7BE5
Crystal structure of MAP kinase p38 alpha in complex with inhibitor SR276
Summary for 7BE5
Entry DOI | 10.2210/pdb7be5/pdb |
Descriptor | Mitogen-activated protein kinase 14, 1,2-ETHANEDIOL, 5-azanyl-~{N}-[[4-[[(2~{S})-4-cyclohexyl-1-[[(3~{R})-1-methylsulfonylpiperidin-3-yl]amino]-1-oxidanylidene-butan-2-yl]carbamoyl]phenyl]methyl]-1-methyl-pyrazole-4-carboxamide, ... (4 entities in total) |
Functional Keywords | mapk14, kinase inhibitor, structure-guided design, structural genomics consortium, transferase |
Biological source | Mus musculus (Mouse) |
Total number of polymer chains | 1 |
Total formula weight | 42121.11 |
Authors | Joerger, A.C.,Schroeder, M.,Roehm, S.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2020-12-22, release date: 2021-03-03, Last modification date: 2024-01-31) |
Primary citation | Rohm, S.,Berger, B.T.,Schroder, M.,Chatterjee, D.,Mathea, S.,Joerger, A.C.,Pinkas, D.M.,Bufton, J.C.,Tjaden, A.,Kovooru, L.,Kudolo, M.,Pohl, C.,Bullock, A.N.,Muller, S.,Laufer, S.,Knapp, S. Development of a Selective Dual Discoidin Domain Receptor (DDR)/p38 Kinase Chemical Probe. J.Med.Chem., 64:13451-13474, 2021 Cited by PubMed: 34506142DOI: 10.1021/acs.jmedchem.1c00868 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.80005236022 Å) |
Structure validation
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