6GGA

p53 cancer mutant Y220C in complex with small-molecule stabilizer PK9284

Summary for 6GGA

DescriptorCellular tumor antigen p53, (7-bromanyl-9-ethyl-carbazol-3-yl)methyl-methyl-azanium, ZINC ION, ... (4 entities in total)
Functional Keywordsp53, transcription factor, tumor supressor, cancer therapy, oncogenic mutant, protein misfolding, small-molecule stabilizer, molecular chaperone, dna binding protein
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total molecular weight49828.9
Authors
Joerger, A.C.,Bauer, M.R. (deposition date: 2018-05-03, release date: 2019-05-22)
Primary citation
Jones, R.N.,Bauer, M.R.,Springett, B.,Dingler, F.A.,Verduci, L.,Patel, K.J.,Fersht, A.R.,Joerger, A.C.,Spencer, J.
A structure-guided molecular chaperone approach for restoring the transcriptional activity of the p53 cancer mutant Y220C
to be published,
Experimental method
X-RAY DIFFRACTION (1.55000123008 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.20030 0.6% 8.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution