6GGB
p53 cancer mutant Y220C in complex with small-molecule stabilizer PK9318
Summary for 6GGB
Entry DOI | 10.2210/pdb6ggb/pdb |
Descriptor | Cellular tumor antigen p53, ZINC ION, [9-ethyl-7-(4-methylthiophen-2-yl)carbazol-3-yl]methyl-methyl-azanium, ... (7 entities in total) |
Functional Keywords | p53, transcription factor, tumor supressor, cancer therapy, oncogenic mutant, protein misfolding, small-molecule stabilizer, molecular chaperone, dna binding protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 50255.88 |
Authors | Joerger, A.C.,Bauer, M.R. (deposition date: 2018-05-03, release date: 2019-05-22, Last modification date: 2024-01-17) |
Primary citation | Bauer, M.R.,Jones, R.N.,Tareque, R.K.,Springett, B.,Dingler, F.A.,Verduci, L.,Patel, K.J.,Fersht, A.R.,Joerger, A.C.,Spencer, J. A structure-guided molecular chaperone approach for restoring the transcriptional activity of the p53 cancer mutant Y220C. Future Med Chem, 11:2491-2504, 2019 Cited by PubMed: 31633398DOI: 10.4155/fmc-2019-0181 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.32 Å) |
Structure validation
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