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1E4C
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BU of 1e4c by Molmil
L-Fuculose 1-Phosphate Aldolase from Escherichia coli Mutant S71Q
Descriptor: BETA-MERCAPTOETHANOL, L-FUCULOSE 1-PHOSPHATE ALDOLASE, SULFATE ION, ...
Authors:Joerger, A.C, Schulz, G.E.
Deposit date:2000-06-30
Release date:2000-11-06
Last modified:2019-01-30
Method:X-RAY DIFFRACTION (1.66 Å)
Cite:Structures of L-Fuculose-1-Phosphate Aldolase Mutants Outlining Motions During Catalysis
J.Mol.Biol., 303, 2000
1E49
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BU of 1e49 by Molmil
L-Fuculose 1-Phosphate Aldolase from Escherichia coli Mutant N29L/S71A
Descriptor: BETA-MERCAPTOETHANOL, L-FUCULOSE 1-PHOSPHATE ALDOLASE, SULFATE ION, ...
Authors:Joerger, A.C, Schulz, G.E.
Deposit date:2000-06-30
Release date:2000-11-06
Last modified:2019-01-30
Method:X-RAY DIFFRACTION (2.53 Å)
Cite:Structures of L-Fuculose-1-Phosphate Aldolase Mutants Outlining Motions During Catalysis
J.Mol.Biol., 303, 2000
1E46
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BU of 1e46 by Molmil
L-Fuculose 1-Phosphate Aldolase from Escherichia coli Mutant E73S
Descriptor: BETA-MERCAPTOETHANOL, L-FUCULOSE 1-PHOSPHATE ALDOLASE, SULFATE ION, ...
Authors:Joerger, A.C, Schulz, G.E.
Deposit date:2000-06-30
Release date:2000-11-06
Last modified:2019-01-30
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Structures of L-Fuculose-1-Phosphate Aldolase Mutants Outlining Motions During Catalysis
J.Mol.Biol., 303, 2000
1E4B
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BU of 1e4b by Molmil
L-Fuculose 1-Phosphate Aldolase from Escherichia coli Mutant N29Q
Descriptor: BETA-MERCAPTOETHANOL, L-FUCULOSE 1-PHOSPHATE ALDOLASE, SULFATE ION, ...
Authors:Joerger, A.C, Schulz, G.E.
Deposit date:2000-06-30
Release date:2000-11-06
Last modified:2019-01-30
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:Structures of L-Fuculose-1-Phosphate Aldolase Mutants Outlining Motions During Catalysis
J.Mol.Biol., 303, 2000
1E48
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BU of 1e48 by Molmil
L-Fuculose 1-Phosphate Aldolase from Escherichia coli Mutant E73Q/Y113F/Y209F
Descriptor: 1,3-DIHYDROXYACETONEPHOSPHATE, BETA-MERCAPTOETHANOL, L-FUCULOSE 1-PHOSPHATE ALDOLASE, ...
Authors:Joerger, A.C, Schulz, G.E.
Deposit date:2000-06-30
Release date:2000-11-06
Last modified:2019-01-30
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:Structures of L-Fuculose-1-Phosphate Aldolase Mutants Outlining Motions During Catalysis
J.Mol.Biol., 303, 2000
4CZ5
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BU of 4cz5 by Molmil
Truncated tetramerization domain of zebrafish p53 (crystal form I)
Descriptor: CELLULAR TUMOR ANTIGEN P53
Authors:Joerger, A.C.
Deposit date:2014-04-16
Release date:2014-08-27
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.02 Å)
Cite:Tracing the Evolution of the P53 Tetramerization Domain
Structure, 22, 2014
4CZ6
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BU of 4cz6 by Molmil
Truncated tetramerization domain of zebrafish p53 (crystal form II)
Descriptor: CELLULAR TUMOR ANTIGEN P53, DI(HYDROXYETHYL)ETHER
Authors:Joerger, A.C.
Deposit date:2014-04-16
Release date:2014-08-27
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.53 Å)
Cite:Tracing the Evolution of the P53 Tetramerization Domain
Structure, 22, 2014
4CZ7
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BU of 4cz7 by Molmil
Truncated tetramerization domain of zebrafish p53 (crystal form III)
Descriptor: CELLULAR TUMOR ANTIGEN P53, GLYCEROL, PHOSPHATE ION
Authors:Joerger, A.C.
Deposit date:2014-04-16
Release date:2014-08-27
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Tracing the Evolution of the P53 Tetramerization Domain
Structure, 22, 2014
4D1L
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BU of 4d1l by Molmil
Tetramerization domain of zebrafish p53 (crystal form I)
Descriptor: CELLULAR TUMOR ANTIGEN P53, ZINC ION
Authors:Joerger, A.C.
