A. | | Deposit date: | 2001-08-03 | | Release date: | 2001-09-28 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (2.85 Å) | | Cite: | IL-17s adopt a cystine knot fold: structure and activity of a novel cytokine, IL-17F, and implications for receptor binding.
EMBO J., 20, 2001
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1JBF
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4EUU
 | | Structure of BX-795 Complexed with Human TBK1 Kinase Domain Phosphorylated on Ser172 | | Descriptor: | GLYCEROL, IODIDE ION, N-(3-{[5-iodo-4-({3-[(thiophen-2-ylcarbonyl)amino]propyl}amino)pyrimidin-2-yl]amino}phenyl)pyrrolidine-1-carboxamide, ... | | Authors: | Ma, X, Helgason, E, Phung, Q.T, Quan, C.L, Iyer, R.S, Lee, M.W, Bowman, K.K, Starovasnik, M.A, Dueber, E.C. | | Deposit date: | 2012-04-25 | | Release date: | 2012-05-23 | | Last modified: | 2017-11-15 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Molecular basis of Tank-binding kinase 1 activation by transautophosphorylation.
Proc.Natl.Acad.Sci.USA, 109, 2012
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4EUT
 | | Structure of BX-795 Complexed with Unphosphorylated Human TBK1 Kinase-ULD Domain | | Descriptor: | IODIDE ION, N-(3-{[5-iodo-4-({3-[(thiophen-2-ylcarbonyl)amino]propyl}amino)pyrimidin-2-yl]amino}phenyl)pyrrolidine-1-carboxamide, SULFATE ION, ... | | Authors: | Ma, X, Helgason, E, Phung, Q.T, Quan, C.L, Iyer, R.S, Lee, M.W, Bowman, K.K, Starovasnik, M.A, Dueber, E.C. | | Deposit date: | 2012-04-25 | | Release date: | 2012-05-23 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Molecular basis of Tank-binding kinase 1 activation by transautophosphorylation.
Proc.Natl.Acad.Sci.USA, 109, 2012
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4DKE
 | | Crystal Structure of Human Interleukin-34 Bound to FAb1.1 | | Descriptor: | FAb1.1 Heavy Chain, FAb1.1 Light Chain, Interleukin-34, ... | | Authors: | Ma, X, Chen, Y, Stawicki, S, Wu, Y, Bazan, J.F, Starovasnik, M.A. | | Deposit date: | 2012-02-03 | | Release date: | 2012-04-11 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Structural Basis for the Dual Recognition of Helical Cytokines IL-34 and CSF-1 by CSF-1R.
Structure, 20, 2012
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4DSN
 | | Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity | | Descriptor: | 1,2-ETHANEDIOL, GTPase KRas, isoform 2B, ... | | Authors: | Oh, A, Maurer, T, Garrenton, L.S, Pitts, K, Anderson, D.J, Skelton, N.J, Fauber, B.P, Pan, B, Malek, S, Stokoe, D, Ludlam, M, Bowman, K.K, Wu, J, Giannetti, A.M, Starovasnik, M.A, Mellman, I, Jackson, P.K, Ruldolph, J, Fang, G, Wang, W. | | Deposit date: | 2012-02-19 | | Release date: | 2012-04-25 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.03 Å) | | Cite: | Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity.
Proc.Natl.Acad.Sci.USA, 109, 2012
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4DKD
 | | Crystal Structure of Human Interleukin-34 Bound to Human CSF-1R | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-34, ... | | Authors: | Ma, X, Bazan, J.F, Starovasnik, M.A. | | Deposit date: | 2012-02-03 | | Release date: | 2012-04-11 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Structural Basis for the Dual Recognition of Helical Cytokines IL-34 and CSF-1 by CSF-1R.
Structure, 20, 2012
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4DKC
 | | Crystal Structure of Human Interleukin-34 | | Descriptor: | Interleukin-34, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | | Authors: | Ma, X, Bazan, J.F, Starovasnik, M.A. | | Deposit date: | 2012-02-03 | | Release date: | 2012-04-11 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Structural Basis for the Dual Recognition of Helical Cytokines IL-34 and CSF-1 by CSF-1R.
Structure, 20, 2012
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1RJ7
 | | Crystal structure of EDA-A1 | | Descriptor: | Ectodysplasin A | | Authors: | Hymowitz, S.G, Compaan, D.M, Yan, M, Ackerly, H, Dixit, V.M, Starovasnik, M.A, de Vos, A.M. | | Deposit date: | 2003-11-18 | | Release date: | 2003-12-09 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | The crystal structures of EDA-A1 and EDA-A2: splice variants with distinct receptor specificity.
Structure, 11, 2003
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1RJ8
 | | The crystal structure of TNF family member EDA-A2 | | Descriptor: | ectodysplasin-A isoform EDA-A2 | | Authors: | Hymowitz, S.G, Compaan, D.M, Yan, M, Ackerly, H, Dixit, V.M, Starovasnik, M.A, de Vos, A.M. | | Deposit date: | 2003-11-18 | | Release date: | 2003-12-09 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.23 Å) | | Cite: | The Crystal Structure of EDA-A1 and EDA-A2: splice variants with distinct receptor specificity
STRUCTURE, 11, 2003
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1DGN
 | | SOLUTION STRUCTURE OF ICEBERG, AN INHIBITOR OF INTERLEUKIN-1BETA GENERATION | | Descriptor: | ICEBERG (PROTEASE INHIBITOR) | | Authors: | Humke, E.W, Shriver, S.K, Starovasnik, M.A, Fairbrother, W.J, Dixit, V.M. | | Deposit date: | 1999-11-24 | | Release date: | 2000-10-09 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | ICEBERG: a novel inhibitor of interleukin-1beta generation.
Cell(Cambridge,Mass.), 103, 2000
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1QTY
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5CVO
 | | WDR48:USP46~ubiquitin ternary complex | | Descriptor: | Polyubiquitin-B, Ubiquitin carboxyl-terminal hydrolase 46, WD repeat-containing protein 48, ... | | Authors: | Harris, S.F, Yin, J. | | Deposit date: | 2015-07-27 | | Release date: | 2015-10-07 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (3.885 Å) | | Cite: | Structural Insights into WD-Repeat 48 Activation of Ubiquitin-Specific Protease 46.
Structure, 23, 2015
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