Deposit date:2014-05-02
Release date:2014-08-27
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:Tracing the Evolution of the P53 Tetramerization Domain
Structure, 22, 2014
4D1M
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BU of 4d1m by Molmil
Tetramerization domain of zebrafish p53 (crystal form II)
Descriptor: CELLULAR TUMOR ANTIGEN P53, ZINC ION
Authors:Joerger, A.C.
Deposit date:2014-05-02
Release date:2014-08-27
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Tracing the Evolution of the P53 Tetramerization Domain
Structure, 22, 2014
1DZX
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BU of 1dzx by Molmil
L-Fuculose-1-Phosphate Aldolase from Escherichia coli Mutant R212A
Descriptor: BETA-MERCAPTOETHANOL, L-fuculose phosphate aldolase, SULFATE ION, ...
Authors:Joerger, A.C, Schulz, G.E.
Deposit date:2000-03-07
Release date:2000-06-02
Last modified:2019-09-25
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:Catalytic Action of Fuculose 1-Phosphate Aldolase (Class II) as Derived from Structure-Directed Mutagenesis
Biochemistry, 39, 2000
1DZW
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BU of 1dzw by Molmil
L-Fuculose-1-Phosphate Aldolase from Escherichia coli Mutant F131A
Descriptor: BETA-MERCAPTOETHANOL, L-fuculose phosphate aldolase, SULFATE ION, ...
Authors:Joerger, A.C, Schulz, G.E.
Deposit date:2000-03-07
Release date:2000-06-02
Last modified:2019-09-25
Method:X-RAY DIFFRACTION (2.17 Å)
Cite:Catalytic Action of Fuculose 1-Phosphate Aldolase (Class II) as Derived from Structure-Directed Mutagenesis
Biochemistry, 39, 2000
1DZV
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BU of 1dzv by Molmil
L-Fuculose-1-Phosphate Aldolase from Escherichia coli Mutant Y113F/Y209F
Descriptor: BETA-MERCAPTOETHANOL, L-fuculose phosphate aldolase, SULFATE ION, ...
Authors:Joerger, A.C, Schulz, G.E.
Deposit date:2000-03-07
Release date:2000-06-02
Last modified:2019-09-25
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Catalytic Action of Fuculose 1-Phosphate Aldolase (Class II) as Derived from Structure-Directed Mutagenesis
Biochemistry, 39, 2000
1DZU
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BU of 1dzu by Molmil
L-Fuculose-1-Phosphate Aldolase from Escherichia coli Mutant T26A
Descriptor: BETA-MERCAPTOETHANOL, L-fuculose phosphate aldolase, SULFATE ION, ...
Authors:Joerger, A.C, Schulz, G.E.
Deposit date:2000-03-07
Release date:2000-06-02
Last modified:2019-09-25
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Catalytic Action of Fuculose 1-Phosphate Aldolase (Class II) as Derived from Structure-Directed Mutagenesis
Biochemistry, 39, 2000
1DZY
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BU of 1dzy by Molmil
L-Fuculose-1-Phosphate Aldolase from Escherichia coli Mutant E214A
Descriptor: BETA-MERCAPTOETHANOL, L-FUCULOSE-1-PHOSPHATE ALDOLASE, SULFATE ION, ...
Authors:Joerger, A.C, Schulz, G.E.
Deposit date:2000-03-07
Release date:2000-06-02
Last modified:2019-01-30
Method:X-RAY DIFFRACTION (2.44 Å)
Cite:Catalytic Action of Fuculose 1-Phosphate Aldolase (Class II) as Derived from Structure-Directed Mutagenesis
Biochemistry, 39, 2000
1DZZ
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BU of 1dzz by Molmil
L-Fuculose-1-Phosphate Aldolase from Escherichia coli Mutant Y113F
Descriptor: BETA-MERCAPTOETHANOL, L-fuculose phosphate aldolase, SULFATE ION, ...
Authors:Joerger, A.C, Schulz, G.E.
Deposit date:2000-03-07
Release date:2000-06-02
Last modified:2019-09-25
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:Catalytic Action of Fuculose 1-Phosphate Aldolase (Class II) as Derived from Structure-Directed Mutagenesis
Biochemistry, 39, 2000
3ZME
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BU of 3zme by Molmil
Structure of the p53 core domain mutant Y220C bound to the small molecule PhiKan7242
Descriptor: 2-(4-(4-fluorophenyl)-5-(1H-pyrrol-1-yl)-1H-pyrazol-1-yl)-N,N-dimethylethanamine, Cellular tumor antigen p53, ZINC ION
Authors:Joerger, A.C, Wilcken, R.
Deposit date:2013-02-07
Release date:2013-05-08
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Small molecule induced reactivation of mutant p53 in cancer cells.
Nucleic Acids Res., 41, 2013
7BE4
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BU of 7be4 by Molmil
Crystal structure of MAP kinase p38 alpha in complex with inhibitor SR159
Descriptor: 5-azanyl-~{N}-[[4-[[(2~{S})-4-cyclohexyl-1-[[(3~{R})-1-methylsulfonylpiperidin-3-yl]amino]-1-oxidanylidene-butan-2-yl]carbamoyl]phenyl]methyl]-1-phenyl-pyrazole-4-carboxamide, Mitogen-activated protein kinase 14
Authors:Joerger, A.C, Schroeder, M, Roehm, S, Knapp, S, Structural Genomics Consortium (SGC)
Deposit date:2020-12-22
Release date:2021-03-03
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Development of a Selective Dual Discoidin Domain Receptor (DDR)/p38 Kinase Chemical Probe.
J.Med.Chem., 64, 2021
7BE5
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BU of 7be5 by Molmil
Crystal structure of MAP kinase p38 alpha in complex with inhibitor SR276
Descriptor: 1,2-ETHANEDIOL, 5-azanyl-~{N}-[[4-[[(2~{S})-4-cyclohexyl-1-[[(3~{R})-1-methylsulfonylpiperidin-3-yl]amino]-1-oxidanylidene-butan-2-yl]carbamoyl]phenyl]methyl]-1-methyl-pyrazole-4-carboxamide, Mitogen-activated protein kinase 14
Authors:Joerger, A.C, Schroeder, M, Roehm, S, Knapp, S, Structural Genomics Consortium (SGC)
Deposit date:2020-12-22
Release date:2021-03-03
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.8000524 Å)
Cite:Development of a Selective Dual Discoidin Domain Receptor (DDR)/p38 Kinase Chemical Probe.
J.Med.Chem., 64, 2021
5LAP
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BU of 5lap by Molmil
p53 cancer mutant Y220C with Cys182 alkylation
Descriptor: 5-chloranylpyrimidine-4-carboxylic acid, Cellular tumor antigen p53, ZINC ION
Authors:Joerger, A.C, Bauer, M.R, Fersht, A.R.
Deposit date:2016-06-14
Release date:2016-08-10
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.42 Å)
Cite:2-Sulfonylpyrimidines: Mild alkylating agents with anticancer activity toward p53-compromised cells.
Proc.Natl.Acad.Sci.USA, 113, 2016
6GGD
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BU of 6ggd by Molmil
p53 cancer mutant Y220C in complex with small-molecule stabilizer PK9324
Descriptor: Cellular tumor antigen p53, GLYCEROL, ZINC ION, ...
Authors:Joerger, A.C, Bauer, M.R.
Deposit date:2018-05-03
Release date:2019-05-22
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.40000892 Å)
Cite:A structure-guided molecular chaperone approach for restoring the transcriptional activity of the p53 cancer mutant Y220C.
Future Med Chem, 11, 2019
6GGB
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BU of 6ggb by Molmil
p53 cancer mutant Y220C in complex with small-molecule stabilizer PK9318
Descriptor: 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Cellular tumor antigen p53, ...
Authors:Joerger, A.C, Bauer, M.R.
Deposit date:2018-05-03
Release date:2019-05-22
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.32 Å)
Cite:A structure-guided molecular chaperone approach for restoring the transcriptional activity of the p53 cancer mutant Y220C.
Future Med Chem, 11, 2019
6GGA
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BU of 6gga by Molmil
p53 cancer mutant Y220C in complex with small-molecule stabilizer PK9284
Descriptor: (7-bromanyl-9-ethyl-carbazol-3-yl)methyl-methyl-azanium, Cellular tumor antigen p53, ZINC ION
Authors:Joerger, A.C, Bauer, M.R.
Deposit date:2018-05-03
Release date:2019-05-22
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.55000126 Å)
Cite:A structure-guided molecular chaperone approach for restoring the transcriptional activity of the p53 cancer mutant Y220C.
Future Med Chem, 11, 2019
6GGE
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BU of 6gge by Molmil
p53 cancer mutant Y220C in complex with small-molecule stabilizer PK9327
Descriptor: Cellular tumor antigen p53, ZINC ION, [9-ethyl-7-(5-methylthiophen-2-yl)carbazol-3-yl]methyl-methyl-azanium
Authors:Joerger, A.C, Bauer, M.R.
Deposit date:2018-05-03
Release date:2019-05-22
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.25000513 Å)
Cite:A structure-guided molecular chaperone approach for restoring the transcriptional activity of the p53 cancer mutant Y220C.
Future Med Chem, 11, 2019
6GGC
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BU of 6ggc by Molmil
p53 cancer mutant Y220C in complex with small-molecule stabilizer PK9320
Descriptor: 1,2-ETHANEDIOL, Cellular tumor antigen p53, GLYCEROL, ...
Authors:Joerger, A.C.
Deposit date:2018-05-03
Release date:2019-05-22
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.24 Å)
Cite:A structure-guided molecular chaperone approach for restoring the transcriptional activity of the p53 cancer mutant Y220C.
Future Med Chem, 11, 2019

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